Fluid and Hemodynamic Disorders Exam
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Questions and Answers

Define hyperemia.

Hyperemia is the increase of blood flow to different tissues in the body.

What are the two main classifications of hyperemia?

  • Arterial and Venous (correct)
  • Active and Passive (correct)
  • Acute and Chronic
  • Local and Systemic
  • Active hyperemia is also known as venous hyperemia.

    False

    What is active hyperemia?

    <p>Active hyperemia is increased blood inflow (arterial blood) to different tissues in the body.</p> Signup and view all the answers

    Active hyperemia is characterized by arteriolar and capillary constriction.

    <p>False</p> Signup and view all the answers

    Which of these is NOT an example of physiological active hyperemia?

    <p>Heart blood vasculature during heart failure</p> Signup and view all the answers

    What is the pathogenesis of passive hyperemia?

    <p>Passive hyperemia is caused by diminished or blocked venous drainage, where blood outflow is impaired due to an obstruction. The mechanism is an obstacle that impairs blood flow out of the area.</p> Signup and view all the answers

    What are the effects of passive hyperemia?

    <p>The effects of passive hyperemia include dilation of veins, venules, and capillaries, leading to a buildup of venous blood in the affected area. This can cause edema (swelling) and cyanosis (bluish discoloration).</p> Signup and view all the answers

    What are the clinical features of passive hyperemia?

    <p>Blue-red color</p> Signup and view all the answers

    Edema is a component of passive congestion.

    <p>True</p> Signup and view all the answers

    What is local passive congestion?

    <p>Local passive congestion involves one vein in one limb or organ.</p> Signup and view all the answers

    What is superior vena cava syndrome?

    <p>Superior vena cava syndrome results from passive congestion of the superior vena cava.</p> Signup and view all the answers

    What are the effects of superior vena cava syndrome?

    <p>The effects of superior vena cava syndrome include edema and cyanosis of the head, neck, shoulders, and upper chest.</p> Signup and view all the answers

    What is portal hypertension?

    <p>Portal hypertension is a condition where the pressure within the portal vein increases.</p> Signup and view all the answers

    What are the main causes of portal hypertension?

    <p>Liver cirrhosis, lesions of the portal vein such as neoplastic invasion, thrombosis, phlebitis, and compression are the main causes of portal hypertension.</p> Signup and view all the answers

    What are the consequences of portal hypertension?

    <p>Consequences of portal hypertension include splenomegaly, collateral circulation (portosystemic or portocaval shunts), esophageal varices, rectal varices/hemorrhoids, caput medusae, and ascites.</p> Signup and view all the answers

    What is pulmonary passive congestion?

    <p>Pulmonary passive congestion is the inability of the left heart to evacuate the pulmonary venous blood, which leads to an increase in pressure in the pulmonary veins, and in turn leads to increased pulmonary capillary pressure.</p> Signup and view all the answers

    What is the etiology of pulmonary passive congestion?

    <p>Pulmonary passive congestion can be caused by acute left-sided heart failure, usually associated with myocardial infarction, or chronic left-sided heart failure, often caused by mitral stenosis or chronic left-sided heart failure.</p> Signup and view all the answers

    What are the effects of lung congestion?

    <p>The effects of lung congestion include impaired gas diffusion across the alveolar-capillary membrane, decrease in pulmonary excursions, and pulmonary artery hypertension.</p> Signup and view all the answers

    Liver passive congestion is also known as passive hepatic congestion.

    <p>True</p> Signup and view all the answers

    What is ischemia?

    <p>Ischemia is a condition where the blood flow to an area of the body is decreased.</p> Signup and view all the answers

    Which of the following is NOT a cause of arterial obstruction?

    <p>Increased blood flow</p> Signup and view all the answers

    What are decubitus ulcers?

    <p>Decubitus ulcers, also known as pressure ulcers or bed sores, are areas of ischemic necrosis of the skin that occur in individuals who are bedridden or confined to a wheelchair due to compression of the dermal capillaries between the bed and the bone prominences.</p> Signup and view all the answers

    What are the factors that determine the consequences of ischemia?

    <p>The consequences of ischemia are determined by a combination of factors including previous blood or cardiovascular diseases, tissue resistance during hypoxia, the pattern of arterial supply, and the type of ischemia.</p> Signup and view all the answers

    What is hemorrhage?

    <p>Hemorrhage is the loss of blood from the circulatory system due to blood extravasation.</p> Signup and view all the answers

    What are the mechanisms of hemorrhage?

    <p>All of the above</p> Signup and view all the answers

    Define external hemorrhage.

    <p>External hemorrhage is visible on the outside of the body and typically occurs due to trauma such as open fractures or sectioning of an artery.</p> Signup and view all the answers

    What is a thrombus?

