Fundamentals of the Nervous System

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Questions and Answers

Which function of the nervous system involves gathering information via sensory receptors about internal and external changes?

  • Integration
  • Sensory input (correct)
  • Motor output
  • Effector activation

What is the primary function of the integration center within the nervous system?

  • To transmit electrical signals throughout the body
  • To interpret sensory input and dictate motor output (correct)
  • To activate effector organs such as muscles and glands
  • To gather information about internal and external changes

If a person touches a hot stove, which division of the nervous system is responsible for transmitting the signal from the skin to the spinal cord?

  • Motor (efferent) division
  • Sensory (afferent) division (correct)
  • Central nervous system (CNS)
  • Autonomic nervous system (ANS)

What is the main role of the motor (efferent) division of the peripheral nervous system?

<p>To transmit impulses from the CNS to effector organs (A)</p> Signup and view all the answers

Which of the following best describes the function of somatic sensory fibers?

<p>Conveying impulses from the skin, skeletal muscles, and joints to the CNS (A)</p> Signup and view all the answers

What is the primary distinction between the somatic and autonomic nervous systems?

<p>The somatic system is voluntary, while the autonomic system is involuntary. (C)</p> Signup and view all the answers

Which of the following is an example of a function controlled by the autonomic nervous system?

<p>Breathing rate (A)</p> Signup and view all the answers

What physiological response is characteristic of the sympathetic nervous system?

<p>Mobilization of the body's energy reserves (B)</p> Signup and view all the answers

Which of the following is a characteristic of nervous tissue?

<p>It consists of neuroglia and neurons (B)</p> Signup and view all the answers

What is the primary function of neuroglia?

<p>To surround and support neurons (B)</p> Signup and view all the answers

Which type of neuroglial cell is responsible for forming the myelin sheath in the central nervous system (CNS)?

<p>Oligodendrocytes (B)</p> Signup and view all the answers

What is the role of ependymal cells in the central nervous system?

<p>To circulate cerebrospinal fluid (B)</p> Signup and view all the answers

Which of the following is a primary function of astrocytes?

<p>Controlling the chemical environment around neurons in the CNS (D)</p> Signup and view all the answers

Which neuroglia can transform to phagocytize microorganisms and neuronal debris?

<p>Microglial cells (B)</p> Signup and view all the answers

Which of the following best describes the function of satellite cells?

<p>Insulating neuron cell bodies in the PNS (B)</p> Signup and view all the answers

What is the primary function of Schwann cells (neurolemmocytes)?

<p>To form myelin sheaths around axons in the PNS (B)</p> Signup and view all the answers

Which characteristic is unique to neurons?

<p>Ability to conduct impulses (C)</p> Signup and view all the answers

What does it mean when neurons are described as amitotic?

<p>They cannot divide and replicate. (B)</p> Signup and view all the answers

Where are most neuron cell bodies located?

<p>In the central nervous system (B)</p> Signup and view all the answers

What is the primary function of the neuron cell body (soma)?

<p>To synthesize proteins and chemicals (D)</p> Signup and view all the answers

What is the term for clusters of neuron cell bodies in the CNS?

<p>Nuclei (A)</p> Signup and view all the answers

What term describes bundles of neuron processes in the PNS?

<p>Nerves (A)</p> Signup and view all the answers

Which part of the neuron is the main receptive region?

<p>Dendrites (A)</p> Signup and view all the answers

Where is the axon hillock located and what is its significance?

<p>At the junction of the cell body and axon, where the nerve impulse is generated. (B)</p> Signup and view all the answers

What is the functional significance of the axon terminal (terminal bouton)?

<p>It is the region that secretes neurotransmitters. (D)</p> Signup and view all the answers

What is the function of the axolemma?

<p>To conduct nerve impulses along the axon to the axon terminal (C)</p> Signup and view all the answers

What is the difference between anterograde and retrograde movement in an axon?

<p>Anterograde movement is away from the cell body, while retrograde is towards the cell body. (C)</p> Signup and view all the answers

Which of the following best describes the composition and function of the myelin sheath?

<p>Composed of protein-lipid substance, it protects and electrically insulates the axon. (D)</p> Signup and view all the answers

What is the function of myelin in myelinated nerve fibers?

<p>To protect and insulate the axon, increasing the speed of nerve impulse transmission. (A)</p> Signup and view all the answers

What are myelin sheath gaps (nodes of Ranvier)?

<p>Regions where the axon is directly exposed, allowing for faster impulse conduction. (B)</p> Signup and view all the answers

How does myelination differ between the PNS and the CNS?

<p>In the PNS, one Schwann cell forms one segment of myelin sheath, while in the CNS, oligodendrocytes can myelinate up to 60 axons at once. (B)</p> Signup and view all the answers

Which structural class of neurons is most common in the body and a major neuron type in the CNS?

<p>Multipolar (B)</p> Signup and view all the answers

Where are bipolar neurons typically found?

<p>In special sensory organs such as the retina and olfactory mucosa. (A)</p> Signup and view all the answers

Sensory neurons are functionally classified as:

<p>Unipolar (B)</p> Signup and view all the answers

Which structural type of neuron is predominantly found as interneurons?

<p>Multipolar (C)</p> Signup and view all the answers

Based on function, how are motor neurons classified?

<p>They carry impulses from the CNS to effectors. (B)</p> Signup and view all the answers

Which type of neuron lies between motor and sensory neurons, shuttling signals through CNS pathways?

<p>Interneurons (A)</p> Signup and view all the answers

Approximately what percentage of the body's neurons are classified as interneurons?

<p>99% (C)</p> Signup and view all the answers

How does the presence of myelin sheaths affect the color of brain and spinal cord regions?

<p>Regions with myelinated fibers appear white matter, while regions dominated by cell bodies appear gray matter. (D)</p> Signup and view all the answers

Which of the following best describes the structural arrangement of myelin sheaths in the CNS?

<p>They are formed by oligodendrocytes, which can myelinate multiple axons and lack an outer collar of perinuclear cytoplasm. (B)</p> Signup and view all the answers

How do drugs typically influence the nervous system according to the 'Why This Matters' introduction?

<p>By affecting neurotransmitter function. (A)</p> Signup and view all the answers

What is the functional relationship between sensory input, integration, and motor output in the nervous system?

<p>Sensory input leads to integration, which then dictates motor output. (C)</p> Signup and view all the answers

What distinguishes the central nervous system (CNS) from the peripheral nervous system (PNS)?

<p>The CNS is the integration and control center, while the PNS provides communication lines to and from the CNS. (C)</p> Signup and view all the answers

How do somatic and autonomic nervous systems differ in terms of their control over effector organs?

<p>The somatic nervous system controls skeletal muscles via voluntary control, whereas the autonomic nervous system controls glands, cardiac muscle, and smooth muscle via involuntary control. (C)</p> Signup and view all the answers

In what key way do the sympathetic and parasympathetic divisions of the autonomic nervous system interact?

<p>They usually work in opposition to each other to maintain balance. (B)</p> Signup and view all the answers

How do neuroglia and neurons differ in their primary functions within nervous tissue?

