Genetics: Gregor Mendel's Experiments

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Questions and Answers

Consider two pure-breeding pea plants, one with inflated pods and axial flowers, and the other with constricted pods and terminal flowers. Assuming independent assortment and complete dominance (inflated and axial are dominant), what proportion of the F2 generation would phenotypically resemble the dihybrid cross's 'novel' phenotypes (constricted pods, axial flowers AND inflated pods, terminal flowers)?

  • 6/16 (correct)
  • 9/16
  • 3/16
  • 1/16

In a scenario involving incomplete dominance, a cross between a homozygous red flower ($RR$) and a homozygous white flower ($WW$) yields all $RW$ offspring with pink flowers. If two $RW$ plants are crossed, what statistical test would most appropriately determine if the observed phenotypic ratios deviate significantly from Mendelian expectations, considering the presence of an intermediate phenotype?

  • A one-tailed t-test
  • ANOVA (Analysis of Variance)
  • Pearson's Chi-squared test (correct)
  • A two-tailed t-test

A researcher is studying a population of wildcats in northeast Kansas, where coat color is determined by a single gene with incomplete dominance: $BB$ (blue), $bb$ (red), and $Bb$ (purple). Over several generations, the researcher observes a gradual shift in allele frequencies, with the blue allele ($B$) becoming increasingly rare. Ignoring any effects of mutations, migration, or selection, which evolutionary mechanism is most likely responsible for this shift, assuming the wildcat population is geographically isolated?

  • Directional selection favoring red coat color
  • Genetic drift due to random sampling error in a small population (correct)
  • Non-random mating based on coat color preference
  • Founder effect causing random allele frequency shifts

Consider a scenario where a plant species exhibits heterostyly (different style lengths) as a mechanism to promote outcrossing. In a population of these plants, a novel mutation arises that disrupts the heterostylous system, leading to increased self-pollination. What would be the most likely evolutionary consequence of this mutation on the genetic diversity and fitness of the plant population?

<p>Decreased genetic diversity and reduced fitness due to inbreeding depression (A)</p> Signup and view all the answers

Imagine a population of pea plants where flower color is determined by a single gene with two alleles: $P$ (purple) and $p$ (white). A researcher collects data on flower color in this population over several generations and observes that the frequency of the $p$ allele decreases over time, even though the white flowers do not appear to have any obvious disadvantage. Which of the following scenarios could best explain this observation, considering factors beyond simple natural selection?

<p>The $P$ allele is linked to a gene conferring resistance to a common fungal pathogen, providing an indirect selective advantage (B)</p> Signup and view all the answers

In a population of pea plants, the gene for plant height ($T$) exhibits complete dominance, with $T$ (tall) dominant over $t$ (dwarf). A large population of pea plants is sampled, and the following genotypic frequencies are observed: $TT$ = 0.49, $Tt$ = 0.42, $tt$ = 0.09. Assuming random mating, no selection, mutation, or gene flow, what is the predicted frequency of the $t$ allele in the next generation, based on the Hardy-Weinberg principle?

<p>0.3 (C)</p> Signup and view all the answers

Consider a population of pea plants where seed color is determined by a single gene with two alleles: $Y$ (yellow) and $y$ (green). A researcher performs a series of crosses and observes that the offspring phenotypes do not consistently match the expected Mendelian ratios. Which of the following phenomena could explain this deviation, other than non-random mating, selection, or small sample size?

<p>The seed color gene is involved in a complex epistatic interaction with another gene influencing seed texture (D)</p> Signup and view all the answers

A geneticist discovers a novel mutation in pea plants that causes reduced pollen viability but also confers resistance to a previously devastating fungal pathogen. Under what conditions would this mutation most likely spread through a population of pea plants, assuming the pathogen is endemic?

