Podcast
Questions and Answers
Which function of the nervous system involves gathering information via sensory receptors about internal and external changes?
Which function of the nervous system involves gathering information via sensory receptors about internal and external changes?
- Integration
- Sensory input (correct)
- Motor output
- Effector activation
What is the primary function of the integration center within the nervous system?
What is the primary function of the integration center within the nervous system?
- To transmit electrical signals throughout the body
- To interpret sensory input and dictate motor output (correct)
- To activate effector organs such as muscles and glands
- To gather information about internal and external changes
If a person touches a hot stove, which division of the nervous system is responsible for transmitting the signal from the skin to the spinal cord?
If a person touches a hot stove, which division of the nervous system is responsible for transmitting the signal from the skin to the spinal cord?
- Motor (efferent) division
- Sensory (afferent) division (correct)
- Central nervous system (CNS)
- Autonomic nervous system (ANS)
What is the main role of the motor (efferent) division of the peripheral nervous system?
What is the main role of the motor (efferent) division of the peripheral nervous system?
Which of the following best describes the function of somatic sensory fibers?
Which of the following best describes the function of somatic sensory fibers?
What is the primary distinction between the somatic and autonomic nervous systems?
What is the primary distinction between the somatic and autonomic nervous systems?
Which of the following is an example of a function controlled by the autonomic nervous system?
Which of the following is an example of a function controlled by the autonomic nervous system?
What physiological response is characteristic of the sympathetic nervous system?
What physiological response is characteristic of the sympathetic nervous system?
Which of the following is a characteristic of nervous tissue?
Which of the following is a characteristic of nervous tissue?
What is the primary function of neuroglia?
What is the primary function of neuroglia?
Which type of neuroglial cell is responsible for forming the myelin sheath in the central nervous system (CNS)?
Which type of neuroglial cell is responsible for forming the myelin sheath in the central nervous system (CNS)?
What is the role of ependymal cells in the central nervous system?
What is the role of ependymal cells in the central nervous system?
Which of the following is a primary function of astrocytes?
Which of the following is a primary function of astrocytes?
Which neuroglia can transform to phagocytize microorganisms and neuronal debris?
Which neuroglia can transform to phagocytize microorganisms and neuronal debris?
Which of the following best describes the function of satellite cells?
Which of the following best describes the function of satellite cells?
What is the primary function of Schwann cells (neurolemmocytes)?
What is the primary function of Schwann cells (neurolemmocytes)?
Which characteristic is unique to neurons?
Which characteristic is unique to neurons?
What does it mean when neurons are described as amitotic?
What does it mean when neurons are described as amitotic?
Where are most neuron cell bodies located?
Where are most neuron cell bodies located?
What is the primary function of the neuron cell body (soma)?
What is the primary function of the neuron cell body (soma)?
What is the term for clusters of neuron cell bodies in the CNS?
What is the term for clusters of neuron cell bodies in the CNS?
What term describes bundles of neuron processes in the PNS?
What term describes bundles of neuron processes in the PNS?
Which part of the neuron is the main receptive region?
Which part of the neuron is the main receptive region?
Where is the axon hillock located and what is its significance?
Where is the axon hillock located and what is its significance?
What is the functional significance of the axon terminal (terminal bouton)?
What is the functional significance of the axon terminal (terminal bouton)?
What is the function of the axolemma?
What is the function of the axolemma?
What is the difference between anterograde and retrograde movement in an axon?
What is the difference between anterograde and retrograde movement in an axon?
Which of the following best describes the composition and function of the myelin sheath?
Which of the following best describes the composition and function of the myelin sheath?
What is the function of myelin in myelinated nerve fibers?
What is the function of myelin in myelinated nerve fibers?
What are myelin sheath gaps (nodes of Ranvier)?
What are myelin sheath gaps (nodes of Ranvier)?
How does myelination differ between the PNS and the CNS?
How does myelination differ between the PNS and the CNS?
Which structural class of neurons is most common in the body and a major neuron type in the CNS?
Which structural class of neurons is most common in the body and a major neuron type in the CNS?
Where are bipolar neurons typically found?
Where are bipolar neurons typically found?
Sensory neurons are functionally classified as:
Sensory neurons are functionally classified as:
Which structural type of neuron is predominantly found as interneurons?
Which structural type of neuron is predominantly found as interneurons?
Based on function, how are motor neurons classified?
Based on function, how are motor neurons classified?
Which type of neuron lies between motor and sensory neurons, shuttling signals through CNS pathways?
Which type of neuron lies between motor and sensory neurons, shuttling signals through CNS pathways?
Approximately what percentage of the body's neurons are classified as interneurons?
Approximately what percentage of the body's neurons are classified as interneurons?
How does the presence of myelin sheaths affect the color of brain and spinal cord regions?
How does the presence of myelin sheaths affect the color of brain and spinal cord regions?
Which of the following best describes the structural arrangement of myelin sheaths in the CNS?
Which of the following best describes the structural arrangement of myelin sheaths in the CNS?
How do drugs typically influence the nervous system according to the 'Why This Matters' introduction?
How do drugs typically influence the nervous system according to the 'Why This Matters' introduction?
What is the functional relationship between sensory input, integration, and motor output in the nervous system?
What is the functional relationship between sensory input, integration, and motor output in the nervous system?
What distinguishes the central nervous system (CNS) from the peripheral nervous system (PNS)?
What distinguishes the central nervous system (CNS) from the peripheral nervous system (PNS)?
