12 Questions
What is the primary cytotoxic action of antitumor antibiotics?
Production of free radicals
How is Gemcitabine administered?
By IV infusion
What happens to Gemcitabine after deamination?
It is converted to difluorodeoxyuridine
Which enzyme phosphorylates Gemcitabine to 2′,2′-difluorodeoxycytidine triphosphate?
Deoxycytidine kinase
What is a notable adverse effect of Doxorubicin?
Cardiac toxicity
What is the significant impact of cumulative doses exceeding 450 mg/m2 with Doxorubicin?
Increased risk of cardiotoxicity
Which anthracycline is used in the treatment of prostate cancer?
Mitoxantrone
What is a potential fatal side effect associated with 'Bleomycin'?
Pulmonary Fibrosis
How are anthracyclines like Doxorubicin administered?
Intravenously
What is a significant issue that can result from extravasation of anthracycline antibiotics?
Tissue Necrosis
Which of the following is NOT a mechanism of cytotoxicity induced by anthracyclines?
Growth Inhibition
'Cimetidine' is associated with which side effect among the following?
Renal Toxicity
This quiz covers information about Gemcitabine, an analog of the nucleoside deoxycytidine commonly used for pancreatic cancer and non–small cell lung cancer. Learn about its mechanism of action, administration, and metabolic pathway.
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