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Questions and Answers

Apa yang terjadi pada saluran ion ketika ligan berikatan dengan reseptor saluran ion?

  • Saluran ion terbuka tetapi tidak memungkinkan ion masuk
  • Saluran ion membuka dan ion dapat masuk ke sitosol (correct)
  • Saluran ion menutup permanen
  • Saluran ion membuka namun hanya untuk ion tertentu

Apa fungsi pengikatan asetilkolin pada sel otot?

  • Menghasilkan kontraksi otot akibat masuknya ion Ca2+ (correct)
  • Menghasilkan relaksasi otot dengan mengeluarkan ion Ca2+
  • Mencegah transmisi sinyal dalam sel otot
  • Menutup saluran ion Na+ dan K+

Di mana letak reseptor intraseluler pada sel target?

  • Di sitoplasma atau nukleus (correct)
  • Di dalam saluran ion
  • Di luar sel
  • Di membran plasma

Apa contoh molekul sinyal yang dapat melewati membran plasma?

<p>Hormon steroid dan oksida nitrat (B)</p> Signup and view all the answers

Apa peran molekul relay dalam transduksi sinyal?

<p>Mentransmisikan sinyal dari reseptor hingga menghasilkan respon sel (B)</p> Signup and view all the answers

Apa yang menjadi dasar respon sel terhadap sinyal yang diterima?

<p>Variasi sinyal, reseptor, molekul relay, dan protein (D)</p> Signup and view all the answers

Mengapa induksi respon seluler dapat dilakukan melalui beberapa jalur pensinyalan yang berbeda?

<p>Karena interaksi jalur pensinyalan memungkinkan aktivitas seluler berjalan dengan baik (D)</p> Signup and view all the answers

Apa akibat dari mutasi pada gen reseptor androgen?

<p>Jaringan target hormon androgen tidak berfungsi (C)</p> Signup and view all the answers

Apa yang terjadi pada ovarium akibat mutasi pada reseptor FSH?

<p>Ovarium tidak berkembang dengan baik (A)</p> Signup and view all the answers

Apa dampak dari stimulasi GPCRs dan RTKs dalam jalur transduksi sinyal?

<p>Menghasilkan sejumlah second messengers yang sama (B)</p> Signup and view all the answers

Apa yang dimaksud dengan molekul sinyal dalam konteks pensinyalan sel?

<p>Molekul yang tergantung pada adanya kontak antar sel (B)</p> Signup and view all the answers

Apa yang terjadi ketika ligan berikatan dengan reseptor terkait-protein G (GPCR)?

<p>Mengaktifkan protein G yang terikat pada reseptor (C)</p> Signup and view all the answers

Pada tahap penerimaan sinyal, reseptor mana yang terlibat dalam mendeteksi molekul sinyal?

<p>Reseptor yang terdapat di sitoplasma dan membran sel (A)</p> Signup and view all the answers

Apa yang terjadi pada tahap transduksi sinyal?

<p>Perubahan sinyal menjadi bentuk yang dapat menimbulkan respon seluler spesifik (C)</p> Signup and view all the answers

Apa fungsi utama dari reseptor tirosin-kinase?

<p>Mengkatalisis pemfosforilan tirosin pada protein substrat (C)</p> Signup and view all the answers

Apa yang akan terjadi dengan protein G yang menstimulasi (Gs) setelah aktivasi reseptor GPCR?

<p>Menstimulasi effector enzyme (A)</p> Signup and view all the answers

Apa contoh molekul sinyal yang berperan dalam pensinyalan sel?

<p>Hormon epinefrin (D)</p> Signup and view all the answers

Apa yang dihasilkan sebagai respon seluler spesifik setelah penerimaan sinyal?

<p>Aktivitas seluler seperti reaksi enzimatik (A)</p> Signup and view all the answers

Proses apa yang terjadi setelah pengikatan ligan pada reseptor tirosin-kinase?

<p>Pembentukan dimer dari polipeptida (A)</p> Signup and view all the answers

Apa peran protein delta dalam proses kontak antar sel?

<p>Sebagai molekul sinyal yang berguna untuk komunikasi (C)</p> Signup and view all the answers

Apa yang diproduksi oleh aktivasi enzim seperti adenylil cyclase dalam GPCR?