How do somatic and autonomic nervous systems differ in terms of their control over effector organs?
How do somatic and autonomic nervous systems differ in terms of their control over effector organs?
In what key way do the sympathetic and parasympathetic divisions of the autonomic nervous system interact?
In what key way do the sympathetic and parasympathetic divisions of the autonomic nervous system interact?
How do neuroglia and neurons differ in their primary functions within nervous tissue?
How do neuroglia and neurons differ in their primary functions within nervous tissue?
What is the primary role of astrocytes among the neuroglia of the CNS?
What is the primary role of astrocytes among the neuroglia of the CNS?
How do ependymal cells contribute to the function of the CNS?
How do ependymal cells contribute to the function of the CNS?
Why is the myelin sheath important for neuron function and what are its constituents?
Why is the myelin sheath important for neuron function and what are its constituents?
How do oligodendrocytes and Schwann cells differ in their myelination functions?
How do oligodendrocytes and Schwann cells differ in their myelination functions?
What are myelin sheath gaps and their role in nerve signal transmission?
What are myelin sheath gaps and their role in nerve signal transmission?
What structural feature defines unipolar neurons, and where are these neurons typically located?
What structural feature defines unipolar neurons, and where are these neurons typically located?
How do the structural characteristics of a neuron (e.g. multipolar, bipolar, unipolar) relate to its primary function?
How do the structural characteristics of a neuron (e.g. multipolar, bipolar, unipolar) relate to its primary function?
What is the significance of the axon hillock in a neuron?
What is the significance of the axon hillock in a neuron?
What are the different types of neuron processes?
What are the different types of neuron processes?
How is voltage, as it relates to neurons, best described?
How is voltage, as it relates to neurons, best described?
In the context of electrical principles in neurons, what characterizes resistance?
In the context of electrical principles in neurons, what characterizes resistance?
According to Ohm's law, how are current, voltage, and resistance related?
According to Ohm's law, how are current, voltage, and resistance related?
Which feature is characteristic of leakage channels?
Which feature is characteristic of leakage channels?
What causes chemically gated channels to open?
What causes chemically gated channels to open?
How do mechanically gated channels operate to transport ions?
How do mechanically gated channels operate to transport ions?
When gated channels open, what primarily drives the movement of ions across the membrane?
When gated channels open, what primarily drives the movement of ions across the membrane?
What measurable characteristic defines the voltage of a cell's membrane?
What measurable characteristic defines the voltage of a cell's membrane?
What maintains the ionic composition differences between intracellular fluid (ICF) and extracellular fluid (ECF)?
What maintains the ionic composition differences between intracellular fluid (ICF) and extracellular fluid (ECF)?
In a neuron, which ion is at a higher concentration within the intracellular fluid (ICF) compared to the extracellular fluid (ECF)?
In a neuron, which ion is at a higher concentration within the intracellular fluid (ICF) compared to the extracellular fluid (ECF)?
How does the permeability of the plasma membrane contribute to the resting membrane potential?
How does the permeability of the plasma membrane contribute to the resting membrane potential?
How does the sodium-potassium pump (Na+/K+ ATPase) stabilize the resting membrane potential?
How does the sodium-potassium pump (Na+/K+ ATPase) stabilize the resting membrane potential?
How is depolarization defined in the context of membrane potential?
How is depolarization defined in the context of membrane potential?
How does hyperpolarization affect the likelihood of generating an impulse?
How does hyperpolarization affect the likelihood of generating an impulse?
What characteristic defines graded potentials?
What characteristic defines graded potentials?
What effect does a stronger stimulus have on graded potentials?
What effect does a stronger stimulus have on graded potentials?
What is the primary feature of action potentials that makes them crucial for long-distance communication?
What is the primary feature of action potentials that makes them crucial for long-distance communication?
What is another term for action potential?
What is another term for action potential?
Which best describes the state of voltage-gated Na+ and K+ channels during the resting state of a neuron?
Which best describes the state of voltage-gated Na+ and K+ channels during the resting state of a neuron?
What occurs when a neuron reaches the threshold potential?
What occurs when a neuron reaches the threshold potential?
What is the role of $Na^+$ channel inactivation gates during repolarization?
What is the role of $Na^+$ channel inactivation gates during repolarization?
What primarily leads to the hyperpolarization phase following an action potential?
What primarily leads to the hyperpolarization phase following an action potential?
Why does the action potential only propagate in one direction?
Why does the action potential only propagate in one direction?
What is the key difference in how the CNS distinguishes between a weak stimulus versus a strong stimulus?
What is the key difference in how the CNS distinguishes between a weak stimulus versus a strong stimulus?
During the absolute refractory period, what prevents a neuron from generating another action potential?
During the absolute refractory period, what prevents a neuron from generating another action potential?
What is a key feature of the relative refractory period that influences neural excitability?
What is a key feature of the relative refractory period that influences neural excitability?
Which factor will increase the conduction velocity of an action potential?
Which factor will increase the conduction velocity of an action potential?
In myelinated axons, where are the voltage-gated Na+ channels concentrated?
In myelinated axons, where are the voltage-gated Na+ channels concentrated?
How does saltatory conduction affect the propagation of action potentials?
How does saltatory conduction affect the propagation of action potentials?
What are the typical effects of multiple sclerosis (MS) on nerve impulse conduction?
What are the typical effects of multiple sclerosis (MS) on nerve impulse conduction?
Which nerve fiber group possesses the largest diameter and the fastest transmission speed?
Which nerve fiber group possesses the largest diameter and the fastest transmission speed?
