Gemcitabine: An Anticancer Drug
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Questions and Answers

What is the primary cytotoxic action of antitumor antibiotics?

  • Interference with RNA synthesis
  • Induction of cell cycle arrest
  • Inhibition of deoxycytidine kinase
  • Production of free radicals (correct)

    • How is Gemcitabine administered?

  • By IV infusion (correct)
  • Orally
  • Intramuscularly
  • Subcutaneously

    • What happens to Gemcitabine after deamination?

  • It becomes cytotoxic
  • It becomes a substrate for deoxycytidine kinase
  • It is excreted in feces
  • It is converted to difluorodeoxyuridine (correct)

    • Which enzyme phosphorylates Gemcitabine to 2′,2′-difluorodeoxycytidine triphosphate?

    <p>Deoxycytidine kinase</p> Signup and view all the answers

    What is a notable adverse effect of Doxorubicin?

    <p>Cardiac toxicity</p> Signup and view all the answers

    What is the significant impact of cumulative doses exceeding 450 mg/m2 with Doxorubicin?

    <p>Increased risk of cardiotoxicity</p> Signup and view all the answers

    Which anthracycline is used in the treatment of prostate cancer?

    <p>Mitoxantrone</p> Signup and view all the answers

    What is a potential fatal side effect associated with 'Bleomycin'?

    <p>Pulmonary Fibrosis</p> Signup and view all the answers

    How are anthracyclines like Doxorubicin administered?

    <p>Intravenously</p> Signup and view all the answers

    What is a significant issue that can result from extravasation of anthracycline antibiotics?

    <p>Tissue Necrosis</p> Signup and view all the answers

    Which of the following is NOT a mechanism of cytotoxicity induced by anthracyclines?

    <p>Growth Inhibition</p> Signup and view all the answers

    'Cimetidine' is associated with which side effect among the following?

    <p>Renal Toxicity</p> Signup and view all the answers

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