Podcast
Questions and Answers
Which of the following is the primary function of the rumen in ruminants?
Which of the following is the primary function of the rumen in ruminants?
- Main fermentation vat, creating VFAs for energy (correct)
- Starting the digestion process
- Initiating contractions in the digestive system
- Water and electrolyte balance
What type of epithelium lines the forestomach?
What type of epithelium lines the forestomach?
- Transitional epithelium
- Simple columnar epithelium
- Ciliated pseudostratified columnar epithelium
- Thick keratinizing stratified squamous epithelium (correct)
What is the purpose of the diverse microflora and alkaline pH in the forestomach?
What is the purpose of the diverse microflora and alkaline pH in the forestomach?
- To aid in the secretion of digestive enzymes
- To prevent colonization and multiplication of pathogens (correct)
- To produce volatile fatty acids
- To facilitate water absorption
In ruminants, what is traumatic reticulopericarditis commonly caused by?
In ruminants, what is traumatic reticulopericarditis commonly caused by?
What is the primary cause of primary tympany (frothy bloat) in ruminants?
What is the primary cause of primary tympany (frothy bloat) in ruminants?
What is the result of proteins creating small bubbles in the rumen?
What is the result of proteins creating small bubbles in the rumen?
What is the consequence of damage or compression of the vagus nerve in the context of ruminal tympany?
What is the consequence of damage or compression of the vagus nerve in the context of ruminal tympany?
What is the only reliable indicator of antemortem bloat?
What is the only reliable indicator of antemortem bloat?
What type of bacteria thrive in the rumen when lactic acidosis occurs?
What type of bacteria thrive in the rumen when lactic acidosis occurs?
What is the primary cause of death in animals suffering from rumenitis and lactic acidosis?
What is the primary cause of death in animals suffering from rumenitis and lactic acidosis?
What is the primary mechanism by which bacteria reach the liver and lungs, leading to abscess formation in bacterial rumenitis?
What is the primary mechanism by which bacteria reach the liver and lungs, leading to abscess formation in bacterial rumenitis?
Which of the following is a common fungal species involved in mycotic rumenitis?
Which of the following is a common fungal species involved in mycotic rumenitis?
What is the primary outcome of vessel invasion in cases of mycotic rumenitis?
What is the primary outcome of vessel invasion in cases of mycotic rumenitis?
True or False: An animal undergoing lactic acidosis experiences an increase in pH.
True or False: An animal undergoing lactic acidosis experiences an increase in pH.
Which of the following outcomes is more closely associated with 'Bloat' than 'Lactic Acidosis'?
Which of the following outcomes is more closely associated with 'Bloat' than 'Lactic Acidosis'?
Which of the following is NOT generally an etiology of abomasitis?
Which of the following is NOT generally an etiology of abomasitis?
Which parasite species is a voracious blood sucker that can lead to anemia and hypoproteinemia in infected animals?
Which parasite species is a voracious blood sucker that can lead to anemia and hypoproteinemia in infected animals?
What pathological change is associated with Ostertagia ostertagi infections, leading to impaired digestion?
What pathological change is associated with Ostertagia ostertagi infections, leading to impaired digestion?
What are bracken fern poisonings strongly associated with in cattle
What are bracken fern poisonings strongly associated with in cattle
In monogastric animals, which region of the stomach is lined by squamous epithelium?
In monogastric animals, which region of the stomach is lined by squamous epithelium?
Which cells in the fundus of the monogastric stomach produce hydrochloric acid (HCl)?
Which cells in the fundus of the monogastric stomach produce hydrochloric acid (HCl)?
Which cells secrete gastrin?
Which cells secrete gastrin?
What is the role of gastric mucus cells in protecting the stomach lining?
What is the role of gastric mucus cells in protecting the stomach lining?
What is the function of prostaglandin E2 in the gastric mucosal barrier?
What is the function of prostaglandin E2 in the gastric mucosal barrier?
Gastric Dilation and Volvulus is most common in what kind of animal?
Gastric Dilation and Volvulus is most common in what kind of animal?
What is the direction of the stomach rotation associated with Volvulus?
What is the direction of the stomach rotation associated with Volvulus?
Why might splenic displacement occur in dogs with GDV?
Why might splenic displacement occur in dogs with GDV?
What is meant by the term, 'Torsion'?
What is meant by the term, 'Torsion'?
Gastric dilation and rupture in the horse most frequently results from:
Gastric dilation and rupture in the horse most frequently results from:
Bruxism is a sign of gastrointestinal discomfort. What is bruxism?
Bruxism is a sign of gastrointestinal discomfort. What is bruxism?
Which domestic animal species is most prone to gastric ulcers associated with finely ground feed?
Which domestic animal species is most prone to gastric ulcers associated with finely ground feed?
In horses, where do gastric ulcers most frequently form?
In horses, where do gastric ulcers most frequently form?
What condition is the use of NSAIDs closely associated with?
What condition is the use of NSAIDs closely associated with?
Most common cause for an animal to have deposition of minerals in their stomach?
Most common cause for an animal to have deposition of minerals in their stomach?
Which of the following is the most common gastric neoplasm in cats?
