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Questions and Answers
Which statement accurately describes G6PD deficiency?
Which statement accurately describes G6PD deficiency?
What is the primary screening test for G6PD deficiency?
What is the primary screening test for G6PD deficiency?
Which of the following findings is NOT typically associated with G6PD deficiency in a peripheral blood smear?
Which of the following findings is NOT typically associated with G6PD deficiency in a peripheral blood smear?
Which of the following variants classifies as Class I G6PD deficiency?
Which of the following variants classifies as Class I G6PD deficiency?
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What is the functional role of G6PD in red blood cells?
What is the functional role of G6PD in red blood cells?
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Study Notes
Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency
- G6PD deficiency is an X-linked recessive disorder.
- It's the most common RBC enzyme deficiency.
- It affects approximately 400 million people worldwide.
- It's present in about 5% of the global population.
- Possible findings in Peripheral Blood Smear (PBS) include Heinz bodies, bite cells, and degmacytes.
G6PD Deficiency: Testing and Diagnosis
- Screening test: G6PD fluorescent spot test.
- Confirmatory test: Quantitative G6PD assay.
- Autohemolysis test is a screening test for G6PD deficiency.
G6PD Deficiency Classification
- Classified by WHO based on G6PD enzyme activity levels.
- Class I: Severely deficient (<1% activity or not detectable).
- Class II: Severely deficient (<10% activity).
- Class III: Mild to moderately deficient (10% to 60% activity).
- Symptoms of Class I: chronic, hereditary, non-spherocytic hemolytic anemia (most severe, rare).
- Symptoms of Class II: severe, episodic acute hemolytic anemia associated with infections, certain drugs, and fava beans. Requires possible transfusions during episodes and is not self-limited.
- Symptoms of Class III: episodic, acute hemolytic anemia associated with infections, and certain drugs. Symptoms are self-limiting.
- Examples of G6PD Variants: G6PD-Serres, G6PD-Madrid, G6PD-Mediterranean, G6PD-Chatham, G6PD-A, G6PD-Canton.
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Description
This quiz covers key aspects of Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency, an X-linked recessive disorder affecting red blood cell enzyme activity. It includes details on its prevalence, diagnosis methods, and classification according to WHO standards. Test your understanding of this common enzyme deficiency and its implications.