<p>Neuroglia support, insulate, and protect neurons, while neurons transmit electrical signals. (A)</p> Signup and view all the answers

What is the primary role of astrocytes among the neuroglia of the CNS?

<p>To support and brace neurons, while controlling the chemical environment around them. (C)</p> Signup and view all the answers

How do ependymal cells contribute to the function of the CNS?

<p>By circulating cerebrospinal fluid with their cilia. (A)</p> Signup and view all the answers

Why is the myelin sheath important for neuron function and what are its constituents?

<p>It protects and insulates the axon to increase the speed of nerve impulse transmission, and it's composed of myelin, a protein-lipid substance. (B)</p> Signup and view all the answers

How do oligodendrocytes and Schwann cells differ in their myelination functions?

<p>Schwann cells myelinate nerve fibers in the PNS, while oligodendrocytes myelinate those in the CNS. (C)</p> Signup and view all the answers

What are myelin sheath gaps and their role in nerve signal transmission?

<p>They are areas where the axon is directly exposed, allowing for faster signal transmission. (C)</p> Signup and view all the answers

What structural feature defines unipolar neurons, and where are these neurons typically located?

<p>A single process that extends from the cell body, forming central and peripheral processes; often found in sensory ganglia of the PNS. (C)</p> Signup and view all the answers

How do the structural characteristics of a neuron (e.g. multipolar, bipolar, unipolar) relate to its primary function?

<p>Structural class correlates with the neuron's role in sensory input, integration, or motor output. (C)</p> Signup and view all the answers

What is the significance of the axon hillock in a neuron?

<p>It is the cone-shaped area where the axon extends from the cell body, and where action potentials are typically generated. (B)</p> Signup and view all the answers

What are the different types of neuron processes?

<p>Axons and dendrites (A)</p> Signup and view all the answers

How is voltage, as it relates to neurons, best described?

<p>The measure of potential energy generated by separated charge. (A)</p> Signup and view all the answers

In the context of electrical principles in neurons, what characterizes resistance?

<p>The hindrance to charge flow. (B)</p> Signup and view all the answers

According to Ohm's law, how are current, voltage, and resistance related?

<p>Current is directly proportional to voltage and inversely proportional to resistance. (D)</p> Signup and view all the answers

Which feature is characteristic of leakage channels?

<p>They are always open. (C)</p> Signup and view all the answers

What causes chemically gated channels to open?

<p>The binding of particular chemicals, for example, neurotransmitters. (C)</p> Signup and view all the answers

How do mechanically gated channels operate to transport ions?

<p>By opening and closing in response to physical deformation of receptors. (D)</p> Signup and view all the answers

When gated channels open, what primarily drives the movement of ions across the membrane?

<p>The chemical concentration and electrical gradients. (A)</p> Signup and view all the answers

What measurable characteristic defines the voltage of a cell's membrane?

<p>The potential energy due to separated charges. (B)</p> Signup and view all the answers

What maintains the ionic composition differences between intracellular fluid (ICF) and extracellular fluid (ECF)?

<p>Active and passive transport mechanisms. (C)</p> Signup and view all the answers

In a neuron, which ion is at a higher concentration within the intracellular fluid (ICF) compared to the extracellular fluid (ECF)?

<p>Potassium ($K^+$). (D)</p> Signup and view all the answers

How does the permeability of the plasma membrane contribute to the resting membrane potential?

<p>By being 25 times more permeable to potassium than sodium. (A)</p> Signup and view all the answers

How does the sodium-potassium pump (Na+/K+ ATPase) stabilize the resting membrane potential?

<p>By maintaining the concentration gradients for Na+ and K+. (D)</p> Signup and view all the answers

How is depolarization defined in the context of membrane potential?

<p>A decrease in membrane potential, moving towards zero and above. (B)</p> Signup and view all the answers

How does hyperpolarization affect the likelihood of generating an impulse?

<p>It decreases the impulse probability because the membrane potential moves further from the threshold. (C)</p> Signup and view all the answers

What characteristic defines graded potentials?

<p>They are incoming signals operating over short distances. (D)</p> Signup and view all the answers

What effect does a stronger stimulus have on graded potentials?

<p>It increases the voltage changes and lengthens the current flow. (B)</p> Signup and view all the answers

What is the primary feature of action potentials that makes them crucial for long-distance communication?

<p>They do not decay over distance. (D)</p> Signup and view all the answers

What is another term for action potential?

<p>Nerve impulse. (D)</p> Signup and view all the answers

Which best describes the state of voltage-gated Na+ and K+ channels during the resting state of a neuron?

<p>Both Na+ and K+ channels are closed. (C)</p> Signup and view all the answers

What occurs when a neuron reaches the threshold potential?

<p>A positive feedback cycle causes opening of all $Na^+$ channels, causing a large action potential spike. (B)</p> Signup and view all the answers

What is the role of $Na^+$ channel inactivation gates during repolarization?

<p>They block the channel and stop the action potential from continuously rising. (C)</p> Signup and view all the answers

What primarily leads to the hyperpolarization phase following an action potential?

<p>Prolonged opening of $K^+$ channels. (D)</p> Signup and view all the answers

Why does the action potential only propagate in one direction?

<p>Because Na+ channels closer to the AP origin are still inactivated. (D)</p> Signup and view all the answers

What is the key difference in how the CNS distinguishes between a weak stimulus versus a strong stimulus?

<p>The frequency of action potentials (impulses). (D)</p> Signup and view all the answers

During the absolute refractory period, what prevents a neuron from generating another action potential?

<p>Voltage-gated $Na^+$ channels are open or inactivated. (C)</p> Signup and view all the answers

What is a key feature of the relative refractory period that influences neural excitability?

<p>Most Natchannels have returned to their resting state, but the threshold for AP generation is elevated. (D)</p> Signup and view all the answers

Which factor will increase the conduction velocity of an action potential?

<p>Myelinating the neuron. (A)</p> Signup and view all the answers

In myelinated axons, where are the voltage-gated Na+ channels concentrated?

<p>At the myelin sheath gaps (nodes of Ranvier). (D)</p> Signup and view all the answers

How does saltatory conduction affect the propagation of action potentials?

<p>Allows the action potential to jump rapidly from gap to gap. (A)</p> Signup and view all the answers

What are the typical effects of multiple sclerosis (MS) on nerve impulse conduction?

<p>Turns myelin into hardened lesions called scleroses and impulse conduction slows and eventually ends. (D)</p> Signup and view all the answers

Which nerve fiber group possesses the largest diameter and the fastest transmission speed?

<p>Group A fibers. (D)</p> Signup and view all the answers

Which best describes Group B nerve fibers?

<p>Intermediate diameter and lightly myelinated. (D)</p> Signup and view all the answers

An anesthetic blocks voltage-gated $Na^+$ channels. What direct effect would this have on neuron function?

<p>Prevention of action potential generation. (A)</p> Signup and view all the answers

How do cold temperatures affect nerve impulse propagation?

<p>They interrupt blood circulation and oxygen delivery to neurons, impairing nerve impulse propagation. (B)</p> Signup and view all the answers

What occurs during the depolarization phase of an action potential?

