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Questions and Answers
What is Flecainide primarily used to treat?
What is Flecainide primarily used to treat?
- Hypertension
- Ventricular arrhythmia (correct)
- Heart failure
- Atrial fibrillation
In patients with hepatic disease, what may be necessary when prescribing Flecainide?
In patients with hepatic disease, what may be necessary when prescribing Flecainide?
- Monitor liver enzymes only
- Dose reduction (correct)
- Increase the dose
- Continue with the standard dose
Which of the following conditions may indicate a need for dose adjustment of Flecainide?
Which of the following conditions may indicate a need for dose adjustment of Flecainide?
- Normal liver function
- CrCl impairment (correct)
- Increasing exercise tolerance
- Stable renal function
Which of the following is NOT a characteristic of Flecainide?
Which of the following is NOT a characteristic of Flecainide?
What type of drug is Flecainide classified as?
What type of drug is Flecainide classified as?
What potential condition could require a dose reduction of Flecainide?
What potential condition could require a dose reduction of Flecainide?
For which arrhythmia is Flecainide indicated?
For which arrhythmia is Flecainide indicated?
What type of dysrhythmias can Flecainide also treat besides ventricular arrhythmias?
What type of dysrhythmias can Flecainide also treat besides ventricular arrhythmias?
Which of the following medications might be impacted by hepatic function when dosing Flecainide?
Which of the following medications might be impacted by hepatic function when dosing Flecainide?
What is a primary concern when prescribing Flecainide in patients with hepatic issues?
What is a primary concern when prescribing Flecainide in patients with hepatic issues?
What effect do Class IC antiarrhythmic drugs primarily have on the conduction speed of electrical impulses in the heart?
What effect do Class IC antiarrhythmic drugs primarily have on the conduction speed of electrical impulses in the heart?
Which characteristic helps differentiate between propafenone and flecainide with regards to their half-life?
Which characteristic helps differentiate between propafenone and flecainide with regards to their half-life?
What is the primary factor influencing the bioavailability of propafenone?
What is the primary factor influencing the bioavailability of propafenone?
What is a common feature of both flecainide and propafenone regarding their oral absorption?
What is a common feature of both flecainide and propafenone regarding their oral absorption?
What effect do Class IC antiarrhythmic drugs have on the effective refractory period?
What effect do Class IC antiarrhythmic drugs have on the effective refractory period?
What is a key characteristic of Class IC antiarrhythmic drugs like flecainide and propafenone?
What is a key characteristic of Class IC antiarrhythmic drugs like flecainide and propafenone?
Which statement correctly describes the metabolism of propafenone?
Which statement correctly describes the metabolism of propafenone?
What is the impact of propafenone's racemic mixture on its activity?
What is the impact of propafenone's racemic mixture on its activity?
How does the plasma half-life of flecainide compare to propafenone?
How does the plasma half-life of flecainide compare to propafenone?
What effect do Class IC antiarrhythmic drugs have on the effective refractory period?
What effect do Class IC antiarrhythmic drugs have on the effective refractory period?
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Study Notes
Flecainide
- Flecainide is available as a generic oral medication
- Treats ventricular arrhythmia and life-threatening supraventricular dysrhythmias
- May require dose reduction in patients with hepatic disease
- Dose reduction may be necessary for patients with a reduced creatinine clearance
Flecainide
- Generic: Flecainide
- Route of administration: PO (Oral)
- Indications:
- Ventricular arrhythmia, Life-threatening
- Supraventricular dysrhythmias
- Drug interactions:
- Hepatic: May require dose reduction in patients with hepatic disease
- Renal: Dose reduction required in patients with reduced creatinine clearance (CrCl)
Class 1C Antiarrhythmic Drugs
- Block sodium channels in the heart, slowing electrical impulse conduction
- Exhibit selectivity for cells with a high conductance rate
- Prolong the effective refractory period
- Have beta-adrenergic blocking activity
- Both drugs are well absorbed orally
- Propafenone has low bioavailability due to first-pass metabolism
- Flecainide has a longer plasma half-life (14-20 hours) compared to propafenone (2-10 hours)
- Propafenone is a racemic mixture with both enantiomers exhibiting similar antiarrhythmic activity
- Both drugs undergo extensive metabolism, resulting in decreased activity
Class IC Antiarrhythmic Drugs
- Class IC antiarrhythmic drugs block sodium channels in the heart, slowing the conduction of electrical impulses.
- These drugs have a higher affinity for cells with a rapid rate of conduction.
- Class IC antiarrhythmics prolong the effective refractory period of the heart.
- They can also exhibit beta-adrenergic blocking activity.
- Both flecainide and propafenone are well absorbed orally.
- Propafenone has a lower bioavailability due to extensive first-pass metabolism.
- Flecainide has a significantly longer plasma half-life than propafenone (14-20 hours vs. 2-10 hours).
- Propafenone is a racemic mixture, meaning it contains equal amounts of two enantiomers, both of which have similar antiarrhythmic activity.
- Extensive metabolism of both drugs decreases their activity.
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