Gastrointestinal Anatomy and Physiology Quiz
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Questions and Answers

What is the main function of the submucosa in the alimentary canal?

  • Provides distensibility and elasticity (correct)
  • Acts as the epithelial covering of the alimentary canal
  • Facilitates mixing and movement of food
  • Absorbs digested nutrients into the blood

Which nerve plexus is located in the muscularis externa and is responsible for regulating gut motility?

  • Submucosal nerve plexus of Meissner
  • Plexus of the serosa
  • Enteric nerve plexus
  • Myenteric plexus of Auerbach (correct)

What type of muscle layers are found in the muscularis externa?

  • Circular smooth muscle and longitudinal smooth muscle (correct)
  • Skeletal muscle only
  • Cardiac muscle and circular smooth muscle
  • Transitional muscle and skeletal muscle

Which layer of the alimentary canal serves as the outer connective tissue and epithelial covering?

<p>Serosa (C)</p> Signup and view all the answers

Which of the following is NOT a function of the muscularis externa?

<p>Absorbs nutrients (B)</p> Signup and view all the answers

Which cell type is responsible for secreting hydrochloric acid in the gastric glands?

<p>Parietal cells (D)</p> Signup and view all the answers

What is the primary function of intrinsic factor in the gastric glands?

<p>Vitamin B12 absorption (B)</p> Signup and view all the answers

Which of the following products is secreted by the chief cells?

<p>Pepsinogen (C)</p> Signup and view all the answers

What substance is primarily responsible for gastroprotection in the gastric glands?

<p>Mucus, bicarbonate (C)</p> Signup and view all the answers

Which type of cell is responsible for the secretion of gastrin?

<p>G cells (A)</p> Signup and view all the answers

What role does histamine play in the gastric glands?

<p>Promotes hydrochloric acid secretion (A)</p> Signup and view all the answers

Which of the following is NOT secreted by surface mucous cells?

<p>Histamine (A)</p> Signup and view all the answers

Which of the following substances is considered a neurotransmitter involved in the regulation of gastric secretion?

<p>Gastrin releasing peptide (GRP) (B)</p> Signup and view all the answers

What is the primary function of propulsive movements in the digestive tract?

<p>To propel contents forward through the digestive tract (B)</p> Signup and view all the answers

Which of the following represents exocrine secretions in the GI tract?

<p>HCl (B)</p> Signup and view all the answers

What is the end product of carbohydrate digestion?

<p>Monosaccharides (B)</p> Signup and view all the answers

Where does most absorption of digested nutrients take place?

<p>Small intestine (C)</p> Signup and view all the answers

Which of the following substances is NOT typically secreted into the bloodstream as an endocrine secretion?

<p>Amylase (A)</p> Signup and view all the answers

Which of these is generally included in digestive secretions?

<p>Electrolytes (D)</p> Signup and view all the answers

What type of digestion involves the biochemical breakdown of foodstuffs?

<p>Chemical digestion (D)</p> Signup and view all the answers

Which enzymes are primarily responsible for protein digestion?

<p>Trypsin and pepsin (C)</p> Signup and view all the answers

What is the primary purpose of mixing movements in the digestive process?

<p>To promote the breakdown and digestion of food (B)</p> Signup and view all the answers

Which of the following is an example of an enzyme involved in fat digestion?

<p>Lipase (B)</p> Signup and view all the answers

What triggers the release of secretin in the pancreas?

<p>Acid in chyme (A)</p> Signup and view all the answers

Which type of pancreatic cells secrete insulin?

<p>Beta cells (D)</p> Signup and view all the answers

Which of the following enzymes is NOT secreted by the acinar cells of the pancreas?

<p>Pepsin (A)</p> Signup and view all the answers

What is the primary function of pancreatic bicarbonate?

<p>To neutralize acidity in chyme (C)</p> Signup and view all the answers

What is the primary role of mastication in the digestive process?

<p>To mechanically break down food and mix it with saliva (D)</p> Signup and view all the answers

Which cells in the pancreas are responsible for secreting glucagon?

<p>Alpha cells (D)</p> Signup and view all the answers

How do the exocrine cells of the pancreas function?

<p>They produce enzymes that digests fats. (B)</p> Signup and view all the answers

Which statement best describes the role of saliva in digestion?

<p>It moistens food, lubricates, and has antibacterial properties. (B)</p> Signup and view all the answers

What role do duct cells play in the function of the pancreas?

<p>They secrete bicarbonate solution. (B)</p> Signup and view all the answers

During which stage of swallowing does the bolus move through the pharynx?

<p>Oropharyngeal stage (C)</p> Signup and view all the answers

What is a primary function of the stomach?

<p>Storage of ingested food and secretion of gastric juices (C)</p> Signup and view all the answers

What is the purpose of activating pancreatic enzymes?

<p>To promote digestion of nutrients (A)</p> Signup and view all the answers

Which of the following components is NOT typically found in gastric juice?

<p>Bile salts (C)</p> Signup and view all the answers

How does the stomach contribute to protein digestion?

<p>By secreting enzymes like pepsin that initiate digestion (B)</p> Signup and view all the answers

The term 'chyme' refers to:

<p>Partially digested food mixed with gastric juices (D)</p> Signup and view all the answers

What happens to food as it moves from the stomach to the duodenum?

<p>It is liquefied and moved at a controlled rate (B)</p> Signup and view all the answers

Which feature of the stomach aids in maximizing its volume and surface area?

<p>Mucosal folds (B)</p> Signup and view all the answers

What is the main effect of the intrinsic factor secreted by the stomach?

<p>It is essential for vitamin B12 absorption. (C)</p> Signup and view all the answers

What is the primary site for the absorption of nutrients in the small intestine?

<p>Duodenum and jejunum (C)</p> Signup and view all the answers

Which of the following substances is absorbed in the ileum?

<p>Bile salts (C)</p> Signup and view all the answers

What role do bile salts play in fat digestion?

<p>They form micelles with fatty acids. (D)</p> Signup and view all the answers

How are triglycerides broken down in the small intestine?

<p>By the action of pancreatic lipase. (B)</p> Signup and view all the answers

What happens to monoglycerides and fatty acids after they are released from micelles?

<p>They passively diffuse through the lipid bilayer of epithelial membranes. (C)</p> Signup and view all the answers

Which nutrients are freely absorbed in the small intestine?

<p>Electrolytes, vitamins, and water (A)</p> Signup and view all the answers

How is the absorption of calcium and iron adjusted in the body?

<p>It is adjusted to the body’s needs. (B)</p> Signup and view all the answers

What is the role of water-soluble micelles in fat absorption?

<p>To carry lipid digestion products to the absorptive surface. (A)</p> Signup and view all the answers

Match the digestive processes with their descriptions:

<p>Motility = Movement of food through the digestive tract Secretion = Release of digestive enzymes and fluids Absorption = Transfer of nutrients into the bloodstream Storage = Keeping of indigestible food until elimination</p> Signup and view all the answers

Match the major parts of the digestive tract with their main functions:

<p>Mouth = Initial breakdown and mixing with saliva Stomach = Chemical digestion with acids and enzymes Small intestine = Primary site for nutrient absorption Large intestine = Water absorption and waste storage</p> Signup and view all the answers

Match the components of the GI system with their roles:

<p>Saliva = Aids in digestion and lubricates food Bile = Emulsifies fats for better absorption Pancreatic enzymes = Break down macromolecules in the small intestine Mucus = Protects the lining of the GI tract</p> Signup and view all the answers

Match the sections of the GI tract with their specific absorption sites:

<p>Stomach = Limited nutrient absorption Duodenum = Iron and calcium absorption Jejunum = Most nutrient absorption Ileum = Vitamin B12 and bile salts absorption</p> Signup and view all the answers

Match the nutrients with their absorption methods:

<p>Amino acids = Active transport mechanisms Glucose = Secondary active transport with sodium Fatty acids = Diffusion through intestinal membranes Water = Osmosis</p> Signup and view all the answers

Match the terms of digestive function with their definitions:

<p>Digestion = Biochemical breakdown of food Absorption = Transfer of nutrients into circulation Motility = Movement of contents along the GI tract Elimination = Discharge of indigestible waste</p> Signup and view all the answers

Match the roles of the digestive organs with their functions:

<p>Esophagus = Transports food from mouth to stomach Stomach = Mixes food with gastric juices Pancreas = Produces digestive enzymes and hormones Liver = Produces bile for fat emulsification</p> Signup and view all the answers