<p>Sodium ($Na^+$) ions rush into the cell. (A)</p> Signup and view all the answers

What specific part of the neuron integrates incoming signals to determine if an action potential should be generated?

<p>Axon hillock. (C)</p> Signup and view all the answers

Where do graded potentials primarily occur?

<p>Dendrites and cell body. (C)</p> Signup and view all the answers

How do neurons signal the intensity of a stimulus if all action potentials are the same size?

<p>By modifying the frequency of action potentials. (D)</p> Signup and view all the answers

When opposite charges are separated, what form of energy is established?

<p>Potential energy (D)</p> Signup and view all the answers

Which of the following accurately relates voltage to charge difference?

<p>Greater charge difference between two points results in higher voltage. (C)</p> Signup and view all the answers

How does resistance affect the flow of electrical charge (current)?

<p>Greater resistance reduces the magnitude of the current. (D)</p> Signup and view all the answers

According to Ohm's law, if the resistance is doubled while the voltage remains constant, what happens to the current?

<p>The current is halved. (A)</p> Signup and view all the answers

What characteristic differentiates leakage channels from gated channels?

<p>Leakage channels are always open, while gated channels open and close depending on stimuli. (A)</p> Signup and view all the answers

What is the primary difference between chemically gated and voltage-gated channels?

<p>Chemically gated channels respond to specific chemicals, while voltage-gated channels respond to changes in membrane potential. (C)</p> Signup and view all the answers

Which gradient primarily drives the diffusion of ions across a membrane when gated channels are open?

<p>Electrical and chemical gradients combined (B)</p> Signup and view all the answers

What does a voltmeter measure when connected across a neuron's membrane?

<p>The potential (charge) difference between the inside and outside of the cell. (D)</p> Signup and view all the answers

If a neuron's resting membrane potential is -70 mV, what does the negative sign indicate?

<p>The cytoplasmic side of the membrane is negatively charged relative to the outside. (D)</p> Signup and view all the answers

What two factors generate the resting membrane potential in a neuron?

<p>Differences in ionic composition of intracellular and extracellular fluids, and differences in plasma membrane permeability. (B)</p> Signup and view all the answers

Which of the following ionic conditions is characteristic of a neuron's resting state?

<p>Higher concentration of $K^+$ inside the cell and higher concentration of $Na^+$ outside the cell. (B)</p> Signup and view all the answers

How does the selective permeability of the plasma membrane contribute to the resting membrane potential?

<p>The membrane is more permeable to $K^+$ than $Na^+$, allowing more $K^+$ to diffuse out of the cell. (C)</p> Signup and view all the answers

If a stimulus causes the inside of a neuron to become less negative (more positive), this change in membrane potential is called:

<p>Depolarization (D)</p> Signup and view all the answers

What effect does hyperpolarization have on a neuron's ability to generate an action potential?

<p>It decreases the likelihood of generating an impulse. (C)</p> Signup and view all the answers

What is the main characteristic of graded potentials that distinguishes them from action potentials?

<p>Graded potentials are incoming signals that operate over short distances. (D)</p> Signup and view all the answers

In the context of changing membrane potential, what occurs during depolarization?

<p>The inside of the membrane becomes less negative (B)</p> Signup and view all the answers

What happens to membrane permeability to sodium ($Na^+$) when a neuron reaches threshold?

<p>There is a rapid increase in permeability to $Na^+$. (B)</p> Signup and view all the answers

During repolarization, what is the state of the voltage-gated $Na^+$ channels?

<p>The inactivation gates close. (A)</p> Signup and view all the answers

Following an action potential, what primarily causes the hyperpolarization phase?

<p>Excessive $K^+$ efflux. (D)</p> Signup and view all the answers

Why does an action potential only propagate in one direction down the axon?

<p>Because the $Na^+$ channels closer to the AP origin are still inactivated. (B)</p> Signup and view all the answers

How does the central nervous system (CNS) differentiate between a weak and strong stimulus?

<p>By the frequency of action potentials. (B)</p> Signup and view all the answers

What occurs during the absolute refractory period?

<p>The neuron cannot trigger another action potential. (C)</p> Signup and view all the answers

If a neuron is in the relative refractory period, what condition is most likely to stimulate another action potential?

<p>An exceptionally strong stimulus. (A)</p> Signup and view all the answers

Which of the following factors increases the conduction velocity of an action potential the most?

<p>Myelination of the axon. (B)</p> Signup and view all the answers

In myelinated axons, where are the voltage-gated $Na^+$ channels primarily concentrated?

<p>At the myelin sheath gaps (nodes of Ranvier). (D)</p> Signup and view all the answers

How does saltatory conduction increase the speed of action potential propagation?

<p>By allowing the action potential to jump rapidly from one gap in the myelin sheath to the next. (C)</p> Signup and view all the answers

Which of the following is a direct consequence of demyelination in conditions like multiple sclerosis (MS)?

<p>Slowed or ceased impulse conduction (A)</p> Signup and view all the answers

Which nerve fiber group has the fastest conduction velocity?

<p>Group A fibers (A)</p> Signup and view all the answers

What characterizes Group B nerve fibers?

<p>Intermediate diameter and lightly myelinated (A)</p> Signup and view all the answers

What is the primary role of synapses in the nervous system?

<p>To serve as junctions that mediate information transfer between neurons or between a neuron and an effector cell. (C)</p> Signup and view all the answers

How does a presynaptic neuron transmit information to a postsynaptic neuron across a chemical synapse?

<p>By releasing neurotransmitters that diffuse across the synaptic cleft and bind to receptors on the postsynaptic neuron. (A)</p> Signup and view all the answers

Which type of synapse involves direct physical contact between neurons, allowing for rapid electrical communication?

<p>Electrical synapse (D)</p> Signup and view all the answers

What is the role of voltage-gated $Ca^{2+}$ channels in synaptic transmission?

<p>To trigger the fusion of synaptic vesicles with the presynaptic neuron's membrane, leading to neurotransmitter release. (D)</p> Signup and view all the answers

Which of the following mechanisms is involved in the termination of neurotransmitter effects after it has been released into the synaptic cleft?

<p>All of the above. (D)</p> Signup and view all the answers

What is the definition of synaptic delay and why does it occur?

<p>The brief delay between the arrival of an action potential at the axon terminal and the effect on the postsynaptic cell; primarily due to the time required for neurotransmitter release and diffusion. (C)</p> Signup and view all the answers

Neurotransmitter receptors on the postsynaptic membrane cause graded potentials. What primarily determines the strength of these graded potentials?

<p>The amount of neurotransmitter released and the time it stays in the cleft. (C)</p> Signup and view all the answers

What distinguishes an excitatory postsynaptic potential (EPSP) from an inhibitory postsynaptic potential (IPSP)?

<p>EPSPs increase the likelihood of an action potential, while IPSPs decrease the likelihood of an action potential. (B)</p> Signup and view all the answers

What happens during temporal summation?

<p>A single presynaptic neuron stimulates the postsynaptic neuron with high frequency, leading to the summation of EPSPs. (B)</p> Signup and view all the answers

What is the mechanism behind spatial summation in neurons?

<p>The combined effect of multiple EPSPs arriving simultaneously at different locations on the neuron. (D)</p> Signup and view all the answers

Synaptic potentiation can increase the efficiency of neural transmission. What cellular mechanism underlies synaptic potentiation?

<p>Increased levels of $Ca^{2+}$ in the presynaptic terminal, leading to increased neurotransmitter release. (D)</p> Signup and view all the answers

How does presynaptic inhibition affect synaptic transmission?

<p>By reducing the amount of neurotransmitter released by the presynaptic neuron. (B)</p> Signup and view all the answers

Neural integration allows for complex processing of information in the CNS. Why is neural integration essential for proper nervous system function?

<p>It enables the billions of neurons in the CNS to work together, creating a smoothly operating whole. (B)</p> Signup and view all the answers

Which statement best describes the role of a 'discharge zone' within a neuronal pool?

<p>It is the area where neurons are most likely to generate an impulse due to close proximity to the incoming fiber and synapses. (B)</p> Signup and view all the answers

What is the key feature of serial processing in neural circuits?

<p>Input travels along one pathway to a specific destination, with neurons stimulating each other in a sequence. (C)</p> Signup and view all the answers

What are the five essential components of a reflex arc?

<p>Receptor, sensory neuron, CNS integration center, motor neuron, and effector. (B)</p> Signup and view all the answers

How does parallel processing differ from serial processing in neural circuits?

<p>Parallel processing handles different parts of the circuitry simultaneously, whereas serial processing handles information sequentially. (B)</p> Signup and view all the answers

In a diverging circuit, what is the relationship between the input and output?

<p>A single input leads to multiple outputs. (C)</p> Signup and view all the answers

What is the primary characteristic of a converging circuit?

<p>It concentrates signals from multiple sources into a single output. (C)</p> Signup and view all the answers

What functional role is associated with reverberating circuits?

<p>Controlling rhythmic activities, such as breathing and sleep-wake cycles. (D)</p> Signup and view all the answers

Which of the following characterizes a parallel after-discharge circuit?

<p>A single neuron stimulates multiple parallel pathways that converge on an output cell, resulting in a prolonged after-discharge. (C)</p> Signup and view all the answers

During embryonic development, from which of the following does the nervous system originate?

<p>Neural tube and neural crest derived from ectoderm (B)</p> Signup and view all the answers

What role do neurotropins play in the development of neurons?

<p>They guide the growth cone towards or away from a target. (B)</p> Signup and view all the answers

Roughly what proportion of neurons created die during normal brain development, and what is this process called?

<p>Two-thirds; apoptosis (C)</p> Signup and view all the answers

What is the term for the specialized structure at the tip of a growing axon that allows it to interact with its environment?

<p>Growth cone (B)</p> Signup and view all the answers

How do astrocytes support synapse formation?

<p>By providing physical support and cholesterol needed for synapse construction. (A)</p> Signup and view all the answers

During which period of life does learning reinforce certain neuronal synapses and prune others?

<p>Childhood and adolescence (B)</p> Signup and view all the answers

After birth, most neurons are considered amitotic, but which neuronal populations can continue to divide?

<p>Olfactory neurons and neurons in the hippocampus (D)</p> Signup and view all the answers

Which neurotransmitter is synthesized from acetic acid and choline, and is degraded by acetylcholinesterase (AChE)?

<p>Acetylcholine (ACh) (C)</p> Signup and view all the answers

Which of the following neurotransmitters is classified as a catecholamine?

<p>Norepinephrine (C)</p> Signup and view all the answers

Which of the following neurotransmitters is considered an amino acid neurotransmitter?

<p>GABA (D)</p> Signup and view all the answers

Which class of neurotransmitters includes substance P and endorphins?

<p>Peptides (D)</p> Signup and view all the answers

Which of the following is a gasotransmitter that is involved in learning and memory as well as brain damage in stroke patients?

<p>NO (B)</p> Signup and view all the answers

Which of the following neurotransmitters acts at the same receptors as THC (the active ingredient in marijuana)?

<p>Endocannabinoids (A)</p> Signup and view all the answers

How is a neurotransmitter's effect determined, and which of the following is an example of its effect?

<p>By the receptor to which it binds; can be either excitatory (depolarizing) or inhibitory (hyperpolarizing). (D)</p> Signup and view all the answers

What is a neuromodulator?

<p>A chemical messenger that does not directly cause EPSPs or IPSPs but affects the strength of synaptic transmission. (D)</p> Signup and view all the answers

What is the primary action of channel-linked receptors?

<p>Opening or closing ion channels directly, resulting in immediate and brief actions. (D)</p> Signup and view all the answers

G protein-linked receptors are characterized by which of the following?

<p>Responses that are indirect, complex, slow, and often prolonged. (A)</p> Signup and view all the answers

What is the initial step in the mechanism of G protein-linked receptors?

<p>Neurotransmitter binds to the G protein-linked receptor, activating the G protein. (D)</p> Signup and view all the answers

What crucial role do synaptic vesicles play in the process of chemical synaptic transmission?

<p>Storing and releasing neurotransmitters into the synaptic cleft. (C)</p> Signup and view all the answers

What is the functional significance of the synaptic cleft in chemical synapses?

<p>It physically separates the pre- and postsynaptic neurons, ensuring unidirectional communication. (A)</p> Signup and view all the answers

How would the introduction of a substance that significantly reduces the amount of available synaptotagmin affect synaptic transmission?

<p>It would prevent the fusion of synaptic vesicles with the axon membrane. (D)</p> Signup and view all the answers

What is the immediate consequence of neurotransmitter binding to receptors on the postsynaptic membrane?

<p>Change in receptor protein shape, which causes ion channels to open and generate graded potentials. (A)</p> Signup and view all the answers

What is the consequence of blocking voltage-gated calcium channels at the axon terminal of a presynaptic neuron?

<p>Prevention of neurotransmitter release into the synaptic cleft. (A)</p> Signup and view all the answers

What mechanisms contribute to the termination of neurotransmitter effects in the synaptic cleft?

<p>Reuptake by astrocytes or the axon terminal, degradation by enzymes, and diffusion away from the synaptic cleft. (B)</p> Signup and view all the answers

How does synaptic delay impact neural transmission?

<p>It is the rate-limiting step in neural transmission, caused by the time required for neurotransmitter processes. (B)</p> Signup and view all the answers

What distinguishes electrical synapses from chemical synapses?

<p>Electrical synapses facilitate faster, bidirectional communication through gap junctions. (A)</p> Signup and view all the answers

Which factor most directly determines whether a postsynaptic potential is excitatory or inhibitory?

<p>The type of receptor on the postsynaptic membrane and the ion channels it affects. (B)</p> Signup and view all the answers

How does temporal summation enable a postsynaptic neuron to reach threshold and fire an action potential?

<p>It involves repeated, rapid-fire stimulation from one or more presynaptic neurons before initial EPSPs can dissipate. (D)</p> Signup and view all the answers

What cellular process underlies synaptic potentiation, enhancing neural transmission efficiency?

<p>An increase in calcium concentration in the presynaptic terminal, leading to increased neurotransmitter release. (D)</p> Signup and view all the answers

Why is neural integration essential for proper nervous system function?

