Gastrointestinal Diagnostic Approaches

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Questions and Answers

In diagnosing achalasia, after a barium swallow shows a bird’s beak appearance, the next step is _____ to confirm the diagnosis.

monometry

Patients with _____ can experience dysphagia to both solids and liquids simultaneously, indicating a neurogenic cause.

achalasia

In suspected cases of cholecystitis, if the abdominal ultrasound is negative, a _____ scan may be performed.

HIDA

The most common cause of death in patients with anorexia is _____ due to hypokalemia.

<p>arrhythmia</p> Signup and view all the answers

For diabetic gastroparesis, it is important to do _____ before medication to rule out any physical obstruction.

<p>endoscopy</p> Signup and view all the answers

After the diagnosis of cholelithiasis, the recommended treatment is _____ to remove the gallbladder.

<p>cholecystectomy</p> Signup and view all the answers

In individuals with bulimia nervosa or anorexia, it is crucial to avoid prescribing _____ due to seizure risk.

<p>buproprion</p> Signup and view all the answers

In pregnant women, the presence of cholelithiasis may be influenced by estrogen, which upregulates _____.

<p>HMG-CoA reductase</p> Signup and view all the answers

The first step in evaluating a patient with a history of GERD and dysphagia is _____ to rule out cancer.

<p>endoscopy</p> Signup and view all the answers

Patients with anorexia may exhibit amenorrhea associated with low _____ and low estrogen levels.

<p>FSH</p> Signup and view all the answers

Flashcards

Neurogenic Dysphagia: Solids & Liquids

A disorder of the esophagus characterized by difficulty swallowing both solids and liquids, often due to a neurogenic cause. This is distinct from dysphagia that progresses from solids to liquids, which is more suggestive of esophageal cancer.

Zenker's Diverticulum

A rare condition involving a weakening in the upper esophageal sphincter resulting in food accumulating in a pouch before being regurgitated. Often presents with halitosis, gurgling sounds during swallowing, and expulsion of undigested food.

Barium Swallow

A diagnostic procedure used to visualize the esophagus and detect abnormalities like a bird's beak appearance associated with achalasia.

Achalasia

A rare disorder where the lower esophageal sphincter fails to relax properly, leading to food becoming trapped in the esophagus. This can be confirmed after a barium swallow reveals a characteristic bird's beak appearance.

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Anorexia Nervosa

A serious condition characterized by a lack of appetite, severe weight loss, and distorted body image. This is more than just picky eating; it's a life-threatening eating disorder.

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Refeeding Syndrome

A potentially fatal complication that can occur during refeeding of malnourished patients, particularly those with anorexia nervosa. It involves electrolyte and mineral imbalances, mainly hypophosphatemia.

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Cholelithiasis

A disorder characterized by the presence of gallstones in the gallbladder. It's often linked to the "four F's": fat, forties, female, fertile. Diagnosed with an abdominal ultrasound.

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Biliary Colic

A painful episode of gallstone blockage in the gallbladder.

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Cholecystitis

An inflammation of the gallbladder usually triggered by a gallstone blocking the cystic duct. It is often accompanied by fever and abdominal pain.

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Cholecystectomy

A medical procedure to surgically remove the gallbladder, typically recommended for the treatment of cholecystitis and cholelithiasis.

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Study Notes

Diagnostic Approaches and Treatments for Gastrointestinal Conditions

  • Abdominal Pain and Possible Peritonitis: Perform paracentesis (peritoneal aspiration) to analyze fluid for signs of infection. (Gram stain and WBC count >250/HPF)

  • Dysphagia (Difficulty Swallowing):

    • Solids and liquids from the start: Suspect neurogenic cause like achalasia.
    • Solids to solids and liquids: May indicate esophageal cancer; require endoscopy.
    • Halitosis (bad breath), gurgling, undigested food regurgitation: Possible Zenker's diverticulum; barium swallow is first-line diagnostic imaging.
  • Achalasia Diagnosis: Barium swallow showing a "bird's beak" appearance is followed by esophageal manometry for confirmation.

  • GERD with Dysphagia: Endoscopy is the primary investigation to rule out cancer.

  • GERD in Diabetes: Suspect diabetic gastroparesis. Avoid PPIs; metoclopramide is more appropriate. Endoscopy is needed to rule out physical obstructions prior to metoclopramide use. If endoscopy is negative, perform gastric-emptying scintigraphy to confirm gastroparesis.

  • Eating Disorders (Anorexia, Bulimia):

    • Avoid bupropion: High seizure risk.
    • Anorexia complications:
      • Hypokalemia (electrolyte imbalance).
      • Arrhythmia is a significant cause of death.
      • Refeeding syndrome (risk of hypophosphatemia).
    • Treatment for anorexia with depression: Mirtazapine (appetite stimulant).
    • Anorexia hormonal changes: Hypogonadotropic hypogonadism (low FSH + low estrogen).
  • Amenorrhea/Menopause:

    • Premature ovarian failure + Turner syndrome: High FSH (low inhibin) and low estrogen.

Gallbladder Conditions

  • Cholelithiasis (Gallstones):

    • Diagnosis using abdominal ultrasound (often in patients with fat, older age, female sex, and fertility).
    • Biliary Colic + fever: Possible cholecystitis (inflammation of the gallbladder).
    • Treatment: Cholecystectomy (gallbladder removal) is typical.
    • Alternatives: Ursodiol (ursodeoxycholic acid) for expectant patients or pregnancy.
    • Diagnostic uncertainty: If abdominal ultrasound is negative for cholecystitis, a HIDA scan can be used for better assessment. A non-visualized gallbladder on HIDA scan confirms cholecystitis.
  • Cholelithiasis in Pregnancy: Estrogen increases HMG-CoA reductase and progesterone reduces biliary peristalsis.

Other Gastrointestinal Conditions

  • Trichotillomania (hair-pulling) and GI symptoms: Gastric bezoar (hair ball) may be present.

  • High-Pitched Bowel Sounds and Acute Abdominal Symptoms: Suspect small bowel obstruction (SBO).

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