Match the GI functions with their primary objectives:

<p>Digestion = To break down food into absorbable units Absorption = To assimilate nutrients into the body Secretion = To provide enzymes and fluids for digestion Motility = To facilitate the movement of food along the tract</p> Signup and view all the answers

Match the following digestive processes with their descriptions:

<p>Mastication = Mechanical breakdown of food with saliva Deglutition = Swallowing food from the mouth Gastric secretion = Release of enzymes and acid in the stomach Chyme movement = Controlled passage of partially digested food to the duodenum</p> Signup and view all the answers

Match the components of gastric juice with their functions:

<p>Hydrochloric acid = Creates an acidic environment for digestion Mucus = Protects the gastric lining from acid Pepsinogen = Activated to pepsin for protein digestion Intrinsic factor = Necessary for vitamin B12 absorption</p> Signup and view all the answers

Match the stages of swallowing with their descriptions:

<p>Oropharyngeal stage = Movement of food through the pharynx Oesophageal stage = Transport of the bolus to the stomach Bolus formation = Mixing of food with saliva Pharyngeal reflex = Prevention of food entering the airway</p> Signup and view all the answers

Match the functions of the stomach with their descriptions:

<p>Storage = Holds ingested food until digestion begins Secretion = Releases digestive enzymes and acid Mixing = Combines food with gastric juices Killing bacteria = Uses acid to eliminate pathogens</p> Signup and view all the answers

Match the terms with their corresponding definitions:

<p>Chyme = Partially digested food in the stomach Peristalsis = Rhythmic contraction for food movement Saliva = Fluid that aids in digestion and lubrication Bolus = Chewed food formed into a mass for swallowing</p> Signup and view all the answers

Match the digestive organs with their primary roles:

<p>Mouth = Initiates digestion through chewing Stomach = Mixes food with gastric juices Duodenum = First part of the small intestine for chemical digestion Esophagus = Conducts food to the stomach</p> Signup and view all the answers

Match the types of digestion with their descriptions:

<p>Mechanical digestion = Physical breakdown of food into smaller pieces Chemical digestion = Enzymatic breakdown of food substances Absorption = Uptake of nutrients in the intestine Secretion = Release of digestive enzymes and juices</p> Signup and view all the answers

Match the processes with their regulating mechanisms:

<p>Gastric motility = Controlled by smooth muscle contractions Salivary secretion = Stimulated by the sight and smell of food Enzyme activation = Triggered by the presence of food in the stomach Hormonal regulation = Influenced by secretions like gastrin</p> Signup and view all the answers

Match the digestive secretions with their origins:

<p>Gastric juice = Secreted by the gastric glands Saliva = Produced by salivary glands Bile = Secreted by the liver Pancreatic juice = Produced by the pancreas</p> Signup and view all the answers

Match the types of digestive enzymes with their substrates:

<p>Amylase = Breaks down carbohydrates Lipase = Digests fats and lipids Pepsin = Digests proteins in the stomach Trypsin = Continues protein digestion in the intestine</p> Signup and view all the answers

Match the following components of bile with their respective descriptions:

<p>Bile salts = Fat emulsifiers that assist in digestion Bile pigments = Waste products from the breakdown of hemoglobin Cholesterol = A waxy substance that is a component of cell membranes Electrolytes = Mineral ions that help maintain fluid balance</p> Signup and view all the answers

Match the following liver functions with their details:

<p>Production of bile = Main digestive function of the liver Storage of glycogen = Energy reserve in the form of glucose Detoxification = Processing and elimination of harmful substances Synthesis of proteins = Creation of important blood proteins like albumin</p> Signup and view all the answers

Match the following liver structures with their characteristics:

<p>Hepatocytes = Plate-like cells responsible for liver function Gallbladder = Storage site for bile Hepatic portal vein = Carries nutrient-rich blood from the digestive tract Liver lobule = The functional unit of the liver</p> Signup and view all the answers

Match the following terms related to bile with their meanings:

<p>Bile = Alkaline solution produced by the liver for fat digestion Emulsification = Process of breaking down fat into smaller droplets Enterohepatic circulation = Recycling pathway of bile salts through the liver and intestines Cholecystokinin = Hormone that stimulates bile release from the gallbladder</p> Signup and view all the answers

Match the following bile components with their functions:

<p>Bile salts = Aid in fat digestion and absorption Phospholipids = Form part of the micelle necessary for fat absorption Neutral fats = Stored energy sources in the body Cholesterol = Component of cell membranes and bile acids</p> Signup and view all the answers

Match the following structures of the small intestine with their functions:

<p>Duodenum = First site of intensive digestion and receives bile Jejunum = Main site for nutrient absorption Ileum = Absorption of bile salts and vitamin B12 Villi = Increase the surface area for absorption</p> Signup and view all the answers

Match the components of the gastric mucosal barrier with their descriptions:

<p>HCO3–-rich mucus = Neutralizes acid close to gastric mucosa Tight junctions = Impedes passage of HCl between cells Rapid cell division = Entire stomach lining replaced in 3 days Prostaglandins = Inhibit acid secretion and promote mucus secretion</p> Signup and view all the answers

Match the digestive processes with their respective characteristics:

<p>Segmentation = Mixes and propels chyme Peristalsis = Facilitates movement of contents through the intestine Chemical digestion = Involves bile and pancreatic enzymes Absorption = Mainly occurs in the duodenum and jejunum</p> Signup and view all the answers

Match the types of digestive enzymes found in the small intestine with their functions:

<p>Enteropeptidase = Activates pancreatic enzymes Disaccharidases = Break down carbohydrates into simple sugars Aminopeptidases = Degrade proteins to amino acids Brush border enzymes = Facilitate digestion at the intestinal membrane</p> Signup and view all the answers

Match the terms associated with the gastric environment to their roles:

<p>HCl = Provides acidic environment for digestion Mucus = Protects gastric lining from acid Digestive enzymes = Break down food components Intrinsic factor = Essential for vitamin B12 absorption</p> Signup and view all the answers

Match the secretions of the pancreas with their functions:

<p>Bile = Emulsifies fats for easier digestion Pancreatic juice = Contains enzymes for digesting proteins, fats, and carbohydrates Hepatic secretions = Release stimulated by fatty chyme Bicarbonate = Neutralizes stomach acid in the duodenum</p> Signup and view all the answers

Match the components of the small intestine structure with their descriptions:

<p>Circular folds = Increases surface area threefold Villi = Finger-like projections that enhance absorption Microvilli = Hair-like structures on epithelial cells Mucosal surface = Where digestion and absorption occur</p> Signup and view all the answers

Match the types of contractions in the intestine with their purposes:

<p>Segmentation = Mixes and breaks down contents Peristaltic contractions = Forces contents forward Chyme = Partially digested food moving towards the large intestine Aqueous solution = Facilitates lubrication and transport of nutrients</p> Signup and view all the answers

Match the components of the gastric juices to their functions:

<p>Gastrin = Stimulates secretion of gastric acid Pepsin = Breaks down proteins into peptides Mucous cells = Secrete mucus for protection Intrinsic factor = Facilitates vitamin B12 absorption</p> Signup and view all the answers

Match the important gastric secretory products with their sources:

<p>Hydrochloric acid (HCl) = Parietal cell Pepsinogen = Chief cell Mucus, bicarbonate = Surface mucous cells Histamine = ECL cells</p> Signup and view all the answers

Match the gastric secretory products with their primary functions:

<p>Intrinsic factor = Vitamin B12 absorption Gastrin = Regulation of gastric secretion Somatostatin = Regulation of gastric secretion Trefoil factors = Gastroprotection</p> Signup and view all the answers

Match the cells with the substances they secrete:

<p>G cells = Gastrin D cells = Somatostatin Nerves = Acetylcholine (ACh) Surface mucous cells = Mucus, bicarbonate</p> Signup and view all the answers

Match the gastric secretions to their roles in digestion:

<p>Pepsinogen = Protein digestion Hydrochloric acid (HCl) = Sterilization of meal Mucus = Gastroprotection Histamine = Regulation of gastric secretion</p> Signup and view all the answers

Match the gastric products to their regulation mechanisms:

<p>Gastrin releasing peptide (GRP) = Regulation of gastric secretion Acetylcholine (ACh) = Regulation of gastric secretion Histamine = Regulation of gastric secretion Somatostatin = Regulation of gastric secretion</p> Signup and view all the answers