<p>When the mutation is dominant and the fitness advantage conferred by pathogen resistance outweighs the reduced pollen viability (D)</p> Signup and view all the answers

A population of pea plants is established in a new habitat with limited resources. Initially, there is high phenotypic variation in plant height, ranging from very tall to very short. Over several generations, the population evolves towards an intermediate height, with the extreme phenotypes becoming less common. Which type of selection is most likely responsible for this evolutionary trend?

<p>Stabilizing selection favoring intermediate height (D)</p> Signup and view all the answers

Consider a scenario where a population of pea plants is divided into several smaller, isolated subpopulations due to habitat fragmentation. Over time, the allele frequencies in these subpopulations diverge due to genetic drift. Which of the following outcomes is most likely to occur if these subpopulations are later reunited and allowed to interbreed freely, assuming no strong selection pressures?

<p>The overall genetic diversity of the combined population will increase as the different subpopulations contribute unique alleles to the gene pool (D)</p> Signup and view all the answers

A researcher discovers a coding mutation in pea plants that results in complete loss of function in a crucial enzyme required for chlorophyll synthesis. This mutation is recessive ($cc$). Despite the lack of chlorophyll (resulting in albino seedlings), the heterozygotes ($Cc$) appear phenotypically normal. If two heterozygotes happen to grow next to each other, and produce 100 seeds, what will likely happen?

<p>Approximately 25 of the seeds will grow into albino seedlings that die shortly after germination, demonstrating Mendelian segregation (B)</p> Signup and view all the answers

In pea plants, axial flower position ($A$) is dominant to terminal ($a$). A plant breeder has a tall pea plant with axial flowers, but its exact genotype is unknown. To determine its genotype, the breeder crosses this plant with a dwarf plant with terminal flowers. Which of the following outcomes would definitively reveal that the tall, axial plant is heterozygous for both traits (i.e., $TtAa$), but assuming you don't know the linkage relationship of the genes?

<p>The offspring display a 1:1:1:1 phenotypic ratio for tall, axial; tall, terminal; dwarf, axial; and dwarf, terminal (B)</p> Signup and view all the answers

A researcher investigates a novel trait in pea plants: resistance to a specific aphid species. She crosses a true-breeding resistant plant with a susceptible plant and finds that all the F1 offspring are resistant. However, when she crosses the F1 offspring with each other, the F2 generation shows a ratio of 15 resistant plants to 1 susceptible plant. What genetic phenomenon is most likely responsible for this inheritance pattern?

<p>Epistasis (A)</p> Signup and view all the answers

In a specific species of flowering plant, petal color is controlled by two genes, A and B. Gene A controls the production of a red pigment. The dominant allele A produces the pigment, while the recessive allele a does not. Gene B controls the deposition of the red pigment only if Gene A expresses. The dominant allele B allows deposition, while the recessive allele b blocks deposition. Furthermore, the epistatic function of B completely overrides any other expression if a plant has the aa genotype, resulting in no pigment. What phenotypic ratio would you expect in the F2 generation of a dihybrid cross (AaBb x AaBb)?

<p>12:3:1 (A)</p> Signup and view all the answers

A population of pea plants exhibits a range of flower colors, influenced by several interacting genes. A plant breeder wants to create a true-breeding line with a specific, novel flower color that is not present in the current population. Which breeding strategy would be most effective in achieving this goal, assuming the desired color is determined by a complex combination of recessive alleles at multiple loci?

<p>Inbreeding through repeated self-pollination, followed by selection for the desired color in homozygous lines (C)</p> Signup and view all the answers

A researcher is studying a population of pea plants and discovers a new recessive mutation that causes the plants to be highly susceptible to a particular fungal disease. However, the heterozygous carriers of the mutation show slightly increased growth rates compared to homozygous wild-type plants in the absence of the disease. How would you describe this type of selection?

<p>Balancing selection (D)</p> Signup and view all the answers

Assume flower color in a particular plant species is determined by two genes, R and W, following the pathway: Precursor --(Gene R)--> Intermediate --(Gene W)--> Pigment (color). Plants with the genotype $rr$ have white flowers because they cannot convert the precursor. Plants with the genotype $ww$ have pale flowers as they cannot efficiently convert the intermediate to pigment. In a cross between two plants heterozygous for both genes ($RrWw \times RrWw$), what proportion of the offspring would you expect to have pale flowers, assuming the genes assort independently?