Which of the following is the most common gastric neoplasm in cats?
A relative diffuse, soft tan/white homogenous thickening +/- nodules of the stomach is associated with which condition?
A relative diffuse, soft tan/white homogenous thickening +/- nodules of the stomach is associated with which condition?
Which benign smooth muscle neoplasm is also common in the GIST: Interstitial cells of Cajal?
Which benign smooth muscle neoplasm is also common in the GIST: Interstitial cells of Cajal?
Which of these characteristics is LEAST likely pertaining to Leiomyosarcoma?
Which of these characteristics is LEAST likely pertaining to Leiomyosarcoma?
A horse has squamous cell carcinoma. Where would we expect the lesion to be?
A horse has squamous cell carcinoma. Where would we expect the lesion to be?
Uremic gastritis is most likely to be diagnosed in which animal?
Uremic gastritis is most likely to be diagnosed in which animal?
What is the role of Enteroendocrine cells?
What is the role of Enteroendocrine cells?
In ruminants, what is the omasum primarily responsible for?
In ruminants, what is the omasum primarily responsible for?
Which of the following processes primarily occurs in the rumen?
Which of the following processes primarily occurs in the rumen?
What is the primary role of the reticulum in the ruminant digestive system?
What is the primary role of the reticulum in the ruminant digestive system?
Which component of the ruminant stomach is considered the 'glandular stomach' and is where digestion starts?
Which component of the ruminant stomach is considered the 'glandular stomach' and is where digestion starts?
What is the main function associated with the omasum?
What is the main function associated with the omasum?
What kind of protection does the thick keratinizing stratified squamous epithelium of the forestomach provide?
What kind of protection does the thick keratinizing stratified squamous epithelium of the forestomach provide?
What characteristic of the normal forestomach helps prevent pathogen colonization?
What characteristic of the normal forestomach helps prevent pathogen colonization?
Which of the following represents a primary cause of disease in the rumen?
Which of the following represents a primary cause of disease in the rumen?
What is 'hardware disease' in ruminants most commonly associated with?
What is 'hardware disease' in ruminants most commonly associated with?
Excess dietary protein in ruminants can lead to which condition?
Excess dietary protein in ruminants can lead to which condition?
Which of the following is a potential consequence of damage or compression of the vagus nerve in ruminants?
Which of the following is a potential consequence of damage or compression of the vagus nerve in ruminants?
What is the key post-mortem finding that suggests bloat occurred before death?
What is the key post-mortem finding that suggests bloat occurred before death?
Dehydration is the result of water being sucked into the rumen. What causes this influx of water?
Dehydration is the result of water being sucked into the rumen. What causes this influx of water?
What is the primary reason animals die from rumenitis and lactic acidosis?
What is the primary reason animals die from rumenitis and lactic acidosis?
Which route does bacteria take to reach the liver and lungs in cases of bacterial rumenitis, leading to abscesses?
Which route does bacteria take to reach the liver and lungs in cases of bacterial rumenitis, leading to abscesses?
What is a key pathological consequence of vessel invasion in mycotic rumenitis?
What is a key pathological consequence of vessel invasion in mycotic rumenitis?
Which factor is associated with abomasal ulcers in feedlot cattle?
Which factor is associated with abomasal ulcers in feedlot cattle?
In cases of parasitic abomasitis, what is the primary pathogenic mechanism of Haemonchus contortus?
In cases of parasitic abomasitis, what is the primary pathogenic mechanism of Haemonchus contortus?
An animal presents with submandibular edema and anemia. Which parasitic infection is more closely associated with this presentation?
An animal presents with submandibular edema and anemia. Which parasitic infection is more closely associated with this presentation?
In cattle, what pathological change in the abomasum is caused by Ostertagia ostertagi infections?
In cattle, what pathological change in the abomasum is caused by Ostertagia ostertagi infections?
Which of the following viruses can cause abomasitis primarily in cattle as part of a more systemic disease?
Which of the following viruses can cause abomasitis primarily in cattle as part of a more systemic disease?
Which of the following best describes the pathogenesis of Gastric Dilation-Volvulus (GDV)?
Which of the following best describes the pathogenesis of Gastric Dilation-Volvulus (GDV)?
What causes elevated acid secretion in small animal patients with Gastric Ulcers?
What causes elevated acid secretion in small animal patients with Gastric Ulcers?
What condition in horses does not commonly cause gastric ulcers?
What condition in horses does not commonly cause gastric ulcers?
What is the main component found in the stomach of dogs with Uremic gastritis?
What is the main component found in the stomach of dogs with Uremic gastritis?
What is the most common result of Gastrointestinal stromal tumors (GIST) and leiomyosarcomas?
What is the most common result of Gastrointestinal stromal tumors (GIST) and leiomyosarcomas?
What is the primary source of volatile fatty acids (VFAs) in the rumen?
What is the primary source of volatile fatty acids (VFAs) in the rumen?
Which epithelium type lines the rumen, reticulum, and omasum?
Which epithelium type lines the rumen, reticulum, and omasum?
In 'hardware disease', which organ is typically perforated first by ingested foreign bodies?