Which best describes Group B nerve fibers?
Which best describes Group B nerve fibers?
An anesthetic blocks voltage-gated $Na^+$ channels. What direct effect would this have on neuron function?
An anesthetic blocks voltage-gated $Na^+$ channels. What direct effect would this have on neuron function?
How do cold temperatures affect nerve impulse propagation?
How do cold temperatures affect nerve impulse propagation?
What occurs during the depolarization phase of an action potential?
What occurs during the depolarization phase of an action potential?
What specific part of the neuron integrates incoming signals to determine if an action potential should be generated?
What specific part of the neuron integrates incoming signals to determine if an action potential should be generated?
Where do graded potentials primarily occur?
Where do graded potentials primarily occur?
How do neurons signal the intensity of a stimulus if all action potentials are the same size?
How do neurons signal the intensity of a stimulus if all action potentials are the same size?
When opposite charges are separated, what form of energy is established?
When opposite charges are separated, what form of energy is established?
Which of the following accurately relates voltage to charge difference?
Which of the following accurately relates voltage to charge difference?
How does resistance affect the flow of electrical charge (current)?
How does resistance affect the flow of electrical charge (current)?
According to Ohm's law, if the resistance is doubled while the voltage remains constant, what happens to the current?
According to Ohm's law, if the resistance is doubled while the voltage remains constant, what happens to the current?
What characteristic differentiates leakage channels from gated channels?
What characteristic differentiates leakage channels from gated channels?
What is the primary difference between chemically gated and voltage-gated channels?
What is the primary difference between chemically gated and voltage-gated channels?
Which gradient primarily drives the diffusion of ions across a membrane when gated channels are open?
Which gradient primarily drives the diffusion of ions across a membrane when gated channels are open?
What does a voltmeter measure when connected across a neuron's membrane?
What does a voltmeter measure when connected across a neuron's membrane?
If a neuron's resting membrane potential is -70 mV, what does the negative sign indicate?
If a neuron's resting membrane potential is -70 mV, what does the negative sign indicate?
What two factors generate the resting membrane potential in a neuron?
What two factors generate the resting membrane potential in a neuron?
Which of the following ionic conditions is characteristic of a neuron's resting state?
Which of the following ionic conditions is characteristic of a neuron's resting state?
How does the selective permeability of the plasma membrane contribute to the resting membrane potential?
How does the selective permeability of the plasma membrane contribute to the resting membrane potential?
If a stimulus causes the inside of a neuron to become less negative (more positive), this change in membrane potential is called:
If a stimulus causes the inside of a neuron to become less negative (more positive), this change in membrane potential is called:
What effect does hyperpolarization have on a neuron's ability to generate an action potential?
What effect does hyperpolarization have on a neuron's ability to generate an action potential?
What is the main characteristic of graded potentials that distinguishes them from action potentials?
What is the main characteristic of graded potentials that distinguishes them from action potentials?
In the context of changing membrane potential, what occurs during depolarization?
In the context of changing membrane potential, what occurs during depolarization?
What happens to membrane permeability to sodium ($Na^+$) when a neuron reaches threshold?
What happens to membrane permeability to sodium ($Na^+$) when a neuron reaches threshold?
During repolarization, what is the state of the voltage-gated $Na^+$ channels?
During repolarization, what is the state of the voltage-gated $Na^+$ channels?
Following an action potential, what primarily causes the hyperpolarization phase?
Following an action potential, what primarily causes the hyperpolarization phase?
Why does an action potential only propagate in one direction down the axon?
Why does an action potential only propagate in one direction down the axon?
How does the central nervous system (CNS) differentiate between a weak and strong stimulus?
How does the central nervous system (CNS) differentiate between a weak and strong stimulus?
What occurs during the absolute refractory period?
What occurs during the absolute refractory period?
If a neuron is in the relative refractory period, what condition is most likely to stimulate another action potential?
If a neuron is in the relative refractory period, what condition is most likely to stimulate another action potential?
Which of the following factors increases the conduction velocity of an action potential the most?
Which of the following factors increases the conduction velocity of an action potential the most?
In myelinated axons, where are the voltage-gated $Na^+$ channels primarily concentrated?
In myelinated axons, where are the voltage-gated $Na^+$ channels primarily concentrated?
How does saltatory conduction increase the speed of action potential propagation?
How does saltatory conduction increase the speed of action potential propagation?
Which of the following is a direct consequence of demyelination in conditions like multiple sclerosis (MS)?
Which of the following is a direct consequence of demyelination in conditions like multiple sclerosis (MS)?
Which nerve fiber group has the fastest conduction velocity?
Which nerve fiber group has the fastest conduction velocity?
What characterizes Group B nerve fibers?
What characterizes Group B nerve fibers?
What is the primary role of synapses in the nervous system?
What is the primary role of synapses in the nervous system?
How does a presynaptic neuron transmit information to a postsynaptic neuron across a chemical synapse?
How does a presynaptic neuron transmit information to a postsynaptic neuron across a chemical synapse?
Which type of synapse involves direct physical contact between neurons, allowing for rapid electrical communication?
Which type of synapse involves direct physical contact between neurons, allowing for rapid electrical communication?
What is the role of voltage-gated $Ca^{2+}$ channels in synaptic transmission?
What is the role of voltage-gated $Ca^{2+}$ channels in synaptic transmission?
Which of the following mechanisms is involved in the termination of neurotransmitter effects after it has been released into the synaptic cleft?
