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Questions and Answers
What is the most important factor in drug absorption?
What is the most important factor in drug absorption?
- pH of the medium
- Lipid Solubility (correct)
- Molecular weight
- Drug concentration
Which type of drug is likely to be lipid soluble and non-ionized in an acidic medium?
Which type of drug is likely to be lipid soluble and non-ionized in an acidic medium?
- Water-soluble drug
- Ionized drug
- Acidic drug (correct)
- Basic drug
Which branch of pharmacology deals with the effect of the body on drugs?
Which branch of pharmacology deals with the effect of the body on drugs?
- Pharmacodynamics
- Pharmacovigilance
- Pharmacogenetics
- Pharmacokinetics (correct)
What happens to bioavailability when first-pass metabolism decreases?
What happens to bioavailability when first-pass metabolism decreases?
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If a drug is given via the intravenous (IV) route, what is the bioavailability?
If a drug is given via the intravenous (IV) route, what is the bioavailability?
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Study Notes
Drug Absorption and Bioavailability
- The most important factor in drug absorption is the lipid solubility of the drug.
Factors Affecting Lipid Solubility
- Drugs that are likely to be lipid soluble and non-ionized in an acidic medium are weak bases.
Pharmacology Branches
- Pharmacokinetics is the branch of pharmacology that deals with the effect of the body on drugs.
Bioavailability
- A decrease in first-pass metabolism increases bioavailability.
- The bioavailability of a drug given via the intravenous (IV) route is 100%.
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