16 Questions
What is a misconception regarding generating Treg cells by overexpressing FOXP3 in a Th17 cell?
It leads to the direct conversion of Th17 cells into Treg cells.
Which type of Tregs are thymic-derived and also known as 'natural' Tregs according to the text?
tTregs
In the context of T cell development in the thymus, what does the transcription factor AIRE induce?
Expression of self-antigens
What is a common feature among individuals who do not develop autoimmune diseases despite having autoreactive effector T cells?
Regulation by suppressive mechanisms like Tregs
What is the role of FOXP3 in Treg cells?
Suppressive function
Which cells express high levels of CD25 and are associated with autoimmunity?
CD4+ effector T cells
What characterizes the phenotype of CD4+ effector T cells from scurfy mice?
Hyperresponsive and activated
What is the inheritance pattern of IPEX syndrome in humans?
X-linked recessive
Which factor allows the development of new mouse tools to analyze Treg function?
FOXP3-GFP reporter mice
What is the main consequence of FOXP3 mutations in humans?
Defective Treg immunosuppressive function
What is the main reason for the death of CTLA-4 knockout mice at 2-3 weeks of age?
Massive lymphoproliferation leading to organ destruction
Which type of regulatory T cell does not express Foxp3 but secretes large amounts of immunosuppressive cytokines?
Tr1 cells
What is the characteristic phenotype of Tregs in solid tumors?
Suppression of tumor-specific CD8+ cytotoxic T cells
Which regulatory mechanism involves the production of high amounts of IL-10 and TGF-beta by Tr1 cells?
Tr1 cells
What is the main role of FOXP3 in regulatory T cell function?
Maintenance of Treg lineage and function
In the context of autoimmune diseases, what can happen to Tregs leading to reduced suppressive capacity?
Loss of FOXP3 expression resulting in 'exTreg' cells
Test your knowledge on the FOXP3 locus mutation in scurfy mice and its effects on CD4+ effector T cells. Learn about the similarities between scurfy mice and Human IPEX patients. Explore the genetic inheritance and autoimmune disorders associated with FOXP3 mutations.
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