<p>It combines and processes incoming signals so the nervous system can respond appropriately. (B)</p> Signup and view all the answers

In a simple neuronal pool, how do neurons in the discharge zone differ from those in the facilitated zone?

<p>Neurons in the discharge zone are more likely to generate an impulse because they are closer to the incoming fiber. (A)</p> Signup and view all the answers

What is the defining characteristic of serial processing in neural circuits?

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What are the five essential components of a reflex arc, in order?

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How does parallel processing enhance the speed and efficiency of neural computation?

<p>It allows different parts of a neural circuit to deal simultaneously with information. (B)</p> Signup and view all the answers

What is the primary effect of a diverging circuit in neural processing?

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What is the defining feature of a converging circuit?

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In what functional processes are reverberating circuits primarily involved?

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What characterizes a parallel after-discharge circuit?

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During embryonic development, from which primary germ layer does the nervous system originate?

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Why are neurotropins essential for the development of neurons?

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What is the average proportion of neurons that undergo apoptosis during normal brain development and why does it occur?

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What is the function of filopodia in a growth cone?

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How do astrocytes contribute to synapse formation and function during neuronal development?

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How does synaptic pruning contribute to brain development during childhood and adolescence?

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Which specific neuronal populations retain the ability to divide postnatally, even though most neurons become amitotic?

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How do channel-linked receptors mediate their effects?

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In the context of neurotransmitter effects, what is the primary role of a neuromodulator?

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How do G protein-linked receptors typically initiate changes within a neuron?

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Which action is the initial step in the mechanism of G protein-linked receptors upon neurotransmitter binding?

<p>The neurotransmitter-receptor complex activates a G protein. (B)</p> Signup and view all the answers

Which of the following is the correct order of events that occur at a chemical synapse?

<p>Action Potential -&gt; Calcium Influx -&gt; Vesicle Fusion -&gt; Neurotransmitter Binding (B)</p> Signup and view all the answers

What type of synapse has direct physical contact, allowing for rapid electrical communication?

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What happens to the impulse frequency when synaptic vesicles exocytose?

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Where are neurotransmitters typically received on the postsynaptic neuron?

<p>A and C (D)</p> Signup and view all the answers

How does the synaptic cleft ensure unidirectional communication?

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Which of the following scenarios best illustrates spatial summation?

<p>Multiple presynaptic neurons simultaneously releasing neurotransmitters onto different locations of the same postsynaptic neuron, causing it to reach threshold. (B)</p> Signup and view all the answers

If a drug were to block voltage-gated calcium channels on the presynaptic neuron, what would be the most likely direct effect?

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In a reverberating circuit, what would be the most likely effect of a drug that blocks neuronal feedback?

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How do astrocytes facilitate synapse formation?

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How does the action of a neuromodulator differ from that of a typical neurotransmitter?

<p>A neuromodulator affects the strength of synaptic transmission, while a neurotransmitter directly causes EPSPs or IPSPs. (A)</p> Signup and view all the answers

Flashcards

Nervous System

Master controlling and communicating system of the body. Communicates via electrical and chemical signals that are rapid and specific, causing immediate responses.

Sensory Input

Gathering information about internal and external changes via sensory receptors.

Integration (Nervous System)

Processing and interpretation of sensory input to decide what should be done at each moment.

Motor Output

Activation of effector organs ( muscles and glands ) to cause a response.

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Central Nervous System (CNS)

Brain and spinal cord; integration and control center that interprets sensory input and dictates motor output.

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Peripheral Nervous System (PNS)

Portion of nervous system outside CNS that consists mainly of nerves (spinal and cranial) that extend from brain and spinal cord.

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Somatic Sensory Fibers

Conveys impulses from skin, skeletal muscles, and joints to CNS.

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Visceral Sensory Fibers

Conveys impulses from visceral organs to CNS.

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Motor (Efferent) Division

Transmits impulses from the CNS to effector organs (muscles and glands).

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Somatic Nervous System

Somatic motor nerve fibers conduct impulses from CNS to skeletal muscle; voluntary nervous system with conscious control of skeletal muscles.

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Autonomic Nervous System

Consists of visceral motor nerve fibers; regulates smooth muscle, cardiac muscle, and glands; involuntary nervous system.

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Sympathetic Division

Mobilizes body systems during activity.

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Parasympathetic Division

Conserves energy and promotes housekeeping functions during rest.

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Neuroglia (Glial Cells)

Small cells that surround and wrap delicate neurons.

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Neurons (Nerve Cells)

Excitable cells that transmit electrical signals.

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Astrocytes

Most abundant, versatile, and highly branched of glial cells; cling to neurons, synaptic endings, and capillaries.

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Microglial Cells

Small, ovoid cells with thorny processes that touch and monitor neurons; migrate toward injured neurons and can transform to phagocytize microorganisms and neuronal debris.

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Ependymal Cells

Range in shape from squamous to columnar; may be ciliated, line the central cavities of the brain and spinal column, and form a permeable barrier between cerebrospinal fluid (CSF) in cavities and tissue fluid bathing CNS cells.

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Oligodendrocytes

Branched cells; processes wrap CNS nerve fibers, forming insulating myelin sheaths in thicker nerve fibers.

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Satellite Cells

Surround neuron cell bodies in PNS, with function similar to astrocytes of CNS.

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Schwann Cells (Neurolemmocytes)

Surround all peripheral nerve fibers and form myelin sheaths in thicker nerve fibers. Vital to regeneration of damaged peripheral nerve fibers.

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Neurons

Structural units of the nervous system; large, highly specialized cells that conduct impulses.

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Neuron Cell Body

Also called the perikaryon or soma; biosynthetic center of neuron, synthesizes proteins, membranes, chemicals. Contains spherical nucleus with nucleolus.

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Nuclei (Nervous System)

Clusters of neuron cell bodies in CNS.

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Ganglia

Clusters of neuron cell bodies in PNS.

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Tracts

Bundles of neuron processes in CNS.

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Nerves

Bundles of neuron processes in PNS.

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Dendrites

100s of short, tapering, diffusely branched processes that are the receptive (input) region of neuron. Convey incoming messages toward cell body as graded potentials.

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Axon

Each neuron has one axon that starts at cone-shaped area called axon hillock. Generates nerve impulses and transmits them along axolemma to axon terminal.

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Function of Axon

Conducting region of neuron that generates nerve impulses and transmits them along axolemma to axon terminal which secretes neurotransmitters into extracellular space.

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Anterograde

Movement down the axon away from cell body that include mitochondria, cytoskeletal elements, membrane components, enzymes.

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Retrograde

Movement down the axon towards cell body that includes organelles to be degraded, signal molecules, viruses, and bacterial toxins.

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Myelin Sheath

Composed of myelin, a whitish, protein-lipid substance with function of electrically insulate axon and increase speed of nerve impulse transmission.

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Myelinated Fibers

Segmented sheath that surrounds most long or large-diameter axons.

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Nonmyelinated Fibers

Axons without myelin on them.

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Myelination in the PNS

Form myelin in PNS wrapping around axon in jelly roll fashion with one cell forming one segment of myelin sheath.

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Myelin Sheath Gaps

Gaps in myelin where axon collaterals can emerge.

