F6- EEG

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Questions and Answers

Gamma waves, with frequencies starting at 30 Hz, are the highest frequency waves in the EEG spectrum.

False (B)

The ECoG method is particularly suitable for studying gamma waves due to their low amplitude.

True (A)

Gamma wave activity is primarily associated with long-term memory formation and retrieval.

False (B)

A study by an American scientist showed an inverse relationship between neuronal spiking and increases in gamma band amplitude.

<p>False (B)</p> Signup and view all the answers

‘Spikes’ on an EEG recording are considered a typical feature of normal brain activity.

<p>False (B)</p> Signup and view all the answers

The visual evoked potential (VEP) is a measure of the brain's electrical response to a specific visual stimulus.

<p>True (A)</p> Signup and view all the answers

Latencies in the VEP are determined by the time it takes for the stimulus to reach the occipital lobe from the eyes.

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EEG recordings are not particularly useful for studying the different stages of sleep.

<p>False (B)</p> Signup and view all the answers

The EEG is a technique primarily used to record muscle activity during exercise.

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The EEG signal is generated solely by the activity of a single neuron.

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The EEG utilizes invasive techniques to record brain activity.

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Electrical stimulation of cholinergic neurons in the reticular formation can induce wakefulness and arousal, a phenomenon known as the reticular activating system.

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Hans Berger was the first to record brain activity in humans, pioneering the field of electroencephalography.

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The research by Horace Magoun and Giuseppe Moruzzi indicated that wakefulness is primarily a result of sensory input rather than an active neural circuitry.

<p>False (B)</p> Signup and view all the answers

Cortical pyramidal neurons are oriented parallel to the cortical surface, contributing to the EEG signal.

<p>False (B)</p> Signup and view all the answers

Walter Hess's work demonstrated that stimulating the thalamus with low-frequency pulses in an awake cat induced a state resembling slow-wave sleep, typical of deep sleep phases.

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The EEG signal is static, representing a single snapshot of the brain's electrical activity.

<p>False (B)</p> Signup and view all the answers

During REM sleep, the EEG signal closely resembles that of the awake state, suggesting a similar neural origin for both.

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The 'current sink' created by an EPSP is caused by a negative charge entering the dendrite.

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The EEG signal is generated exclusively by the activity of inhibitory postsynaptic potentials.

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The superior colliculus plays a role in regulating the timing and heading of eye movements during sleep.

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The EEG signal is amplified and converted to a digital signal before it can be analyzed by a computer.

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The pontine-geniculo-occipital (PGO) waves, originating in the pons, are directly responsible for the occurrence of REM sleep.

<p>False (B)</p> Signup and view all the answers

The 'active' electrode used in EEG recordings is typically placed on a reference point on the body, such as the earlobe.

<p>False (B)</p> Signup and view all the answers

FMRIs are used alongside EEGs to pinpoint precisely the brain regions active during both REM and non-REM sleep.

<p>True (A)</p> Signup and view all the answers

The descending inhibitory projections from the pons to the dorsal column nuclei contribute to a heightened response to sensory stimuli.

<p>False (B)</p> Signup and view all the answers

The reticular activating system primarily functions to regulate sleep-wake transitions while the thalamus plays minimal role in this process.

<p>False (B)</p> Signup and view all the answers

The pontine reticular formation’s role is strictly limited to generating PGO waves during REM sleep, leaving minimal involvement in other sleep stages.

<p>False (B)</p> Signup and view all the answers

The EEG technique provides better temporal resolution compared to fMRI.

<p>True (A)</p> Signup and view all the answers

Delta waves are classified within the frequency range of 8-12 Hz.

<p>False (B)</p> Signup and view all the answers

Functional MRI captures direct electrical activity of neurons in real-time.

<p>False (B)</p> Signup and view all the answers

Theta waves occur in the frequency range of 4-7 Hz and are associated with deep sleep.

<p>False (B)</p> Signup and view all the answers

Evoked potentials can detect responses even from small stimuli due to their physiological nature.

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The nucleus located in the anterior part of the thalamus is crucial for maintaining homeostatic balances.

<p>False (B)</p> Signup and view all the answers

During non-REM sleep, physiological activities such as heart rate and blood pressure decrease significantly.

<p>True (A)</p> Signup and view all the answers

REM sleep is characterized by slow, rolling eye movements and increased muscle activity.

<p>False (B)</p> Signup and view all the answers

A decrease in detected frequencies is observed as one progresses through the stages of non-REM sleep.

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Penile erection during sleep is a significant indicator of deep non-REM sleep.

<p>False (B)</p> Signup and view all the answers

The transition between non-REM sleep stages to REM sleep typically occurs after approximately 60 minutes of sleep.

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Increased activity of inhibitory GABAergic neurons during REM sleep leads to paralysis of large muscle groups.

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During both non-REM and REM sleep, muscle tone and body movements are consistently high.

