Genetics and Heredity Overview
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What is DNA and what role does it play in heredity?

DNA, or deoxyribonucleic acid, is the genetic material inherited from parents that controls all the chemical changes in cells, serving as a blueprint for traits in offspring.

Explain how genes function as units of heredity.

Genes are segments of DNA that are passed from parents to offspring, determining specific traits and contributing to the similarities between generations.

What are Punnett Squares used for in genetics?

Punnett Squares are used to predict the probability of inheritance patterns for specific traits in offspring based on the genetic makeup of the parents.

How do inherited traits evolve at the population level?

<p>Inherited traits evolve at the population level through genetic variation and natural selection, influencing which traits become more common or rare over generations.</p> Signup and view all the answers

Discuss the importance of analysing patterns of inheritance.

<p>Analysing patterns of inheritance is crucial for understanding genetic diseases, predicting trait distributions, and improving breeding programs in agriculture and conservation.</p> Signup and view all the answers

What is the primary outcome of mitosis in terms of cell production?

<p>Mitosis results in two identical cells, each containing the same genetic information as the original cell.</p> Signup and view all the answers

How does meiosis differ from mitosis in terms of the number of cells produced?

<p>Meiosis produces four daughter cells, while mitosis produces two identical cells.</p> Signup and view all the answers

Explain the source of the gene pairs in offspring.

<p>Each gene pair in an offspring originates from one gene inherited from the male parent and one from the female parent.</p> Signup and view all the answers

What role did Mendel play in our understanding of genetics?

<p>Mendel was the first biologist to use mathematics to explain genetic inheritance and introduced the concepts of genes and gene pairs.</p> Signup and view all the answers

Describe the genetic outcome of meiosis in terms of genetic variation.

<p>Meiosis results in genetically unique cells, contributing to genetic variation in the population.</p> Signup and view all the answers

What determines the type of cell produced in an organism?

<p>The type of cell produced is determined by DNA.</p> Signup and view all the answers

What are the three components that make up a nucleotide?

<p>A nucleotide is made up of a sugar (deoxyribose), a phosphate group, and an organic base (A, C, T, or G).</p> Signup and view all the answers

Describe the structure of DNA.

<p>DNA is a very large molecule shaped as a double helix, consisting of two coiled strands.</p> Signup and view all the answers

What occurs during the process of DNA replication?

<p>During DNA replication, the strands unwind and separate, allowing each strand to form a new partner by adding the appropriate nucleotides.</p> Signup and view all the answers

What is the triplet code in DNA?

<p>The triplet code is a sequence of three bases that codes for a specific amino acid.</p> Signup and view all the answers

What role do histones play in the structure of chromosomes?

<p>Histones condense the DNA into chromatin, making the chromosomes visible before cell division.</p> Signup and view all the answers

What are sister chromatids?

<p>Sister chromatids are the replicated copies of a chromosome that join at the centromere.</p> Signup and view all the answers

What are the short and long arms of chromosomes called?

<p>The short arms are called 'p' arms and the longer arms are called 'q' arms.</p> Signup and view all the answers

What is the role of restriction enzymes in recombinant DNA technology?

<p>Restriction enzymes cleave DNA at specific sequences, generating fragments with known ends necessary for DNA manipulation.</p> Signup and view all the answers

How does natural cloning differ from artificial cloning?

<p>Natural cloning involves asexual reproduction leading to genetically identical offspring, while artificial cloning requires techniques like nuclear transfer to create clones.</p> Signup and view all the answers

What types of cells can embryonic stem cells produce compared to skin and bone marrow stem cells?

<p>Embryonic stem cells can produce all types of body cells, while skin stem cells yield only skin cells and bone marrow stem cells produce up to six types of blood cells.</p> Signup and view all the answers

From which developmental stage can human embryonic stem cells be obtained?

<p>Human embryonic stem cells can be obtained from 10-day-old embryos.</p> Signup and view all the answers

What potential advancements are suggested for specialized stem cells?

<p>Specialized stem cells may be treated with hormones and growth factors to produce a broader range of specialized cells.</p> Signup and view all the answers

What did Mendel observe in the F2 generation of a dihybrid cross?

<p>Mendel observed four phenotypes: tall purple (9), tall white (3), short purple (3), and short white (1).</p> Signup and view all the answers

Why might dihybrid crosses not work if genes are physically close on the same chromosome?

<p>If genes are linked on the same chromosome, they are likely to be inherited together, making separation during crossing over less probable.</p> Signup and view all the answers

How does incomplete dominance differ from complete dominance?