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Myelin Sheaths in the CNS

Formed by the processes of oligodendrocytes, not whole cells, that can wrap up to 60 axons at once. Myelin sheath gap is present, but has no outer collar of perinuclear cytoplasm.

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White Matter

Regions of brain and spinal cord with dense collections of myelinated fibers; Usually fiber tracts.

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Gray Matter

Regions of brain and spinal cord with mostly neuron cell bodies and nonmyelinated fibers.

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Multipolar Neurons

Three or more processes (1 axon, others dendrites); Most common and major neuron type in CNS.

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Bipolar Neurons

Two processes (one axon, 1one dendrite); Rare (ex: retina and olfactory mucosa).

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Unipolar Neurons

One T-like process (two axons); Also called pseudounipolar.

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Sensory Neurons

Neurons that transmit impulses from sensory receptors toward CNS; Almost all are unipolar. Cell bodies are located in ganglia in PNS.

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Motor Neurons

Neurons that carry impulses from CNS to effectors; Multipolar. Most cell bodies are located in CNS (except some autonomic neurons).

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Interneurons

Neurons that lie between motor and sensory neurons; Shuttle signals through CNS pathways. 99% of body's neurons are these.

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Resting Membrane Potential

Electrical potential difference across the plasma membrane of a neuron when it is not conducting an impulse.

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Potential Energy (Electricity)

Energy is needed to keep opposite charges separated; when they are separated, the system has this.

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Voltage

Measure of potential energy generated by separated charge; measured in volts (V) or millivolts (mV).

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Current

Flow of electrical charge (ions) between two points.

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Resistance

Hindrance to charge flow.

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Ohm's Law

Gives the relationship of voltage, current, and resistance: Current (I) = Voltage (V)/Resistance (R).

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Membrane Ion Channels

Serve as selective pathways on the plasma membrane of cells.

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Leakage (Nongated) Channels

Ion channels that are always open.

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Gated Channels

Channels in which part of the protein changes shape to open/close the channel.

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Chemically Gated Channels

Open only with binding of a specific chemical (example: neurotransmitter).

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Voltage-Gated Channels

Open and close in response to changes in membrane potential.

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Mechanically Gated Channels

Open and close in response to physical deformation of receptors, as in sensory receptors.

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Chemical Concentration Gradients

When gated channels are open, ions diffuse quickly along these gradients.

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Electrical Gradients

The diffusion of ions when gated channels are open, from one electrical charge to an opposite electrical charge.

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Electrochemical Gradient

Electrical and chemical gradients combined.

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Polarized Membrane

The cytoplasmic side of the membrane is negatively charged relative to the outside.

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Depolarization

Decrease in membrane potential (moves toward zero and above).

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Hyperpolarization

Increase in membrane potential (away from zero).

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Graded Potentials

Short-lived, localized changes in membrane potential that can be either depolarizations or hyperpolarizations.

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Receptor Potential

Graded potentials in receptors of sensory neurons.

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Postsynaptic Potential

Neuron graded potential.

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Action Potentials

Principal way neurons send signals; a brief reversal of membrane potential with a change in voltage of ~100 mV.

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Activation Gates

Closed at rest; open with depolarization, allowing Na+ to enter cell.

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Inactivation Gates

Open at rest; block channel once it is open to prevent more Na+ from entering cell.

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Threshold

The level to which a membrane must be depolarized for an action potential to be generated.

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Propagation (Action Potential)

Allows AP to be transmitted from origin down entire axon length toward terminals.

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Action Potential (Stimulus Intensity)

All action potentials are alike and are independent of stimulus intensity.

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Refractory Period

Time in which neuron cannot trigger another action potential.

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Absolute Refractory Period

Time from opening of Na+ channels until resetting of the channels.

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Relative Refractory Period

Follows absolute refractory period; Most Na+ channels have returned to their resting state.

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Action Potential (Location)

APs occur only in axons, not other cell areas.

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Axon Diameter & Myelination

Rate of AP propagation depends on these two factors.

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Continuous Conduction

Slow conduction that occurs in nonmyelinated axons.

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Saltatory Conduction

Occurs only in myelinated axons and is about 30 times faster.

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Group A Fibers

Largest diameter, myelinated somatic sensory and motor fibers of skin, skeletal muscles, and joints; Transmit at 150 m/s (~300 mph).

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Myelin Sheaths (MS)

Multiple sclerosis (MS) is an autoimmune disease that attacks this.

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Voltage-gated Na+ channels (anesthetics)

Local anesthetics act by blocking these.

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Synapses

Junctions that mediate information transfer from one neuron to another, or to an effector cell.

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Presynaptic Neuron

Neuron conducting impulses toward the synapse, sending information.

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Postsynaptic Neuron

Neuron transmitting electrical signal away from the synapse, receiving information.

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Axodendritic Synapse

Synapse between axon terminals of one neuron and dendrites of another.

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Axosomatic Synapse

Synapse between axon terminals of one neuron and the soma of another.

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Axoaxonal Synapse

Synaptic connection from axon to axon.

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Dendrodendritic Synapse

Synaptic connection from dendrite to dendrite.

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Somatodendritic Synapse

Synaptic connection from dendrite to soma.

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Chemical Synapse

Synapse using neurotransmitters for communication.

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Chemical Synapse features

Most common type of synapse, specialized for neurotransmitter release and reception.

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Synaptic Cleft

Fluid-filled space separating the pre- and postsynaptic neurons.

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Synaptic Vesicles

The axon terminal at a chemical synapse contains these things filled with neurotransmitters.

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Receptor Region

Region on postsynaptic neuron's membrane that receives neurotransmitters.

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Step 1 of Chemical Synapse

Action potential arrives at the axon terminal of the presynaptic neuron.

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Step 2 of Chemical Synapse

Voltage-gated Ca2+ channels open allowing Ca2+ to enter axon terminal.

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Step 3 of Chemical Synapse

Ca2+ entry causes synaptic vesicles to release neurotransmitter.

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Step 4 of Chemical Synapse

Neurotransmitter diffuses across synaptic cleft and binds to postsynaptic receptors.

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Step 5 of Chemical Synapse

Neurotransmitter binding opens ion channels, creating graded potentials.

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Step 6 of Chemical Synapse

Neurotransmitter effects are terminated through reuptake, degradation, or diffusion.

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Synaptic Delay

Time needed for neurotransmitter release and diffusion across the synapse.

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Synaptic Delay Significance

Neural transmission is slowed significantly by this factor at the synapse.

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Electrical Synapses

Neurons electrically coupled via gap junctions; rapid communication.

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EPSP

A postsynaptic potential that depolarizes the membrane.

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IPSP

A postsynaptic potential that hyperpolarizes the membrane.

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Summation

The addition of multiple EPSPs to influence postsynaptic neuron.

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Temporal Summation

The rapid-fire transmission of impulses when one or more presynaptic neurons transmit impulses in order.

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Spatial Summation

Postsynaptic neuron stimulated by large number of terminals simultaneously.

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Synaptic Potentiation

Repeated use of synapse enhances presynaptic cell's ability to excite postsynaptic neuron.

