Gastroenterology: Diarrhea and Intestinal Water Absorption
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Questions and Answers

What is the normal daily water intake in the GI tract?

  • 2 liters
  • 3 liters
  • 200 mL
  • 9 liters (correct)

What is the maximum water content in the stool at the end of the day for normal intestinal function?

  • 9 liters
  • 200 mL (correct)
  • 8.8 liters
  • 1 liter

What is the driving force for water reabsorption in the intestine?

  • Calcium
  • Chloride
  • Potassium
  • Sodium (correct)

Which of the following regulates chloride gates for water secretion in the intestine?

<p>Intracellular Calcium levels (A)</p> Signup and view all the answers

What influences cAMP levels, which in turn regulate chloride channels in the intestine?

<p>Endogenous and exogenous factors (A)</p> Signup and view all the answers

In a condition where the water content of stool exceeds 200 mL per day, what type of condition does it bring about?

<p>Watery condition (A)</p> Signup and view all the answers

Which factor influences cyclic AMP production in the context of cholera diarrhea?

<p>Vibrio secretes cholera toxin (A)</p> Signup and view all the answers

What is the main effect of enkephalin on cAMP levels?

<p>Closure of chloride gates (A)</p> Signup and view all the answers

Which enzyme neutralizes the effect of enkephalins?

<p>Enkephalinase (B)</p> Signup and view all the answers

What is a potential effect of inhibiting enkephalinase?

<p>Decreased water secretion (D)</p> Signup and view all the answers

What is the classification for diarrhea with a duration of 2-3 weeks?

<p>Chronic diarrhea (C)</p> Signup and view all the answers

What is the most common cause of acute diarrhea?

<p>Infectious agents (D)</p> Signup and view all the answers

What is the main mode of transmission for infectious diarrhea?

<p>Fecal-oral route (D)</p> Signup and view all the answers

'Fever', 'nausea', and 'vomiting' are common clinical manifestations of:

<p>Acute diarrhea (B)</p> Signup and view all the answers

What is the incidence of ulcerative colitis in North America per person-years?

<p>0 - 19.2 per 100,000 (B)</p> Signup and view all the answers

At what age does ulcerative colitis typically onset?

<p>Second to fourth decades and seventh to ninth decades (D)</p> Signup and view all the answers

Which ethnicity has the highest risk of ulcerative colitis?

<p>Jewish (A)</p> Signup and view all the answers

What is the female to male ratio in ulcerative colitis?

<p>0.51 – 1.58 (B)</p> Signup and view all the answers

Which factor may prevent ulcerative colitis according to the provided data?

<p>Appendectomy (D)</p> Signup and view all the answers

In ulcerative colitis, what is the most common segmental distribution of the lesion?

<p>Rectal involvement (B)</p> Signup and view all the answers

What is the primary cause of chronic state of dysregulated mucosal immune function in individuals genetically predisposed to IBD?

<p>Defective immune regulation and environmental factors combined (C)</p> Signup and view all the answers

Which genetic syndromes are associated with IBD, according to the provided data?

<p>Turner’s Syndrome and Hypergammaglobulinemia (B)</p> Signup and view all the answers

What is the normal function of the GI mucosal immune system in response to luminal contents?

<p>Unreactive due to oral tolerance (A)</p> Signup and view all the answers

What is indicative of Crohn’s disease when seen in biopsy?

<p>Granuloma (D)</p> Signup and view all the answers

When inflammation heals with fibrosis and strictures, what does it lead to?

<p>Obstructions (B)</p> Signup and view all the answers

What is the imbalance between in IBD where pro-inflammatory mediators predominate?

<p>Defective immune regulation (C)</p> Signup and view all the answers

In Crohn’s disease patient, what immune response is observed against certain components?

<ul> <li>Immune response vs Ompc and Flagellin (A)</li> </ul> Signup and view all the answers

What are the potential beneficial effects noted in Crohn’s disease patient in relation to certain antibiotics and diet?

<ul> <li>Immune response vs inhibitory cytokines (C)</li> </ul> Signup and view all the answers

What manifestations are commonly observed in Crohn’s disease?

<p>Intra-abdominal abscess and thickened bowel wall (B)</p> Signup and view all the answers

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