<p>3/16 (A)</p> Signup and view all the answers

Consider a plant species where fruit size is governed by three unlinked genes (A, B, and C), each with two alleles (A/a, B/b, C/c) that show additive effects. The more dominant alleles present, the larger the fruit. A plant with the genotype aabbcc has fruits weighing 20g, while a plant with the genotype AABBCC has fruits weighing 50g. What would be the expected weight of the fruits from a plant with the genotype AaBbCc?

<p>35g (C)</p> Signup and view all the answers

Mendel's work laid the foundation for understanding patterns of inheritance. However, certain phenomena deviate from his laws. Which of the following conditions would MOST directly violate Mendel's Law of Independent Assortment?

<p>Two genes are located very close together on the same chromosome (D)</p> Signup and view all the answers

In pea plants, the tall allele ($T$) exhibits complete dominance over the dwarf allele ($t$). A researcher crosses a tall plant of unknown genotype with a dwarf plant and obtains 50% tall offspring and 50% dwarf offspring. What is the genotype of the tall parent plant?

<p>$Tt$ (C)</p> Signup and view all the answers

Consider the pedigree of a rare genetic disorder in a family. Several affected individuals are present in each generation, and both males and females are equally affected. However, affected fathers do not pass the trait to their sons. What is the most likely mode of inheritance for this disorder?

<p>Autosomal dominant (C)</p> Signup and view all the answers

A researcher discovers a mutant allele in pea plants that causes wrinkled seeds. However, the wrinkled seed phenotype is only observed when the plants are grown at high temperatures. At lower temperatures, the mutant allele has no effect, and the seeds are round. What phenomenon is being observed?

<p>Conditional expression (D)</p> Signup and view all the answers

In a population of pea plants, the frequency of the allele for yellow seeds ($Y$) is 0.6, and the frequency of the allele for green seeds ($y$) is 0.4. Assuming Hardy-Weinberg equilibrium, what percentage of the population is expected to be heterozygous ($Yy$)?

<p>48% (D)</p> Signup and view all the answers

A researcher is studying a population of pea plants where seed color is determined by a single gene with two alleles: $Y$ (yellow) and $y$ (green). The researcher observes that certain individuals with the $Yy$ genotype have seeds that are mottled, with patches of both yellow and green color. Which genetic phenomenon is most likely responsible for this observation?

<p>Codominance (D)</p> Signup and view all the answers

A plant breeder wants to develop a true-breeding line of pea plants that are both tall and have green seeds. However, these two traits are controlled by genes that are located close together on the same chromosome. What breeding strategy would be most effective in achieving this goal, and why?

<p>Identifying rare recombinant offspring that have both traits and then inbreeding them to establish a true-breeding line, as this will break the linkage between the genes (A)</p> Signup and view all the answers

A researcher is studying flower color inheritance in a certain plant species. She crosses a true-breeding plant with red flowers to a true-breeding plant with white flowers and obtains F1 offspring with pink flowers. When she intercrosses the F1 offspring, the F2 generation exhibits a phenotypic ratio of 1 red : 2 pink : 1 white. Which of the following experimental procedures could best confirm that flower color inheritance in this species is governed by a single gene with incomplete dominance?

<p>Performing a Chi-square statistical analysis to compare the observed F2 phenotypic ratio to the expected ratio under the incomplete dominance hypothesis (B)</p> Signup and view all the answers

Two seemingly identical varieties of true-breeding pea plants exhibit different heights when grown in different locations with varying soil conditions. However, within each location, the height differences between the varieties remain consistent over multiple generations. Which explanation best accounts for this observation?

