Genetics in Future Studies Quiz

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What is the main regulator of serotonin?

5-HTTLPR

What is the goal of pharmacogenetics?

To use genetic information to help personalize treatment.

According to the differential susceptibility hypothesis, who might benefit the most from interventions?

Those at greatest need

What type of studies are needed to predict which individuals are more suited to pharmacological or psychological therapy?

Future studies with large homogeneous samples Signup and view all the answers

What is an example of a biological mechanism that can explain how interventions work?

Epigenetics Signup and view all the answers

What did the authors of the study suggest as a reason for the mixed findings in the literature regarding the 5HTTLPR genotype and response to CBT for anxiety disorders?

Differences in study samples, methodology, and treatment protocols. Signup and view all the answers

How did children with the short (s) allele of the gene compare to children with the long (l) allele in terms of improvement in anxiety symptoms?

No significant difference in improvement was observed. Signup and view all the answers

What did the Genome Wide Analysis of MZ twin differences aim to identify?

Markers of environmental plasticity. Signup and view all the answers

In twin pairs who are more susceptible to environmental influences, what should be observed in terms of differences?

Larger differences should be observed. Signup and view all the answers

What can genetic variants associated with larger differences in MZ twins index?

Genes that govern plasticity. Signup and view all the answers

What is the main purpose of an intervention in medicine?

To help treat or cure a condition Signup and view all the answers

Explain why genetic risk is not deterministic.

DNA is just code and there are numerous developmental steps that can be interfered with. Signup and view all the answers

What is the significance of family studies in understanding antidepressant response?

Family studies can help determine if response to antidepressants runs in families due to shared environment or shared genes. Signup and view all the answers

What is the aim of Genome-wide Complex Trait Analysis (GCTA)?

To identify genes that influence behavior. Signup and view all the answers

Explain the concept of genome editing and its applications.

Genome editing involves adding, removing, or changing DNA sequences, and its applications include modifying crops and treating diseases like Sickle Cell disease. Signup and view all the answers

What does pharmacogenetics study?

Pharmacogenetics studies heritable differences in the metabolism and activity of drugs or environmental toxins. Signup and view all the answers

What did past meta-analyses reveal about the efficacy of antidepressants?

Past meta-analyses reported only modest benefits over placebo treatment. Signup and view all the answers

What is the focus of therapygenetics?

Differential response to cognitive behavioural therapy based on genotype. Signup and view all the answers

What are some ethical questions related to genome editing?

Modified germline and possible unintended consequences. Signup and view all the answers

What is the primary aim of studying differential response to cognitive behavioural therapy?

To understand how genotype may impact the effectiveness of therapy. Signup and view all the answers