Fungal Infections of the Respiratory Tract

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Which type of infections are more common than fungal infections of the lung?

Bacterial and viral infections

What is the range of virulence for fungal infections of the lung?

From causing no symptoms to causing death

Which population is at an increased risk for invasive fungal infections?

Patients with chronic debilitating diseases

Which group of patients is NOT included in the population at risk for invasive fungal infections?

<p>Patients with acute illnesses</p> Signup and view all the answers

What is the main reason for the surge in rates of invasive fungal infections?

<p>Increased size of the population at risk</p> Signup and view all the answers

Which of the following is a characteristic of opportunistic fungal infections?

<p>They are more common in individuals with compromised immune systems</p> Signup and view all the answers

Which of the following is the most prevalent opportunistic fungal infection?

<p>Systemic candidiasis</p> Signup and view all the answers

Which fungal infection is the leading cause of infection-related death in stem cell transplant recipients?

<p>Invasive pulmonary aspergillosis</p> Signup and view all the answers

Which of the following is NOT a major endemic mycosis found in North America and Africa?

<p>Aspergillosis</p> Signup and view all the answers

Endemic fungal infections are primarily influenced by which factors?

<p>Soil and climate conditions</p> Signup and view all the answers

Which regions are home to three major endemic mycoses?

<p>North America and Africa</p> Signup and view all the answers

Which of the following fungal infections is considered an endemic dimorphic mycosis?

<p>Histoplasmosis</p> Signup and view all the answers

Which of the following fungal infections can cause invasive disease only in immunocompromised patients?

<p>Aspergillosis</p> Signup and view all the answers

Which category of mycoses can cause disease in both normal and immunocompromised patients?

<p>Endemic dimorphic mycoses</p> Signup and view all the answers

Which fungal pathogen is commonly found growing on human skin or mucosa and does not require a shift to a spore form to infect a host?

<p>C. albicans</p> Signup and view all the answers

Which fungal pathogen forms cysts with sexual spores, but it is unclear if they play a role in spreading infection to new hosts?

<p>Pneumocystis jirovecii</p> Signup and view all the answers

Which species of Candida is the most frequently isolated from respiratory samples?

<p>Candida albicans</p> Signup and view all the answers

Which predisposing clinical circumstances are commonly associated with Candida pneumonia?

<p>Hematologic malignancy</p> Signup and view all the answers

What is the prevalence of Candida pneumonia?

<p>Rare</p> Signup and view all the answers

In which part of the body is Candida pneumonia primarily observed?

<p>Lungs</p> Signup and view all the answers

Which species is the most frequent cause of invasive pulmonary aspergillosis (IPA)?

<p>Aspergillus fumigatus</p> Signup and view all the answers

How are Aspergillus conidia primarily transmitted?

<p>Airborne transmission</p> Signup and view all the answers

How are Aspergillus conidia typically eliminated by the human body?

<p>By the immune system</p> Signup and view all the answers

Which patient population is commonly affected by respiratory infections caused by Aspergillus spp.?

<p>Critically ill patients</p> Signup and view all the answers

Which of the following animals is NOT commonly affected by Blastomycosis?

<p>Birds</p> Signup and view all the answers

Which of the following symptoms is NOT associated with Blastomycosis?

<p>Skin rash</p> Signup and view all the answers

Which organism causes blastomycosis in humans and other animals?

<p>Blastomyces dermatitidis</p> Signup and view all the answers

What is another name for blastomycosis?

<p>Gilchrist's disease</p> Signup and view all the answers

Which immune cells are involved in the phagocytosis of Blastomyces dermatitidis conidia in the lungs?

<p>Neutrophils and macrophages</p> Signup and view all the answers

What happens to some of the inhaled conidia of B. dermatitidis after phagocytosis?

<p>They escape phagocytosis and transform into yeast phase rapidly</p> Signup and view all the answers

What is the treatment of choice for most forms of blastomycosis?

<p>Itraconazole</p> Signup and view all the answers

What can be said about the cure rates in blastomycosis with appropriate treatment?

<p>Cure rates are high</p> Signup and view all the answers

Which cells are responsible for engulfing and neutralizing fungi in the lungs?

<p>Macrophages</p> Signup and view all the answers

What is the term for collections of immune cells that form in response to fungal infection?

<p>Granulomas</p> Signup and view all the answers

What are the long-term consequences of fungal infections in the lungs?

<p>Formation of calcified granulomas and scars</p> Signup and view all the answers

What can be seen on X-ray images years after a fungal infection?

<p>Calcified granulomas</p> Signup and view all the answers

How do most pulmonary fungal infections occur?

<p>Through inhalation of aerosolized fungi</p> Signup and view all the answers

How is fungal infection typically controlled in healthy individuals?

<p>Through activation of secondary or adaptive immunity</p> Signup and view all the answers

What is the characteristic ability of some fungi that enables them to evade destruction by macrophages?

<p>Rapid growth and multiplication inside macrophages</p> Signup and view all the answers

Which of the following is the most effective preventive measure for individuals at risk of fungal infections?

<p>Avoiding activities associated with exposure to fungi</p> Signup and view all the answers

Which antifungal class presents the widest spectrum of activity?

<p>Polyenes</p> Signup and view all the answers

Which azole is active against Mucorales?

<p>Posaconazole</p> Signup and view all the answers

Which antifungal medication is not active against filamentous fungi?

<p>Fluconazole</p> Signup and view all the answers

What is the mechanism of action of azoles?

<p>Fungistatic</p> Signup and view all the answers

Which organism is the most common cause of opportunistic infection in persons with HIV infection?

<p>Pneumocystis jirovecii</p> Signup and view all the answers

What is the recommended treatment for mild, moderate, or severe Pneumocystis jirovecii pneumonia (PJP)?

<p>Antibiotics</p> Signup and view all the answers

When are corticosteroids used as adjunctive initial therapy for Pneumocystis jirovecii pneumonia (PJP)?

<p>In patients with HIV infection who have severe PJP</p> Signup and view all the answers

Which treatment has been shown to be as effective as intravenous pentamidine in managing PJP/PCP?

<p>Trimethoprim-sulfamethoxazole (TMP-SMX)</p> Signup and view all the answers

Which of the following is the most common route of transmission for Cryptococcus neoformans?

<p>Inhalation of contaminated soil</p> Signup and view all the answers

What are the recommended treatment options for Cryptococcus neoformans infection?

<p>Azoles or amphotericin B, with or without flucytosine</p> Signup and view all the answers

Cryptococcosis neoformans is a defining opportunistic infection for which condition?

<p>AIDS</p> Signup and view all the answers

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