Match the gastric glands with their secretory roles:

<p>Parietal cell = Hydrochloric acid (HCl) Chief cell = Pepsinogen ECL cell = Histamine G cells = Gastrin</p> Signup and view all the answers

Match the gastric cells to their primary secretions:

<p>Surface mucous cells = Mucus, bicarbonate D cells = Somatostatin Chief cells = Pepsinogen Parietal cells = Intrinsic factor</p> Signup and view all the answers

Match the secretions to the types of cells they are derived from:

<p>Intrinsic factor = Parietal cells Pepsinogen = Chief cells Gastrin = G cells Histamine = ECL cells</p> Signup and view all the answers

Match the pancreatic cell type to its function:

<p>Duct cells = Secrete aqueous bicarbonate solution Acinar cells = Secrete pancreatic juice Beta cells = Secrete insulin Alpha cells = Secrete glucagon</p> Signup and view all the answers

Match the pancreatic enzyme to its category:

<p>Proteases = Protein digestion Amylase = Carbohydrate digestion Lipase = Fat digestion Nucleases = Nucleic acid digestion</p> Signup and view all the answers

Match the type of secretion with its characteristic:

<p>Exocrine secretion = Transported via ducts Endocrine secretion = Released directly into bloodstream Bicarbonate secretion = Neutralizes acidity in chyme Pancreatic juice = Contains digestive enzymes</p> Signup and view all the answers

Match the hormone to its source:

<p>Insulin = Beta cells Glucagon = Alpha cells Secretin = S cells of the duodenum Cholecystokinin = I cells of the duodenum</p> Signup and view all the answers

Match the pancreatic secretion trigger with the cause:

<p>Release of secretin = Presence of acid in chyme Release of cholecystokinin = Presence of fats and proteins Bicarbonate secretion = Neutralizes stomach acid Enzyme secretion = Facilitates digestion in the intestine</p> Signup and view all the answers

Match the pancreatic structure to its description:

<p>Islets of Langerhans = Endocrine part of the pancreas Acinar cells = Exocrine functional units Duct cells = Modify pancreatic juice composition Pancreatic duct = Main duct draining digestive secretions</p> Signup and view all the answers

Match the digestive process with its enzyme:

<p>Protein digestion = Proteases Carbohydrate digestion = Amylase Fat digestion = Lipase Nucleic acid digestion = Nucleases</p> Signup and view all the answers

Match the phase of digestion to its action:

<p>Cephalic phase = Stimulates gastric secretions before food intake Gastric phase = Involves mixing and enzymatic digestion Intestinal phase = Regulates secretion in the small intestine Absorptive phase = Nutrients are absorbed into the bloodstream</p> Signup and view all the answers

Salivary amylase is completely inhibited by the acidity in the stomach.

<p>False (B)</p> Signup and view all the answers

Proteins undergo complete digestion by pepsin in the antrum of the stomach.

<p>False (B)</p> Signup and view all the answers

Alcohol and aspirin are the only substances absorbed in the stomach.

<p>True (A)</p> Signup and view all the answers

The alimentary canal is approximately 30 yards long.

<p>False (B)</p> Signup and view all the answers

The duodenum plays a role in stimulating gastric secretion processes.

<p>False (B)</p> Signup and view all the answers

The primary components of the GI system include the mouth, oesophagus, small intestine, and large intestine.

<p>True (A)</p> Signup and view all the answers

Gastric secretions are primarily responsible for the digestion of carbohydrates.

<p>False (B)</p> Signup and view all the answers

The exocrine pancreas is responsible for producing hormones that regulate glucose levels.

<p>False (B)</p> Signup and view all the answers

The gallbladder is classified as an accessory organ of the digestive system.

<p>True (A)</p> Signup and view all the answers

Exocrine secretions in the GI tract are released directly into the bloodstream.

<p>False (B)</p> Signup and view all the answers

The small intestine is where the initial digestive processes occur.

<p>False (B)</p> Signup and view all the answers

The large intestine consists of the caecum, colon, and rectum.

<p>True (A)</p> Signup and view all the answers

Absorption of nutrients occurs primarily in the large intestine.

<p>False (B)</p> Signup and view all the answers

Hydrochloric acid is classified as an exocrine secretion.

<p>True (A)</p> Signup and view all the answers

The mucosa is the outermost layer of the alimentary canal wall structure.

<p>False (B)</p> Signup and view all the answers

The middle part of the alimentary canal is primarily responsible for waste elimination.

<p>False (B)</p> Signup and view all the answers

The GI system only utilizes water and electrolytes in its secretions.

<p>False (B)</p> Signup and view all the answers

Salivary glands are considered accessory digestive organs.

<p>True (A)</p> Signup and view all the answers

Carbohydrates are broken down into glycerol during digestion.

<p>False (B)</p> Signup and view all the answers

Propulsive movements are responsible for mixing food with digestive juices.

<p>False (B)</p> Signup and view all the answers

The rectum is part of the upper portion of the alimentary canal.

<p>False (B)</p> Signup and view all the answers

Gastrin and secretin are examples of endocrine secretions.

<p>True (A)</p> Signup and view all the answers

The process of chemical digestion involves enzyme-mediated hydrolysis.

<p>True (A)</p> Signup and view all the answers

Lipase is an enzyme responsible for protein digestion.

<p>False (B)</p> Signup and view all the answers

Absorption in the GI tract involves the transfer of small units into blood or lymph.

<p>True (A)</p> Signup and view all the answers

The cephalic phase of gastric secretion is triggered by the presence of food in the stomach.

<p>False (B)</p> Signup and view all the answers

The intestinal phase of gastric secretion occurs after food moves from the stomach into the duodenum.

<p>True (A)</p> Signup and view all the answers

Gastric secretion is inhibited during the intestinal phase.

<p>True (A)</p> Signup and view all the answers

The gastric phase of gastric secretion is stimulated by the thought of food.

<p>False (B)</p> Signup and view all the answers

The activation of the proton pump occurs during the cephalic phase of gastric secretion.

<p>True (A)</p> Signup and view all the answers

The parietal cell receptor activation is crucial for controlling gastric secretion.

<p>True (A)</p> Signup and view all the answers

The excitatory cephalic and gastric phases increase gastric secretion and are controlled by neural signals.

<p>True (A)</p> Signup and view all the answers

The intestinal phase primarily stimulates gastric secretion through the release of gastrin.

<p>False (B)</p> Signup and view all the answers

The pancreatic acinar cells secrete only aqueous bicarbonate solution.

<p>False (B)</p> Signup and view all the answers

Secretin is primarily responsible for triggering the release of insulin from the pancreas.

<p>False (B)</p> Signup and view all the answers

The Islets of Langerhans in the pancreas are responsible for the exocrine functions of the pancreas.

<p>False (B)</p> Signup and view all the answers

Chyme that enters the duodenum is typically rich in pancreatic enzymes.

<p>False (B)</p> Signup and view all the answers

Alpha cells in the pancreas secrete glucagon to raise blood sugar levels.

<p>True (A)</p> Signup and view all the answers

Pancreatic bicarbonate functions only to increase the acidity of the intestinal contents.

<p>False (B)</p> Signup and view all the answers

The exocrine cells of the pancreas are involved in the secretion of digestive enzymes.

<p>True (A)</p> Signup and view all the answers

Duct cells of the pancreas secrete digestive enzymes directly into the bloodstream.

<p>False (B)</p> Signup and view all the answers

The duodenum and jejunum are the primary sites for absorption of carbohydrates, proteins, and fats.

<p>True (A)</p> Signup and view all the answers

Calcium and iron absorption occurs exclusively in the ileum without any regulation according to the body's needs.

<p>False (B)</p> Signup and view all the answers

Fat globules in the form of triglycerides are emulsified by bile salts to form a lipid emulsion.

<p>True (A)</p> Signup and view all the answers

Monoglycerides and free fatty acids are absorbed directly into the bloodstream after digestion in the stomach.

<p>False (B)</p> Signup and view all the answers

Bile salts are responsible for forming micelles that transport lipids to the intestinal cells.

<p>True (A)</p> Signup and view all the answers

The ileum is primarily responsible for the absorption of glucose and amino acids following digestion.

<p>False (B)</p> Signup and view all the answers

Lipase converts triglycerides into diglycerides and free fatty acids during fat digestion.

