Genetics Quiz on Mutations

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Questions and Answers

A mutation that occurs when a base is inserted into or deleted from a DNA sequence completely altering an entire amino acid sequence is called:

  • Missense mutation
  • Nonsense mutation
  • Frameshift Mutation (correct)
  • Silent mutation

DNA glycosylases are involved specifically with which of the following repair mechanisms?

  • Base excision repair (correct)
  • UV repair mechanism
  • Post-replicative repair
  • Mismatch repair

When a mutation in a gene that alters a codon, but the resulting new codon translates for the same amino acid, it can be referred to as a...

  • Nonsense mutation
  • Silent mutation (correct)
  • Insertion
  • Deletion

Flashcards

Frameshift Mutation

A type of mutation where an insertion or deletion of one or more nucleotides in a DNA sequence shifts the reading frame, altering the entire sequence of amino acids downstream.

Base Excision Repair

A DNA repair mechanism that removes damaged or incorrect bases from DNA, primarily by using DNA glycosylases.

Silent Mutation

Mutations that change a codon but still code for the same amino acid. This leads to no change in the protein produced.

Missense Mutation

A mutation where a codon is altered, resulting in a different amino acid being incorporated into the protein.

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Nonsense Mutation

A mutation where a codon is changed to a stop codon, prematurely terminating protein synthesis.

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Mismatch Repair

A type of DNA repair that fixes errors that occur during DNA replication.

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DNA Glycosylase

DNA glycosylases are enzymes involved in removing damaged or incorrect bases from DNA. They are the first step in base excision repair.

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Nonsense Mutation

A mutation where a codon is changed to one that codes for a stop codon, resulting in premature termination of protein synthesis.

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Post Replicative Repair

A group of repair mechanisms that operate after DNA replication has been completed, fixing any remaining errors. These mechanisms are often less efficient than other repair mechanisms.

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Silent Mutation

Mutations in a gene that do not change the amino acid sequence even though the codon may be different.

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Study Notes

Mutations

  • A mutation that completely alters an amino acid sequence by inserting or deleting a base is called a frameshift mutation
  • DNA glycosylases are involved in base excision repair
  • When a codon is changed but still results in the same amino acid, it's called a silent mutation.

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