<p>The observed height differences are due to a combination of genetic variation and genotype-by-environment interaction, where the relative performance of the varieties depends on the environment (A)</p> Signup and view all the answers

A plant breeder crosses two true-breeding lines of pea plants: one with purple flowers and smooth seeds, and another with white flowers and wrinkled seeds. The F1 generation all has purple flowers and smooth seeds. However, when the F1 plants are testcrossed to a plant with white flowers and wrinkled seeds, the following progeny are obtained: 40% purple flowers, smooth seeds; 40% white flowers, wrinkled seeds; 10% purple flowers, wrinkled seeds; 10% white flowers, smooth seeds. Besides other more obvious factors, what accounts for this occurrence?

<p>Linkage affecting probabilities (B)</p> Signup and view all the answers

Flashcards

Genetics

The study of heredity and variation of inherited characteristics.

Gregor Johann Mendel

An Austrian Monk and the first person to study genetics, known as the Father of Genetics.

P1 Generation (Parental Generation)

The original parents in a genetic cross, exhibiting contrasting traits.

F1 Generation (First Filial Generation)

The offspring from the cross-pollination of the P1 generation.

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F2 Generation (Second Filial Generation)

The offspring from the self-pollination of the F1 generation.

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Allele

Two forms of a gene.

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Dominant (A)

A superior character that masks the expression of the other allele.

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Recessive (a)

An inferior character that is masked by the dominant allele.

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Homozygous

Having the same alleles for a trait.

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Heterozygous

Having different alleles for a trait.

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Genotype

A gene combination for a trait.

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Phenotype

The physical feature resulting from a genotype.

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Punnett Square

Diagram used to predict an outcome of a particular cross or breeding experiment.

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Law of Segregation

The two alleles of one trait separate from each other during gamete formation.

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Law of Independent Assortment

When more than one pair of characters are involved in a cross, factor pairs assort independently of each other.

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Incomplete Dominance

A cross between organisms with two different phenotypes produces offspring with a third phenotype that is a blending of the parental traits.

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Codominance

Occurs when both alleles are expressed equally in the phenotype of the heterozygote.

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Multiple Allele

A type of inheritance when more than two alleles can code or represent a gene or trait.

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Blood Type Determination

Protein molecules found on the surface of RBC's and in the blood plasma determine the blood type of an individual.

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Mutation

The changes or random errors in the DNA sequence.

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Point Mutation

A change in one base in the DNA sequence.

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Frameshift Mutation

Insertion or deletion of nucleotide bases.

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Chromosomal Mutations

Many genes are affected caused by any change in structure or number of chromosomes

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Deletion

A region of the chromosome is lost, resulting in the absence of genes in that area.

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Duplication

A region of the chromosome is repeated, resulting in an increase of dosage from the genes in that region.

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Inversion

A region of the chromosome is flipped and reinserted.

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Translocation

A region from one chromosome is aberrantly attached to another.

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Non-disjunction

Chromosomes fail to separate correctly during meiosis.

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Evolution

It refers to the change in inherited traits over successive generations in populations of organisms.

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Comparative Anatomy

Study of similarities and differences in the structures of different species.

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Study Notes

  • Study of genetics focuses on heredity and the variation of inherited characteristics.

Gregor Johann Mendel

  • An Austrian monk, was the first person to study genetics.
  • Known as the Father of Genetics
  • He bred plants and subsequently identified consistent patterns in the inheritance of traits from one plant set to the next.

Experiment on Peas

  • Used pollen to fertilize selected pea plants.
  • Allowed the resulting plants to self-pollinate.
  • Cross-pollinated pea plants with contrasting traits, forming the P1 Generation (Parental Generation).
  • Offspring from this cross-pollination, referred to the F1 Generation (First Filial Generation).
  • Self-pollinated the plants from the F1 Generation, producing the F2 Generation (Second Filial Generation).

Results of Mendel's Crosses Between Pure-breeding Pea Plants

  • Traits are inherited as discrete units.
  • One form of a feature always concealed the other form.
  • Organisms inherit two copies of each gene, one from each parent.
  • Features were inherited independently.