Which of the following mechanisms is involved in the termination of neurotransmitter effects after it has been released into the synaptic cleft?
What is the definition of synaptic delay and why does it occur?
What is the definition of synaptic delay and why does it occur?
Neurotransmitter receptors on the postsynaptic membrane cause graded potentials. What primarily determines the strength of these graded potentials?
Neurotransmitter receptors on the postsynaptic membrane cause graded potentials. What primarily determines the strength of these graded potentials?
What distinguishes an excitatory postsynaptic potential (EPSP) from an inhibitory postsynaptic potential (IPSP)?
What distinguishes an excitatory postsynaptic potential (EPSP) from an inhibitory postsynaptic potential (IPSP)?
What happens during temporal summation?
What happens during temporal summation?
What is the mechanism behind spatial summation in neurons?
What is the mechanism behind spatial summation in neurons?
Synaptic potentiation can increase the efficiency of neural transmission. What cellular mechanism underlies synaptic potentiation?
Synaptic potentiation can increase the efficiency of neural transmission. What cellular mechanism underlies synaptic potentiation?
How does presynaptic inhibition affect synaptic transmission?
How does presynaptic inhibition affect synaptic transmission?
Neural integration allows for complex processing of information in the CNS. Why is neural integration essential for proper nervous system function?
Neural integration allows for complex processing of information in the CNS. Why is neural integration essential for proper nervous system function?
Which statement best describes the role of a 'discharge zone' within a neuronal pool?
Which statement best describes the role of a 'discharge zone' within a neuronal pool?
What is the key feature of serial processing in neural circuits?
What is the key feature of serial processing in neural circuits?
What are the five essential components of a reflex arc?
What are the five essential components of a reflex arc?
How does parallel processing differ from serial processing in neural circuits?
How does parallel processing differ from serial processing in neural circuits?
In a diverging circuit, what is the relationship between the input and output?
In a diverging circuit, what is the relationship between the input and output?
What is the primary characteristic of a converging circuit?
What is the primary characteristic of a converging circuit?
What functional role is associated with reverberating circuits?
What functional role is associated with reverberating circuits?
Which of the following characterizes a parallel after-discharge circuit?
Which of the following characterizes a parallel after-discharge circuit?
During embryonic development, from which of the following does the nervous system originate?
During embryonic development, from which of the following does the nervous system originate?
What role do neurotropins play in the development of neurons?
What role do neurotropins play in the development of neurons?
Roughly what proportion of neurons created die during normal brain development, and what is this process called?
Roughly what proportion of neurons created die during normal brain development, and what is this process called?
What is the term for the specialized structure at the tip of a growing axon that allows it to interact with its environment?
What is the term for the specialized structure at the tip of a growing axon that allows it to interact with its environment?
How do astrocytes support synapse formation?
How do astrocytes support synapse formation?
During which period of life does learning reinforce certain neuronal synapses and prune others?
During which period of life does learning reinforce certain neuronal synapses and prune others?
After birth, most neurons are considered amitotic, but which neuronal populations can continue to divide?
After birth, most neurons are considered amitotic, but which neuronal populations can continue to divide?
Which neurotransmitter is synthesized from acetic acid and choline, and is degraded by acetylcholinesterase (AChE)?
Which neurotransmitter is synthesized from acetic acid and choline, and is degraded by acetylcholinesterase (AChE)?
Which of the following neurotransmitters is classified as a catecholamine?
Which of the following neurotransmitters is classified as a catecholamine?
Which of the following neurotransmitters is considered an amino acid neurotransmitter?
Which of the following neurotransmitters is considered an amino acid neurotransmitter?
Which class of neurotransmitters includes substance P and endorphins?
Which class of neurotransmitters includes substance P and endorphins?
Which of the following is a gasotransmitter that is involved in learning and memory as well as brain damage in stroke patients?
Which of the following is a gasotransmitter that is involved in learning and memory as well as brain damage in stroke patients?
Which of the following neurotransmitters acts at the same receptors as THC (the active ingredient in marijuana)?
Which of the following neurotransmitters acts at the same receptors as THC (the active ingredient in marijuana)?
How is a neurotransmitter's effect determined, and which of the following is an example of its effect?
How is a neurotransmitter's effect determined, and which of the following is an example of its effect?
What is a neuromodulator?
What is a neuromodulator?
What is the primary action of channel-linked receptors?
What is the primary action of channel-linked receptors?
G protein-linked receptors are characterized by which of the following?
G protein-linked receptors are characterized by which of the following?
What is the initial step in the mechanism of G protein-linked receptors?
What is the initial step in the mechanism of G protein-linked receptors?
What crucial role do synaptic vesicles play in the process of chemical synaptic transmission?
What crucial role do synaptic vesicles play in the process of chemical synaptic transmission?
What is the functional significance of the synaptic cleft in chemical synapses?
What is the functional significance of the synaptic cleft in chemical synapses?
How would the introduction of a substance that significantly reduces the amount of available synaptotagmin affect synaptic transmission?
How would the introduction of a substance that significantly reduces the amount of available synaptotagmin affect synaptic transmission?
What is the immediate consequence of neurotransmitter binding to receptors on the postsynaptic membrane?
What is the immediate consequence of neurotransmitter binding to receptors on the postsynaptic membrane?
What is the consequence of blocking voltage-gated calcium channels at the axon terminal of a presynaptic neuron?
What is the consequence of blocking voltage-gated calcium channels at the axon terminal of a presynaptic neuron?