<p>False (B)</p> Signup and view all the answers

The absorption of electrolytes and vitamins occurs predominantly in the stomach.

<p>False (B)</p> Signup and view all the answers

What is the primary digestive function of the liver?

<p>Production of bile (B)</p> Signup and view all the answers

Which substances are primarily found in bile?

<p>Bile salts and bile pigments (D)</p> Signup and view all the answers

What is the significance of bile salts in digestion?

<p>They emulsify fats for easier digestion. (D)</p> Signup and view all the answers

How is bile stored and released?

<p>Stored in the gallbladder and released into the small intestine (D)</p> Signup and view all the answers

What describes the nature of bile?

<p>An alkaline solution (D)</p> Signup and view all the answers

Which gastric secretory product is essential for the absorption of Vitamin B12?

<p>Intrinsic factor (C)</p> Signup and view all the answers

What is the primary function of pepsinogen in the gastric glands?

<p>Protein digestion (C)</p> Signup and view all the answers

Which cell type is responsible for secreting histamine in the gastric gland?

<p>ECL cells (A)</p> Signup and view all the answers

Which substance is secreted by surface mucous cells to provide gastroprotection?

<p>Trefoil factors (B)</p> Signup and view all the answers

What role does somatostatin play in gastric secretion?

<p>Inhibits gastric acid secretion (C)</p> Signup and view all the answers

Which of the following substances is released by nerves to regulate gastric secretion?

<p>Acetylcholine (ACh) (A)</p> Signup and view all the answers

Which gastric gland secretory product is primarily responsible for the hydrolysis of food?

<p>Hydrochloric acid (A)</p> Signup and view all the answers

Where are triglycerides resynthesized after fat digestion?

<p>In the epithelial cells of the intestines (C)</p> Signup and view all the answers

What component forms a coating around triglycerides, allowing them to become water-soluble?

<p>Lipoproteins (C)</p> Signup and view all the answers

Which gastric secretion is produced by G cells to influence gastric activity?

<p>Gastrin (D)</p> Signup and view all the answers

What is the primary function of the large intestine?

<p>Storage and drying of waste (D)</p> Signup and view all the answers

Which beneficial substances are produced by bacteria in the large intestine?

<p>Vitamin K and folic acid (A)</p> Signup and view all the answers

How do chylomicrons exit epithelial cells after their formation?

<p>By exocytosis (D)</p> Signup and view all the answers

Why can chylomicrons not directly cross into capillaries?

<p>They are too large. (A)</p> Signup and view all the answers

What is the primary role of the large intestine's beneficial bacteria?

<p>Fermentation of soluble fibers. (C)</p> Signup and view all the answers

Which vitamins are absorbed by the large intestine?

<p>Vitamin B complexes and vitamin K (A)</p> Signup and view all the answers

What mechanism allows the gastric mucosal barrier to protect against hydrochloric acid damage?

<p>Tight junctions between adjacent mucosal cells (D)</p> Signup and view all the answers

Which statement best describes the primary role of the small intestine?

<p>It acts as the main site for digestion and absorption of food. (A)</p> Signup and view all the answers

Which structure in the small intestine greatly increases the absorptive surface area?

<p>Both A and C (D)</p> Signup and view all the answers

What initiates the release of pancreatic juice into the duodenum?

<p>Fatty chyme detected by intestinal cells (D)</p> Signup and view all the answers

Prostaglandins in the gastric mucosa primarily function to:

<p>Stimulate mucus secretion and inhibit acid secretion (D)</p> Signup and view all the answers

Which of the following substances is involved in neutralizing acids near the gastric mucosa?

<p>HCO3–-rich mucus (B)</p> Signup and view all the answers

Which section of the small intestine is primarily responsible for the absorption of nutrients?

<p>Jejunum (B)</p> Signup and view all the answers

What physical structure allows the small intestine to increase its surface area for absorption?

<p>Permanent circular folds in the mucosa (D)</p> Signup and view all the answers

What is primarily secreted by the brush border of the small intestine?

<p>Digestive enzymes (D)</p> Signup and view all the answers

What triggers the rapid turnover of gastric mucosal cells?

<p>Injury or erosion in the mucosa (A)</p> Signup and view all the answers

During which stage of swallowing does the bolus pass from the pharynx to the oesophagus?

<p>Oropharyngeal stage (B)</p> Signup and view all the answers

Which of the following correctly describes the stomach's primary function?

<p>Mixes food with gastric juice and initiates digestion. (A)</p> Signup and view all the answers

Which cells in the pancreas are specifically responsible for secreting aqueous bicarbonate solution?

<p>Duct cells (A)</p> Signup and view all the answers

What characterizes the churning action in the stomach?

<p>It mixes food with gastric juices to form chyme. (D)</p> Signup and view all the answers

Which pancreatic enzyme is primarily responsible for digesting carbohydrates?

<p>Amylase (B)</p> Signup and view all the answers

Which component of gastric juice is primarily responsible for protein digestion?

<p>Pepsin (B)</p> Signup and view all the answers

How does saliva aid in the digestion process?

<p>It moistens food and begins starch digestion. (D)</p> Signup and view all the answers

What is the main purpose of secretin in the digestive process?

<p>Stimulate secretion of pancreatic bicarbonate (C)</p> Signup and view all the answers

What is the significance of the gastric mucosal folds?

<p>They allow for increased absorption surface area. (D)</p> Signup and view all the answers

In which part of the pancreas are insulin and glucagon secreted?

<p>Islets of Langerhans (D)</p> Signup and view all the answers

Which of the following best describes the composition of gastric juice?

<p>Contains acid, mucus, intrinsic factor, and digestive enzymes. (D)</p> Signup and view all the answers

Which of the following correctly describes the composition of pancreatic juice?

<p>Proteases, amylase, and lipase (A)</p> Signup and view all the answers

What is chyme?

<p>The mixture of food and gastric juices in the stomach. (A)</p> Signup and view all the answers

What triggers the release of pancreatic enzymes into the duodenum?

<p>Release of cholecystokinin (CCK) (D)</p> Signup and view all the answers

What movement is primarily responsible for the transport of chyme from the stomach into the duodenum?

<p>Peristalsis (A)</p> Signup and view all the answers

Why is the neutralization of acidity in chyme important during digestion?

<p>To protect the intestinal lining (B)</p> Signup and view all the answers

What is the overall function of exocrine secretions from the pancreas?

<p>Aid in the digestion of nutrients (C)</p> Signup and view all the answers

Flashcards

Digestive Motility

Muscle movements that mix and move food through the digestive tract.

Propulsive Movements

Movements that propel or push food forward through the digestive tract.

Mixing Movements

Movements that mix food with digestive juices to enhance digestion.

Digestive Juices

Fluids released by the digestive tract to aid in digestion and absorption.

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Digestion

The process of breaking down complex food molecules into smaller, absorbable units using enzymes.

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Absorption

The process of transferring digested nutrients, water, vitamins, and electrolytes from the digestive tract into the bloodstream or lymph.

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Exocrine Secretions

Secretions released by the digestive tract into the lumen, such as water, electrolytes, and enzymes.

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Endocrine Secretions

Secretions released by the digestive tract into the bloodstream like hormones, such as gastrin and secretin.

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Digestive Enzymes

Substances that catalyze (speed up) the breakdown of complex molecules during digestion.

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Carbohydrate Digestion

The process of breaking down carbohydrates into monosaccharides.

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Submucosa

A layer of dense connective tissue found beneath the mucosa of the alimentary canal. It contains essential structures like blood and lymphatic vessels, lymphoid follicles, and nerve fibers, aiding in the digestive tract's distensibility and elasticity.

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Submucosal Nerve Plexus of Meissner

A network of nerves located within the submucosa of the alimentary canal. It controls the smooth muscle contractions in the mucosa and regulates the release of digestive secretions.

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Muscularis Externa

The muscular layer of the alimentary canal, responsible for the movement of food through the digestive tract via peristalsis and segmentation.

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Myenteric Plexus of Auerbach

A network of nerves located within the muscularis externa of the alimentary canal. It controls the contractions of the circular and longitudinal smooth muscle layers, regulating the movement of food through the digestive tract.

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Serosa

The outermost layer of the alimentary canal, composed of connective tissue and epithelium. It helps to hold the digestive tract in place within the abdomen.

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Mastication

The act of chewing food, breaking it down into smaller pieces, and mixing it with saliva containing salivary amylase, which partially digests starch.

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Deglutition

The process of swallowing food and moving it from the mouth to the stomach, involving the oropharyngeal and oesophageal stages.

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Oropharyngeal stage

The first stage of swallowing, where food is moved from the mouth through the pharynx to the oesophagus.

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Oesophageal stage

The second stage of swallowing, where food moves through the oesophagus to the stomach using rhythmic muscular contractions.

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What is the stomach?

The stomach is a J-shaped, distensible part of the GI tract that plays a critical role in food storage, mixing, digestion, and controlled delivery of food to the intestines.

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What is gastric juice?

The stomach secretes gastric juice, a mix of acid, mucus, intrinsic factor, and digestive enzymes, which aids in the digestion of proteins and fats, kills bacteria, and prepares food for onward movement to the duodenum.

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What are the key functions of the stomach?

The stomach mixes food with gastric juice, pulverizes it, partially digests proteins and fat, and then moves the partially digested food (chyme) to the duodenum.

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What are gastric mucosal folds, gastric pits, and gastric glands?

Gastric mucosal folds, gastric pits, and gastric glands are microscopic structures within the stomach lining that produce the various components of gastric juice, including enzymes and acid for digestion.

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What type of cells produce pepsinogen?

Chief cells are responsible for producing and secreting pepsinogen, the inactive form of pepsin, a key enzyme involved in protein digestion.

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What cells produce HCl and intrinsic factor?

Parietal cells are responsible for secreting hydrochloric acid (HCl), a strong acid essential for food digestion and sterilization, and intrinsic factor, a protein vital for vitamin B12 absorption.

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Which cells release histamine?

ECL cells release histamine, an important signaling molecule that regulates the secretion of gastric acid, ensuring efficient digestion.

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What cells secrete gastrin?

G cells primarily secrete gastrin, a hormone vital for promoting the production of gastric juice, ensuring optimal digestion within the stomach.

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How is pepsinogen activated?

Pepsinogen, an inactive precursor, is converted into its active form, pepsin, when exposed to the acidic environment of the stomach, initiating protein digestion.

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What triggers the activation of pepsinogen?

The activation of pepsinogen relies on the acidic conditions created by hydrochloric acid (HCl), secreted by the parietal cells in the stomach.

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What are the main products secreted by parietal cells?

Parietal cells produce both hydrochloric acid (HCl) and intrinsic factor. HCl is essential for digestion, while intrinsic factor is vital for absorbing vitamin B12.

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Why are gastric glands important?

Gastric glands are essential for producing digestive enzymes like pepsinogen and hydrochloric acid (HCl), crucial for protein digestion and overall digestion in the stomach.

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What do acinar cells secrete?

Acinar cells are responsible for producing and secreting pancreatic juice, a mixture of enzymes essential for digestion. These enzymes include proteases, amylase, and lipase, which break down proteins, carbohydrates, and fats, respectively.

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What is the exocrine function of the pancreas?

The exocrine function of the pancreas involves the production and secretion of pancreatic juice, which contains digestive enzymes and bicarbonate, aiding in the breakdown and neutralization of food in the small intestine.

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What is the endocrine function of the pancreas?

The endocrine function of the pancreas involves the production and secretion of hormones like insulin and glucagon, which regulate blood glucose levels.

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How does secretin contribute to the digestive process?

Secretin is a hormone released in response to acidic chyme entering the duodenum. It stimulates the pancreas to produce bicarbonate, which helps neutralize the acidity and create a suitable environment for digestive enzymes.

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What is pancreatic juice and what does it do?

Pancreatic juice is a mixture of digestive enzymes and bicarbonate that is secreted by the exocrine pancreas. It helps break down food components into smaller, more absorbable molecules.

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What are the islets of Langerhans and what is their role?

The islets of Langerhans are clusters of endocrine cells within the pancreas responsible for producing and secreting hormones like insulin and glucagon, which regulate blood glucose levels.

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What are brush border enzymes and where are they found?

Brush border enzymes are enzymes located on the microvilli of the small intestine. They are important for final digestion of carbohydrates and proteins, breaking them down into smaller, absorbable units.

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Where and how are pancreatic enzymes activated?

Pancreatic enzymes are activated in the small intestine, specifically in the duodenum. This activation ensures that the enzymes are only active when they reach their target site, preventing self-digestion of the pancreas.

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Where does most absorption occur in the small intestine?

The duodenum and jejunum are the primary sites of nutrient absorption, absorbing carbohydrates, proteins, fats, electrolytes, vitamins, and water. The ileum primarily absorbs bile salts, vitamin B12, electrolytes, and water.

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How are carbohydrates digested?

Carbohydrate digestion begins in the mouth with salivary amylase breaking down starch into smaller sugar molecules. In the small intestine, pancreatic amylase further breaks down starches into disaccharides. Finally, disaccharidases on the surface of intestinal cells break down disaccharides into monosaccharides, the absorbable form of carbohydrates.

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How are proteins digested?

Proteins are broken down into smaller peptides by pepsin in the stomach. In the small intestine, pancreatic proteases further break down peptides into amino acids, the absorbable form.

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How are fats digested?

Fats are emulsified by bile salts in the small intestine, creating smaller fat droplets. Lipase then breaks down triglycerides into monoglycerides and fatty acids, which are absorbed by intestinal cells.

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How is calcium and iron absorption regulated?

Calcium and iron absorption are not passive, they are regulated by the body to meet its needs.

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How are the products of digestion absorbed?

Monosaccharides, amino acids, and fatty acids are absorbed from the small intestine into the bloodstream.

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What is the role of bile salts in fat digestion?

Bile salts are crucial for fat digestion and absorption. They are produced in the liver, stored in the gallbladder, and released into the small intestine.

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Where is vitamin B12 absorbed?

Vitamin B12 is an essential nutrient that is absorbed in the ileum. It is needed for the production of red blood cells.

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What is the gastrointestinal system?

The gastrointestinal system, also known as the digestive system, is a group of organs responsible for breaking down food into smaller, absorbable nutrient molecules, which are then absorbed into the bloodstream for distribution to all cells in the body.

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What are the main functions of the GI system?

The main functions of the gastrointestinal system include digesting food into smaller nutrient molecules, absorbing these nutrients into the bloodstream, providing energy and building blocks for the body, and eliminating indigestible food waste.

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What are the five basic processes of digestion?

The gastrointestinal system performs five basic digestive processes: motility, secretion, digestion, absorption, and storage and elimination.

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What is digestive motility?

Motility refers to the muscular movements of the digestive tract, which mix and propel food forward.

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What is secretion in digestion?

Secretion involves the release of digestive juices containing enzymes, acids, and other substances that aid in digestion and absorption.

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What is digestion?

Digestion is the process of breaking down complex food molecules into smaller absorbable units through enzymatic reactions.

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What is absorption?

Absorption is the movement of digested nutrients, water, and salts from the digestive tract into the bloodstream or lymph.

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What is the role of storage and elimination in digestion?

Storage and elimination involve temporary storage of indigestible food residues and their eventual elimination from the body as feces.

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What is the liver?

The largest gland in the body, composed of plates of liver cells (hepatocytes). Its main digestive function is the production of bile, a fat emulsifier.

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What is bile?

A yellow-green, alkaline solution produced by the liver that helps in the digestion of fats.

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What is fat emulsification?

The process of increasing the surface area of fat globules by breaking them down into smaller droplets, making them easier to digest.

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How is bile release controlled?

The release of bile from the gallbladder is controlled by the hormone cholecystokinin (CCK). When fatty food reaches the duodenum, CCK signals the gallbladder to release bile.

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What is enterohepatic circulation?

The continuous circulation of bile salts between the liver, gallbladder, small intestine, and back to the liver.

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Oropharyngeal stage of swallowing

The movement of food from the mouth through the pharynx into the oesophagus. This phase is crucial to ensure the food does not enter the trachea, or the airway.

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Oesophageal stage of swallowing

The movement of food through the oesophagus to the stomach using rhythmic muscle contractions. This allows for efficient transport.

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Gastric Mucosal Barrier

A protective layer that shields the stomach lining from the damaging effects of hydrochloric acid (HCl). It consists of several key components, including: impermeable cell membranes, tight junctions between cells, bicarbonate-rich mucus, and rapid cell renewal.

