10 Questions
What is the most common manifestation of G6PD deficiency?
Neonatal jaundice and episodic acute hemolytic anemia
Which of the following drugs is NOT listed as potentially eliciting hemolysis in individuals with G6PD deficiency?
Metformin
In individuals with G6PD deficiency, what is the typical timeframe for the onset of hemolysis after ingesting a substance with oxidant properties?
About 24-48 hours
Which of the following statements about favism is NOT true?
Favism is thought to be more frequently associated with the G6PD A− variant.
What is the typical finding in unstained or supravital preparations of red blood cells during an episode of acute hemolysis in G6PD deficiency?
Presence of Heinz bodies
What is the primary function of G6PD enzyme?
Converting glucose 6-phosphate to 6-phosphogluconic acid
Why do most heterozygous females not experience clinical hemolysis after exposure to oxidant drugs?
The inactivation of the normal X chromosome is random and sometimes exaggerated
In which population is the variant G6PD A− enzyme commonly found?
Americans of African descent
What is the incidence range of the G6PD B− variant in certain ethnic groups?
5% to 40%
Which population has approximately 5% with the G6PD Canton mutant enzyme?
Chinese population
Learn about G6PD deficiency, an X-linked disease with over 140 mutations affecting more than 400 million people worldwide. Discover how G6PD catalyzes the conversion of glucose 6-phosphate and its role in providing protection against oxidant threats.
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