FOXP3 Mutation in Scurfy Mice Quiz
16 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is a misconception regarding generating Treg cells by overexpressing FOXP3 in a Th17 cell?

  • It is a successful method for inducing Treg cells.
  • It leads to the direct conversion of Th17 cells into Treg cells. (correct)
  • It bypasses the requirement for specific transcription factors for Treg cell generation.
  • It is an ineffective method due to the need for additional transcription factors.

    • Which type of Tregs are thymic-derived and also known as 'natural' Tregs according to the text?

  • tTregs (correct)
  • pTregs
  • CD8 T cells
  • Effector T cells

    • In the context of T cell development in the thymus, what does the transcription factor AIRE induce?

  • Avoidance of autoimmunity
  • TCR-MHC compatibility
  • Expression of self-antigens (correct)
  • Development of autoreactive effector T cells

    • What is a common feature among individuals who do not develop autoimmune diseases despite having autoreactive effector T cells?

    <p>Regulation by suppressive mechanisms like Tregs</p> Signup and view all the answers

    What is the role of FOXP3 in Treg cells?

    <p>Suppressive function</p> Signup and view all the answers

    Which cells express high levels of CD25 and are associated with autoimmunity?

    <p>CD4+ effector T cells</p> Signup and view all the answers

    What characterizes the phenotype of CD4+ effector T cells from scurfy mice?

    <p>Hyperresponsive and activated</p> Signup and view all the answers

    What is the inheritance pattern of IPEX syndrome in humans?

    <p>X-linked recessive</p> Signup and view all the answers

    Which factor allows the development of new mouse tools to analyze Treg function?

    <p>FOXP3-GFP reporter mice</p> Signup and view all the answers

    What is the main consequence of FOXP3 mutations in humans?

    <p>Defective Treg immunosuppressive function</p> Signup and view all the answers

    What is the main reason for the death of CTLA-4 knockout mice at 2-3 weeks of age?

    <p>Massive lymphoproliferation leading to organ destruction</p> Signup and view all the answers

    Which type of regulatory T cell does not express Foxp3 but secretes large amounts of immunosuppressive cytokines?

    <p>Tr1 cells</p> Signup and view all the answers

    What is the characteristic phenotype of Tregs in solid tumors?

    <p>Suppression of tumor-specific CD8+ cytotoxic T cells</p> Signup and view all the answers

    Which regulatory mechanism involves the production of high amounts of IL-10 and TGF-beta by Tr1 cells?

    <p>Tr1 cells</p> Signup and view all the answers

    What is the main role of FOXP3 in regulatory T cell function?

    <p>Maintenance of Treg lineage and function</p> Signup and view all the answers

    In the context of autoimmune diseases, what can happen to Tregs leading to reduced suppressive capacity?

    <p>Loss of FOXP3 expression resulting in 'exTreg' cells</p> Signup and view all the answers

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser