FLT3 Oncogene Signaling in Leukemia

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Questions and Answers

What is the name of the proto-oncogene that encodes a cytokine receptor on hematopoietic progenitor cells?

TP53
FLT3 (correct)
BCR-ABL
KRAS

Which of the following is the most frequent genetic abnormality in acute myeloid leukemia (AML)?

Mutations in the FLT3 gene (correct)
Mutations in the TP53 gene
Translocation t(9;22)
Mutations in the NRAS gene

What is the significance of the aspartate 835 residue in the FLT3 kinase domain?

It is the site of the kinase insert in the cytoplasmic tyrosine kinase domain.
It is the site of most tyrosine kinase domain mutations in FLT3. (correct)
It is the site of the ligand-binding extracellular domain in the FLT3 receptor.
It is the site of the transmembrane domain in the FLT3 receptor.

What is the role of FLT3 signaling in hematopoietic progenitor cells?

<p>FLT3 signaling plays a role in cell survival, proliferation, and differentiation. (C)</p> Signup and view all the answers

What is the structure of the FLT3 receptor?

<p>It has a ligand-binding extracellular domain with 5 immunoglobulin-like folds, a transmembrane domain, and a cytoplasmic tyrosine kinase domain. (A)</p> Signup and view all the answers

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