Fluid and Electrolyte Imbalances

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Questions and Answers

What characterizes diabetes mellitus?

  • Increased plasma colloid osmotic pressure
  • Excessive excretion of dilute urine
  • Deficiency of antidiuretic hormone
  • High blood sugar levels (correct)

Which component plays a key role in maintaining plasma oncotic pressure?

  • Potassium
  • Albumin (correct)
  • Sodium
  • Chloride

Which substance is defined as a nonelectrolyte?

  • Glucose (correct)
  • Sodium chloride (NaCl)
  • Potassium chloride (KCl)
  • Calcium carbonate (CaCO3)

What is the primary function of buffers in the body?

<p>To resist changes in pH (C)</p> Signup and view all the answers

Which buffer system acts the fastest in the human body?

<p>Bicarbonate buffer system (C)</p> Signup and view all the answers

What does rebreathing CO2 accomplish in terms of acid-base balance?

<p>Increases carbonic acid levels (D)</p> Signup and view all the answers

Which condition can lead to metabolic acidosis?

<p>Renal failure (D)</p> Signup and view all the answers

Which ions are classified as major intracellular cations?

<p>Potassium and magnesium (A)</p> Signup and view all the answers

Which condition is a direct cause of metabolic alkalosis?

<p>Vomiting (C)</p> Signup and view all the answers

What is the primary affect of diuretic use on acid-base balance?

<p>Causes metabolic alkalosis (C)</p> Signup and view all the answers

In which type of acidosis is airway obstruction primarily involved?

<p>Respiratory acidosis (A)</p> Signup and view all the answers

What indicates that the body is unable to correct an acid-base imbalance?

<p>No compensation (B)</p> Signup and view all the answers

Which system compensates for metabolic imbalances by altering bicarbonate levels?

<p>Renal system (B)</p> Signup and view all the answers

How does the body respond if the respiratory rate is the cause of an imbalance?

<p>pH and pCO2 will move in opposite directions (C)</p> Signup and view all the answers

What happens to potassium levels during severe acidosis initially?

<p>They may decrease due to transcellular shifts (D)</p> Signup and view all the answers

Which of the following conditions is NOT a direct cause of glomerular disease?

<p>COPD (C)</p> Signup and view all the answers

Flashcards

Diabetes Insipidus

Excessive dilute urine due to lack of antidiuretic hormone (ADH).

Diabetes Mellitus

High blood sugar due to insulin deficiency or insensitivity.

Electrolyte

Substance that dissociates into ions in solution, conducting electricity.

Acid-Base Balance

Maintaining proper pH level in the blood.

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Bicarbonate Buffer System

Fastest acting buffer system, controlling pH balance in the blood.

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Carbon Dioxide Transport

Primarily transported in the blood as bicarbonate ions.

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Metabolic Acidosis

Blood pH falls below normal due to metabolic problems, not respiration

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Respiratory Alkalosis Prevention

Rebreathing CO2, increases CO2, decreasing blood pH, prevents respiratory alkalosis.

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Metabolic Alkalosis Causes

Vomiting, excessive antacid intake, and diuretic use are common causes.

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Respiratory Acidosis Causes

Conditions like COPD, respiratory depression, and airway obstruction can cause respiratory acidosis.

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Respiratory Alkalosis Causes

Hyperventilation, anxiety, and high altitude exposure are potential causes.

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Diabetic Ketoacidosis (DKA)

A serious diabetic complication caused by insufficient insulin leading to high ketone levels.

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Compensation (Acid-Base)

The body's response to maintain acid-base balance through respiratory or renal function adjustments.

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Compensation Types

No compensation (no correction), partial compensation (incomplete correction), and complete compensation (full correction).

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Respiratory Compensation

The respiratory system adjusts breathing to compensate for metabolic imbalances.

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Renal Compensation

The kidneys regulate bicarbonate to compensate for respiratory imbalances.

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Study Notes

Fluid and Electrolyte Imbalances

  • Diabetes Insipidus: Excessive dilute urine excretion due to ADH deficiency.
  • Diabetes Mellitus: High blood sugar due to insulin deficiency/insensitivity.
  • Hypovolemia: Lower blood plasma volume.
  • Dehydration: Lower total body water.
  • Edema: Swelling caused by increased capillary permeability, decreased plasma oncotic pressure, lymphatic obstruction, or sodium retention.
  • Albumin: Maintains plasma oncotic pressure.
  • Sodium: Influences water movement across cell membranes.
  • Total Body Water: Affected by age, body composition, gender, and health.
  • Electrolytes: Substances dissociating into ions, conducting electricity.
  • Nonelectrolytes: Substances not dissociating, non-conducting.
  • Intracellular Cations: Potassium and magnesium.
  • Extracellular Cations: Sodium and calcium.
  • Intracellular Anions: Phosphate and proteins.
  • Extracellular Anions: Chloride and bicarbonate.

Acid-Base Balance

  • Acids: Donate hydrogen ions (H+).
  • Bases: Accept hydrogen ions.
  • pH Scale: Measures acidity/alkalinity (0-14).
  • Buffers: Resist pH changes by absorbing/releasing H+.
  • Buffer Systems: Bicarbonate, phosphate, and protein. (Bicarbonate is fastest, protein is slowest.)
  • Carbon Dioxide Equilibrium: CO2 + H2O ⇌ H2CO3 ⇌ H+ + HCO3- (Carbonic anhydrase is the enzyme).
  • Carbon Dioxide Transport: Primarily as bicarbonate ions.
  • Oxygen Transport: Primarily bound to hemoglobin.
  • CO2 in Acid-Base Homeostasis: Equivalent to an acid.
  • CO2 Rebreathing: Prevents respiratory alkalosis by increasing CO2.
  • Metabolic Acidosis Causes: Diabetic ketoacidosis, lactic acidosis, renal failure.
  • Metabolic Alkalosis Causes: Vomiting, excessive antacids, diuretics.
  • Respiratory Acidosis Causes: COPD, respiratory depression, airway obstruction.
  • Respiratory Alkalosis Causes: Hyperventilation, anxiety, high altitude.
  • Diabetic Ketoacidosis (DKA): Serious diabetes complication, high ketones due to insulin deficiency; leads to dehydration, electrolyte imbalances.
  • Potassium in Acidosis: May initially decrease, but can rapidly increase with treatment.

Acid-Base Compensation

  • Compensation: Body's response to maintain balance (respiratory or renal).
  • Compensation Types:
    • No Compensation: Body cannot correct imbalance.
    • Partial Compensation: Incomplete response
    • Complete Compensation: Restoring normal pH.
  • Respiratory System Compensation: Adjusting breathing to change CO2 levels.
  • Renal System Compensation: Regulating bicarbonate excretion/retention.
  • Complete Compensation: Successful pH restoration, may still have imbalance.
  • Kidney's Role: More likely for complete compensation, longer adjustment of bicarbonate.
  • Determining the Cause: Analyze pH, pCO2, and HCO3- changes for direction of imbalance.
  • Respiratory vs. Compensatory Directions: Opposite direction for respiratory cause, same direction for compensation.

Kidney Dysfunction

  • Glomerular Disease/Damage Causes: Diabetes, hypertension, autoimmune disorders, infections.

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