Genetic Research Flashcards

Questions and Answers

Can Investigator B use the biospecimens for cancer research without re-consent if the specimens are de-identified?

True

Under which of the following conditions is it appropriate to re-contact the individuals who provided biological specimens?

Original signed consent documents include provisions for recontacting subjects (correct)

Participants have expressed a desire to be contacted (correct)

The researchers decide to contact individuals

There are no conditions

What is the best definition of 'genetic determinism'?

Genes are primarily responsible for human traits, including health, behavior, and disease.

What is the primary purpose of most pharmacogenomic research?

To evaluate the association between individual genotypes and the safety and efficacy of a particular drug or class of drugs. Signup and view all the answers

What is critical in determining subject risk involved in a genetic study?

Understanding the purpose and context of a specific study. Signup and view all the answers

What types of discrimination does the Genetic Information Non-Discrimination Act (GINA) protect individuals from?

Health insurance and employment discrimination. Signup and view all the answers

Is Investigator B's research using the biospecimens considered human subjects research according to federal regulations?

False Signup and view all the answers

What is the most important issue for the IRB to consider when conducting research that involves collecting biological specimens for genetic testing?

Effects of findings on other family members. Signup and view all the answers

Study Notes

Biospecimens and Research

Investigator A's research on emphysema uses biospecimens under consent for that specific study.
Investigator B can use de-identified biospecimens for cancer research without re-consent, as this is not classified as human subjects research.

Re-contacting Subjects

It is acceptable to re-contact individuals for research if original consent documents explicitly allow it.

Genetic Determinism

Defined as the notion that genetic makeup predominantly influences human traits, including health, behavior, and disease.

Pharmacogenomic Research Purpose

Focuses on assessing the relationship between individual genetic profiles and the safety and efficacy of specific medications or drug classes.

Assessing Risk in Genetic Studies

Determining risk in a genetic study hinges on a thorough understanding of the study's purpose and context.

Genetic Information Non-Discrimination Act (GINA)

GINA safeguards individuals from discrimination regarding health insurance and employment based on genetic information.

Coded Specimens in Research

Investigator B's research is not classified as human subjects research since B cannot identify the source individuals and has agreed not to attempt re-identification.

Ethical Considerations in Genetic Testing

When collecting biological specimens for genetic testing, it is crucial for the IRB to evaluate the impact of findings on family members.

Description

Explore the ethical considerations and regulations in genetic research within human populations. This quiz focuses on scenarios involving the use of biospecimens and consent. Test your knowledge with pivotal questions that unravel the complexities of conducting research ethically.