<p>False (B)</p> Signup and view all the answers

The biggest drops in physiological activity during sleep occur in stage II of non-REM sleep.

<p>False (B)</p> Signup and view all the answers

The activities of the heart rate and blood pressure are at their lowest during REM sleep.

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Flashcards

Gamma Waves

The highest frequency band in the EEG, typically starting at 30 Hz, associated with cognitive functions like memory and sensory processing.

Binding Hypothesis of Gamma Waves

A theory suggesting that gamma waves represent the synchronized activity of neurons working together to perform a specific function, like recognizing an object or moving a limb.

Electrocorticography (ECoG)

A technique that records electrical activity directly from the surface of the brain, useful for studying high-frequency brainwaves like gamma waves.

EEG Spike

A brief, sharp spike in the EEG signal, often associated with epilepsy.

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Evoked Potential

The potential difference in electrical charge recorded in response to a specific stimulus, commonly used to assess the integrity of sensory pathways.

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Visual Evoked Potential

A specific type of evoked potential that assesses the visual pathways from the eyes to the cortex.

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Latency

The time it takes for a stimulus to reach the cortical target, measured in evoked potentials.

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Sleep Stages

The different stages of sleep characterized by specific patterns of brainwave activity, measured using electroencephalography (EEG).

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Electroencephalogram (EEG)

The recording of electrical activity in the brain using electrodes placed on the scalp.

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Functional Magnetic Resonance Imaging (fMRI)

A type of neuroimaging technique that measures brain activity by detecting changes in blood flow. It provides good spatial resolution but has a slower temporal resolution.

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Alpha Waves (α)

The frequency range of brain waves that are typically associated with normal wakefulness.

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Delta Waves (Δ)

A type of brain wave that is typically associated with sleep.

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What is EEG?

A non-invasive technique that records brain electrical activity from the scalp, primarily used to diagnose epilepsy and sleep disorders.

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What is an EEG cap?

A specialized cap placed on the head to record brain waves.

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What is the main principle of EEG recording?

The difference in electrical potential between a recording electrode placed on the scalp and a reference electrode.

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What are pyramidal neurons?

The synchronized activity of a large group of pyramidal neurons in the cerebral cortex is responsible for the EEG signal.

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What is an EPSP?

The point where a dendrite receives an input from another neuron, often generating a positive charge.

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What is a current sink?

An area where current flows into a neuron, usually associated with an EPSP.

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How does the EEG detect neural activity?

The EEG measures the sum of excitatory and inhibitory postsynaptic potentials from many neurons firing synchronously.

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What makes the EEG a dynamic measure?

The EEG is a dynamic measure because it records the changes in electrical potential over time.

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What makes the EEG non-invasive?

The EEG is a non-invasive technique, meaning it does not require surgery or punctures to record brain signals.

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What are the applications of the EEG?

The EEG has a wide range of applications in medicine, including diagnosing epilepsy, sleep disorders, and brain tumors.

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Hypothalamus and its role

The hypothalamus, found in the posterior part of the thalamus, plays a crucial role in regulating various bodily functions like body temperature, hormone secretion, blood pressure, urine production, and more, impacting both vegetative and homeostatic balances.

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EEG and sleep staging

The electroencephalogram (EEG) allows us to observe and classify different sleep stages, distinguishing between wakefulness, non-REM sleep (stages I to IV), and REM sleep.

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Non-REM sleep characteristics

Non-REM sleep is characterized by a gradual decrease in brain activity, muscle tone, and overall bodily functions as sleep deepens, reaching its lowest point in stage IV.

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REM sleep characteristics

REM sleep (Rapid Eye Movement) is a stage of sleep characterized by brain activity similar to wakefulness, rapid eye movements, muscle paralysis, and vivid dreams.

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EEG changes in non-REM sleep

The transition from stage I to stage IV non-REM sleep shows a gradual transition in EEG signals. Deeper sleep reveals bigger EEG amplitudes and lower frequencies.

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Sleep stage cycling

Following a cycle of non-REM sleep stages, the body reverses back through these stages before entering the REM sleep phase.

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Physiological changes during REM sleep

While non-REM sleep is characterized by decreased activity, REM sleep exhibits increased heart rate, blood pressure, and metabolism, all of which are nearly as high as the awake state.

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Penile erection in REM sleep

REM sleep is marked by the presence of spontaneous penile erections, which can be used as an indicator of the REM phase and potentially related reproductive system health.

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Muscle activity regulation during REM sleep

Muscle movement during REM sleep is regulated by increased activity of GABAergic neurons in the pontine reticular formation, which inhibit lower motor neurons in the spinal cord.

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GABA and its role

GABA (gamma-aminobutyric acid) is an inhibitory neurotransmitter, meaning it decreases or stops the activity of other neurons, playing a crucial role in regulating sleep and muscle activity.

