Podcast
Questions and Answers
What does incomplete dominance refer to in genetics?
What does incomplete dominance refer to in genetics?
- The phenotype is a blend of the two alleles. (correct)
- Both alleles are completely expressed.
- Only one allele is active while the other is silent.
- One allele masks the expression of another.
Which of the following is true about codominance?
Which of the following is true about codominance?
- Only one allele is expressed at a time.
- Both alleles are expressed simultaneously. (correct)
- It occurs only in lethal alleles.
- It results in a completely different phenotype.
What is an example of lethal alleles?
What is an example of lethal alleles?
- Alleles that never show phenotypic expression.
- Alleles that cause disease only when inherited from one parent.
- Alleles that express a dominant trait only.
- Alleles that result in offspring mortality when homozygous. (correct)
How do genes interact to create more complex phenotypes?
How do genes interact to create more complex phenotypes?
What is genomic imprinting?
What is genomic imprinting?
Epigenetics primarily studies what aspect of genetics?
Epigenetics primarily studies what aspect of genetics?
What is the double helix structure of DNA formed from?
What is the double helix structure of DNA formed from?
Which component is NOT part of the DNA structure?
Which component is NOT part of the DNA structure?
What is the primary goal of pharmacogenetic testing?
What is the primary goal of pharmacogenetic testing?
Which of the following is a method used for delivering genes in gene therapy?
Which of the following is a method used for delivering genes in gene therapy?
What is the focus of preimplantation genetic diagnosis?
What is the focus of preimplantation genetic diagnosis?
How does cytochrome P450 contribute to pharmacogenomics?
How does cytochrome P450 contribute to pharmacogenomics?
What is one of the aims of utilizing genetic information in precision medicine?
What is one of the aims of utilizing genetic information in precision medicine?
What is the first step in the transcription process?
What is the first step in the transcription process?
Which sugar is used in RNA that differs from DNA?
Which sugar is used in RNA that differs from DNA?
What base is found in RNA that is not present in DNA?
What base is found in RNA that is not present in DNA?
During which phase of transcription does RNA polymerase synthesize RNA?
During which phase of transcription does RNA polymerase synthesize RNA?
What is added to the RNA during post-transcription processing?
What is added to the RNA during post-transcription processing?
Which term refers to the final step of transcription?
Which term refers to the final step of transcription?
What does the process of translation involve?
What does the process of translation involve?
Which part of the process is responsible for reading the genetic code?
Which part of the process is responsible for reading the genetic code?
What is the typical size comparison of prokaryotic cells to eukaryotic cells?
What is the typical size comparison of prokaryotic cells to eukaryotic cells?
What is the function of the plasma membrane in a cell?
What is the function of the plasma membrane in a cell?
What is the term for alternative versions of a gene?
What is the term for alternative versions of a gene?
Which structure primarily protects prokaryotic cells from pressure changes?
Which structure primarily protects prokaryotic cells from pressure changes?
How many copies of each gene do most individuals inherit from their parents?
How many copies of each gene do most individuals inherit from their parents?
What is the difference between genes on sex chromosomes in males compared to females?
What is the difference between genes on sex chromosomes in males compared to females?
What term describes the liquid interior of a cell?
What term describes the liquid interior of a cell?
What is a locus?
What is a locus?
What distinguishes eukaryotic cells from prokaryotic cells?
What distinguishes eukaryotic cells from prokaryotic cells?
How is the DNA organized in prokaryotic cells?
How is the DNA organized in prokaryotic cells?
Human eye color is determined by how many genes?
Human eye color is determined by how many genes?
Which of the following statements about eukaryotic cells is correct?
Which of the following statements about eukaryotic cells is correct?
What do phenotypes refer to?
What do phenotypes refer to?
In which phase do most cells typically grow and prepare for division?
In which phase do most cells typically grow and prepare for division?
What is the role of the nucleus in eukaryotic cells?
What is the role of the nucleus in eukaryotic cells?
What term describes the life cycle of a typical somatic cell?
What term describes the life cycle of a typical somatic cell?
Which of the following statements about the publication rights of the book is true?
Which of the following statements about the publication rights of the book is true?
What year was this edition of the book published?
What year was this edition of the book published?
What must one do to gain permission to reproduce parts of the book?
What must one do to gain permission to reproduce parts of the book?
Which entity is not mentioned as a trademark associated with the book?
Which entity is not mentioned as a trademark associated with the book?
Which of the following best describes the liability disclaimer presented by the publisher?
Which of the following best describes the liability disclaimer presented by the publisher?
What is the main purpose of the disclaimer in this publication?
What is the main purpose of the disclaimer in this publication?
Which publication format is mentioned in the copyright statement?
Which publication format is mentioned in the copyright statement?
Who are the authors of the book?
Who are the authors of the book?