<p>Second messenger (A)</p> Signup and view all the answers

Di mana kebanyakan reseptor hormon steroid bekerja?

<p>Di sitoplasma (A)</p> Signup and view all the answers

Apa peran utama second messenger dalam jalur GPCR?

<p>Menentukan respon seluler terhadap sinyal (D)</p> Signup and view all the answers

Apa yang terjadi pada protein G yang menginhibisi (Gi) setelah teraktivasi?

<p>Menghentikan aktivitas enzim effector (A)</p> Signup and view all the answers

Apa yang dimaksud dengan mediator sinyal dalam konteks kontak antar sel?

<p>Kontak langsung antara membran plasma (D)</p> Signup and view all the answers

Apa yang dihasilkan dari aktivasi reseptor tirosin-kinase setelah pemfosforilan tirosin?

<p>Respon seluler (A)</p> Signup and view all the answers

Apa peran utama dari komunikasi antar sel dalam tubuh?

<p>Mengkoordinasi pertumbuhan, diferensiasi, dan metabolisme (A)</p> Signup and view all the answers

Apa yang dimaksud dengan transduksi sinyal?

<p>Proses pengubahan bentuk sinyal dari ekstraseluler ke respon dalam sel (C)</p> Signup and view all the answers

Apa yang terjadi selama terminasi sinyal?

<p>Molekul sinyal didegradasi oleh enzim ektraseluler (A)</p> Signup and view all the answers

Apa yang dimaksud dengan pensinyalan autokrine?

<p>Sinyal yang mempengaruhi dirinya sendiri (A)</p> Signup and view all the answers

Apa contoh dari pensinyalan jarak jauh?

<p>Pengaruh hormon terhadap sel yang jauh (C)</p> Signup and view all the answers

Apa yang biasanya menjadi molekul sinyal dalam pensinyalan paracrine?

<p>Neurotransmiter dan faktor pertumbuhan (A)</p> Signup and view all the answers

Apa yang dimaksud dengan sinyal yang memberikan respon berbeda pada sel yang berbeda?

<p>Respon sel bergantung pada jenis sel (B)</p> Signup and view all the answers

Apa yang membuat pensinyalan sinaptik berbeda dari bentuk komunikasi lainnya?

<p>Melibatkan pelepasan neurotransmiter dalam celah sinaps (C)</p> Signup and view all the answers

Apa yang terjadi setelah ligan berikatan dengan reseptor intraseluler?

<p>Kompleks ligan-reseptor memasuki nukleus dan berikatan dengan DNA. (D)</p> Signup and view all the answers

Apa fungsi dari enzim glikogen fosforilase dalam respon sel?

<p>Memecah molekul glikogen menjadi glukosa. (A)</p> Signup and view all the answers

Apa yang dimaksud dengan transduksi sinyal?

<p>Serangkaian perubahan yang mengarah pada aktivasi enzim. (C)</p> Signup and view all the answers

Apa yang dimaksud dengan aktivitas sel sebagai respon terhadap sinyal?

<p>Reaksi enzimatik seperti pemecahan glikogen. (C)</p> Signup and view all the answers

Apa yang menghasilkan protein baru dalam proses transduksi sinyal?

<p>Transkripsi dan translasi yang dipicu oleh kompleks ligan-reseptor. (A)</p> Signup and view all the answers

Apa efek dari kompleks ligan-reseptor pada gen dalam nukleus?

<p>Mengatur aktivasi atau inaktivasi gen. (D)</p> Signup and view all the answers

Apa yang diperlukan agar ligan dapat melakukan aktifitasnya di dalam sel?

<p>Berdifusi melewati membran plasma dan berikatan dengan reseptornya. (D)</p> Signup and view all the answers

Apa yang terjadi pada reseptor setelah berikatan dengan ligan?

<p>Reseptor mengalami konformasi atau perubahan bentuk. (C)</p> Signup and view all the answers

Flashcards

Cell Signaling

The process of communication between cells, coordinated by chemical signals, for growth, differentiation, and metabolism.

Transduction

The conversion of an external signal into a cellular response, relayed from outside the cell to inside the cell.