What mechanisms contribute to the termination of neurotransmitter effects in the synaptic cleft?
What mechanisms contribute to the termination of neurotransmitter effects in the synaptic cleft?
How does synaptic delay impact neural transmission?
How does synaptic delay impact neural transmission?
What distinguishes electrical synapses from chemical synapses?
What distinguishes electrical synapses from chemical synapses?
Which factor most directly determines whether a postsynaptic potential is excitatory or inhibitory?
Which factor most directly determines whether a postsynaptic potential is excitatory or inhibitory?
How does temporal summation enable a postsynaptic neuron to reach threshold and fire an action potential?
How does temporal summation enable a postsynaptic neuron to reach threshold and fire an action potential?
What cellular process underlies synaptic potentiation, enhancing neural transmission efficiency?
What cellular process underlies synaptic potentiation, enhancing neural transmission efficiency?
Why is neural integration essential for proper nervous system function?
Why is neural integration essential for proper nervous system function?
In a simple neuronal pool, how do neurons in the discharge zone differ from those in the facilitated zone?
In a simple neuronal pool, how do neurons in the discharge zone differ from those in the facilitated zone?
What is the defining characteristic of serial processing in neural circuits?
What is the defining characteristic of serial processing in neural circuits?
What are the five essential components of a reflex arc, in order?
What are the five essential components of a reflex arc, in order?
How does parallel processing enhance the speed and efficiency of neural computation?
How does parallel processing enhance the speed and efficiency of neural computation?
What is the primary effect of a diverging circuit in neural processing?
What is the primary effect of a diverging circuit in neural processing?
What is the defining feature of a converging circuit?
What is the defining feature of a converging circuit?
In what functional processes are reverberating circuits primarily involved?
In what functional processes are reverberating circuits primarily involved?
What characterizes a parallel after-discharge circuit?
What characterizes a parallel after-discharge circuit?
During embryonic development, from which primary germ layer does the nervous system originate?
During embryonic development, from which primary germ layer does the nervous system originate?
Why are neurotropins essential for the development of neurons?
Why are neurotropins essential for the development of neurons?
What is the average proportion of neurons that undergo apoptosis during normal brain development and why does it occur?
What is the average proportion of neurons that undergo apoptosis during normal brain development and why does it occur?
What is the function of filopodia in a growth cone?
What is the function of filopodia in a growth cone?
How do astrocytes contribute to synapse formation and function during neuronal development?
How do astrocytes contribute to synapse formation and function during neuronal development?
How does synaptic pruning contribute to brain development during childhood and adolescence?
How does synaptic pruning contribute to brain development during childhood and adolescence?
Which specific neuronal populations retain the ability to divide postnatally, even though most neurons become amitotic?
Which specific neuronal populations retain the ability to divide postnatally, even though most neurons become amitotic?
How do channel-linked receptors mediate their effects?
How do channel-linked receptors mediate their effects?
In the context of neurotransmitter effects, what is the primary role of a neuromodulator?
In the context of neurotransmitter effects, what is the primary role of a neuromodulator?
How do G protein-linked receptors typically initiate changes within a neuron?
How do G protein-linked receptors typically initiate changes within a neuron?
Which action is the initial step in the mechanism of G protein-linked receptors upon neurotransmitter binding?
Which action is the initial step in the mechanism of G protein-linked receptors upon neurotransmitter binding?
Which of the following is the correct order of events that occur at a chemical synapse?
Which of the following is the correct order of events that occur at a chemical synapse?
What type of synapse has direct physical contact, allowing for rapid electrical communication?
What type of synapse has direct physical contact, allowing for rapid electrical communication?
What happens to the impulse frequency when synaptic vesicles exocytose?
What happens to the impulse frequency when synaptic vesicles exocytose?
Where are neurotransmitters typically received on the postsynaptic neuron?
Where are neurotransmitters typically received on the postsynaptic neuron?
How does the synaptic cleft ensure unidirectional communication?
How does the synaptic cleft ensure unidirectional communication?
Which of the following scenarios best illustrates spatial summation?
Which of the following scenarios best illustrates spatial summation?
If a drug were to block voltage-gated calcium channels on the presynaptic neuron, what would be the most likely direct effect?
If a drug were to block voltage-gated calcium channels on the presynaptic neuron, what would be the most likely direct effect?
In a reverberating circuit, what would be the most likely effect of a drug that blocks neuronal feedback?
In a reverberating circuit, what would be the most likely effect of a drug that blocks neuronal feedback?
How do astrocytes facilitate synapse formation?
How do astrocytes facilitate synapse formation?
How does the action of a neuromodulator differ from that of a typical neurotransmitter?
How does the action of a neuromodulator differ from that of a typical neurotransmitter?
Flashcards
Nervous System
Nervous System
Master controlling and communicating system of the body. Communicates via electrical and chemical signals that are rapid and specific, causing immediate responses.
Sensory Input
Sensory Input
Gathering information about internal and external changes via sensory receptors.
Integration (Nervous System)
Integration (Nervous System)
Processing and interpretation of sensory input to decide what should be done at each moment.
