FLT3 Oncogene Signaling in Leukemia
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Questions and Answers

What is the name of the proto-oncogene that encodes a cytokine receptor on hematopoietic progenitor cells?

  • TP53
  • FLT3 (correct)
  • BCR-ABL
  • KRAS

    • Which of the following is the most frequent genetic abnormality in acute myeloid leukemia (AML)?

  • Mutations in the FLT3 gene (correct)
  • Mutations in the TP53 gene
  • Translocation t(9;22)
  • Mutations in the NRAS gene

    • What is the significance of the aspartate 835 residue in the FLT3 kinase domain?

  • It is the site of the kinase insert in the cytoplasmic tyrosine kinase domain.
  • It is the site of most tyrosine kinase domain mutations in FLT3. (correct)
  • It is the site of the ligand-binding extracellular domain in the FLT3 receptor.
  • It is the site of the transmembrane domain in the FLT3 receptor.

    • What is the role of FLT3 signaling in hematopoietic progenitor cells?

    <p>FLT3 signaling plays a role in cell survival, proliferation, and differentiation.</p> Signup and view all the answers

    What is the structure of the FLT3 receptor?

    <p>It has a ligand-binding extracellular domain with 5 immunoglobulin-like folds, a transmembrane domain, and a cytoplasmic tyrosine kinase domain.</p> Signup and view all the answers

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