Genetic Linkage Analysis Methods Quiz
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Questions and Answers

Which gene mutation accounts for approximately half of early-onset Alzheimer Disease cases?

  • Hepatocyte nuclear factor 1-α (HNF1α)
  • Insulin promoter factor 1 (IPF1)
  • Presenilin 1 (correct)
  • KCNJ11
  • Which of the following genes is involved in adipocyte differentiation and increases the risk of Type II Diabetes by 25%?

  • Hepatic nuclear factor 1-ß (HNF1ß)
  • PPAR-gamma (correct)
  • Neurogenic differentiation 1 (NEUROD1)
  • TCF7L2
  • What is the recurrence risk of Type I diabetes if a sibling shares the HLA DR3 or DR4 gene?

  • 20% (correct)
  • 10-15%
  • 50%
  • 100%
  • What is the heritability range for obesity, as mentioned in the text?

    <p>0.6 to 0.8</p> Signup and view all the answers

    Which gene mutation is responsible for approximately 50% of MODY cases?

    <p>Glucokinase</p> Signup and view all the answers

    What is the most significant transcription factor involved in secreting insulin and linked to a 50% increase in risk of Type II Diabetes?

    <p>TCF7L2</p> Signup and view all the answers

    What is the approximate percentage of Type II Diabetes cases that are increasing in younger people in affluent areas?

    <p>90%</p> Signup and view all the answers

    What is the risk of Alzheimer Disease if a person has an affected first-degree relative, according to the text?

    <p>It doubles</p> Signup and view all the answers

    Which gene mutation is implicated in clearance of amyloid from the brain and can increase the risk of Alzheimer Disease in certain populations?

    <p>ApoE</p> Signup and view all the answers

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