Allele

  • Refers to two forms of a gene, categorized as: Homozygous Dominant, Homozygous Recessive, or Heterozygous
  • Dominant (A) is a superior character, while Recessive (a) is an inferior character.

Mendel's Laws

  • Rule of Unit Factors in Pairs: Genetic characters are controlled by unit factors existing in pairs within an individual, with each containing a gene pair for each trait.
  • Principle of Dominance & Recessiveness: One unit factor in a pair may mask the expression of the other; dominant alleles are expressed exclusively in a heterozygote, while recessive traits are expressed only if the organism is homozygous for the recessive allele.
  • Law of Segregation: Two alleles of one trait segregate from each other during gamete formation.
  • Law of Independent Assortment: When multiple character pairs are involved in a cross, factor pairs assort independently.

Solving Genetics Problems

  • Choose a letter to represent the genes in the cross.
  • Write the genotypes of the parents involved in the cross.
  • Determine the possible gametes that the parents can produce.
  • Place these gametes at the top and side of the Punnett square.
  • Fill in the empty boxes of Punnett square by writing the alleles from the gametes that combine in the appropriate boxes.
  • Use the results written inside the boxes to answer the problem.

Non-Mendelian Genetics - Incomplete Dominance

  • A cross between organisms with two different phenotypes yields offspring with a third, blended phenotype
  • Occurs when one allele is not completely dominant over another and neither allele fully expresses itself.
  • The heterozygous phenotype becomes a blend or intermediate of the two homozygous phenotypes.

Multiple Allele

  • A type of inheritance where more than two alleles can code or represent a gene or trait.
  • Alleles A & B are dominant, while O (oo) is recessive.

Determining Blood Type

  • Protein molecules found on red blood cells and in the blood plasma determine an individual's blood type.
  • Antigens are located on the surface of the red blood cells.
  • Antibodies are in the blood plasma.

Sex-Linked Traits

  • Genes located on sex chromosomes (which determine sex) are sex-linked.
  • Disorders that are sex-linked are much more common in males, because they would only need one recessive allele to have the trait unlike females.
  • Chromosomes X & Y are for male, while X & X are female
  • Sex-linked disorders are inherited conditions found on x chromosome; is also typically recessive.

Mutation

  • Mutations, changes or random errors, in the DNA sequence, can be at the molecular or chromosome level, affecting many genes.
  • Mutations can be harmful, have no effect, or be beneficial to an organism.
  • Mutations in gametes can be passed to offspring, but those in somatic cells can not.

Causes

  • Mutagens, any agent that can cause a mutation
  • Examples include: Radiation (UV sun rays, food preheated in a microwave, x-ray) and, Chemicals (cigarettes, burnt parts of the food, benzoyl peroxide, nitrate and nitrite preservatives)
  • Mutations may also be caused by infectious agents (bacteria).

Types of Mutation

  • Gene Mutations: Small-scale mutations where one gene is affected, including point and frameshift mutations.

Chromosomal Mutations

  • Large scale: many genes are affected caused by any change in structure or number of chromosomes.
  • includes: deletion, duplication, inversion, translocation and non-disjunction.
  • Deletion: A region of the chromosome is lost, with an absence of genes in that area, can cause Cri du Chat Syndrome
  • Duplication: A region of the chromosome is repeated, increasing the dosage of genes in that region.
  • Inversion: A region of the chromosome is flipped and reinserted.
  • Translocation: A region from one chromosome is aberrantly attached to another.
  • Non-disjunction: Chromosomes fail to separate correctly during meiosis which can cause Klinefelter Syndrome, Down Syndrome, and Turner's Syndrome

Mutation Disorders

  • Down Syndrome: Results from nondisjunction, resulting in an embryo with three copies of chromosome.
  • Klinefelter Syndrome: Males are born with an extra X chromosome.
  • Turner's Syndrome: Females with one X chromosome missing or partially missing
  • Cri du Chat Syndrome: Chromosomal condition resulting when a piece of chromosome 5 is missing.
  • Sickle Cell Anemia: A genetic condition altering red blood cells into a crescent shape, leading to blood flow blockages.
  • Cystic Fibrosis: Causes thick mucus to accumulate in the lungs, resulting in difficulties in breathing and infections.
  • Genetic variation of species and adaptations are benefits of mutation, factor in evolutionary changes.
  • Mutations play a significant role in biotechnology.

