General Pharmacology: Antineoplastic Drugs Overview Quiz
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Questions and Answers

What are the causes of cancer according to the text?

  • Aflatoxins, benzene, low fiber diet (correct)
  • High fat diet, ionizing radiation, HPV
  • EBV, inherited mutations, alkylating agents
  • Tobacco smoke, asbestos, anabolic steroids
  • What are the types of neoplastic cells mentioned in the text?

  • Lymphomas and sarcomas
  • Carcinomas and sarcomas (correct)
  • Melanomas and leukemias
  • Adenomas and gliomas
  • Which genetic factors may underlie carcinogenesis according to the text?

  • Inherited mutations and increased activity of oncogenes (correct)
  • Increased activity of tumor suppressor genes
  • Loss of tumor suppressor genes and mutation of proto-oncogenes
  • Mutation or loss of proto-oncogenes
  • What are examples of environmental initiators of cancer mentioned in the text?

    <p>Azo dyes and radon</p> Signup and view all the answers

    Which type of tumor is associated with epithelial cells according to the text?

    <p>Carcinoma</p> Signup and view all the answers

    Which of the following is NOT mentioned as a type of environmental initiator of cancer in the text?

    <p>Ultraviolet light</p> Signup and view all the answers

    What are the two types of neoplastic cells based on location mentioned in the text?

    <p>Carcinomas and sarcomas</p> Signup and view all the answers

    Which genetic factor is specifically mentioned as a cause of cancer in the text?

    <p>Inherited mutations</p> Signup and view all the answers

    Which of the following is NOT mentioned as a biological initiator of cancer in the text?

    <p>HIV (Human immunodeficiency virus)</p> Signup and view all the answers

    Which type of tumor is associated with neoplastic cells derived from connective tissue?

    <p>Sarcomas</p> Signup and view all the answers

    Study Notes

    Cell Cycle and Regulation

    • Cell cycle consists of four major phases: G1, S, G2, and M
    • G1-Phase: preparatory phase for DNA synthesis, where Histone is synthesized
    • S-Phase: DNA synthesis phase, where base synthesis and base-pairing occur
    • G2-Phase: preparatory phase for mitosis, where Mitotic spindles and other proteins are formed
    • M-Phase: Mitotic phase, where division of DNA and cytoplasm takes place
    • G0-Phase: dormant phase

    Regulation of Cell Cycle

    • Proto-oncogenes stimulate proliferation of cells, e.g. MYC gene
    • Tumor suppressor genes inhibit proliferation and promote apoptosis of cells, e.g. TP53 gene

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    Description

    Test your knowledge of antineoplastic drugs and their activity in the cell life cycle. This quiz covers the cell cycle phases, DNA synthesis, and the rational use of chemotherapeutic agents.

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