Motor Output
Motor Output
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Central Nervous System (CNS)
Central Nervous System (CNS)
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Peripheral Nervous System (PNS)
Peripheral Nervous System (PNS)
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Somatic Sensory Fibers
Somatic Sensory Fibers
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Visceral Sensory Fibers
Visceral Sensory Fibers
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Motor (Efferent) Division
Motor (Efferent) Division
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Somatic Nervous System
Somatic Nervous System
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Autonomic Nervous System
Autonomic Nervous System
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Sympathetic Division
Sympathetic Division
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Parasympathetic Division
Parasympathetic Division
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Neuroglia (Glial Cells)
Neuroglia (Glial Cells)
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Neurons (Nerve Cells)
Neurons (Nerve Cells)
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Astrocytes
Astrocytes
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Microglial Cells
Microglial Cells
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Ependymal Cells
Ependymal Cells
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Oligodendrocytes
Oligodendrocytes
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Satellite Cells
Satellite Cells
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Schwann Cells (Neurolemmocytes)
Schwann Cells (Neurolemmocytes)
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Neurons
Neurons
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Neuron Cell Body
Neuron Cell Body
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Nuclei (Nervous System)
Nuclei (Nervous System)
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Ganglia
Ganglia
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Tracts
Tracts
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Nerves
Nerves
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Dendrites
Dendrites
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Axon
Axon
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Function of Axon
Function of Axon
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Anterograde
Anterograde
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Retrograde
Retrograde
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Myelin Sheath
Myelin Sheath
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Myelinated Fibers
Myelinated Fibers
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Nonmyelinated Fibers
Nonmyelinated Fibers
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Myelination in the PNS
Myelination in the PNS
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Myelin Sheath Gaps
Myelin Sheath Gaps
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Myelin Sheaths in the CNS
Myelin Sheaths in the CNS
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White Matter
White Matter
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Gray Matter
Gray Matter
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Multipolar Neurons
Multipolar Neurons
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Bipolar Neurons
Bipolar Neurons
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Unipolar Neurons
Unipolar Neurons
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Sensory Neurons
Sensory Neurons
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Motor Neurons
Motor Neurons
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Interneurons
Interneurons
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Resting Membrane Potential
Resting Membrane Potential
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Potential Energy (Electricity)
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Membrane Ion Channels
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Chemically Gated Channels
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Electrochemical Gradient
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Polarized Membrane
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Hyperpolarization
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Graded Potentials
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Receptor Potential
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Postsynaptic Potential
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Action Potentials
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Activation Gates
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Inactivation Gates
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Threshold
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Propagation (Action Potential)
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Action Potential (Stimulus Intensity)
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Action Potential (Location)
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Axon Diameter & Myelination
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Group A Fibers
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Myelin Sheaths (MS)
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Voltage-gated Na+ channels (anesthetics)
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Synapses
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Presynaptic Neuron
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Postsynaptic Neuron
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Axodendritic Synapse
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Axosomatic Synapse
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Axoaxonal Synapse
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Dendrodendritic Synapse
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Somatodendritic Synapse
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Chemical Synapse
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Chemical Synapse features
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Synaptic Cleft
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Synaptic Vesicles
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Receptor Region
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Step 1 of Chemical Synapse
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Step 2 of Chemical Synapse
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Step 3 of Chemical Synapse
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Step 4 of Chemical Synapse
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Step 5 of Chemical Synapse
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Step 6 of Chemical Synapse
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Synaptic Delay
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Synaptic Delay Significance
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Electrical Synapses
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EPSP
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IPSP
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Summation
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Temporal Summation
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Spatial Summation
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Synaptic Potentiation
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Presynaptic Inhibition
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Neural Integration
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Neuronal Pool
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Discharge Zone
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Facilitated Zone
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Serial Processing
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Reflexes
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Reflex Arcs
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Circuits (Neural)
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Diverging Circuit
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Converging Circuit
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Reverberating Circuit
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Parallel After-Discharge Circuit
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Channel-linked receptors
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G protein-linked receptors