    <p>A thrombus is a solid mass of blood constituents that forms inside a blood vessel or the heart in living individuals.</p> Signup and view all the answers

    What are the three main factors involved in the pathogenesis of thrombosis?

    <p>The three factors involved in the pathogenesis of thrombosis include endothelial injury, alterations in normal blood flow, and hypercoagulability.</p> Signup and view all the answers

    What are the main types of hypercoagulable states?

    <p>Hypercoagulable states can be classified into primary (genetic) and secondary (acquired) states.</p> Signup and view all the answers

    Which of the following are considered high risk factors for thrombosis?

    <p>All of the above</p> Signup and view all the answers

    Thrombi can develop anywhere in the cardiovascular system.

    <p>True</p> Signup and view all the answers

    Lines of Zahn are characteristic of all thrombi.

    <p>False</p> Signup and view all the answers

    What are lines of Zahn?

    <p>Lines of Zahn are alternating pale platelet and fibrin deposits with darker red cell-rich layers that are often apparent in thrombi, particularly those formed in flowing blood.</p> Signup and view all the answers

    How are thrombi classified?

    <p>All of the above</p> Signup and view all the answers

    What is an embolus?

    <p>An embolus is a foreign material that travels through the bloodstream, often dislodging from a thrombus.</p> Signup and view all the answers

    Define anterograde (direct) embolism.

    <p>Anterograde embolism is the most frequent form of embolism where emboli move in the direction of blood flow.</p> Signup and view all the answers

    What is paradoxical embolism?

    <p>Paradoxical embolism is a rare condition where emboli from the venous system reach the systemic arterial circulation.</p> Signup and view all the answers

    What is retrograde embolism?

    <p>Retrograde embolism is a less common form of embolism where emboli move in the opposite direction of blood flow.</p> Signup and view all the answers

    Thromboembolism is the most common form of embolism.

    <p>True</p> Signup and view all the answers

    What are the sources of arterial thromboembolism?

    <p>Both A and B</p> Signup and view all the answers

    What is venous thromboembolism?

    <p>Venous thromboembolism is a condition where a thrombus travels from the venous system into the pulmonary arterial circulation, commonly originating from deep vein thrombosis.</p> Signup and view all the answers

    What are the effects of pulmonary thromboembolism?

    <p>The effects of pulmonary thromboembolism depend on the size of the embolus, ranging from sudden death in cases of large emboli to mild symptoms or even no symptoms at all in cases of small emboli.</p> Signup and view all the answers

    What is amniotic fluid embolism?

    <p>Amniotic fluid embolism is a rare but serious condition that occurs when amniotic fluid or fetal tissue enters the maternal circulation, typically during childbirth.</p> Signup and view all the answers

    What is cholesterol embolism?

    <p>Cholesterol embolism is a condition where cholesterol crystals break off from atherosclerotic plaques and travel through the bloodstream, often lodging in small blood vessels.</p> Signup and view all the answers

    Define infarction.

    <p>Infarction is an area of ischemic necrosis, where tissue death occurs due to a lack of blood flow.</p> Signup and view all the answers

    What are the main causes of infarction?

    <p>All of the above</p> Signup and view all the answers

    What is the difference between white infarcts and red infarcts?

    <p>White infarcts are typically seen in organs with terminal arterial circulation, while red infarcts are more common in organs with a dual blood supply or in areas of congested venous drainage.</p> Signup and view all the answers

    What are the macroscopic features of a recent white infarct?

    <p>A recent white infarct is wedge-shaped, well-defined, pale in color, and has a red frame at the periphery.</p> Signup and view all the answers

    What is the microscopic appearance of an old white infarct?

    <p>An old white infarct is replaced by fibrosis, forming a white, contracted scar.</p> Signup and view all the answers

    Hemorrhagic infarcts are more common in the brain.

    <p>True</p> Signup and view all the answers

    A brain infarct is usually associated with a hemorrhagic appearance.

    <p>False</p> Signup and view all the answers

    What is disseminated intravascular coagulation (DIC)?

    <p>Disseminated intravascular coagulation (DIC) is a serious, life-threatening condition that involves widespread activation of the coagulation cascade, leading to both thrombosis and bleeding.</p> Signup and view all the answers

    What are the major consequences of DIC?

    <p>The major consequences of DIC include microthrombosis, microangiopathic hemolytic anemia, and microhemorrhages.</p> Signup and view all the answers

    Define shock.

    <p>Shock is a life-threatening condition that involves profound hemodynamic and metabolic disturbances that lead to inadequate perfusion of vital organs, causing severe hypoxia and cell injury.</p> Signup and view all the answers

    What are the main types of shock?

    <p>All of the above</p> Signup and view all the answers

    What are the key features of shock on a microscopic level?