In 'hardware disease', which organ is typically perforated first by ingested foreign bodies?
Rumen atony, or stasis, is most commonly associated with dysfunction of which cranial nerve?
Rumen atony, or stasis, is most commonly associated with dysfunction of which cranial nerve?
What is the underlying cause of primary tympany (frothy bloat) in ruminants?
What is the underlying cause of primary tympany (frothy bloat) in ruminants?
In frothy bloat, the stable foam formation is primarily attributed to:
In frothy bloat, the stable foam formation is primarily attributed to:
The 'bloat line' observed post-mortem in the esophagus of a ruminant that died from bloat is characterized by:
The 'bloat line' observed post-mortem in the esophagus of a ruminant that died from bloat is characterized by:
Rumen acidosis is primarily caused by the overgrowth of which type of bacteria in the rumen?
Rumen acidosis is primarily caused by the overgrowth of which type of bacteria in the rumen?
Dehydration in animals with rumen acidosis is primarily due to:
Dehydration in animals with rumen acidosis is primarily due to:
Hepatic abscesses in ruminants are a common sequela to rumenitis and lactic acidosis because bacteria typically reach the liver via the:
Hepatic abscesses in ruminants are a common sequela to rumenitis and lactic acidosis because bacteria typically reach the liver via the:
In mycotic rumenitis, fungal invasion of blood vessels leads to which primary pathological outcome in the rumen mucosa?
In mycotic rumenitis, fungal invasion of blood vessels leads to which primary pathological outcome in the rumen mucosa?
Haemonchus contortus parasitism in the abomasum primarily causes disease through which mechanism?
Haemonchus contortus parasitism in the abomasum primarily causes disease through which mechanism?
Ostertagia ostertagi infection in cattle leads to 'Moroccan leather' appearance of the abomasal mucosa due to:
Ostertagia ostertagi infection in cattle leads to 'Moroccan leather' appearance of the abomasal mucosa due to:
Bracken fern poisoning in cattle is most strongly associated with the development of which type of neoplasia in the forestomach?
Bracken fern poisoning in cattle is most strongly associated with the development of which type of neoplasia in the forestomach?
In monogastric animals, the region of the stomach lined by squamous epithelium is the:
In monogastric animals, the region of the stomach lined by squamous epithelium is the:
Which cells in the fundic glands of the monogastric stomach are responsible for producing hydrochloric acid (HCl)?
Which cells in the fundic glands of the monogastric stomach are responsible for producing hydrochloric acid (HCl)?
Gastrin, which stimulates hydrochloric acid production, is secreted by cells located primarily in which region of the monogastric stomach?
Gastrin, which stimulates hydrochloric acid production, is secreted by cells located primarily in which region of the monogastric stomach?
Prostaglandin E2 (PGE2) plays a crucial role in gastric mucosal protection by:
Prostaglandin E2 (PGE2) plays a crucial role in gastric mucosal protection by:
Gastric Dilation and Volvulus (GDV) in dogs is primarily a life-threatening condition due to:
Gastric Dilation and Volvulus (GDV) in dogs is primarily a life-threatening condition due to:
In Gastric Dilation Volvulus (GDV), splenic displacement is a common occurrence. Why does the spleen often become displaced in GDV?
In Gastric Dilation Volvulus (GDV), splenic displacement is a common occurrence. Why does the spleen often become displaced in GDV?
Gastric dilation and rupture in horses is most frequently a secondary condition resulting from:
Gastric dilation and rupture in horses is most frequently a secondary condition resulting from:
Bruxism, a clinical sign sometimes associated with gastrointestinal discomfort, is best described as:
Bruxism, a clinical sign sometimes associated with gastrointestinal discomfort, is best described as:
In horses, gastric ulcers most commonly develop in which region of the stomach?
In horses, gastric ulcers most commonly develop in which region of the stomach?
The use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) is a significant risk factor for gastric ulcers because NSAIDs:
The use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) is a significant risk factor for gastric ulcers because NSAIDs:
Uremic gastritis, associated with chronic kidney disease, is characterized by deposition of what substance in the stomach mucosa?
Uremic gastritis, associated with chronic kidney disease, is characterized by deposition of what substance in the stomach mucosa?
A diffuse, soft, tan-white thickening of the stomach wall, often with nodules, is most suggestive of which type of gastric neoplasm?
A diffuse, soft, tan-white thickening of the stomach wall, often with nodules, is most suggestive of which type of gastric neoplasm?
Gastrointestinal stromal tumors (GISTs) originate from which cell type within the stomach wall?
Gastrointestinal stromal tumors (GISTs) originate from which cell type within the stomach wall?
Which characteristic is LEAST typical of a leiomyosarcoma in the stomach?
Which characteristic is LEAST typical of a leiomyosarcoma in the stomach?
In a horse diagnosed with squamous cell carcinoma of the stomach, where would the lesion most likely be located?
In a horse diagnosed with squamous cell carcinoma of the stomach, where would the lesion most likely be located?