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Actions: direct vs indirect (cont.)
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Study Notes
The Synapse
- The nervous system works because information flows from one neuron to another
- Neurons are functionally connected by synapses
- Synapses are junctions that mediate information transfer
- Information transfer can occur from one neuron to another
- Information transfer can occur from one neuron to an effector cell
- The presynaptic neuron conducts impulses toward the synapse and sends information
- The postsynaptic neuron transmits electrical signals away from the synapse and receives information
- The postsynaptic neuron may be a neuron, muscle cell, or gland cell in the PNS
- Most neurons function as both pre- and postsynaptic neurons
Synaptic Connections
- Axodendritic connections occur between axon terminals of one neuron and dendrites of others
- Axosomatic connections occur between axon terminals of one neuron and soma (cell body) of others
- Less common synaptic connections
- Axoaxonal connections are axon to axon
- Dendrodendritic connections are dendrite to dendrite
- Somatodendritic connections are dendrite to soma
Types of Synapses
- Chemical synapses
- Most common type of synapse
- Specialized for release and reception of chemical neurotransmitters
- Typically composed of two parts:
- Axon terminal of the presynaptic neuron: contains synaptic vesicles filled with neurotransmitter
- Receptor region on the postsynaptic neuron's membrane: receives neurotransmitter, usually on the dendrite or cell body
- Two parts are separated by a fluid-filled synaptic cleft
- Electrical impulse is changed to chemical signal across synapse, then back into electrical signal
Transmission Across the Synaptic Cleft
- The synaptic cleft prevents nerve impulses from directly passing from one neuron to the next
- Transmission across the synaptic cleft is a chemical, not an electrical, event
- It depends on the release, diffusion, and receptor binding of neurotransmitters
- Transmission ensures unidirectional communication between neurons
Information Transfer Across Chemical Synapses
- Six steps are involved in information transfer across chemical synapses:
- An action potential (AP) arrives at the axon terminal of the presynaptic neuron
- Voltage-gated Ca2+ channels open, and Ca2+ enters the axon terminal
- Ca2+ flows down the electrochemical gradient from the ECF to inside of the axon terminal
- Ca2+ entry causes synaptic vesicles to release neurotransmitter
- Ca2+ causes synaptotagmin protein to react with SNARE proteins that control fusion of synaptic vesicles with axon membrane
- Fusion results in exocytosis of neurotransmitter into synaptic cleft
- The higher the impulse frequency, the more vesicles exocytose, leading to a greater effect on the postsynaptic cell
- Neurotransmitter diffuses across the synaptic cleft and binds to specific receptors on the postsynaptic membrane
- Often, receptors are chemically gated ion channels
- Binding of neurotransmitter opens ion channels, creating graded potentials
- Binding causes receptor protein to change shape, which causes ion channels to open
- This causes a graded potential in the postsynaptic cell
- Graded potential can be an excitatory or inhibitory event
- Neurotransmitter effects are terminated
- As long as neurotransmitter is binding to the receptor, graded potentials will continue, so the process needs to be regulated
- Within a few milliseconds, a neurotransmitter's effect is terminated in one of three ways:
- Reuptake by astrocytes or axon terminal
- Degradation by enzymes
- Diffusion away from the synaptic cleft
Synaptic Delay
- Represents the time needed for neurotransmitter to be released, diffuse across synapse, and bind to receptors
- Can take anywhere from 0.3 to 5.0 ms
- Is the rate-limiting step of neural transmission
- Transmission of AP down axon can be very quick, but synapse slows transmission to postsynaptic neuron down significantly
- Not noticeable, because these are still very fast
Electrical Synapses
- Less common than chemical synapses
- Neurons are electrically coupled:
- Joined by gap junctions that connect the cytoplasm of adjacent neurons
- Communication is very rapid and may be unidirectional or bidirectional
- Found in some brain regions responsible for eye movements or hippocampus, in areas involved in emotions and memory
- Most abundant in embryonic nervous tissue
Postsynaptic Potentials
- Neurotransmitter receptors cause graded potentials that vary in strength based on:
- Amount of neurotransmitter released
- Time neurotransmitter stays in cleft
- Based on the effect of the chemical synapse, there are two types of postsynaptic potentials
- EPSP: excitatory postsynaptic potentials
- IPSP: inhibitory postsynaptic potentials
Excitatory Synapses and EPSPs
- Neurotransmitter binding opens chemically gated channels
- Simultaneous flow of Na+ and K+ in opposite directions
- Na+ influx is greater than K+ efflux, resulting in local net graded potential depolarization called excitatory postsynaptic potential (EPSP)
- EPSPs trigger an action potential (AP) if EPSP is of threshold strength
- It can spread to the axon hillock and trigger opening of voltage-gated channels, causing AP to be generated
Inhibitory Synapses and IPSPs
- Neurotransmitter binding to receptor opens chemically gated channels that allow entrance/exit of ions that cause hyperpolarization
- Makes postsynaptic membrane more permeable to K+ or Cl-:
- If K+ channels open, it moves out of cell
- If Cl- channels open, it moves into cell
- Makes postsynaptic membrane more permeable to K+ or Cl-:
- Reduces postsynaptic neuron's ability to produce an action potential:
- Moves the neuron farther away from the threshold (makes it more negative)
Integration and Modification of Synaptic Events
- Summation by the postsynaptic neuron
- A single EPSP cannot induce an AP, but EPSPs can summate (add together) to influence postsynaptic neuron
- IPSPs can also summate
- Most neurons receive both excitatory and inhibitory inputs from thousands of other neurons
- Only if EPSPs predominate and bring to threshold will an AP be generated
- Two types of summations: temporal and spatial
- A single EPSP cannot induce an AP, but EPSPs can summate (add together) to influence postsynaptic neuron
Temporal Summation
- One or more presynaptic neurons transmit impulses in rapid-fire order
- The first impulse produces an EPSP, and before it can dissipate, another EPSP is triggered, adding on top of the first impulse
Spatial Summation
- The postsynaptic neuron is stimulated by a large number of terminals simultaneously
- Many receptors are activated, each producing EPSPs, which can then add together
Synaptic Potentiation
- Repeated use of synapse increases ability of presynaptic cell to excite postsynaptic neuron
- Ca2+ concentration increases in presynaptic terminal, causing an increased release of neurotransmitter
- Leads to more EPSPs in the postsynaptic neuron
- Potentiation can cause Ca2+ voltage gates to open on the postsynaptic neuron
- Ca2+ activates kinase enzymes, leading to a more effective response to subsequent stimuli
- Long-term potentiation: learning and memory
Presynaptic Inhibition
- Release of excitatory neurotransmitter by one neuron is inhibited by another neuron via an axoaxonal synapse
- Less neurotransmitter is released, leading to smaller EPSPs
Neural Integration
- Neural integration occurs when neurons function together in groups to contribute to broader neural functions
- There are billions of neurons in CNS, which requires integration for individual parts to fuse and make a smoothly operating whole
Neuronal Pools
- Neuronal pool: functional groups of neurons that integrate incoming information received from receptors or other neuronal pools and forward processed information to other destinations
Simple Neuronal Pool
- Single presynaptic fiber branches and synapses with several neurons in the pool
- Discharge zone: neurons closer to the incoming fiber are more likely to generate impulses
- Facilitated zone: neurons on the periphery of the pool are farther away from the incoming fiber; usually not excited to the threshold unless stimulated by another source
Patterns of Neural Processing
- Serial processing: input travels along one pathway to a specific destination
- One neuron stimulates the next one, which stimulates the next one, etc.