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Reticular Activating System (RAS)

A group of cholinergic neurons in the reticular formation near the junction of the pons and midbrain that, when stimulated, induce wakefulness and arousal.

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RAS-Thalamus Interaction

The RAS, located in the brainstem, interacts with the thalamus to regulate the transition between sleep and wakefulness.

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Slow-wave Sleep

Slow-wave sleep, characterized by high-amplitude, slow brain waves, is associated with deep sleep and is induced by stimulating the thalamus.

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PRF and Eye Movements

The pontine reticular formation (PRF) sends signals to the superior colliculus, which controls eye movements, leading to the rapid eye movements characteristic of REM sleep.

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REM Sleep Neural Pathway

Brain waves during REM sleep originate from the activation of the PRF and propagate through specific pathways, including the lateral geniculate nucleus of the thalamus and the visual cortex.

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PGO Waves

Brain waves associated with REM sleep that originate in the PRF and travel through the thalamus to the visual cortex, contributing to the rapid eye movements and vivid dreams of REM.

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fMRI and Sleep Stages

fMRI is used to identify brain regions active during different sleep stages, including REM and non-REM sleep.

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REM Sleep Brain Waves

REM sleep is characterized by brain wave patterns that resemble wakefulness, but its neural origin is different, stemming from the activation of the PRF.

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Brainstem and Thalamus in Sleep Regulation

The brainstem is involved in controlling wakefulness, while the thalamus plays a crucial role in regulating sleep.

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REM and Non-REM Sleep Importance

While both REM and non-REM sleep have distinct brain wave patterns, they are both crucial for physical and mental restoration.

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Study Notes

EEG and Sleep Principles

  • Electroencephalography (EEG) is a non-invasive technique used to record scalp activity, often during tasks like running or in epileptic patients.

  • Hans Berger, a psychiatrist, first recorded scalp activity in humans in 1929. EEG recording was considered clinically non-relevant for some time before this.

  • EEG involves placing electrodes on the scalp to record cortical brainwaves. These waves are then sent to an amplifier and digitized for analysis by a computer.

  • EEG is essentially a graphic representation of the potential difference between an active electrode placed on the scalp and a reference electrode.

EEG Components

  • Active Electrode (REC): Placed on the skull, ideally over areas where many neurons fire.

  • Reference Electrode (REF): Usually placed on another body area (like an earlobe).

  • Amplifier/ADC: Converts the analog EEG signal to a digital signal, allowing computer analysis.

Factors Affecting EEG Amplitude

  • Distance between electrodes: Increased distance generally results in a larger amplitude.

  • Number of neurons: A larger number of neurons firing synchronously leads to a larger amplitude.

  • Cortical structure: Sulci (grooves) in the brain's surface can affect the amplitude of signals. A neuron perpendicular to the scalp generates larger signals than one in a sulcus. Neurons at the base of a sulcus could partially cancel signals from opposite sides.

EEG Principles

  • EEG signals are primarily generated by cortical pyramidal neurons firing synchronously.

  • The signal is a result of postsynaptic potentials (EPSPs), which are excitatory postsynaptic potentials and current sources.

  • EPSPs result in a positive charge entering a dendrite, forming a current ‘sink’. The charge completes a loop through the neuron to exit at a current ‘source’, creating a dipole.

  • Action potentials contribute minimally to the EEG signal due to their short duration and rapid decrease in amplitude.

  • MEG is similar to EEG, but it measures the magnetic fields generated by neural activity.

  • Local field potentials (LFPs) recorded from within the cortex measure activity from many nearby neurons.

  • Electrocorticography (ECoG): Electrodes are placed directly on the brain's surface. Provides higher cortical resolution.

EEG Stages of Sleep

  • EEG is crucial for characterizing sleep stages. Sleep transitions from awake to progressively deeper stages, to REM sleep, and back.

  • Different frequencies and amplitudes are associated with different sleep stages: -Awake: High frequency, low amplitude -Non-REM: Progressively lower frequency and increased amplitude (stages 1–4), which are characterized as the deepest sleep stages. -REM sleep: Shows high frequency, low amplitude EEG waves that resemble wakefulness.

  • Various other waves (Delta, Theta, Alpha, Beta, Gamma) are seen at different stages and durations.

Sleep and EEG

  • Sleep stages are categorized and measured using EEG patterns.

  • EEG helps to pinpoint unusual features of sleep, like spontaneous penile erection in REM sleep.

  • The circadian rhythm influences sleep cycles, impacting sleep stages and various bodily functions (like hormone production and temperature).

Applications

  • EEG is used to detect evoked potentials, specifically visual evoked potentials (VEPs), caused by specific stimuli to evaluate the integrity of visual pathways.

  • Clinical tests, which can detect and understand latencies and unusual amplitudes of visual evoked potentials (VEPs), can be used to observe damage to visual pathways.

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