GERD and PUD Pathophysiology Quiz
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Questions and Answers

Which of the following is a risk factor for Peptic Ulcer Disease (PUD)?

  • Hypertension
  • Diabetes mellitus
  • Asthma
  • Stress-related mucosal damage (correct)

What is a common cause of Peptic Ulcer Disease (PUD) extending deep into the gastrointestinal mucosa?

  • NSAID use (correct)
  • Hormonal imbalance
  • Bacterial infection
  • Excessive fiber intake

Which of the following is NOT a risk factor for Peptic Ulcer Disease (PUD)?

  • NSAID use
  • Fruit and vegetable intake (correct)
  • H. pylori infection
  • Alcohol consumption

What is the main bacterial cause associated with Peptic Ulcer Disease (PUD)?

<p>H. pylori (A)</p> Signup and view all the answers

How can Stress-Related Mucosal Damage (SRMD) occur?

<p>By taking NSAIDs (C)</p> Signup and view all the answers

Which diagnostic method is commonly used for Gastroesophageal Reflux Disease (GERD)?

<p>Endoscopy (D)</p> Signup and view all the answers

What is the main mechanism through which NSAIDs contribute to peptic ulcer disease (PUD)?

<p>Inhibition of prostaglandin synthesis (A)</p> Signup and view all the answers

Which of the following risk factors is NOT associated with peptic ulcer disease (PUD)?

<p>Regular exercise routine (B)</p> Signup and view all the answers

What is one of the key risk factors for Stress Related Mucosal Damage (SRMD) in an ICU setting?

<p>Mechanical ventilation for more than 48 hours (A)</p> Signup and view all the answers

How is Helicobacter pylori typically transmitted?

<p>Contaminated water (C)</p> Signup and view all the answers

Which of the following statements about GERD diagnosis is TRUE?

<p>ALARMD symptoms should be present for endoscopy to be warranted. (D)</p> Signup and view all the answers

What is a common way in which H. pylori contributes to peptic ulcer disease?

<p>Producing urease, lipases, and proteases (C)</p> Signup and view all the answers

What is the main defense mechanism against reflux in Gastroesophageal Reflux Disease (GERD)?

<p>Lower Esophageal Sphincter (LES) relaxation during swallowing (C)</p> Signup and view all the answers

Which of the following is NOT a risk factor for Gastroesophageal Reflux Disease (GERD)?

<p>Recent onset of symptoms (&lt;3 months) (C)</p> Signup and view all the answers

Which cell type secretes histamine in the stomach and contributes to gastric acid secretion?

<p>Enterochromaffin-Like (ECL) Cells (B)</p> Signup and view all the answers

What is the main role of Parietal Cells in the stomach?

<p>Secretion of gastric acid via H-K-ATPase (C)</p> Signup and view all the answers

Which of the following medications is NOT listed as a risk factor for Gastroesophageal Reflux Disease (GERD)?

<p>Potassium Chloride (A)</p> Signup and view all the answers

What is the acid pH range that activates pepsin from its inactive precursor, pepsinogen?

<p>$1.5-3.5$ (C)</p> Signup and view all the answers

What is the main function of Surface Mucus Cells in the stomach?

<p>Secretion of bicarbonate and mucus (B)</p> Signup and view all the answers

What is the main risk factor for Stress Related Mucosal Damage (SRMD) in an ICU setting?

<p>Mechanical ventilation over 48 hours (D)</p> Signup and view all the answers

What is a common method of transmission for H. pylori?

<p>Fecal-oral transmission (A)</p> Signup and view all the answers

Which factor contributes to NSAID-induced Peptic Ulcer Disease (PUD)?

<p>Decreased bicarbonate secretion (D)</p> Signup and view all the answers

What is a key feature of Helicobacter pylori that aids in its pathogenesis?

<p>Production of urease (B)</p> Signup and view all the answers

What is a significant risk factor for Gastroesophageal Reflux Disease (GERD)?

<p>High alcohol consumption (D)</p> Signup and view all the answers

Which characteristic is associated with Stress Related Mucosal Damage (SRMD) in an ICU setting?

<p>High dose steroids use (A)</p> Signup and view all the answers

What is the main difference between Symptomatic heart burn without injury and with injury?

<p>The development of esophagitis (D)</p> Signup and view all the answers

Which condition is characterized by symptoms like cough, laryngitis, and wheezing?