Uremic gastritis is most commonly encountered in animals suffering from:
Uremic gastritis is most commonly encountered in animals suffering from:
Enteroendocrine cells in the stomach mucosa are primarily responsible for:
Enteroendocrine cells in the stomach mucosa are primarily responsible for:
Which of the following conditions is more likely to result in epistaxis (nosebleed) as a secondary complication in ruminants?
Which of the following conditions is more likely to result in epistaxis (nosebleed) as a secondary complication in ruminants?
Differentiating between antemortem and postmortem gastric rupture in a horse during necropsy relies heavily on identifying:
Differentiating between antemortem and postmortem gastric rupture in a horse during necropsy relies heavily on identifying:
In the context of gastric ulcers in dogs, which of the following paraneoplastic syndromes is associated with hypersecretion of gastric acid due to histamine release?
In the context of gastric ulcers in dogs, which of the following paraneoplastic syndromes is associated with hypersecretion of gastric acid due to histamine release?
Which of the following statements accurately contrasts adenocarcinoma and lymphoma as gastric neoplasms?
Which of the following statements accurately contrasts adenocarcinoma and lymphoma as gastric neoplasms?
A feedlot steer presents with lethargy, dehydration, and abdominal distension. Necropsy reveals a rumen with watery contents, mucosal hyperemia, and hepatic abscesses. Which of the following is the most likely primary diagnosis?
A feedlot steer presents with lethargy, dehydration, and abdominal distension. Necropsy reveals a rumen with watery contents, mucosal hyperemia, and hepatic abscesses. Which of the following is the most likely primary diagnosis?
A dog presents with hematemesis and melena. Endoscopy reveals a deep gastric ulcer. Further investigation for paraneoplastic syndromes would be most warranted if which of the following clinical findings were also present?
A dog presents with hematemesis and melena. Endoscopy reveals a deep gastric ulcer. Further investigation for paraneoplastic syndromes would be most warranted if which of the following clinical findings were also present?
Consider a scenario where a cow is grazing on lush alfalfa pasture and suddenly develops severe abdominal distension and respiratory distress. What is the most appropriate immediate intervention?
Consider a scenario where a cow is grazing on lush alfalfa pasture and suddenly develops severe abdominal distension and respiratory distress. What is the most appropriate immediate intervention?
A horse presents with acute onset of severe abdominal pain, gastric reflux, and marked gastric distension on nasogastric intubation. Which of the following diagnostic procedures would be LEAST helpful in determining the underlying cause?
A horse presents with acute onset of severe abdominal pain, gastric reflux, and marked gastric distension on nasogastric intubation. Which of the following diagnostic procedures would be LEAST helpful in determining the underlying cause?
What is the primary function of the forestomach in ruminants?
What is the primary function of the forestomach in ruminants?
Which of the following best describes the epithelium lining the rumen and reticulum?
Which of the following best describes the epithelium lining the rumen and reticulum?
What is the significance of volatile fatty acids (VFAs) produced in the forestomach?
What is the significance of volatile fatty acids (VFAs) produced in the forestomach?
In ruminants, 'hardware disease' primarily affects which part of the forestomach?
In ruminants, 'hardware disease' primarily affects which part of the forestomach?
Which of the following is a common consequence of traumatic reticulopericarditis in cattle?
Which of the following is a common consequence of traumatic reticulopericarditis in cattle?
Primary tympany (frothy bloat) in ruminants is mainly caused by:
Primary tympany (frothy bloat) in ruminants is mainly caused by:
In frothy bloat, what component of the diet is most likely responsible for the stable foam formation?
In frothy bloat, what component of the diet is most likely responsible for the stable foam formation?
Secondary tympany (gas bloat) is often associated with:
Secondary tympany (gas bloat) is often associated with:
Damage to the vagus nerve can lead to which type of ruminal tympany?
Damage to the vagus nerve can lead to which type of ruminal tympany?
The 'bloat line' in the esophagus is a post-mortem finding characteristic of:
The 'bloat line' in the esophagus is a post-mortem finding characteristic of:
Rumen acidosis is primarily caused by the overproduction of:
Rumen acidosis is primarily caused by the overproduction of:
In rumen acidosis, dehydration occurs due to:
In rumen acidosis, dehydration occurs due to:
Hepatic abscesses in ruminants are a common sequela to rumenitis because bacteria gain access to the liver via the:
Hepatic abscesses in ruminants are a common sequela to rumenitis because bacteria gain access to the liver via the:
Mycotic rumenitis is characterized by fungal invasion of:
Mycotic rumenitis is characterized by fungal invasion of:
Which volatile fatty acid (VFA) production process is essential for ruminant energy and occurs primarily in the forestomach?
Which volatile fatty acid (VFA) production process is essential for ruminant energy and occurs primarily in the forestomach?
An abrupt dietary change in ruminants is most likely to disrupt which aspect of forestomach physiology, potentially leading to disease?
An abrupt dietary change in ruminants is most likely to disrupt which aspect of forestomach physiology, potentially leading to disease?
In 'hardware disease', a metallic foreign body is most likely to penetrate which compartment of the ruminant stomach first due to its anatomical position?
In 'hardware disease', a metallic foreign body is most likely to penetrate which compartment of the ruminant stomach first due to its anatomical position?
