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Gemcitabine: An Anticancer Drug

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Questions and Answers

What is the primary cytotoxic action of antitumor antibiotics?

Interference with RNA synthesis

Induction of cell cycle arrest

Inhibition of deoxycytidine kinase

Production of free radicals (correct)

How is Gemcitabine administered?

By IV infusion (correct)

Orally

Intramuscularly

Subcutaneously

What happens to Gemcitabine after deamination?

It becomes cytotoxic

It becomes a substrate for deoxycytidine kinase

It is excreted in feces

It is converted to difluorodeoxyuridine (correct)

Which enzyme phosphorylates Gemcitabine to 2′,2′-difluorodeoxycytidine triphosphate?

Deoxycytidine kinase (C) Signup and view all the answers

What is a notable adverse effect of Doxorubicin?

Cardiac toxicity (C) Signup and view all the answers

What is the significant impact of cumulative doses exceeding 450 mg/m2 with Doxorubicin?

Increased risk of cardiotoxicity (A) Signup and view all the answers

Which anthracycline is used in the treatment of prostate cancer?

Mitoxantrone (A) Signup and view all the answers

What is a potential fatal side effect associated with 'Bleomycin'?

Pulmonary Fibrosis (A) Signup and view all the answers

How are anthracyclines like Doxorubicin administered?

Intravenously (D) Signup and view all the answers

What is a significant issue that can result from extravasation of anthracycline antibiotics?

Tissue Necrosis (A) Signup and view all the answers

Which of the following is NOT a mechanism of cytotoxicity induced by anthracyclines?

Growth Inhibition (D) Signup and view all the answers

'Cimetidine' is associated with which side effect among the following?

Renal Toxicity (B) Signup and view all the answers

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