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Questions and Answers
What is the role of FmlH in UTI pathogenesis?
What is the role of FmlH in UTI pathogenesis?
FmlH is involved in UTI pathogenesis.
What strategy was used to develop high-affinity galactoside antagonists of FmlH?
What strategy was used to develop high-affinity galactoside antagonists of FmlH?
An X-ray structure-guided medicinal chemistry approach was used.
What was the first step in developing galactoside antagonists of FmlH?
What was the first step in developing galactoside antagonists of FmlH?
Screening a select library of galactosides through multiplex ELISA arrays for initial lead compound identification.
What type of assay was developed to detect binding in the competition assay?
What type of assay was developed to detect binding in the competition assay?
What glycan receptors does FmlH bind to?
What glycan receptors does FmlH bind to?
What approach was used to identify the early lead inhibitor of the F9 Pilus Adhesin FmlH?
What approach was used to identify the early lead inhibitor of the F9 Pilus Adhesin FmlH?
What was the iterative process involved in developing high-affinity galactoside antagonists of FmlH?
What was the iterative process involved in developing high-affinity galactoside antagonists of FmlH?
What was the purpose of evaluating the top lead compound in a mouse model of UTI?
What was the purpose of evaluating the top lead compound in a mouse model of UTI?
What was the goal of adapting Gal, GalNAc, and TF to function as soluble, competitive inhibitors of FmlH?
What was the goal of adapting Gal, GalNAc, and TF to function as soluble, competitive inhibitors of FmlH?
What type of assay was developed to detect binding in the competition assay?
What type of assay was developed to detect binding in the competition assay?
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