Podcast
Questions and Answers
What is the primary cytotoxic action of antitumor antibiotics?
What is the primary cytotoxic action of antitumor antibiotics?
- Interference with RNA synthesis
- Induction of cell cycle arrest
- Inhibition of deoxycytidine kinase
- Production of free radicals (correct)
How is Gemcitabine administered?
How is Gemcitabine administered?
- By IV infusion (correct)
- Orally
- Intramuscularly
- Subcutaneously
What happens to Gemcitabine after deamination?
What happens to Gemcitabine after deamination?
- It becomes cytotoxic
- It becomes a substrate for deoxycytidine kinase
- It is excreted in feces
- It is converted to difluorodeoxyuridine (correct)
Which enzyme phosphorylates Gemcitabine to 2′,2′-difluorodeoxycytidine triphosphate?
Which enzyme phosphorylates Gemcitabine to 2′,2′-difluorodeoxycytidine triphosphate?
What is a notable adverse effect of Doxorubicin?
What is a notable adverse effect of Doxorubicin?
What is the significant impact of cumulative doses exceeding 450 mg/m2 with Doxorubicin?
What is the significant impact of cumulative doses exceeding 450 mg/m2 with Doxorubicin?
Which anthracycline is used in the treatment of prostate cancer?
Which anthracycline is used in the treatment of prostate cancer?
What is a potential fatal side effect associated with 'Bleomycin'?
What is a potential fatal side effect associated with 'Bleomycin'?
How are anthracyclines like Doxorubicin administered?
How are anthracyclines like Doxorubicin administered?
What is a significant issue that can result from extravasation of anthracycline antibiotics?
What is a significant issue that can result from extravasation of anthracycline antibiotics?
Which of the following is NOT a mechanism of cytotoxicity induced by anthracyclines?
Which of the following is NOT a mechanism of cytotoxicity induced by anthracyclines?
'Cimetidine' is associated with which side effect among the following?
'Cimetidine' is associated with which side effect among the following?