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Mucus

A vital component of the gastric mucosal barrier. It forms a thick, gel-like layer that physically separates the stomach lining from the acidic gastric contents. Also, the bicarbonate in mucus neutralizes acid close to the mucosa.

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Small Intestine

The primary site for digestion and absorption of nutrients in the digestive tract. It is also where most of the digestive enzymes are active.

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Villi (singular: villus)

These tiny finger-like projections on the inner surface of the small intestine increase the surface area for absorption of nutrients and other substances.

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Microvilli (singular: microvillus)

Microscopic, hair-like projections on the surface of the villi, further increasing the surface area for absorption.

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Duodenum

The first 10 inches of the small intestine where chemical digestion and absorption of nutrients begin. Also, it is the first site of digestion for food entering the small intestine after leaving the stomach.

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Pancreatic Juice

A vital component of the digestive process. It contains enzymes that break down fat, carbohydrates, and proteins. It originates from the pancreas.

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Bile

A fluid released by the liver into the small intestine, containing bile salts and other essential substances. Bile salts emulsify fats, making them smaller droplets for digestion.

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Intrinsic Factor

A protein produced by the stomach's parietal cells. It is involved in the absorption of Vitamin B12 in the ileum of the small intestine.

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What are Parietal Cells?

Parietal cells are responsible for producing and secreting hydrochloric acid (HCl) which is essential for digestion. This strong acid plays a crucial role in breaking down food, killing harmful bacteria, and activating pepsinogen for protein digestion.

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What are Chief Cells?

Chief cells are responsible for producing and secreting pepsinogen, the inactive precursor of pepsin. Pepsin is a crucial enzyme responsible for breaking down proteins into smaller peptides, a vital step in protein digestion.

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What is pepsinogen?

Pepsinogen is the inactive precursor of pepsin. Pepsin is a protein-digesting enzyme that is only active in the acidic environment of the stomach. The conversion of pepsinogen to its active form, pepsin, is triggered by the presence of hydrochloric acid (HCl).

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What is Intrinsic Factor?

Intrinsic factor is a protein secreted by parietal cells in the stomach. It is essential for the absorption of vitamin B12 in the small intestine. Vitamin B12 is crucial for the formation of red blood cells and proper neurological function.

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What are ECL Cells?

ECL cells are responsible for producing and secreting histamine. Histamine is an important signaling molecule that stimulates the release of hydrochloric acid (HCl) by parietal cells. Histamine plays a key role in regulating gastric acid secretion and ensures optimal food digestion in the stomach.

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What are G cells?

G cells are responsible for producing and secreting gastrin, a hormone that stimulates the release of hydrochloric acid (HCl) and pepsinogen from other cells in the stomach. Gastrin plays a key role in regulating gastric emptying and ensuring optimal digestion.

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What is Gastrin?

Gastrin is a hormone produced and secreted by G cells. It plays a crucial role in regulating gastric function, stimulating the release of hydrochloric acid (HCl) and pepsinogen from the stomach lining. Gastrin also regulates gastric emptying and ensures optimal food digestion.

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What is Somatostatin?

Somatostatin is a hormone produced and secreted by D cells in the stomach. It plays a role in inhibiting the release of hormones such as gastrin and insulin. Somatostatin also inhibits the production of hydrochloric acid (HCl) in the stomach and helps to regulate gastric emptying.

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What are the main enzymes secreted by the pancreas?

The pancreas secretes digestive enzymes like protease, amylase, and lipase, which break down proteins, carbohydrates, and fats, respectively.

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What role does the pancreas play in neutralizing stomach acid?

The exocrine pancreas secretes pancreatic juice, containing bicarbonate, which neutralizes acid from the stomach, creating an optimal pH for enzymatic digestion in the small intestine.

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What are the main hormones produced by the pancreas and what are their roles?

Insulin and glucagon are the main hormones produced by the pancreas. Insulin lowers blood sugar levels, while glucagon raises them.

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What is the role of the hormone 'secretin' in pancreatic secretion?

Secretin is a hormone released by the duodenum in response to acidic chyme. It stimulates the pancreas to release bicarbonate, which neutralizes the acidity.

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What are the two main functions of the pancreas?

The pancreas has both an exocrine and an endocrine function. The exocrine function involves producing digestive enzymes, while the endocrine function involves producing hormones.

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What is the overall role of the pancreas in the digestive system?

The pancreas plays a major role in digestion by secreting enzymes that break down food molecules and bicarbonate that neutralizes stomach acid, creating a suitable environment for digestion.

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Where is the pancreas located and what is its primary role?

The pancreas, located near the stomach and small intestine, is a crucial organ for both digestion and blood glucose regulation.

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Alimentary Canal

A continuous tube stretching from the mouth to the anus, approximately 30 feet long, responsible for the digestion and absorption of food.

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Accessory Digestive Organs

Organs that assist the alimentary canal in digestion, but are not part of the tube itself.

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Proton Pump Activation

Proton pumps are activated by the binding of H+K+ ATPase to the parietal cell membrane. This results in the movement of hydrogen ions from the parietal cell into the stomach lumen. The proton pump is a critical component of gastric acid secretion.

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Phases of Gastric Secretion

Gastric secretion is a complex process that involves three phases: cephalic, gastric, and intestinal. The cephalic phase is triggered by the thought, sight, smell, or taste of food. The gastric phase is stimulated by food in the stomach, particularly protein. The intestinal phase is activated by food entering the duodenum.

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Excitatory Phases

The cephalic and gastric phases of gastric secretion are excitatory, meaning they increase gastric acid production. This is due to the release of acetylcholine and gastrin, respectively.

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Inhibitory Intestinal Phase

The intestinal phase of gastric secretion is inhibitory, meaning it decreases gastric acid production. This is due to the release of hormones like cholecystokinin (CCK) and secretin.

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Parietal Cells and HCl

Parietal cells are responsible for producing hydrochloric acid (HCl), a key component of gastric juice. HCl plays a vital role in digestion by breaking down food, activating pepsinogen, and killing harmful bacteria in the stomach.

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Chief Cells and Pepsinogen

Chief cells produce and secrete pepsinogen, the inactive precursor of pepsin. Pepsin is a key enzyme involved in protein digestion, breaking down protein molecules into smaller peptides.

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ECL Cells and Histamine

ECL cells secrete histamine, which stimulates the release of HCl from parietal cells. Histamine is a key regulator of gastric acid secretion, ensuring optimal digestion.

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G Cells and Gastrin

G cells produce and secrete gastrin, a hormone that stimulates the release of both HCl and pepsinogen. Gastrin plays a vital role in regulating gastric emptying and ensures optimal digestion.

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Gastric Juice

The stomach releases gastric juice to break down food. This juice is a mix of acid, mucus, intrinsic factor, and digestive enzymes.

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What are propulsive movements?

Movements that push food forward through the digestive tract.

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What are mixing movements?

Movements that mix food with digestive juices to aid digestion.

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What are digestive juices?

Fluids released by the digestive tract containing enzymes, acids, and other substances that help break down food.

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What are exocrine secretions?

Secretions released into the lumen of the digestive tract. Examples include: water, HCl, HCO3-, bile, lipase, pepsin, amylase, trypsin & histamine.

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What are endocrine secretions?

Secretions released into the bloodstream. Examples include: gastrin, secretin, CCK, VIP & somatostatin.

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What are digestive enzymes?

Specialized proteins that speed up chemical reactions in digestion, breaking down complex molecules into smaller units.

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What is carbohydrate digestion?

The process of breaking down carbohydrates into simple sugars (monosaccharides).

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What is pancreatic juice?

The exocrine portion of the pancreas releases this bicarbonate-rich fluid, which neutralizes the acidic chyme coming from the stomach, creating an optimal environment for digestive enzymes in the small intestine.

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What are acinar cells?

These cells, found in the acini of the pancreas, are responsible for synthesizing and secreting pancreatic juice containing digestive enzymes.

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What are duct cells?

Located within the pancreas, these cells secrete bicarbonate ions into pancreatic juice, which is crucial for neutralizing the acidity of chyme entering the small intestine.

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What is secretin?

This hormone, secreted by the duodenum in response to acidic chyme, triggers the pancreas to release bicarbonate to neutralize the acidity, creating a suitable environment for digestive enzymes.

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What are the main digestive enzymes secreted by the pancreas?

Pancreatic enzymes like trypsin, chymotrypsin, and carboxypeptidase break down proteins into smaller peptides. Amylase digests carbohydrates into simple sugars. Lipase breaks down fats (lipids) into fatty acids and glycerol.