- The system works in an all-or-none manner to produce a specific, anticipated response
- Best example is a spinal reflex
Reflexes
- Rapid, automatic responses to stimuli
- A particular stimulus always causes the same response
- Occur over pathways called reflex arcs that have five components:
- Receptor
- Sensory neuron
- CNS integration center
- Motor neuron
- Effector
Parallel Processing
- Input travels along several pathways
- Different parts of circuitry deal simultaneously with the information
- One stimulus promotes numerous responses
- Important for higher-level mental functioning
- Sensed smell may remind one of an odor and any associated experiences
Types of Circuits
- Represent patterns of synaptic connections in neuronal pools
- Four types:
- Diverging
- Converging
- Reverberating
- Parallel after-discharge
Diverging Circuit
- One input, many outputs
- Amplifying circuit:
- A single neuron in the brain can activate 100 or more motor neurons in the spinal cord and thousands of skeletal muscle fibers
Converging Circuit
- Many inputs, one output
- Concentrating circuit:
- Different sensory stimuli can all elicit the same memory
Reverberating Circuit
- Signal travels through a chain of neurons, each feeding back to previous neurons
- Oscillating circuit:
- Involved in breathing, sleep-wake cycle, and repetitive motor activities such as walking
Parallel After-Discharge Circuit
- Signal stimulates neurons arranged in parallel arrays that eventually converge on a single output cell
- Impulses reach output cell at different times, causing a burst of impulses called after-discharge
- May be involved in exacting mental processes such as mathematical calculations
Developmental Aspects of Neurons
- The nervous system originates from the neural tube and neural crest, derived from the ectoderm
- The neural tube becomes CNS:
- Neuroepithelial cells of neural tube proliferate into the number of cells needed for development
- Neuroblasts become amitotic and migrate
- Neuroblasts sprout axons to connect with targets and become neurons
Growth Cone
- The prickly structure at the tip of the axon that allows it to interact with its environment
- Via cell surface adhesion proteins (laminin, integrin, and nerve cell adhesion molecules, or N-CAMs), which provide anchor points
- Neurotropins that attract or repel the growth cone
- Nerve growth factor (NGF), which keeps neuroblast alive
- Filopodia are growth cone processes that follow signals toward target
- The axon must find the right place to form a synapse once it finds its target
- Astrocytes provide physical support and the cholesterol needed for construction of synapses
- Two-thirds of neurons die before birth:
- If axons do not form a synapse with their target, they are triggered to undergo apoptosis (programmed cell death)
- Many other cells also undergo apoptosis during development
- During childhood and adolescence, learning reinforces certain synapses and prunes others away
- Recent evidence suggests that genes that promote excessive synaptic pruning may predispose an individual to schizophrenia
- Neurons are amitotic after birth; however, there are a few special neuronal populations that continue to divide
- Olfactory neurons and hippocampus
Neurotransmitters
- Language of the nervous system
- Fifty or more neurotransmitters have been identified
- Most neurons make two or more neurotransmitters
- Neurons can exert several influences
- Usually released at different stimulation frequencies
- Classified by:
- Chemical structure
- Function
Classification of Neurotransmitters by Chemical Structure
- Acetylcholine (ACh):
- First identified and best understood
- Released at neuromuscular junctions
- Also used by many ANS neurons and some CNS neurons
- Synthesized from acetic acid and choline by the enzyme choline acetyltransferase
- Degraded by the enzyme acetylcholinesterase (AChE)
- Biogenic amines:
- Catecholamines: dopamine, norepinephrine (NE), and epinephrine, made from the amino acid tyrosine
- Indolamines: serotonin (made from the amino acid tryptophan) and histamine (made from the amino acid histidine)
- All widely used in the brain, play roles in emotional behaviors and the biological clock
- Used by some ANS motor neurons, especially NE
- Imbalances are associated with mental illness
- Catecholamines: dopamine, norepinephrine (NE), and epinephrine, made from the amino acid tyrosine
- Amino acids:
- Difficult to prove because amino acids make up all proteins
- Neurotransmitters:
- Glutamate
- Aspartate
- Glycine
- GABA (gamma()-aminobutyric acid) -Peptides (neuropeptides):
- Strings of amino acids that have diverse functions
- Substance P: mediator of pain signals
- Endorphins: act as natural opiates, reduce pain perception (including beta endorphin, dynorphin, and enkephalins)
- Gut-brain peptides: somatostatin and cholecystokinin regulate digestion
- Purines:
- Monomers of nucleic acids (ATP) that have effects in both the CNS and PNS
- ATP (the energy molecule) is now considered a neurotransmitter
- Adenosine is a potent inhibitor in the brain
- Caffeine blocks adenosine receptors
- Can induce Ca2+ influx in astrocytes
- Monomers of nucleic acids (ATP) that have effects in both the CNS and PNS
- Gases and lipids:
- Gasotransmitters: nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) gases
- Bind with G protein-coupled receptors in the brain
- Lipid-soluble and synthesized on demand
- NO involved in learning and formation of new memories, brain damage in stroke patients, and smooth muscle relaxation in the intestine
- H2S acts directly on ion channels to alter function
- Endocannabinoids:
- Act at the same receptors as THC (active ingredient in marijuana)
- Most common G protein-linked receptors in the brain
- Gasotransmitters: nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) gases
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