What is the primary pathophysiological mechanism by which ruminal tympany (bloat) leads to death in ruminants?
What is the primary pathophysiological mechanism by which ruminal tympany (bloat) leads to death in ruminants?
The 'bloat line', a distinct demarcation in the esophagus, is a crucial post-mortem indicator of antemortem bloat. Which description accurately characterizes the cranial portion of the esophagus relative to the distal portion at this line?
The 'bloat line', a distinct demarcation in the esophagus, is a crucial post-mortem indicator of antemortem bloat. Which description accurately characterizes the cranial portion of the esophagus relative to the distal portion at this line?
In rumen acidosis, the influx of water into the rumen is primarily driven by:
In rumen acidosis, the influx of water into the rumen is primarily driven by:
Hepatic abscesses are a common sequela to bacterial rumenitis because bacteria gain access to the liver primarily via the:
Hepatic abscesses are a common sequela to bacterial rumenitis because bacteria gain access to the liver primarily via the:
Haemonchus contortus primarily causes disease in the abomasum through which of the following mechanisms?
Haemonchus contortus primarily causes disease in the abomasum through which of the following mechanisms?
The 'Moroccan leather' appearance of the abomasal mucosa is a characteristic lesion associated with infection by which parasite?
The 'Moroccan leather' appearance of the abomasal mucosa is a characteristic lesion associated with infection by which parasite?
In monogastric animals, the region of the stomach lined by squamous epithelium and most susceptible to ulceration due to acid exposure is the:
In monogastric animals, the region of the stomach lined by squamous epithelium and most susceptible to ulceration due to acid exposure is the:
Which cells in the fundic glands of the monogastric stomach are responsible for producing hydrochloric acid (HCl) necessary for digestion?
Which cells in the fundic glands of the monogastric stomach are responsible for producing hydrochloric acid (HCl) necessary for digestion?
Prostaglandin E2 (PGE2) plays a crucial role in maintaining the gastric mucosal barrier by:
Prostaglandin E2 (PGE2) plays a crucial role in maintaining the gastric mucosal barrier by:
In dogs with Gastric Dilation Volvulus (GDV), splenic displacement often occurs concurrently due to:
In dogs with Gastric Dilation Volvulus (GDV), splenic displacement often occurs concurrently due to:
Gastric dilation and rupture in horses is most frequently a secondary condition, most commonly resulting from:
Gastric dilation and rupture in horses is most frequently a secondary condition, most commonly resulting from:
Bruxism, as a clinical sign associated with gastrointestinal discomfort in animals, is best described as:
Bruxism, as a clinical sign associated with gastrointestinal discomfort in animals, is best described as:
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are a significant risk factor for gastric ulcers because they directly inhibit the synthesis of:
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are a significant risk factor for gastric ulcers because they directly inhibit the synthesis of:
Uremic gastritis, associated with chronic kidney disease, is characterized by the deposition of which substance in the gastric mucosa?
Uremic gastritis, associated with chronic kidney disease, is characterized by the deposition of which substance in the gastric mucosa?
A diffuse, soft, tan-white thickening of the stomach wall, often with nodules, in a cat is most suggestive of which type of gastric neoplasm?
A diffuse, soft, tan-white thickening of the stomach wall, often with nodules, in a cat is most suggestive of which type of gastric neoplasm?
Gastrointestinal stromal tumors (GISTs) and leiomyosarcomas of the stomach primarily originate from which layer of the stomach wall?
Gastrointestinal stromal tumors (GISTs) and leiomyosarcomas of the stomach primarily originate from which layer of the stomach wall?
In a horse diagnosed with squamous cell carcinoma of the stomach, where would the lesion be most likely located, considering the stomach's unique anatomical divisions?
In a horse diagnosed with squamous cell carcinoma of the stomach, where would the lesion be most likely located, considering the stomach's unique anatomical divisions?
Flashcards
Rumen
Rumen
Main fermentation vat in ruminants, creating VFAs for energy.
Reticulum
Reticulum
Starts the contractions of the rumen.
Omasum
Omasum
Likely balances water and electrolytes in ruminants.