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Presynaptic Inhibition

Inhibition of neurotransmitter release by one neuron via an axoaxonal synapse.

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Neural Integration

Neurons function together in groups for broader functions.

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Neuronal Pool

Functional groups of neurons that integrate and forward information.

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Discharge Zone

Neurons closer to incoming fiber are more likely to generate impulses.

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Facilitated Zone

Neurons on periphery of pool are farther away from incoming fiber, not easily excited.

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Serial Processing

Input travels along one pathway to a specific destination.

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Reflexes

Rapid, automatic responses to stimuli.

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Reflex Arcs

Pathway over which reflexes occur.

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Parallel Processing

Input travels along several pathways; different parts of circuitry deal simultaneously with information.

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Circuits (Neural)

Patterns of synaptic connections in neuronal pools.

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Diverging Circuit

One input, many outputs. Amplifying circuit example.

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Converging Circuit

Many inputs, one output; concentrating circuit.

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Reverberating Circuit

Signal travels through a chain of neurons, each feeding back to previous neurons.

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Parallel After-Discharge Circuit

Signal stimulates neurons arranged in parallel arrays that eventually converge.

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Channel-linked receptors

Gated ion channels (proteins) allows/blocks an influx/outflux of ions.

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G protein-linked receptors

Triggers responses by a membrane protein by indirectly/slowly activating transmembrane proteins.

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Actions: direct vs indirect (cont.)

In this stage chemical messenger is released by neuron.

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Study Notes

The Synapse

  • The nervous system works because information flows from one neuron to another
  • Neurons are functionally connected by synapses
  • Synapses are junctions that mediate information transfer
  • Information transfer can occur from one neuron to another
  • Information transfer can occur from one neuron to an effector cell
  • The presynaptic neuron conducts impulses toward the synapse and sends information
  • The postsynaptic neuron transmits electrical signals away from the synapse and receives information
  • The postsynaptic neuron may be a neuron, muscle cell, or gland cell in the PNS
  • Most neurons function as both pre- and postsynaptic neurons

Synaptic Connections

  • Axodendritic connections occur between axon terminals of one neuron and dendrites of others
  • Axosomatic connections occur between axon terminals of one neuron and soma (cell body) of others
  • Less common synaptic connections
    • Axoaxonal connections are axon to axon
    • Dendrodendritic connections are dendrite to dendrite
    • Somatodendritic connections are dendrite to soma

Types of Synapses

  • Chemical synapses
    • Most common type of synapse
    • Specialized for release and reception of chemical neurotransmitters
    • Typically composed of two parts:
      • Axon terminal of the presynaptic neuron: contains synaptic vesicles filled with neurotransmitter
      • Receptor region on the postsynaptic neuron's membrane: receives neurotransmitter, usually on the dendrite or cell body
    • Two parts are separated by a fluid-filled synaptic cleft
    • Electrical impulse is changed to chemical signal across synapse, then back into electrical signal

Transmission Across the Synaptic Cleft

  • The synaptic cleft prevents nerve impulses from directly passing from one neuron to the next
  • Transmission across the synaptic cleft is a chemical, not an electrical, event
  • It depends on the release, diffusion, and receptor binding of neurotransmitters
  • Transmission ensures unidirectional communication between neurons

Information Transfer Across Chemical Synapses

  • Six steps are involved in information transfer across chemical synapses:
    • An action potential (AP) arrives at the axon terminal of the presynaptic neuron
    • Voltage-gated Ca2+ channels open, and Ca2+ enters the axon terminal
      • Ca2+ flows down the electrochemical gradient from the ECF to inside of the axon terminal
    • Ca2+ entry causes synaptic vesicles to release neurotransmitter
      • Ca2+ causes synaptotagmin protein to react with SNARE proteins that control fusion of synaptic vesicles with axon membrane
      • Fusion results in exocytosis of neurotransmitter into synaptic cleft
      • The higher the impulse frequency, the more vesicles exocytose, leading to a greater effect on the postsynaptic cell
    • Neurotransmitter diffuses across the synaptic cleft and binds to specific receptors on the postsynaptic membrane
      • Often, receptors are chemically gated ion channels
    • Binding of neurotransmitter opens ion channels, creating graded potentials
      • Binding causes receptor protein to change shape, which causes ion channels to open
      • This causes a graded potential in the postsynaptic cell
      • Graded potential can be an excitatory or inhibitory event
    • Neurotransmitter effects are terminated
      • As long as neurotransmitter is binding to the receptor, graded potentials will continue, so the process needs to be regulated
      • Within a few milliseconds, a neurotransmitter's effect is terminated in one of three ways:
        • Reuptake by astrocytes or axon terminal
        • Degradation by enzymes
        • Diffusion away from the synaptic cleft

Synaptic Delay

  • Represents the time needed for neurotransmitter to be released, diffuse across synapse, and bind to receptors
  • Can take anywhere from 0.3 to 5.0 ms
  • Is the rate-limiting step of neural transmission
    • Transmission of AP down axon can be very quick, but synapse slows transmission to postsynaptic neuron down significantly
    • Not noticeable, because these are still very fast

Electrical Synapses

  • Less common than chemical synapses
  • Neurons are electrically coupled:
    • Joined by gap junctions that connect the cytoplasm of adjacent neurons
    • Communication is very rapid and may be unidirectional or bidirectional
    • Found in some brain regions responsible for eye movements or hippocampus, in areas involved in emotions and memory
    • Most abundant in embryonic nervous tissue

Postsynaptic Potentials

  • Neurotransmitter receptors cause graded potentials that vary in strength based on:
    • Amount of neurotransmitter released
    • Time neurotransmitter stays in cleft
  • Based on the effect of the chemical synapse, there are two types of postsynaptic potentials
    • EPSP: excitatory postsynaptic potentials
    • IPSP: inhibitory postsynaptic potentials

Excitatory Synapses and EPSPs

  • Neurotransmitter binding opens chemically gated channels
    • Simultaneous flow of Na+ and K+ in opposite directions
  • Na+ influx is greater than K+ efflux, resulting in local net graded potential depolarization called excitatory postsynaptic potential (EPSP)
  • EPSPs trigger an action potential (AP) if EPSP is of threshold strength
    • It can spread to the axon hillock and trigger opening of voltage-gated channels, causing AP to be generated

Inhibitory Synapses and IPSPs

  • Neurotransmitter binding to receptor opens chemically gated channels that allow entrance/exit of ions that cause hyperpolarization
    • Makes postsynaptic membrane more permeable to K+ or Cl-:
      • If K+ channels open, it moves out of cell
      • If Cl- channels open, it moves into cell
  • Reduces postsynaptic neuron's ability to produce an action potential:
    • Moves the neuron farther away from the threshold (makes it more negative)

Integration and Modification of Synaptic Events

  • Summation by the postsynaptic neuron
    • A single EPSP cannot induce an AP, but EPSPs can summate (add together) to influence postsynaptic neuron
      • IPSPs can also summate
    • Most neurons receive both excitatory and inhibitory inputs from thousands of other neurons
      • Only if EPSPs predominate and bring to threshold will an AP be generated
    • Two types of summations: temporal and spatial