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What is activation of pancreatic enzymes?

This key process involves the conversion of inactive forms of pancreatic enzymes, like trypsinogen, into their active forms, such as trypsin, within the small intestine.

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Villi

Tiny finger-like projections on the inner lining of the small intestine that increase the surface area for nutrient absorption.

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Microvilli

Microscopic, hair-like projections on the surface of villi that further increase the surface area for absorption in the small intestine.

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Fat Emulsification

The process of breaking down large fat globules into smaller droplets, making them easier to digest.

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Enterohepatic Circulation

The continuous circulation of bile salts between the liver, gallbladder, small intestine, and back to the liver.

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What are villi?

They are tiny finger-like projections on the inner surface of the small intestine increasing the surface area for absorption of nutrients and other substances.

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What are microvilli?

They are microscopic, hair-like projections on the surface of the villi, further increasing the surface area for absorption.

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Parietal Cell

A cell type found in the gastric glands that secretes hydrochloric acid (HCl) and intrinsic factor. HCl is essential for digestion, and intrinsic factor is crucial for the absorption of Vitamin B12.

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Pepsinogen

An inactive precursor of pepsin, a protein-digesting enzyme. Pepsinogen is released by chief cells and activated by the acidic environment of the stomach.

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Gastrin

A hormone produced by G cells in the stomach that stimulates the release of hydrochloric acid (HCl) and pepsinogen, both vital for digestion.

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ECL Cell

A cell type found in the gastric glands that releases histamine, a signaling molecule that stimulates the release of HCl from parietal cells. Histamine indirectly helps in digestion by increasing HCl production.

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Somatostatin

A hormone produced by D cells in the stomach that inhibits the release of various hormones, such as gastrin and insulin. It also slows down gastric emptying and lowers stomach acidity.

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Chief Cell

A cell type found in the gastric glands that secretes pepsinogen, the inactive precursor of pepsin. Pepsinogen is converted to its active form, pepsin, by hydrochloric acid.

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Pepsinogen Activation

The activation of pepsinogen, the inactive precursor of pepsin, into its active form, pepsin, by the acidic environment of the stomach.

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What is the pancreas and what is its primary role?

The pancreas, located near the stomach and small intestine, is crucial for both digestion and regulating blood glucose levels.

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What is the duodenum?

The first 10 inches of the small intestine where chemical digestion and absorption of nutrients begin. Also, it is the first site of digestion for food entering the small intestine after leaving the stomach.

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What are the phases of gastric secretion?

Gastric secretion is a complex process that involves three phases: cephalic, gastric, and intestinal. The cephalic phase is triggered by the thought, sight, smell, or taste of food. The gastric phase is stimulated by food in the stomach, particularly protein. The intestinal phase is activated by food entering the duodenum.

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What is the Gastric Mucosal Barrier?

The stomach lining has a protective barrier that prevents damage from the highly acidic environment. This barrier is composed of several elements, including impermeable cell membranes, tight junctions between cells, mucus that neutralizes acid, and rapid cell turnover.

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What does the small intestine do?

The breakdown of complex nutrients into smaller, absorbable units occurs primarily in the small intestine. This process involves specific enzymes like protease, amylase, and lipase, which breakdown proteins, carbohydrates, and fats, respectively.

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What is the duodenum and what does it do?

The duodenum is the first segment of the small intestine. It receives chyme from the stomach and bile and pancreatic juice from the accessory organs. These secretions are vital for digestion and absorption.

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What is the function of the pancreas in digestion?

The pancreas plays a crucial role in digestion by producing and secreting pancreatic juice. This juice contains enzymes that break down food molecules and bicarbonate that neutralizes the acidity of chyme from the stomach.

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What is the role of the liver and bile in digestion?

The liver produces bile, a green-yellow fluid that helps digest fats. Bile is stored in the gallbladder and secreted into the duodenum.

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What are the villi and what is their function?

The villi are small finger-like projections that extend from the inner lining of the small intestine. They increase the surface area available for absorption of nutrients and other substances from digested food.

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What are microvilli and their role?

Microvilli are microscopic, hair-like projections that extend from the surface of the villi. Their presence further increases the surface area for absorption in the small intestine.

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What is the muscularis externa and what role does it play?

The muscularis externa is responsible for the movements within the digestive tract that help mix and propel food along the digestive tract. These movements are crucial for digestion and absorption.

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What are phases of gastric secretion?

The cephalic, gastric, and intestinal phases are the three stages of gastric secretion. The cephalic phase is initiated by the thought or sight of food, the gastric phase is triggered by food in the stomach, and the intestinal phase is regulated by the presence of food in the duodenum.

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The Large Intestine: Its Role

The large intestine is primarily a drying and storage organ, responsible for absorbing water, electrolytes, and certain vitamins. It also hosts a diverse population of bacteria that produce essential vitamins and ferment indigestible molecules.

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Gut Flora: Beneficial Bacteria

The large intestine contains a diverse population of bacteria, often referred to as gut flora, that play a beneficial role in maintaining health, producing certain vitamins, and fermenting indigestible food components.

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What are Chylomicrons?

Chylomicrons are particles that are formed inside the epithelial cells during fat absorption. They are composed of triglycerides, cholesterol, and phospholipids, and they are coated with a layer of protein. Chylomicrons are essential for transporting fats from the small intestine to the rest of the body.

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Parts of the Large Intestine

The colon, caecum, appendix, and rectum are all parts of the large intestine.

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Study Notes

Gastrointestinal System 1

  • The gastrointestinal (GI) or digestive system is a group of organs working together to break down ingested food into smaller, absorbable nutrients.
  • These nutrients are absorbed into the blood for distribution to all body cells.
  • The GI system's main functions include digestion (breaking down food), absorption (taking up nutrients), motility (moving food through the system), secretion (releasing digestive juices), and storage and elimination of indigestible material.
  • The GI system uses 5 basic digestive processes: Motility, Secretion, Digestion, Absorption, and Storage & Elimination.

Outline of Lectures

  • The main functions of the GI system.
  • Organisation and functional anatomy of the GI system.
  • Digestive processes in the mouth and stomach (next week). 3 parts.
  • Digestive processes in the small intestine.
  • Digestive processes in the large intestine.

Learning Outcomes

  • Describe the basic anatomy and main functions of the GI system.
  • Explain digestive processes occurring in major parts of the digestive tract.
  • Describe the neural and chemical control of the GI system.
  • Discuss major sites of absorption within the GI system.

The GI System

  • A group of organs working together to digest ingested food, which consists of:
  • Mouth (oral cavity)
  • Esophagus
  • Liver
  • Gallbladder
  • Small intestine
  • Duodenum
  • Jejunum
  • Ileum
  • Anus
  • Transvers colon
  • Descending colon
  • Ascending colon
  • Cecum
  • Sigmoid colon
  • Rectum
  • Vermiform appendix
  • Salivary glands (parotid, sublingual, submandibular)
  • Pancreas
  • Stomach
  • Pharynx

Main Functions

  • Digests or breaks down ingested food into small, simple nutrient molecules.
  • Absorbs and transfers nutrients, electrolytes, and water from ingested food into the systemic circulation.
  • Makes preformed organic nutrients available to body cells for fuel or energy and building blocks.

Digestive Processes

  • Motility is the muscular contractions that mix and move food through the digestive tract.
  • Two types: propulsive (moves food forward) and mixing (mixes food with digestive juices to promote digestion and facilitate absorption).

Secretion

  • Several digestive juices are secreted in the GI tract in response to neural or hormonal stimulation.
  • These secretions consist of water, electrolytes, and specific organic constituents (enzymes, mucus, etc.).
  • Exocrine secretions are secreted into the lumen (inner space) of the GI tract (e.g., H2O, HCl, HCO3-, bile, lipase, pepsin, amylase, trypsin, and histamine).
  • Endocrine secretions are released into the bloodstream (e.g., gastrin, secretin, CCK, VIP, and somatostatin).

Digestion

  • Biochemical breakdown of complex foodstuffs into smaller absorbable units (chemical digestion).
  • Achieved through enzyme-mediated hydrolysis.
  • Example products: Carbohydrate --> monosaccharides, Protein --> amino acids, Fats --> glycerol & fatty acids.