Abomasum
Abomasum
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Trichobezoars
Trichobezoars
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Phytobezoars
Phytobezoars
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Hardware Disease
Hardware Disease
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Bloat (Ruminal Tympany)
Bloat (Ruminal Tympany)
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Primary Tympany
Primary Tympany
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Secondary Tympany
Secondary Tympany
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Rumenitis
Rumenitis
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Grain Overload
Grain Overload
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Lactobacillus and Streptococcus
Lactobacillus and Streptococcus
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Consequences of Grain Overload
Consequences of Grain Overload
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Bacterial Rumenitis
Bacterial Rumenitis
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Mycotic Rumenitis
Mycotic Rumenitis
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Abomasitis
Abomasitis
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Haemonchus
Haemonchus
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Ostertagia
Ostertagia
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Forestomach Neoplasms
Forestomach Neoplasms
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Fundus
Fundus
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Gastric mucosal barrier
Gastric mucosal barrier
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Gastric Dilation and Volvulus (GDV)
Gastric Dilation and Volvulus (GDV)
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Gastric dilation and rupture in horses
Gastric dilation and rupture in horses
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Gastroduodenal ulcerations
Gastroduodenal ulcerations
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Gastric ulcers in small animals
Gastric ulcers in small animals
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Gastric Ulcers in pigs
Gastric Ulcers in pigs
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Gastric Ulcers in Horses
Gastric Ulcers in Horses
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Abomasal ulcers in cattle
Abomasal ulcers in cattle
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Gastritis
Gastritis
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Uremic gastritis
Uremic gastritis
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Lymphoma in stomach
Lymphoma in stomach
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Forestomach Function
Forestomach Function
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Two Key Forestomach Diseases
Two Key Forestomach Diseases
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Order of Digestion
Order of Digestion
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Normal Rumen Bacteria
Normal Rumen Bacteria
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Reticulum Appearance
Reticulum Appearance
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Omasum Appearance
Omasum Appearance
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Abomasum Appearance
Abomasum Appearance
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Causes of Forestomach Disease
Causes of Forestomach Disease
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Hardware Disease Definition
Hardware Disease Definition
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Hardware Disease Complication
Hardware Disease Complication
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Bloat Line
Bloat Line
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Frothy Bloat Cause
Frothy Bloat Cause
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Eructation Requirement
Eructation Requirement
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Secondary Bloat Causes
Secondary Bloat Causes
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Bloat Pathophysiology
Bloat Pathophysiology
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Rumen Acidosis Pathogenesis
Rumen Acidosis Pathogenesis
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Consequences of Ruminal Acidosis
Consequences of Ruminal Acidosis
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Bacteria Related to Rumenitis
Bacteria Related to Rumenitis
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Liver Abscess Pathogenesis
Liver Abscess Pathogenesis
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Mycotic Rumenitis Lesions
Mycotic Rumenitis Lesions
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Cause of Primary or Frothy Bloat
Cause of Primary or Frothy Bloat
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What could cause secondary bloat
What could cause secondary bloat
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Cause of Vegal Indigestion
Cause of Vegal Indigestion
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Function of Gastrin
Function of Gastrin
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Effect of Mast Cell Tumors
Effect of Mast Cell Tumors
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Causes of Ulcers
Causes of Ulcers
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Study Notes
- The lecture covers diseases of the forestomach and abomasum, emphasizing pathology terms, pathogenesis, gross lesions, clinical signs, and differential diagnoses.
- The main functions of the forestomach are to break down fiber and produce volatile fatty acids (VFAs) for energy, a process carried out by bacteria, protozoa, and some fungi.
- Key forestomach issues include bloat and chemical rumenitis (ruminal acidosis).
- Gram-negative bacteria typically predominate in the rumen, but ruminal acidosis results in the death of the gram-negative bacteria, leading to an overgrowth of gram-positive bacteria
Ruminant Stomach Anatomy Review
- Esophagus leads to the rumen, then to the reticulum, omasum, and abomasum.
- The spleen is typically attached to the rumen.
Rumen
- Characterized by mucosal folds and papillae.
Reticulum
- It has a honeycomb pattern on the mucosa.
Omasum
- has long, thin folds resembling pages of a book.
Abomasum
- It resembles a normal glandular stomach with some folds and is lined by columnar epithelium.
Etiopathogenesis of Rumen Issues
- Issues include foreign bodies (wires, nails), motility problems, imbalance of ruminal flora, abrupt diet change, pH changes, and loss of mucosal lining integrity (ulcers).
- Vagus nerve damage can cause motility problems (rumen atony).
- Imbalance of ruminal flora is often associated with dietary changes, which kill good bacteria and allow bad bacteria to proliferate.
Foreign Bodies
- Hairballs (trichobezoars) and plant balls (phytobezoars) are usually incidental findings
- Nails and wires can perforate the reticulum, diaphragm, and pericardium
- Reticulopericarditis results in chronic, active infection of the pericardial sac
- Lead poisoning from batteries or paints can cause necrosis of the gray matter of the brain (polioencephalomalacia).
- Traumatic reticulopericarditis is diagnosed via finding the foreign body, or a scar in the reticulum.
- Fibrin (yellow, friable material) covering the heart indicates a chronic active infection of the pericardial sac and epicardial surface, leading to heart failure.
Bloat (Ruminal Tympany)
- This can cause death via cardiorespiratory arrest due to pressure on the diaphragm and compressed lung or cardiogenic shock with decreased venous return due to compressed vena cava.
- Severe cases can cause distension on both sides of the animal.
Primary Bloat
- Dietary protein, especially from legumes like alfalfa and clover, can cause primary or frothy bloat.
- Proteins create stable foam that prevents eructation by blocking the cardia and trapping gas in bubbles
Secondary Bloat
- Secondary tympany or gas bloat is caused by obstruction from foreign bodies or tumors, or damage to the vagus nerve.
- Vagal nerve damage or compression, caused by abscesses or inflammation, can lead to vagal indigestion and secondary bloat (ruminal atony and bloat).
Identifying Antemortem Bloat
- Reliable indicator of antemortem bloat is the bloat line which causes congestion of the cranial esophagus and a pale distal esophagus.