Evidences of Revolution

  • Fossil Record: Traces of organisms that lived in the past, preserved by natural processes or catastrophic events. Fossils are preserved remains or traces of organism that is no longer living documents the existence of extinct past species related to present-day species.
  • Main types of fossils: Imprint, mold, cast, petrification, amber, trace

Determining Fossil Age

  • By analyzing the depth of fossils to determine their age
  • Relative Dating: Determining event sequence by comparing rock layers, without specifying the time since the events.
  • Absolute Dating: Giving the exact age of a rock.

Comparative Anatomy

  • It is the study of the similarities and differences In the structures of different species

  • Three types of structures: 1. Homologous structures; 2. Analogous structures; 3. Vestigial structures

  • Homologous Structures: Body parts of organisms that may perform different functions but are of the same origin

  • Analogous Structures: Body Parts of organisms that may perform the same functions but are of a different origin

  • Vestigial Structure: Body parts of organisms that are useless or left over from a previous ancestor that were useful.

  • Embryonic Development: The portion of the life cycle that begins after fertilization; organisms sharing similar embryos suggests a common ancestor.

  • Genetic Information: New species appear as small mutations or changes in DNA occur over time.

Evolution by Natural Selection

  • Descent with Modification: Genetic change in a population over generations, resulting from changes in the gene pool.
  • Causes to the gene pool of a population include shrinking population, non-random mating, mutation, gene flow, and adaptation (natural selection)

Darwin's Voyage

  • Visited the Galapagos Islands off the coast of Ecuador
  • Notes and samples from here started the development of his theory
  • His observation on finches? Different islands have different types of finches not found on any other islands; they were from a common ancestor.
  • Over time, they successfully adapted to their environment; the different groups ate different food depending on the resources that each island offered.
  • Darwin drew his concept of natural selection from artificial selection (selective breeding), where humans choose desired traits and allow reproduction of only the individuals that best express those traits.
  • Darwin made a hypothesis that the same process is happening in nature, but it was occurring naturally rather than by the direction of man; he called this phenomenon natural selection.
  • It states that organisms with traits well suited to an environment are more likely to survive and produce more offspring. "survival of the fittest" with the more variations will survive.
  • Variation: A specific variation within a population which can be inherited.
  • Competition: A specific variation within a population which can be inherited.
  • Adaptation: Individuals with beneficial adaptations are most likely to survive to pass on their genes.
  • Selection: Over many generations, there is an evolution within population and an allele frequency.
  • Bergman's Rule states that organisms in colder environments are larger and thicker than those in warmer environments.
  • Allen's Rule states that animals in cold climates usually have lesser exposed surface areas, e.g., shorter legs, shorter tails, shorter ears.
  • Gloger's Rule states that darker, pigmented species are found in warmer, humid environments lighter or paler species are found in drier, colder environments.

Adaptation

  • Survival of the fittest, organisms with traits well suited to an environment are more likely to survive and produce more offspring.
  • Natural selection will involve the adaptation of the individual to the environment
  • An evolutionary process wherein organisms adjust or change in behavior, physiology, and structure to become more suited to their environment. ####Adaptation Types
  • Structural Adaptation that modifies an organism's physical characteristics (e.g., shape, color, body covering, or internal organization)
  • Behavioral Adaptation through actions that organisms take to help them survive in their environment.
  • This inclues how they move their bodies, how they communicate with each other, and when they are more likely to be active or sleeping
  • Physiological Adaptation that involves internal processes that increase an organism's survival with chemical or metabolism changes.

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