18 Questions
What is the result of acetylation of lysine side chains by histone acetyl transferases?
Reduced positive charge on nucleosomes
What is the effect of histone deacetylases on gene transcription?
It inhibits transcription by compacting nucleosomes
Which histone modification is associated with gene activation?
H3K4me
What is the function of histone demethylases?
To remove methyl groups from histones
What is the result of histone H3 lysine 9 methylation?
Inhibition of gene transcription
What is the role of enzymes in chromatin structure regulation?
They actively regulate chromatin structure by modifying histones
What is the primary function of bromodomains in HATs?
To recognize acetylated histone marks
What is the result of competition between histone acetylation and histone methylation?
The specific histone modification that occurs depends on the specific amino acid position
How are histone modifications inherited by daughter cells?
Through the inheritance of modified histone proteins
What is the function of MeCP2 in DNA methylation?
To recognize methylated cytosine residues
What is the result of DNA methylation in the context of CpG islands?
The inhibition of gene expression
How are histone deacetylation and DNA methylation coordinated?
Through the recognition of methylated cytosine residues by MeCP2
What is the primary function of histone H3 lysine 9 methylation in chromatin compaction?
To drive local chromatin compaction
Which type of elements is subject to high levels of DNA methylation?
Repetitive elements
What is the role of histone deacetylases in chromatin compaction?
To remove acetyl groups from histones
What is the function of insulators in chromatin compaction?
To attenuate the lateral spread of modifications
How is the initiation of heterochromatin formation driven?
Through DNA binding proteins that recognize specific DNA sequences
What is the effect of cytosine methylation on gene expression?
It represses gene expression
Learn about pseudogenes, repetitive sequences, and their impact on genome instability. Discover how errors during DNA repair can lead to genetic disorders like Williams Syndrome. Explore epigenetic modification of histones and enzymes.
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