Inflammation of the Rumen (Rumenitis)
- Grain overload causes excessive carbohydrate fermentation, which lowers pH, kills protozoa, and allows proliferation of Lactobacillus and Streptococcus
- This leads to D-lactate production, increasing osmotic pressure, resulting in water influx and rumen atony and mucosal damage.
- Animals can die of dehydration due to water drawn into the rumen.
- Ruminal scars and mucosal damage may develop in survivors
Bacterial Rumenitis
- Resident flora, such as Fusobacterium necrophorum and T. pyogenes, invade injured mucosa due to ruminal acidosis.
- Bacteria can be transported to the liver via the portal circulation, resulting in hepatic abscesses, and subsequently to the lungs, causing pulmonary abscesses, hemorrhage, and epistaxis.
Mycotic Rumenitis
- Mucosal injury from ruminal acidosis facilitates fungal invasion.
- Fungi invade vessels, causing thrombosis and infarcts.
- Common fungi include Mucor, Absidia, Rhizopus, and Aspergillus.
- Fungi go specifically to the vessel walls, leading to inflammation and obstruction of blood supply and causing areas of ischemia
Lactic Acidosis
- Lactic Acidosis or Grain Overload results in severe dehydration and is lethal
- If the animal recovers, a sequel can be hepatic abscesses and not pancreatic
- Diets high in grain cause the disease and not altafa
- increased protozoa in the rumen does not result in lactic acidosis
Main Rumen Problems:
- Lactic Acidosis and Bloat
Abomasitis
- Bacterial causes are Clostridium septicum (Braxy)
- Parasitic causes are Hemonchus contortus and Ostertagia
- Fungal causes are chronic ulceration or sepsis in calves
- Viral causes are part of systemic diseases like IBR, BVD, and MCF in cattle, or blue tongue in sheep
Parasitic Abomasitis: Haemonchus
- H. contortus impacts sheep and H. placei impacts cattle
- Parasite attaches to mucosa as voracious blood suckers, causes anemia and hypoproteinemia, leading to edema.
- Female parasites have a "barber's pole" appearance due to the pale tan reproductive tract and dark red digestive tract filled with blood.
Parasitic Abomasitis: Ostertagia
- Most prominent characteristic is Moroccan Leather
- Parasite resides in the abomasal glands, causing metaplasia of epithelial cells, replacing parietal and chief cells with mucous cells
- Affects parietal and chief cells responsible for digestion of proteins and production of hydrochloric acid
- Thickening of the mucosa results in a cobblestone or Moroccan leather appearance
- Leads to impaired digestion, hypoproteinemia, diarrhea due to maldigestion and malabsorption, chronic weight loss, and is often untreatable.
Forestomach Neoplasms
- Bracken fern poisoning causes squamous cell carcinoma in cattle
- Ruminal papilloma is associated with bovine papilloma virus 4
- Squamous cell carcinoma can obstruct the cardia leading to secondary bloat.
Stomach Anatomy in Monogastrics
- divided into the cardia, fundus, and pyloric region
- Cardia abuts the esophageal region and is lined by squamous epithelium
- Fundus contains parietal cells, which produce HCL, and chief cells, which produce pepsinogen; lined by columnar mucus cells
- Pyloric region contains tubular glands that secrete gastrin
- Horses have a non-glandular stomach lined by stratified squamous epithelium, susceptible to ulcers
Gastric Anatomy and Histology
- Low luminal pH destroys ingested pathogens, resident bacterial flora can't be cultured by conventional methods
- Parietal cells produce rennin to coagulate milk protein, intrinsic factor for vitamin B12 absorption, and hydrogen chloride (HCI)
- Chief cells produce zymogen and pepsin for digestion
- Enteroendocrine cells produce serotonin, gastrin, somatostatin, endothelin, histamine
- Mucus cells produce bicarbonate and a protective layer
- Activation of pepsinogen requires hydrochloric acid and is affected by decreased production of hydrochloric acid
Gastric Mucosal Barrier
- Gastric mucus cells secrete bicarbonate and mucus to buffer gastric acid
- A thick mucus layer prevents bacterial attachment
- Prostaglandin E2 stimulates mucus secretion, inhibits acid secretion, and regulates blood flow; inhibited by NSAIDs
- HCI kills most organisms
- IgA prevents attachment
Gastric Dilation and Volvulus (GDV)
- GDV is common in deep-chested dog breeds
- Often linked to exercise following ingestion to large meals, water intake, and air
- Spleen may twist
- Compression of the caudal vena cava and portal vein leads to shock
- This is a life-threatening emergency
Gastric Dilation-Volvulus (GDV) Details
- Constriction of blood outflow and decreased venous return
- Increases intra-abdominal pressure
- Reduced perfusion of intra-abdominal organs
- Pressure on diaphragm makes respiration compromised
- Reduced cardiac output and circulatory shock
- In volvulus, the stomach rotates 180-270 degrees clockwise on its mesenteric axis
- Obstruction of both the esophagus (which affects eructation and vomiting) and the pylorus (affecting outflow) leads to hypovolemic shock, cell hypoxia, and poor tissue perfusion
Pathogenesis of GDV
- Dilation involves gas or fluid accumulation from bacterial fermentation, aerophagia, or gastric secretions. Obstruction affects eructation, vomiting, and outflow, leading to hypovolemic shock, cell hypoxia, and poor tissue perfusion.