Absorption

  • Transfer of small digested units (along with water, vitamins, and electrolytes) from the GI tract into the blood or lymph.
  • Primarily occurs in the small intestine.

Functional Anatomy of the Gastrointestinal (Digestive) System

  • Detailed structure/anatomy of the GI tract, including the four layers of the alimentary canal wall: mucosa, submucosa, muscularis externa, and serosa.

The Alimentary Canal

  • A continuous tube stretching from the mouth to the anus.
  • Comprises 3 main parts: upper (mouth, esophagus, and stomach), middle (small intestine), and lower (large intestine).

Wall Structure of the Alimentary Canal

  • Four layers: mucosa (innermost layer), submucosa (connective tissue), muscularis externa (smooth muscle layers), and serosa (outermost layer).
  • Individual layer functions, such as glands, nerves, and blood vessels.

Complex Extrinsic & Intrinsic Regulation of Digestive Function

  • Extrinsic influences (e.g., nervous system and endocrine hormones).
  • Intrinsic influences (e.g., intrinsic nerves and local sensory receptors).
  • How different factors influence processes like motility, digestion, and secretion.

Digestive Processes: From Mouth to Stomach

  • Mastication (chewing)
  • Deglutition (swallowing)
  • Oropharyngeal stage of swallowing: tongue, soft palate, epiglottis, pharynx
  • Esophageal stage of swallowing: peristalsis
  • Detailed steps and factors involved in each stage.

The Stomach

  • Description and shape of the stomach, J-shaped.
  • Main stomach functions: Storing food, secreting gastric juice (acid, mucus, and intrinsic factor, and digestive enzymes), mixing food, initiating protein and fat digestion, and killing bacteria. A J-shaped sac.

Gastric Mucosal Folds, Gastric Pits & Gastric Glands

  • Anatomy of the stomach at a microscopic level including cells like mucous cells, parietal cells, and chief cells.
  • Detailed functions of the different cells.

Structure of Gastric Gland

  • Detailed description of the various cells and their functions in the gastric gland(Mucus cells, mucous neck cells, parietal cells, Chief cells, ECL cells, endocrine, G cells, D cells).

The Stomach Mucosa and the Gastric Glands

  • Structures and functions of the different cells in the stomach mucosa

Gastric Glands: Important Secretory Products

  • Different products of gastric glands, their source, and their function.
  • Examples of products: Hydrochloric acid, intrinsic factor, pepsinogen, mucus, bicarbonate, trefoil factors, histamine, gastrin, gastrin-releasing peptide (GRP), acetylcholine, somatostatin.

Pepsinogen Activation in the Stomach

  • Pepsinogen is activated to pepsin by hydrochloric acid (HCl) in the stomach lumen, and also triggers the autocatalysis process.

Mechanism of Gastric HCI Secretion

  • Detailed steps of acid secretion (including CO2, HCO3-, and Cl- transport)

Parietal Cell - Receptor Activation of the Proton Pump

  • Detailed steps/process of activation of the parietal cell and the subsequent secretion of proton pump (including M3 muscarinic receptors, H2 receptors, gastrin receptors.)

Control of Gastric Secretion

  • The phases of gastric secretion (cephalic, gastric, and intestinal phases).
  • Stimulatory and inhibitory events in each phase including the roles of factors such as vagus nerve, acetylcholine, gastrin, histamine, somatostatin, secretin, CCK, etc..

Digestion & Absorption in the Stomach

  • Digestion of carbohydrates by salivary amylase (partial inhibition due to stomach acidity).
  • Partial digestion of protein by pepsin.
  • Absorption of only water, alcohol, and aspirin.

The Gastric Mucosal Barrier

  • Components of the gastric mucosal barrier(mucus coating, tight junctions between epithelial cells, HCO3-rich mucus, rapid cell division).
  • How the barrier protects the stomach from self-digestion.
  • Rapid rate of cell division to repair the stomach lining..
  • Role of prostaglandins (inhibit acid secretion and promote alkaline mucus secretion).

Digestive Processes: From Small Intestine to Large Intestine

-Processes in the small intestine and large intestine

The Small Intestine

  • Main site of digestion and absorption.
  • Structure-function relationships:
  • Folds, villi, and microvilli to maximize surface area for absorption.
  • Digestive enzymes on the microvilli membrane (e.g. enteropeptidase, disaccharidases, aminopeptidases).
  • Three main subdivisions: Duodenum, Jejunum, Ileum.

The Duodenum and Hepatopancreatic Region

-Description of the primary location for digestion and the role of the accessory organs (pancreas, gallbladder, liver), their ducts and secretions (bile, pancreatic juice, bicarbonate).

The Duodenum

  • First 10 inches of the small intestine.
  • Site of intensive digestion that receives bile and pancreatic juice via the common bile and pancreatic ducts.
  • Arrival of chyme stimulates the release of hepatic and pancreatic secretions.
  • The role of secretions like CCK, secretin, pancreatic bicarbonate in neutralizing stomach acid (acid in chyme stimulates release of secretin, which stimulates the release of pancreatic bicarbonate to neutralize the acidity).

Structure of the Pancreas

  • Exocrine and endocrine functions.
  • Acinar cells: enzyme secretion, including proteases, amylase, and lipase
  • Duct cells: bicarbonate secretion and hormonal control
  • Islets of Langerhans: insulin and glucagon secretion

Hormonal Control of Pancreatic Exocrine Secretion.

  • Regulation and control of bicarbonate and enzyme secretions (e.g., secretin, CCK).

Activation of Pancreatic Enzymes

  • Mechanism/process of activating pancreatic enzymes (e.g., trypsinogen to trypsin by enteropeptidase).

The Liver & Hepatic Portal Circulation

  • Blood supply, processing nutrients, bile production, and role in the processing of nutrients. Blood arriving to liver via the hepatic portal vein carries absorbed nutrients from digestive tract, and then is circulated throughout the liver via sinusoids. Hepatic artery supplies oxygen and blood for liver function. Blood leaving the liver via hepatic vein.

The Liver

  • Largest gland in the body, composed of hepatocytes (liver cells).
  • Bile: A fat emulsifier primarily made of bile salts, pigments, cholesterol, electrolytes.
  • Role in bile storage & release. (Bile stored and released from the gallbladder, controlled by CCK).

Fat Emulsification by Bile Salts.

  • Mechanism of bile salt emulsification of fats

Bile Release Control

  • Factors involved in the production and release of bile, including hormonal (CCK, secretin) and nervous stimuli.

Enterohepatic Circulation of Bile Salts.

  • The process by which bile salts are recycled (reabsorbed and re-secreted)

Digestion & Absorption in the Small Intestine

  • Processes involved in carbohydrates, proteins, and fat digestion and absorption (along with water, electrolytes, and vitamins).

Absorption in Small Intestine

  • Duodenum and jejunum: primarily digestion and absorption of carbohydrates, proteins, fats, water, vitamins, and electrolytes.
  • Ileum mainly absorbs bile salts, vitamin B12, electrolytes, and water.

Carbohydrate, Protein & Fat Digestion

Detailed steps, enzymes, and substrates in digestion

Carbohydrate Digestion

  • Steps and digestive enzymes (salivary amylase, pancreatic amylase, brush-border enzymes like lactase, maltase, sucrase)
  • Location in digestive tract

Carbohydrate Absorption

  • Process of carbohydrate absorption, including the various transport mechanisms (SGLT, GLUT-2, GLUT-5).

Protein Digestion

  • Process, including enzymes like pepsin, pancreatic proteolytic enzymes, aminopeptidases, and intracellular peptidases

Protein Absorption.

  • Process of Protein absorption, involving amino acid transport across the intestinal cells.

Fat Digestion

  • Mechanism/process of fat digestion involving bile salts, pancreatic lipase, and micelle formation.

Minor Absorptive Function of the Large Intestine

-Water, electrolytes, vitamins (e.g., B vitamins, Vitamin K, folic acid) and some minerals

The Large Intestine

  • Structure (colon, caecum, appendix, rectum).
  • Major function is absorbing water, electrolytes, and some vitamins, primarily for waste elimination. Site of fermentation for short-chain fatty acids by beneficial bacteria (~500-1000 sp) that also produce important B vitamins and vitamin K.

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Description

Test your knowledge on the structure and function of the alimentary canal with this quiz. Explore topics such as the layers of the canal, nerve plexuses, and the roles of various cell types in the gastric glands. Perfect for students of anatomy and physiology.

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