Flashcards
Genetics
Genetics
The study of genes, heredity, and variation in living organisms.
Gene
Gene
A specific location on a chromosome that contains the genetic instructions for a trait.
Genome
Genome
The complete set of genetic instructions for an organism, encoded in DNA.
Alleles
Alleles
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Genotype
Genotype
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Phenotype
Phenotype
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Heredity
Heredity
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Mutations
Mutations
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Predictive testing
Predictive testing
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Susceptibility testing
Susceptibility testing
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Preimplantation genetic diagnosis (PGD)
Preimplantation genetic diagnosis (PGD)
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Pharmacogenetic testing
Pharmacogenetic testing
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Gene therapy
Gene therapy
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Incomplete Dominance
Incomplete Dominance
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Codominance
Codominance
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Incomplete Penetrance
Incomplete Penetrance
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Multiple Alleles
Multiple Alleles
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Lethal Allele
Lethal Allele
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Gene Interaction
Gene Interaction
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Pleiotropy
Pleiotropy
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Linked Genes
Linked Genes
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Messenger RNA (mRNA)
Messenger RNA (mRNA)
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Transcription
Transcription
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Ribonucleic Acid (RNA)
Ribonucleic Acid (RNA)
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Uracil (U)
Uracil (U)
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Promoter
Promoter
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Terminator
Terminator
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5' Cap
5' Cap
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Poly-A Tail
Poly-A Tail
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Plasma membrane
Plasma membrane
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Cell wall
Cell wall
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Cytoplasm
Cytoplasm
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Prokaryotic DNA
Prokaryotic DNA
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Eukaryotes
Eukaryotes
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Nucleus
Nucleus
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Chromosomes
Chromosomes
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Homeostasis
Homeostasis
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Locus
Locus
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Homologous chromosomes
Homologous chromosomes
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Mitosis
Mitosis
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Somatic cell
Somatic cell
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Study Notes
Genetics Overview
- Genetics, 4th edition, by René Fester Kratz and Lisa J. Spock, is published by John Wiley & Sons.
- The book covers various aspects of genetics, including DNA structure, gene expression, genetic disorders, and applications of genetics in medicine.
Exceptions to Mendel's Laws
- Incomplete dominance: Blending of traits (e.g., red and white flowers producing pink)
- Codominance: Both traits expressed equally (e.g., AB blood type)
- Incomplete penetrance: A genotype may not always produce its associated phenotype.
- More than two alleles: Some genes have multiple different versions.
- Lethal alleles: Alleles causing death before reproduction.
- Gene interactions: Multiple genes influencing a single trait.
- Genes in hiding: Certain genes only express a trait under specific conditions.
- One gene with many phenotypes: A single gene can influence multiple traits.
- Linked genes: Genes located close together on the same chromosome.
- These are inherited together more often than expected by chance.
Epigenetics and Related Concepts
- Epigenetics: Changes in gene expression without alterations to the DNA sequence.
- Genomic imprinting: Expression of a gene depending on which parent it inherited from.
- Anticipation: A genetic trait becoming more severe or appearing earlier in subsequent generations.
- Environmental effects: Environmental factors influencing gene expression.
DNA Structure and Function
- DNA structure: Double helix composed of nucleotides.
- Nucleotides: Sugar, phosphate, and nitrogenous base (adenine, thymine, guanine, cytosine).
- Different DNA varieties: Rolling circle and D-loop are examples.
Transcription: DNA to RNA
- RNA structure: Similar to DNA except for a different sugar and uracil replacing thymine.
- Transcription steps: Initiation, elongation, termination.
- Post-transcription processing: Adding a cap and tail, editing the message.
Translation: RNA to Protein
- Genetic code: Three-nucleotide codons specify amino acids.
- Degenerate code: Multiple codons can code for the same amino acid.
- Translation steps: Initiation, elongation, termination.
Protein Function
- Proteins: Perform various functions in the body.
- Protein structure: Determined by the sequence of amino acids.
Genetic Testing and Applications
- Predictive testing: Identifies individuals at risk for developing genetic diseases.
- Susceptibility testing: Determines an individual's predisposition to developing a particular disease.
- Preimplantation genetic diagnosis (PGD): Testing embryos before implantation to identify genetic abnormalities.
- Pharmacogenetic testing: Testing to determine how a person's genes affect their response to drugs.
Treating Genetic Disorders
- Gene therapy: Introducing healthy genes to treat genetic diseases.
- Gene therapy methods: Using vectors like viruses to deliver healthy genes into cells.
- Precision medicine: Utilizing genetic information to tailor treatment to individual needs.
- Pharmacogenomics: Studying how a person's genes influence their response to drugs.
- Drug metabolism: How cytochrome P450 enzymes affect drug processing.
- Reducing treatment side effects.
- Increasing treatment effectiveness.
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