    <p>Microscopic findings in shock include microthrombosis, microhemorrhages, and micronecroses, reflecting widespread tissue damage and hypoxia.</p> Signup and view all the answers

    What is the difference between an exudate and a transudate?

    <p>Exudates are inflammatory fluids with higher protein content and specific gravity compared to transudates, which are noninflammatory and have a lower protein concentration.</p> Signup and view all the answers

    Where can generalized edema occur?

    <p>Generalized edema can occur in various body areas, including visceral organs, body cavities, and subcutaneous tissues.</p> Signup and view all the answers

    What is pulmonary edema?

    <p>Pulmonary edema is an accumulation of fluid in the lung tissue, often causing shortness of breath, coughing, and difficulty breathing.</p> Signup and view all the answers

    What is the etiology of pulmonary edema?

    <p>Pulmonary edema can be caused by a variety of factors, including left-sided heart failure, volume overload, obstruction to pulmonary veins, decreased oncotic pressure, microvascular injury, and lymphatic obstruction.</p> Signup and view all the answers

    What are the clinical features of pulmonary edema?

    <p>Clinical features of pulmonary edema include anxiety, dyspnea at rest, orthopnea, paroxysmal nocturnal dyspnea, and cough productive of pink, frothy sputum.</p> Signup and view all the answers

    What is cerebral edema?

    <p>Cerebral edema is a condition where there is an excess accumulation of fluid within either the cells or extracellular spaces of the brain, causing swelling and increased intracranial pressure.</p> Signup and view all the answers

    What is the main consequence of cerebral edema?

    <p>The main consequence of cerebral edema is increased intracranial pressure, which can lead to herniation of the brain tissue and potentially to death.</p> Signup and view all the answers

    What is lymphedema?

    <p>Lymphedema is a condition where fluid accumulates in the tissues due to a compromised lymphatic system, leading to swelling, often in the extremities.</p> Signup and view all the answers

    What are the main types of lymphedema?

    <p>Both A and B</p> Signup and view all the answers

    What is the pathogenesis of secondary lymphedema?

    <p>Secondary lymphedema occurs due to blockage or obstruction of the lymphatic channels or regional lymph nodes, often caused by tumors, surgery, radiation, or fibrosis.</p> Signup and view all the answers

    What is filariasis?

    <p>Filariasis is a parasitic infection caused by nematode worms that block lymphatic channels, leading to lymphedema, especially in the legs and external genitalia.</p> Signup and view all the answers

    What is primary lymphedema?

    <p>Primary lymphedema is a rare congenital condition caused by a defect in the lymphatic system, leading to swelling that typically begins in childhood, and can progressively worsen over time.</p> Signup and view all the answers

    What are the complications of lymphedema?

    <p>Complications of lymphedema include disability, superimposed infection, chronic ulcerations, and postinflammatory thrombosis and scarring.</p> Signup and view all the answers

    Study Notes

    FLUID AND HEMODYNAMIC DISORDERS

    • Learning objectives for a theoretical exam on fluid and hemodynamic disorders are outlined, covering topics like hyperemia, congestion, ischemia, hemorrhage, thrombosis, embolism, infarction, edema, and blood flow disorders.
    • Hyperemia is defined and categorized, with forms like active (arterial) and passive (venous) hyperemia.
    • Passive hyperemia encompasses congestion in various organs like lungs and liver. 
    • Ischemia and hemorrhage include causes, classifications, and consequences. 
    • Thrombosis and embolism, as well as their clinicopathological correlations, are detailed.
    • Infarction, disseminated intravascular coagulation, shock, edema, and lymphedema are discussed.
    • Blood flow disorders, including hyperemia and passive congestion, are categorized and described
    • Active hyperemia definition and description: mechanisms and effects are covered.
    • Passive (venous) hyperemia definition and description: mechanisms and effects are covered.
    • Various types of passive congestion are classified and described.
    • Local and regional passive congestion are separately addressed
    • The causes, effects, and consequences of portal hypertension are detailed along with relevant examples.
    • Pulmonary stasis is a detailed topic in terms of pathogenesis, causes, and microscopy.
    • Liver passive congestion (passive hepatic congestion) is explained in terms of etiology, pathology, and microscopy.
    • Ischemia is defined and categorized based on its causes (arterial obstruction, capillary obstruction, venous obstruction) and associated factors influencing tissue resistance during hypoxia
    • Hemorrhage is defined, categorized, and described in terms of origin and type (arterial, venous, capillary)
    • The topographic classifications for external and internal hemorrhage are identified.
    • Types of external hemorrhage, sites, and examples are covered.
    • Internal hemorrhage: Definition, types, and sites, with details on petechiae, purpura, ecchymosis, and hematoma
    • Thrombosis, including its definition, classification, pathogenesis, and morphology including lines of Zahn
    • The clinical and microscopic manifestations of arterial, venous, and capillary thrombosis are differentiated. 
    • The process of organized thrombus formations and associated characteristics are highlighted (including thrombi formation).
    • Different types of embolism are classified and described in terms of their nature and direction of travel through the circulatory system (anterograde, retrograde, paradoxical) and discussed.
    • Infarction is defined and classified in its different morphological forms (white and red). Related pathologies and implications are explored.

