FLT3 Oncogene Signaling in Leukemia

TP53

FLT3 (correct)

BCR-ABL

KRAS

Mutations in the FLT3 gene (correct)

Mutations in the TP53 gene

Translocation t(9;22)

Mutations in the NRAS gene

It is the site of the kinase insert in the cytoplasmic tyrosine kinase domain.

It is the site of most tyrosine kinase domain mutations in FLT3. (correct)

It is the site of the ligand-binding extracellular domain in the FLT3 receptor.

It is the site of the transmembrane domain in the FLT3 receptor.

<p>FLT3 signaling plays a role in cell survival, proliferation, and differentiation.</p> Signup and view all the answers

<p>It has a ligand-binding extracellular domain with 5 immunoglobulin-like folds, a transmembrane domain, and a cytoplasmic tyrosine kinase domain.</p> Signup and view all the answers