Podcast
Questions and Answers
What is the effect of SNPs in the GLCC1 gene for asthma patients?
What is the effect of SNPs in the GLCC1 gene for asthma patients?
- Enhanced muscle growth
- Increased risk of developing cancer
- Protein alteration may occur (correct)
- Decreased sensitivity to pain
How does Thiopurine S-methyltransferase (TPMT) activity affect the efficacy of 6-MP drug?
How does Thiopurine S-methyltransferase (TPMT) activity affect the efficacy of 6-MP drug?
- It enhances the drug's potency
- It has no impact on the drug's efficacy
- It reduces the drug's toxicity
- It affects the drug's efficacy based on metabolism rate (correct)
What is the function of Herceptin (trastuzumab) in relation to the aberrant Her-2 gene?
What is the function of Herceptin (trastuzumab) in relation to the aberrant Her-2 gene?
- It inhibits the normal functioning of the gene
- It blocks the overexpressed cell surface receptor (correct)
- It enhances the expression of the aberrant gene
- It has no impact on the gene
What is the role of Cytochrome oxidase P450 enzymes in drug metabolism?
What is the role of Cytochrome oxidase P450 enzymes in drug metabolism?
What is the potential implication of personalized genomic medicine?
What is the potential implication of personalized genomic medicine?
What is the main concern associated with genomic testing according to the text?
What is the main concern associated with genomic testing according to the text?
What is the basis for human genetic diversity as mentioned in the text?
What is the basis for human genetic diversity as mentioned in the text?
What is the purpose of DNA fingerprinting as mentioned in the text?
What is the purpose of DNA fingerprinting as mentioned in the text?
What is the minimum number of STRs used in DNA fingerprinting in forensics?
What is the minimum number of STRs used in DNA fingerprinting in forensics?
What is the role of copy number variation (CNV) in human genetic diversity?
What is the role of copy number variation (CNV) in human genetic diversity?
What is the potential application of human genetic diversity in forensics?
What is the potential application of human genetic diversity in forensics?
What does GWAS stand for?
What does GWAS stand for?
What is the main focus of pharmacogenomics?
What is the main focus of pharmacogenomics?
What is the difference between pharmacogenomics and pharmacogenetics?
What is the difference between pharmacogenomics and pharmacogenetics?
What is the purpose of genotyping chips in the context of GWAS?
What is the purpose of genotyping chips in the context of GWAS?
What is the main concern regarding some GWAS findings?
What is the main concern regarding some GWAS findings?
What is the focus of pharmacogenetics?
What is the focus of pharmacogenetics?
What is the primary concern with rare variants in the context of GWAS?
What is the primary concern with rare variants in the context of GWAS?
What is the aim of precision/personalized medicine in the context of GWAS?
What is the aim of precision/personalized medicine in the context of GWAS?
What is the significance of SNPs in the context of GWAS?
What is the significance of SNPs in the context of GWAS?
What is the primary focus of twin studies in the context of GWAS?
What is the primary focus of twin studies in the context of GWAS?
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Study Notes
Genomics and Pharmacogenomics Overview
- Genome-wide association studies (GWAS) examine SNPs to understand gene regulation in diseases like diabetes type 2
- GWAS identify common genetic variants, but not all heritability is explained, especially in complex diseases like diabetes
- Pharmacogenomics aims to predict drug response based on genetic variation for personalized treatment
- SNPs can alter protein function, affecting drug efficacy, such as in asthma patients with SNPs in the GLCC1 gene
- Pharmacogenomics has applications in modifying drug dosage or prescribing alternative drugs for personalized treatment
- Examples of pharmacogenomics applications include 6-MP for acute lymphoblastic leukemia and Trastuzumab for Her-2 gene variants
- Cytochrome P450 enzyme variants can affect drug metabolism and response, influencing personalized medicine
- Personalized genomic medicine is based on individual genome for medical care, with implications for precision medicine and consumer genomics
- The Filipino Genome Research Project aims to study the genomic diversity among ethnolinguistic groups in the Philippines
- Genomic testing raises concerns about education, insurance coverage, unwanted information, and genetic discrimination
- Genetic polymorphisms include single nucleotide polymorphisms (SNPs) and copy number variations (CNV), which contribute to human genetic diversity
- DNA fingerprinting uses genetic variations for identification and forensics, with a minimum number of loci required for accurate testing.
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