Fungal Infections of the Respiratory Tract

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Questions and Answers

Which type of infections are more common than fungal infections of the lung?

  • Bacterial and viral infections (correct)
  • Fungal infections of the gastrointestinal tract
  • Fungal infections of the skin
  • Parasitic infections

What is the range of virulence for fungal infections of the lung?

  • Always causing severe symptoms
  • From causing no symptoms to causing death (correct)
  • Always causing death
  • From causing mild symptoms to causing death

Which population is at an increased risk for invasive fungal infections?

  • Patients with bacterial infections
  • Patients with acute illnesses
  • Patients with viral infections
  • Patients with chronic debilitating diseases (correct)

Which group of patients is NOT included in the population at risk for invasive fungal infections?

<p>Patients with acute illnesses (A)</p> Signup and view all the answers

What is the main reason for the surge in rates of invasive fungal infections?

<p>Increased size of the population at risk (C)</p> Signup and view all the answers

Which of the following is a characteristic of opportunistic fungal infections?

<p>They are more common in individuals with compromised immune systems (C)</p> Signup and view all the answers

Which of the following is the most prevalent opportunistic fungal infection?

<p>Systemic candidiasis (A)</p> Signup and view all the answers

Which fungal infection is the leading cause of infection-related death in stem cell transplant recipients?

<p>Invasive pulmonary aspergillosis (B)</p> Signup and view all the answers

Which of the following is NOT a major endemic mycosis found in North America and Africa?

<p>Aspergillosis (B)</p> Signup and view all the answers

Endemic fungal infections are primarily influenced by which factors?

<p>Soil and climate conditions (B)</p> Signup and view all the answers

Which regions are home to three major endemic mycoses?

<p>North America and Africa (A)</p> Signup and view all the answers

Which of the following fungal infections is considered an endemic dimorphic mycosis?

<p>Histoplasmosis (A)</p> Signup and view all the answers

Which of the following fungal infections can cause invasive disease only in immunocompromised patients?

<p>Aspergillosis (A)</p> Signup and view all the answers

Which category of mycoses can cause disease in both normal and immunocompromised patients?

<p>Endemic dimorphic mycoses (A)</p> Signup and view all the answers

Which fungal pathogen is commonly found growing on human skin or mucosa and does not require a shift to a spore form to infect a host?

<p>C. albicans (A)</p> Signup and view all the answers

Which fungal pathogen forms cysts with sexual spores, but it is unclear if they play a role in spreading infection to new hosts?

<p>Pneumocystis jirovecii (D)</p> Signup and view all the answers

Which species of Candida is the most frequently isolated from respiratory samples?

<p>Candida albicans (A)</p> Signup and view all the answers

Which predisposing clinical circumstances are commonly associated with Candida pneumonia?

<p>Hematologic malignancy (B)</p> Signup and view all the answers

What is the prevalence of Candida pneumonia?

<p>Rare (C)</p> Signup and view all the answers

In which part of the body is Candida pneumonia primarily observed?

<p>Lungs (A)</p> Signup and view all the answers

Which species is the most frequent cause of invasive pulmonary aspergillosis (IPA)?

<p>Aspergillus fumigatus (D)</p> Signup and view all the answers

How are Aspergillus conidia primarily transmitted?

<p>Airborne transmission (B)</p> Signup and view all the answers

How are Aspergillus conidia typically eliminated by the human body?

<p>By the immune system (D)</p> Signup and view all the answers

Which patient population is commonly affected by respiratory infections caused by Aspergillus spp.?

<p>Critically ill patients (D)</p> Signup and view all the answers

Which of the following animals is NOT commonly affected by Blastomycosis?

<p>Birds (D)</p> Signup and view all the answers

Which of the following symptoms is NOT associated with Blastomycosis?

<p>Skin rash (C)</p> Signup and view all the answers

Which organism causes blastomycosis in humans and other animals?

<p>Blastomyces dermatitidis (C)</p> Signup and view all the answers

What is another name for blastomycosis?

<p>Gilchrist's disease (C)</p> Signup and view all the answers

Which immune cells are involved in the phagocytosis of Blastomyces dermatitidis conidia in the lungs?

<p>Neutrophils and macrophages (D)</p> Signup and view all the answers

What happens to some of the inhaled conidia of B. dermatitidis after phagocytosis?

<p>They escape phagocytosis and transform into yeast phase rapidly (A)</p> Signup and view all the answers

What is the treatment of choice for most forms of blastomycosis?

<p>Itraconazole (B)</p> Signup and view all the answers

What can be said about the cure rates in blastomycosis with appropriate treatment?

<p>Cure rates are high (C)</p> Signup and view all the answers

Which cells are responsible for engulfing and neutralizing fungi in the lungs?

<p>Macrophages (D)</p> Signup and view all the answers

What is the term for collections of immune cells that form in response to fungal infection?

<p>Granulomas (C)</p> Signup and view all the answers

What are the long-term consequences of fungal infections in the lungs?

<p>Formation of calcified granulomas and scars (D)</p> Signup and view all the answers

What can be seen on X-ray images years after a fungal infection?

<p>Calcified granulomas (C)</p> Signup and view all the answers

How do most pulmonary fungal infections occur?

<p>Through inhalation of aerosolized fungi (C)</p> Signup and view all the answers

How is fungal infection typically controlled in healthy individuals?

<p>Through activation of secondary or adaptive immunity (C)</p> Signup and view all the answers

What is the characteristic ability of some fungi that enables them to evade destruction by macrophages?

<p>Rapid growth and multiplication inside macrophages (B)</p> Signup and view all the answers

Which of the following is the most effective preventive measure for individuals at risk of fungal infections?

<p>Avoiding activities associated with exposure to fungi (B)</p> Signup and view all the answers

Which antifungal class presents the widest spectrum of activity?

<p>Polyenes (C)</p> Signup and view all the answers

Which azole is active against Mucorales?

<p>Posaconazole (A)</p> Signup and view all the answers

Which antifungal medication is not active against filamentous fungi?

<p>Fluconazole (B)</p> Signup and view all the answers

What is the mechanism of action of azoles?

<p>Fungistatic (C)</p> Signup and view all the answers

Which organism is the most common cause of opportunistic infection in persons with HIV infection?

<p>Pneumocystis jirovecii (D)</p> Signup and view all the answers

What is the recommended treatment for mild, moderate, or severe Pneumocystis jirovecii pneumonia (PJP)?

<p>Antibiotics (C)</p> Signup and view all the answers

When are corticosteroids used as adjunctive initial therapy for Pneumocystis jirovecii pneumonia (PJP)?

<p>In patients with HIV infection who have severe PJP (A)</p> Signup and view all the answers

Which treatment has been shown to be as effective as intravenous pentamidine in managing PJP/PCP?

<p>Trimethoprim-sulfamethoxazole (TMP-SMX) (D)</p> Signup and view all the answers

Which of the following is the most common route of transmission for Cryptococcus neoformans?

<p>Inhalation of contaminated soil (C)</p> Signup and view all the answers

What are the recommended treatment options for Cryptococcus neoformans infection?

<p>Azoles or amphotericin B, with or without flucytosine (C)</p> Signup and view all the answers

Cryptococcosis neoformans is a defining opportunistic infection for which condition?

<p>AIDS (D)</p> Signup and view all the answers

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