<p>In incomplete dominance, both alleles are partially expressed, resulting in a blended phenotype, whereas in complete dominance, one allele completely masks the other.</p> Signup and view all the answers

Give an example of co-dominance in genetics.

<p>Roan coat color in horses and cocker spaniels illustrates co-dominance, where both alleles are independently and equally expressed.</p> Signup and view all the answers

What is the result of X inactivation in female mammals, and how can it be observed?

<p>X inactivation in female mammals results in one of the two X chromosomes being randomly inactivated, observable as a Barr body.</p> Signup and view all the answers

In the context of sex-linked traits, who transmits Y chromosome traits, and why?

<p>Traits on the Y chromosome are transmitted only from fathers to sons because only males have the Y chromosome.</p> Signup and view all the answers

What phenotype results from a female cat that is heterozygous for the calico gene?

<p>A heterozygous calico female cat will express black and orange splotches on a white coat due to co-dominance.</p> Signup and view all the answers

What represents a key outcome of Mendelian genetics in relation to gametes?

<p>In Mendelian genetics, each gamete carries only one allele from each gene pair, resulting in genetic variation.</p> Signup and view all the answers

What are the possible genotypes and phenotypes of kittens resulting from a cross between a female calico cat and a black male?

<p>The possible genotypes include XB XB (female black), XB Y (male black), XR XB (female calico), and XR Y (male orange). The corresponding phenotypes are 25% black males, 25% orange males, 25% calico females, and 25% black females.</p> Signup and view all the answers

Define polygenic traits and give an example.

<p>Polygenic traits are traits that are controlled by two or more genes, resulting in a range of phenotypes. An example is growth rate in animals, which is influenced by multiple genes and environmental factors.</p> Signup and view all the answers

Explain epistasis and provide an example.

<p>Epistasis is the interaction between different genes where one gene can mask or modify the effect of another. An example is albinism, where the albino gene masks the gene responsible for coat color.</p> Signup and view all the answers

Differentiate between germline and somatic mutations.

<p>Germline mutations occur in gametes and can be inherited by offspring, while somatic mutations occur in non-reproductive cells and are not passed on to offspring.</p> Signup and view all the answers

What are point mutations and how do they differ from frameshift mutations?

<p>Point mutations involve changes in a single nucleotide in the DNA sequence, whereas frameshift mutations involve insertions or deletions that alter the reading frame of the sequence.</p> Signup and view all the answers

Describe one method of genetic engineering for inserting genes from one organism into another.

<p>One method is to coat the genes onto microscopic gold particles and ‘fire’ them into the target cells.</p> Signup and view all the answers

What are chromosome mutations and how do they impact genotype and phenotype?

<p>Chromosome mutations are mutations that change the structure of chromosomes, leading to alterations in both genotype and phenotype.</p> Signup and view all the answers

What role does the environment play in the expression of polygenic traits?

<p>The environment significantly influences the expression of polygenic traits, as factors like nutrition, temperature, and stress can affect the phenotypic outcome.</p> Signup and view all the answers

Study Notes

Genetics and Evolution - Final Revision Session

  • Intended Learning Outcomes: Students will be able to explain genetic material structure and heredity mechanisms, analyze inheritance patterns, discuss evolutionary theory and mechanisms, and understand how inherited and learned traits evolve at the population level.

Assessment Methods

  • Written Exam (50%): Genetics exam on 17.12.24. The exam will cover:
    • Structure of genetic material and heredity mechanisms.
    • Analysis of inheritance patterns.
    • The exam will be one hour, divided into two sections:
      • Section A: 60% - short answer and multiple choice questions.
      • Section B: 40% - inheritance patterns using Punnett Squares.
  • Assignment 1 (50%): Genetics case study.
  • Assignment 2 (50%): Evolution Booklet (1500 words).

What is Genetics?

  • Genetics is the study of genes and chromosomes that hold them.
  • It's also the science of heredity, explaining similarities between parents and offspring.
  • Genes are units of heredity, transferred from parents to offspring, determining traits.
  • Humans have approximately 20,000+ genes (genome).

DNA

  • DNA (deoxyribose nucleic acid) is the genetic material inherited from parents.
  • It's present in all cells' nuclei, tightly packed as chromosomes.
  • DNA controls all cellular chemical changes (e.g., cell type formation – muscle, blood, nerve).
  • It determines the organism type.