Ligand

A signaling molecule, a chemical messenger.

Endocrine Signaling

Long-distance cell signaling using hormones, typically transported through the bloodstream.

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Paracrine Signaling

Short-distance cell signaling between neighboring cells using chemical signals.

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Autocrine Signaling

Cell signaling where a cell signals itself, for example, regulating its own proliferation.

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Synaptic Signaling

Cell signaling using neurotransmitters released between nerve cells across a synapse.

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Signal Termination

The process of stopping a cell signaling pathway.

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Cell Signaling

The process by which cells communicate with each other and respond to external stimuli.

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Signal Molecules

Molecules that carry information between cells.

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Reception

The first step in cell signaling: detecting the signal molecule.

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Membrane-bound receptor

A receptor protein located on the cell membrane, receiving external signaling molecules.

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Intracellular receptor

A receptor protein located inside the cell, receiving signaling molecules that can cross the cell membrane.

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Transduction

The process of converting the signal into a form that can cause a cellular response.

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Cellular Response

The final outcome of successful cell signaling, such as changes in enzyme activity or gene expression.

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Epinephrine

A hormone involved in the fight-or-flight response, triggering various cellular responses.

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Intracellular Receptor

A receptor protein located inside the cell, receiving signaling molecules that can pass through the cell membrane.

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Steroid Hormone Signaling

Signaling pathway where steroid hormones diffuse through cell membranes and bind to intracellular receptors.

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Transduction (Cell Signaling)

The conversion of a signal from outside the cell to a cellular response inside the cell.

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Cellular Response (example)

The cell's activity in response to a signal, such as glycogen breakdown by an enzyme.

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Ligand

A signaling molecule, often a hormone, that binds to a receptor.

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Signal Reception

The process of a cell detecting a signal molecule.

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Glycogen Breakdown

Cellular response example: Breaking down glycogen by the enzyme glycogen phosphorylase.

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Hormone-receptor complex enters the nucleus

The hormone-receptor complex, formed from a steroid hormone binding to an intracellular receptor, enters the nucleus and interacts directly with DNA to regulate gene activity.

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G protein-coupled receptor (GPCR)

Membrane protein working with G proteins & other proteins (often enzymes), detecting signals like light, smell, hormones, and neurotransmitters.

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Gs protein

Stimulatory G protein, activating effector enzymes within the cell.

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Gi protein

Inhibitory G protein, suppressing effector enzymes within the cell.

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Tyrosine Kinase Receptor

Membrane receptor, with intracellular enzyme (tyrosine kinase) that phosphorylates tyrosine molecules in a protein.

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Ligand Binding

Signaling molecule attaching to a receptor, initiating cellular response.

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Second Messenger

Molecule produced from activated enzyme (e.g., adenylyl cyclase), determining cell's response.

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Signal Transduction

Process translating an extracellular signal into a cellular response.

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Receptor Dimerization

Two receptor proteins pairing up after ligand binding, activating kinase activity within the cell.

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Ion Channel Receptor

Membrane protein that opens when a ligand binds, allowing ions to flow into the cell.

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Intracellular Receptor

Receptor located inside the cell, receiving signals that cross the cell membrane. Used by lipid-soluble messengers.

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Signal Transduction

Conversion of a signal into a cellular response, often involving a series of steps.

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Signal Cascade

A series of linked reactions that amplify and direct a signal, passed along by molecules.

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Protein Kinase

Enzyme that adds phosphate groups to other proteins, often part of signal transduction.

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Signal Cascade Amplification

Each step in a signal transduction pathway increases the amount of activated molecules, leading to a larger response.

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Cell Response Variation

A cell's reaction to a signal depends on the signal strength, receptor types, relay molecules, and proteins needed for the response.

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Multiple Signaling Pathways

A single cellular response can be triggered by several different signal transduction pathways.

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Androgen Insensitivity Syndrome (AIS)

A genetic condition caused by a mutation in the androgen receptor gene, leading to the inability of target tissues to respond to androgens.

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FSH Receptor Mutation

A mutation in the follicle-stimulating hormone (FSH) receptor gene prevents proper ovarian development.

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