Geropharmacology Beers Criteria Quiz

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Questions and Answers

Which of the following is the primary intent of the Beers Criteria?

Function as a research tool

Serve as an educational tool

Improve care by decreasing exposure to PIMs (correct)

Act as a quality measure

What is the primary focus of the Beers Criteria?

Assessment of common adherence issues

Identification of potentially inappropriate medications in elderly patients (correct)

Promotion of optimal prescribing patterns

Evaluation of CYP450 enzyme activity

What is the main focus of the drugs listed under 'Drugs to Avoid (except if...)' in the Beers Criteria?

Falls risk

Increased cardiovascular death

Cognitive effects (correct)

Anticholinergic effects

Which enzyme is associated with metabolizing the highest percentage of prescription drugs?

CYP3A4 Signup and view all the answers

In which category do proton pump inhibitors (PPIs) fall under in the Beers Criteria?

Drugs to avoid in specific diseases Signup and view all the answers

What was the focus of the 2015 revision of the Beers Criteria?

Research on Potentially Inappropriate Medicines (PIMs) Signup and view all the answers

Among the drugs mentioned in the Beers Criteria, which one has a potential risk of hypoglycemia?

Sulfonylureas Signup and view all the answers

Which publication featured the 2015 revision of the Beers Criteria?

Journal of American Geriatrics Society Signup and view all the answers

Which drug category in the Beers Criteria is associated with falls risk?

Muscle relaxants Signup and view all the answers

In which year did Dr. Mark H. Beers initially create the Beers Criteria?

1991 Signup and view all the answers

What is the goal of drugs listed under 'Drugs to Avoid in Renal Failure' in the Beers Criteria?

Minimize anticholinergic effects Signup and view all the answers

Which of the following drug classes is most likely to be associated with drug-drug interactions with warfarin due to CYP450 enzyme involvement?

NSAIDs Signup and view all the answers

What is the potential outcome of combining steroids with NSAIDs due to CYP450 enzyme interactions?

PUD, GI bleeding Signup and view all the answers

Which cardiovascular drug should be used with caution in patients with renal failure, considering CYP450 metabolism?

Fondaparinux Signup and view all the answers

Which of the following drug classes is NOT linked with SIADH (Syndrome of Inappropriate Antidiuretic Hormone) secretion?

Trazodone Signup and view all the answers

What is a common outcome of drug-drug interactions involving ACE inhibitors and amiloride/triamterene?

Hyperkalemia Signup and view all the answers

Which of the following drugs interacts with loop diuretics through CYP450 enzymes leading to adverse effects?

Alpha-blockers Signup and view all the answers

Which gastrointestinal drug should be used with caution in renal failure patients due to its metabolism?

Famotidine Signup and view all the answers

Which class of drugs would require caution when used concomitantly with theophylline due to potential CYP450 interactions?

Oral decongestants Signup and view all the answers

What can be a consequence of combining anticholinergic drugs such as antihistamines with tricyclic antidepressants due to CYP450 interactions?

Insomnia Signup and view all the answers

Which CNS drug should be used cautiously in renal failure patients considering its effects on kidney function?

Gabapentin Signup and view all the answers

Study Notes

Beers Criteria Overview

Primary intent is to improve the safety of prescribing medications for older adults, minimizing the risk of adverse drug events.
Focuses on identifying medications that are potentially inappropriate for use in older adults.
Lists 'Drugs to Avoid (except if...)' addressing those that may be harmful unless specific conditions are met.

Medication Metabolism and Risk

CYP450 enzyme, particularly CYP2D6 and CYP3A4, metabolizes a high percentage of prescription drugs.
Proton pump inhibitors (PPIs) fall into the category of medications to use with caution in older adults.
The 2015 revision of the Beers Criteria emphasized improving clinical utility and evidence-base for recommended medications.

Drug-Specific Risks

Potential hypoglycemia risk is associated with sulfonylureas, a class mentioned in the Beers Criteria.
The 2015 revision was published in the "Journal of the American Geriatrics Society."
Drugs associated with falls risk include benzodiazepines and certain anticonvulsants.

Historical Context

Dr. Mark H. Beers initially created the Beers Criteria in 1991.
Drugs listed under 'Drugs to Avoid in Renal Failure' aim to prevent worsening renal function and adverse effects in susceptible patients.

Drug Interactions

Anticoagulants like warfarin are most likely to have drug-drug interactions due to CYP450 enzymes.
Combining steroids with NSAIDs can increase the risk of gastrointestinal bleeding and renal issues.
Caution is advised with the use of digoxin in patients with renal failure due to its renal metabolism pathway.

Drug Classes and Effects

The class of drugs not linked with SIADH includes certain non-psychotropic medications.
Common outcomes of drug-drug interactions involving ACE inhibitors and amiloride/triamterene can include hyperkalemia.
Loop diuretics may interact adversely with NSAIDs, potentially leading to decreased diuretic efficacy.

Renal Considerations

Caution is suggested for the use of metformin in renal failure patients due to its renal clearance.
Theophylline may require caution when used with certain antibiotic classes, as they can affect its metabolism.
Combining anticholinergic drugs (like antihistamines) with tricyclic antidepressants could lead to increased anticholinergic side effects and toxicity.
Caution is recommended for using certain CNS drugs, like certain antidepressants, in renal failure patients due to their potential nephrotoxic effects.

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Description

Test your knowledge on the Beers Criteria in Geropharmacology. Learn about the intent of the criteria, its categories, and drugs to avoid in older adults. Understand how these criteria aim to improve care by decreasing exposure to potentially inappropriate medications.