    PULMONARY PASSIVE CONGESTION (PULMONARY STASIS)

    • Pulmonary stasis pathogenesis, etiology, pathology, and microscopy detailed
    • Causes and effects of both acute and chronic passive pulmonary congestion are explored.
    • The different anatomical and pathological features of both acute and chronic passive lung congestion are elaborated.

    LIVER PASSIVE CONGESTION (PASSIVE HEPATIC CONGESTION)

    • Etiology, pathology, and microscopy of liver passive congestion are described.
    • Specific types or features of hepatic congestion such as "nutmeg" liver and its associated microscopic findings are detailed.
    • The impact of liver congestion on relevant physiological functions is highlighted.

    ISCHEMIA

    • Ischemia definitions, etiologies (arterial, capillary, venous), associated factors (e.g., resistance to hypoxia), and clinical implications are comprehensively outlined.

    HEMORRHAGE

    • Hemorrhage is defined and various kinds are detailed.
    • Different classifications of hemorrhage based on source (locations within the circulatory system) are explained.
    • Pathogenesis and different mechanisms of hemorrhage (rupture of vessels, erosion of vessel walls, and diapedesis) are elaborated

    INFARCTION

    •  Definition, etiologies, and types of infarction are described.
    •  Pathological findings (microscopic and macroscopic) of different forms of infarction (e.g., white and red) are elaborated.

    THROMBOSIS

    • Thrombosis definition and basic types are described.
    •  A detailed breakdown of the steps in thrombogenesis, focusing on endothelial injury, alterations in normal blood flow, and hypercoagulability.
    •  Different types of thrombi are classified and described in terms of their location (e.g., cardiac, arterial, venous) and associated morphological features.
    •  The process of thrombolysis and the factors affecting thrombus organization, propagation, embolisation, and dissolution are highlighted.

    EMBLISM

    • Embolism definition, classification, and etiologies (e.g., thromboembolism, fat embolism, gas embolism, amniotic fluid embolism, bone marrow embolism, tumor embolism, septic embolism, foreign body embolism, and parasitic embolism) which are detailed.
    •  Pathogenesis, incidence, and clinical implications are comprehensively outlined.

    INFARCTION

    •  Infarction's definition, types (white and red), and etiologies including the location in the affected organ, are highlighted.
    •  The clinical implications, such as symptoms and potential complications, are touched upon.
    •  Pathological criteria, microscopic features, and macroscopic morphology are mentioned.

    DISSEMINATED INTRAVASCULAR COAGULATION (DIC)

    •  The definition of DIC, its pathogenesis (activation of the coagulation cascade), and associated factors that trigger it are explained.
    •  Different clinical and pathological effects of DIC (e.g., excessive coagulation, micro-thrombosis, bleeding) are described.
    •  The microscopic findings related to DIC are briefly explained.
    •  The different conditions and situations that predispose to DIC are highlighted

    SHOCK

    •  The definition of shock, its types, and its common causes are listed.
    •  Pathogenesis (circulatory system failing to maintain sufficient organ perfusion, resulting in hypoxia and cellular damage) and consequent effects (e.g., hypoxia, cellular damage, metabolic disturbances) are explained.

    EDEMA

    •  Definition of edema, different types, classifications (inflammatory and non-inflammatory) and underlying causes (increased hydrostatic or decreased oncotic pressure, lymphatic obstruction, inflammation, renal failure, and various other causes) are given.
    •  The underlying pathophysiological mechanisms driving different kinds of edema are outlined.
    •  Differences in exudative versus transudative edema are distinguished at the molecular and structural level.

    LYMPHEDEMA

    • Lymph flow disorders (lymphedema) are delineated, with classifications and etiologies covered, along with the various causal factors.
    • Detailed descriptions of primary (congenital) and secondary (acquired) lymphedema are provided, including the microscopic and macroscopic indicators and characteristics of both.
    •  The pathogenesis and effects of various causes of lymphedema, such as infections, surgeries, and malignancies, are described and explored.

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    Description

    This quiz covers the essential concepts of fluid and hemodynamic disorders, including hyperemia, congestion, ischemia, and thrombosis. It delves into definitions, classifications, and clinical implications of each condition. Prepare to test your understanding of these critical topics in pathology and hemodynamics.

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