DNA Molecule

  • DNA is a large molecule made of nucleotides.
  • Nucleotides have three parts:
    • Deoxyribose (a sugar).
    • Phosphate group (-PO4).
    • Organic base (A, C, T, G).

Nucleotides

  • Ribose is a sugar similar to glucose, but with five carbon atoms (mRNA).
  • Deoxyribose is almost the same but lacks one oxygen atom and found in DNA.

DNA Double Helix

  • The paired DNA strands are coiled into a spiral, called the double helix.
  • The sugar-phosphate chains are on the outside, while the bases are on the inside.

Replication

  • Before cell division, DNA strands unwind and separate.
  • Each strand acts as a template to create a new partner strand by adding nucleotides.
  • The result is two identical double-stranded DNA molecules in the nucleus.

Chromosomes

  • Chromosomes are found in the nucleus.
  • Before cell division, chromosomes condense to become visible.
  • Proteins called histones attach to DNA, forming chromatin.

Sister Chromatids & Centromere

  • Replicated copies of chromosomes are called sister chromatids.
  • They join at the centromere.

Chromosomes and Genes

  • Since chromosomes are in pairs, corresponding genes are also paired.
  • Each member of a gene pair is inherited from either the maternal or paternal parent.

Mitosis

  • Mitosis occurs throughout the animal's life, allowing growth and repair of damaged cells.
  • It results in two identical cells with the same number of chromosomes (2n).

Meiosis

  • Meiosis happens only in sperm and egg cells.
  • It results in four haploid (n) cells with half the original number of chromosomes compared to the parent cell.
  • Each new cell is genetically unique from each other and the parent cell.

Mendel's Laws of Genetics

  • Mendel used mathematics, quantitatively explaining his experiments on inheritance.
  • He predicted the concept of genes occurring in pairs, one gene from each pair being passed to gametes.

Dihybrid Cross

  • When F₁ generation self-pollinates, four phenotypes (for example, tall/short, purple/white) are observed in a specific ratio.

Linked Genes

  • If genes are physically close on the same chromosome, they are often inherited together.
  • Independent assortment of linked genes is less likely compared to genes on separate chromosomes.

Incomplete Dominance

  • When a heterozygous genotype results in an intermediate phenotype, it is called incomplete dominance.
  • Both alleles are expressed to some extent.

Co-dominance

  • In co-dominance, both alleles contribute completely to the phenotype, and the appearance is a mix of both.

Sex Chromosomes

  • Females have XX chromosomes, males have XY.
  • The Y chromosome is smaller than the X; traits on the Y chromosome are passed from fathers to sons.
  • X-inactivation in females involves one X chromosome being randomly inactivated during embryonic development.

Sex-Linked Punnett Squares

  • Some traits, like coat color in cats, are determined by genes on the sex chromosomes.
  • Males and females can exhibit different phenotypes based on X-linked genes.

Polygenic Traits

  • Many traits are controlled by two or more genes, resulting in a range of possible genotypes and phenotypes.
  • These traits can be greatly influenced by environmental factors.

Epistasis

  • Epistasis is when one gene's expression modifies or impacts the phenotypic expression of another gene.

DNA Transcription and Translation

  • Steps in the DNA process for creating proteins.
  • Transcription converts DNA into mRNA, which travels from the nucleus to the cytoplasm.
  • Translation converts mRNA into a protein.

Types of Mutations

  • Mutations are changes in DNA.
    • Germline changes are heritable, somatic changes are not.
    • Point mutations alter single nucleotides.
    • Frameshift mutations shift the reading frame in DNA.

Genetic Engineering

  • Techniques for modifying genes by inserting them into another organism, such as introducing genes to bacteria to do a task, introducing genes to make a different type of plant, or improving crops.
  • Restriction enzymes are used to cut DNA at specific points.

Cloning

  • Natural cloning occurs in asexual reproduction.
  • Artificially, the nucleus from a body cell is transferred into an egg cell to create a clone of the body cell.

Stem Cells

  • Stem cells are undifferentiated cells with the potential to develop into various body cells.
  • Embryonic stem cells can create all body cells.
  • Some specialized body tissues, such as skin and bone marrow, have stem cell characteristics that can be manipulated to produce specific cells.

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This quiz covers essential concepts in genetics, including DNA structure, inheritance patterns, and the roles of mitosis and meiosis. Explore the foundational principles established by Mendel and the importance of genetic variation in populations. Test your knowledge of key terms and processes related to heredity.

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