Temporal Summation

  • One or more presynaptic neurons transmit impulses in rapid-fire order
    • The first impulse produces an EPSP, and before it can dissipate, another EPSP is triggered, adding on top of the first impulse

Spatial Summation

  • The postsynaptic neuron is stimulated by a large number of terminals simultaneously
    • Many receptors are activated, each producing EPSPs, which can then add together

Synaptic Potentiation

  • Repeated use of synapse increases ability of presynaptic cell to excite postsynaptic neuron
    • Ca2+ concentration increases in presynaptic terminal, causing an increased release of neurotransmitter
    • Leads to more EPSPs in the postsynaptic neuron
  • Potentiation can cause Ca2+ voltage gates to open on the postsynaptic neuron
    • Ca2+ activates kinase enzymes, leading to a more effective response to subsequent stimuli
  • Long-term potentiation: learning and memory

Presynaptic Inhibition

  • Release of excitatory neurotransmitter by one neuron is inhibited by another neuron via an axoaxonal synapse
    • Less neurotransmitter is released, leading to smaller EPSPs

Neural Integration

  • Neural integration occurs when neurons function together in groups to contribute to broader neural functions
  • There are billions of neurons in CNS, which requires integration for individual parts to fuse and make a smoothly operating whole

Neuronal Pools

  • Neuronal pool: functional groups of neurons that integrate incoming information received from receptors or other neuronal pools and forward processed information to other destinations

Simple Neuronal Pool

  • Single presynaptic fiber branches and synapses with several neurons in the pool
    • Discharge zone: neurons closer to the incoming fiber are more likely to generate impulses
    • Facilitated zone: neurons on the periphery of the pool are farther away from the incoming fiber; usually not excited to the threshold unless stimulated by another source

Patterns of Neural Processing

  • Serial processing: input travels along one pathway to a specific destination
    • One neuron stimulates the next one, which stimulates the next one, etc.
    • The system works in an all-or-none manner to produce a specific, anticipated response
    • Best example is a spinal reflex

Reflexes

  • Rapid, automatic responses to stimuli
  • A particular stimulus always causes the same response
  • Occur over pathways called reflex arcs that have five components:
    • Receptor
    • Sensory neuron
    • CNS integration center
    • Motor neuron
    • Effector

Parallel Processing

  • Input travels along several pathways
  • Different parts of circuitry deal simultaneously with the information
  • One stimulus promotes numerous responses
  • Important for higher-level mental functioning
  • Sensed smell may remind one of an odor and any associated experiences

Types of Circuits

  • Represent patterns of synaptic connections in neuronal pools
  • Four types:
    • Diverging
    • Converging
    • Reverberating
    • Parallel after-discharge

Diverging Circuit

  • One input, many outputs
  • Amplifying circuit:
    • A single neuron in the brain can activate 100 or more motor neurons in the spinal cord and thousands of skeletal muscle fibers

Converging Circuit

  • Many inputs, one output
  • Concentrating circuit:
    • Different sensory stimuli can all elicit the same memory

Reverberating Circuit

  • Signal travels through a chain of neurons, each feeding back to previous neurons
  • Oscillating circuit:
    • Involved in breathing, sleep-wake cycle, and repetitive motor activities such as walking

Parallel After-Discharge Circuit

  • Signal stimulates neurons arranged in parallel arrays that eventually converge on a single output cell
  • Impulses reach output cell at different times, causing a burst of impulses called after-discharge
    • May be involved in exacting mental processes such as mathematical calculations

Developmental Aspects of Neurons

  • The nervous system originates from the neural tube and neural crest, derived from the ectoderm
  • The neural tube becomes CNS:
    • Neuroepithelial cells of neural tube proliferate into the number of cells needed for development
    • Neuroblasts become amitotic and migrate
    • Neuroblasts sprout axons to connect with targets and become neurons

Growth Cone

  • The prickly structure at the tip of the axon that allows it to interact with its environment
    • Via cell surface adhesion proteins (laminin, integrin, and nerve cell adhesion molecules, or N-CAMs), which provide anchor points
    • Neurotropins that attract or repel the growth cone
    • Nerve growth factor (NGF), which keeps neuroblast alive
    • Filopodia are growth cone processes that follow signals toward target
  • The axon must find the right place to form a synapse once it finds its target
    • Astrocytes provide physical support and the cholesterol needed for construction of synapses
  • Two-thirds of neurons die before birth:
    • If axons do not form a synapse with their target, they are triggered to undergo apoptosis (programmed cell death)
    • Many other cells also undergo apoptosis during development
  • During childhood and adolescence, learning reinforces certain synapses and prunes others away
    • Recent evidence suggests that genes that promote excessive synaptic pruning may predispose an individual to schizophrenia
  • Neurons are amitotic after birth; however, there are a few special neuronal populations that continue to divide
    • Olfactory neurons and hippocampus

Neurotransmitters

  • Language of the nervous system
  • Fifty or more neurotransmitters have been identified
  • Most neurons make two or more neurotransmitters
    • Neurons can exert several influences
  • Usually released at different stimulation frequencies
  • Classified by:
    • Chemical structure
    • Function

Classification of Neurotransmitters by Chemical Structure

  • Acetylcholine (ACh):
    • First identified and best understood
    • Released at neuromuscular junctions
      • Also used by many ANS neurons and some CNS neurons
    • Synthesized from acetic acid and choline by the enzyme choline acetyltransferase
    • Degraded by the enzyme acetylcholinesterase (AChE)
  • Biogenic amines:
    • Catecholamines: dopamine, norepinephrine (NE), and epinephrine, made from the amino acid tyrosine
      • Indolamines: serotonin (made from the amino acid tryptophan) and histamine (made from the amino acid histidine)
    • All widely used in the brain, play roles in emotional behaviors and the biological clock
    • Used by some ANS motor neurons, especially NE
    • Imbalances are associated with mental illness
  • Amino acids:
    • Difficult to prove because amino acids make up all proteins
    • Neurotransmitters:
      • Glutamate
      • Aspartate
      • Glycine
      • GABA (gamma()-aminobutyric acid) -Peptides (neuropeptides):
    • Strings of amino acids that have diverse functions
      • Substance P: mediator of pain signals
      • Endorphins: act as natural opiates, reduce pain perception (including beta endorphin, dynorphin, and enkephalins)
      • Gut-brain peptides: somatostatin and cholecystokinin regulate digestion
  • Purines:
    • Monomers of nucleic acids (ATP) that have effects in both the CNS and PNS
      • ATP (the energy molecule) is now considered a neurotransmitter
      • Adenosine is a potent inhibitor in the brain
        • Caffeine blocks adenosine receptors
    • Can induce Ca2+ influx in astrocytes
  • Gases and lipids:
    • Gasotransmitters: nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) gases
      • Bind with G protein-coupled receptors in the brain
      • Lipid-soluble and synthesized on demand
      • NO involved in learning and formation of new memories, brain damage in stroke patients, and smooth muscle relaxation in the intestine
      • H2S acts directly on ion channels to alter function
    • Endocannabinoids:
      • Act at the same receptors as THC (active ingredient in marijuana)
      • Most common G protein-linked receptors in the brain

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