GDV Risk Factors and Potential Sequelae
- High-risk breeds are typically giant, deep-chested dogs: Great Dane, German Shepherd, Weimaraner, St. Bernard, Standard Poodle
- Splenic displacement causes compression of the caudal vena cava and portal vein which obstructs venous return to the heart, causing blood to pool in other organs
- Gastrointestinal outflow obstruction leads to fluid loss
- Can result in portal hypertension, GI tract ischemia, hypovolemia, and systemic hypotension
- Distended stomach can cause venous infarction, bacterial proliferation, and endotoxemia and fluid loss into the lumen
Gastric Dilation and Rupture in Horses
- Primary gastric dilation and rupture results from excess fermentable carbohydrates via over grain consumption in excess
- Secondary gastric dilation results from obstruction of the small bowel or of colic with ileus
- Rupture can occur post-mortem from gas production, but antemortem ruptures feature hyperemia and edema at the margins.
Gastroduodenal Ulcerations
- Caused by increased acid secretion and/or loss of mucosal integrity
- Result in vomiting, pain, weight loss, salivation, bruxism, anorexia, hematemesis, melena, and anemia
- Erosion is a partial loss of the mucosa and is not transmural
- Ulcer is where the pathogen has moved through the muscularis to submucousal layers
- Perforation is where it is transmural
Gastric Ulcers in Small Animals
- Local disturbances or trauma to the mucosal epithelial barrier can cause damage
- NSAIDs and corticosteroids causes epithelial damage
- Decreased bicarbonate and mucus production
- Elevated acid secretion caused by increased serum gastrin or histamine levels
- Liver disease
- Histamine into the blood binds to receptors on parietal cells and increasing HCL secretion.
Gastric Ulcers in Pigs
- Result from finely ground feed
- Pars esophagia area is where they form
- Often fatal because Perforation, hemoabdomen and acute death are common
Gastric Ulcers in Horses
- Very common
- Ulcers can appear in margo plicatus
- High performance, intensive management, and blister beetles
- Ulcers in pars glandularis are less common
- especially with NSAIDs
- Can be associated with stress via recent transportation
Abomasal Ulcers in Cattle
- Very common in feedlot cattle, in dairy associated with lactic acidosis
- Associated with stress - weaning, transport
- Most common in the pyloric region
- Can be asymptomatic or lead to perforation and acute death
Gastritis
- Gastritis is the inflammation of the stomach in general
- Causes include uremic gastritis, mechanical gastritis from foreign bodies, and infectious gastritis
- Infectious gastritis can be bacterial (Braxy), parasitic, or viral, but viral is rare
Uremic Gastritis
- Mostly in dogs with severe kidney disease
- Uremia damages blood vessels that induces vasculitis
- The mucosal hyperemia, erosions, hemorrhage, and thickening of the stomach wall occur due to edema and calcium deposits
- Diagnosed via thickening of the mucosa due to edema and mineral deposits.
Parasitic Gastritis
- Gasterophilus bots can cause parasitic gastritis
- These are a common finding in stomachs of horses, usually incidental
Gastric Neoplasia
- There are is general 3 types: Epithelial, Mesenchymal and Round cell
Epithelial Neoplasia
- Hyperplastic polyp/Adenoma
- Adenocarcinoma (dogs > cats)
- Squamous cell carcinoma (horses)
Mesenchymal Neoplasia
- Leiomyoma/Leiomyosarcoma (dogs > cats)
- Gastrointestinal stromal tumors (GIST) (dog > horses > cats)
Round Cell Neoplasia
- Lymphoma (cats > cattle > horses > dogs)
Gastric Polyps/Adenomatous Polyps
- Most common in pylorus of dogs
- Exophytic and pedunculated benign nodules/masses
- Can cause obstruction of the pylorus but usually is incidental
Gastric Adenocarcinoma
- Most prevalent in dogs, rare otherwise
- Its ulcerative, aggressive, and can be fibrotic
- Locally aggressive, metastasize
- Causes bleeding, anemia and melena
Squamous Cell Carcinoma
- Most common gastric tumor in horses but still rare
- Pars esophagea is non-glandular
Lymphoma
- Most common gastric neoplasm in cats
- Common in cattle with Bovine Leukemia Virus (retrovirus)
- Causes multicentric tumors
- Also causes lymphoma in heart, kidney, epidural space, retrobulbar
- Relative diffuse, soft tan/white, homogenous thickening +/- nodules
- Lymphoma is a sheet of lymphocytes
Gastrointestinal Stromal Tumor (GIST) and Leiomyosarcoma
- GIST originates from interstitial cells of Cajal within the tunica muscularis
- Leiomyosarcomas originate from smooth muscle fibers
- Leiomyomas are benign as well and can be frequent
- Both GIST and leiomyosarcoma can cause obstruction
- Leiomyosarcomas do not metastasize
- GIST metastasize more often
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