<p>Barrett’s Esophagus (B)</p> Signup and view all the answers

What is the underlying cause of Upper GI bleed in Peptic Ulcer Disease (PUD)?

<p>Ulcerous erosion into an artery (A)</p> Signup and view all the answers

What contributes to the development of Gastric outlet obstruction in Peptic Ulcer Disease (PUD)?

<p>Mechanical obstruction caused by scarring (C)</p> Signup and view all the answers

How do Parietal cells affect ulcer healing in Peptic Ulcer Disease (PUD)?

<p>Impedes ulcer healing (C)</p> Signup and view all the answers

Which factor leads to an increased risk of Gastrointestinal Bleeding (GIB) in Peptic Ulcer Disease (PUD)?

<p>Platelet disaggregation and impaired clot formation (C)</p> Signup and view all the answers

What is the main defense mechanism that separates the gastric and esophageal lumens from each other?

<p>Thickening of the smooth muscle lining of the distal esophagus (D)</p> Signup and view all the answers

Which of the following factors contributes to nocturnal Gastroesophageal Reflux Disease (GERD)?

<p>Decreased saliva production while sleeping (C)</p> Signup and view all the answers

What is the main function of Chief Cells in the stomach?

<p>Synthesizes and secretes pepsinogen (B)</p> Signup and view all the answers

Which of the following factors can directly irritate the stomach mucosa in Gastroesophageal Reflux Disease (GERD)?

<p>High fat meals (D)</p> Signup and view all the answers

What is a common symptom associated with Gastroesophageal Reflux Disease (GERD) that differentiates it from typical symptoms?

<p>Melena or hematemesis (D)</p> Signup and view all the answers

Which cell type secretes histamine in the stomach and contributes to gastric acid secretion?

<p>ECL cells (D)</p> Signup and view all the answers

What is the main role of Surface Mucus Cells in the stomach?

<p>Protects the epithelial cell surface with a mucus layer (A)</p> Signup and view all the answers

How do H2 receptor antagonists (H2RAs) reduce acid secretion?

<p>By binding to H2 receptors on the basolateral surface of parietal cells (A)</p> Signup and view all the answers

What is the main therapeutic use of H2 antagonists?

<p>Treatment of gastric, duodenal, and stress ulcers (D)</p> Signup and view all the answers

Which drug class blocks acid secretion by inhibiting the H+/K+ ATPase enzyme in parietal cells?

<p>Proton pump inhibitors (B)</p> Signup and view all the answers

What is the mechanism of action of H2 receptor antagonists in reducing acid secretion?

<p>Blocking histamine binding to H2 receptors on parietal cells (A)</p> Signup and view all the answers

What effect does more frequent initial dosing of proton pump inhibitors (PPIs) have on the time to achieve full inhibition?

<p>Decreases the time to achieve full inhibition (A)</p> Signup and view all the answers

What is the main effect of PPIs on acid secretion in the stomach?

<p>Acid secretion is suppressed for 24-48 hours (C)</p> Signup and view all the answers

Which ethnic group is more likely to have a CYP2C19 genotype associated with slow metabolism of PPIs?

<p>Asians (C)</p> Signup and view all the answers

How do omeprazole and esomeprazole affect the elimination of phenytoin, diazepam, and warfarin in the body?

<p>Decrease their elimination (B)</p> Signup and view all the answers

Which of the following is a contraindication for using bismuth subsalicylate?

<p>Active bleeding ulcer (A)</p> Signup and view all the answers

What is a potential consequence of high usage of bismuth subsalicylate?

<p>Salicylate toxicity (A)</p> Signup and view all the answers

Which medication's effectiveness may be decreased by bismuth subsalicylate?

<p>Lisinopril (C)</p> Signup and view all the answers

What can cause harmless darkening of the tongue when using liquid formulations?

<p>Allergic reaction (B)</p> Signup and view all the answers

What is the primary function of bismuth subsalicylate when used for the treatment of gastrointestinal symptoms?

<p>To coat ulcers and erosions as a protective layer (A)</p> Signup and view all the answers

How is bismuth subsalicylate excreted from the body?

<p>Minimally absorbed (less than 1%) and excreted in stool (B)</p> Signup and view all the answers

What warning is associated with bismuth subsalicylate regarding its use?

<p>It can cause Reye's syndrome if overlapped with other salicylates (D)</p> Signup and view all the answers

Which of the following is NOT a known function of bismuth subsalicylate?

<p>Enhance bile secretion (B)</p> Signup and view all the answers

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