Chapter 11 - Straight From Textbook

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Questions and Answers

What is the definition for a disease of diffuse airway inflammation caused by a variety of triggering stimuli, resulting in partially or completely reversible bronchoconstriction?

Asthma.

What are the 4 primary symptoms and signs of asthma?

  1. Dyspnea.
  2. Chest tightness.
  3. Cough.
  4. Wheezing.

How fast do most severe exacerbations of asthma that are treated in the emergency department resolve?

Within 2 hours after presentation.

Although the onset and duration of symptoms and the worsening of airflow obstruction before presentation are variable, how fats do these problems usually occur?

<p>Over several hours.</p> Signup and view all the answers

How often does a patient have rapid, catastrophic onset of acute asthma, which can be fatal?

<p>Rarely.</p> Signup and view all the answers

11 signs of a fatal asthma attack:

<ol> <li>Altered level of consciousness</li> <li>Cyanosis</li> <li>Diaphoresis</li> <li>Difficulty speaking because of dyspnea or fatigue</li> <li>Quiet chest in a patient who has dyspnea or reduced level of consciousness</li> <li>Use of accessory muscles of respiration</li> <li>Oxygen saturation &lt;90%</li> <li>Respiratory rate &gt;25-30 breaths/min</li> <li>Inability to lie in the supine position because of breathing distress</li> <li>Heart rate &gt;120 beats/min or increasing</li> <li>Peak expiratory flow (PEF) &lt;30% of predicted or forced expiratory volume (FEV1) in 1 second or &lt;25% of predicted volume 1-2 hours after initial therapy</li> </ol> Signup and view all the answers

3 symptoms of fatal asthma attack

<ol> <li>Sense of progressive breathlessness or air hunger</li> <li>Sense of fear or impending doom</li> <li>Progressive agitation or anxiety</li> </ol> Signup and view all the answers

2 general classes of medications for asthma, and what each is used to treat:

Signup and view all the answers

What are inhaled bronchodilators that are the therapy of choice for relief of acute symptoms and prevention of symptoms called?

<p>Short-acting rescue drugs.</p> Signup and view all the answers

What are short-acting rescue drugs are effective in relieving in the case of an acute asthma exacerbation?

<p>Symptoms and improving lung function.</p> Signup and view all the answers

3 short-acting rescue drugs:

<ol> <li>Short-acting beta-agonists (SABA)</li> <li>Anticholinergics</li> <li>Systemic (oral) corticosteroids</li> </ol> Signup and view all the answers

Why are short-acting beta-agonists considered rescue inhalers?

<p>Because they relieve acute asthma symptoms or exacerbations by quickly opening the airways.</p> Signup and view all the answers

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When does the action of inhaled bronchodilators starts?

<p>Within minutes after inhalation and lasts for 2 to 4 hours.</p> Signup and view all the answers

What are short-acting bronchodilators used before exercise to prevent?

<p>Exercise-induced asthma.</p> Signup and view all the answers

What is the SABA that is administered by a metered-dose inhaler, often with a spacer?

<p>Albuterol.</p> Signup and view all the answers

What type of treatment is preferred for people who have difficulties coordinating MDIs and spacers?

<p>Nebulized treatment.</p> Signup and view all the answers

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What is a nebulizer?

<p>A device that turns liquid medicine into a mist.</p> Signup and view all the answers

When a nebulizer is used, what are the 2 things it could be called?

<p>A breathing treatment A nebulizer treatment</p> Signup and view all the answers

Who should patients be instructed on nebulizer use by?

<p>By their prescriber or pharmacist.</p> Signup and view all the answers

Should ATs be able to assist in the use of a nebulizer?

<p>Yes.</p> Signup and view all the answers

What 2 things should be measured for acute asthma exacerbations, when possible?

<p>Peak expiratory flow (PEF) Symptoms.</p> Signup and view all the answers

For what patients is pharmacological intervention is necessary?

<p>Those who have PEF &lt;80% of personal or predicted best lack of response to SABA treatment, and symptoms such as coughing, breathlessness, wheezing, chest tightness, or use of accessory muscles for breathing.</p> Signup and view all the answers

Recommendations from the NATA Position Statement on Management of Asthma in Athletes indicate that the AT should administer how many up puffs of SABA in 1 hour, and reassessing the patient response to treatment how often?

<p>Three, and every 5 to 10 minutes.</p> Signup and view all the answers

4 steps that are recommended if the episode is severe and response is poor (PEF <60% of personal or predicted best):

<ol> <li>Add prescribed oral corticosteroid drug.</li> <li>Repeat SABA treatment immediately.</li> <li>Add prescribed inhaled anticholinergic medication.</li> <li>Immediately transport the patient to a hospital emergency department.</li> </ol> Signup and view all the answers

May the acute exacerbation be managed in the prehospital athletic training setting when short-acting rescue drugs are effective (symptoms are relieved and PEF returns to >80% of baseline)?

<p>Yes.</p> Signup and view all the answers

What should be done for patients who do not respond or have severe symptoms or a PEF persistently <80% of baseline?

<p>They should be transported to the emergency department.</p> Signup and view all the answers

What do anticholinergic medications do, and how do they do it?

<p>They reduce mucus and open airways by inhibiting muscarinic cholinergic receptors and reducing intrinsic vagal tone of the airway.</p> Signup and view all the answers

What does administration of anticholinergics with SABAs provide?

<p>Improvement in moderate to severe asthma exacerbations.</p> Signup and view all the answers

How long do anticholinergics take to administer compared to SABAs, and why may the replace SABAs in certain situations?

<p>Longer to be effective than SABAs but may be used as an alternative bronchodilator for patients who do not tolerate SABAs.</p> Signup and view all the answers

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What 3 things can anticholinergics be coadministered with for patients who do not respond optimally to albuterol alone

<ol> <li>Nebulized ipratropium (Atrovent)</li> <li>Nebulized albuterol.</li> <li>Soft mist inhaler (SMI)</li> </ol> Signup and view all the answers

What is a soft mist inhaler?

<p>A new generation, propellant-free inhaler that generates a fine, slow-moving cloud (the soft mist) that can be easily inhaled.</p> Signup and view all the answers

How do corticosteroid drugs work?

<p>By reducing inflammation, swelling, and mucus production in the airways of a person with asthma.</p> Signup and view all the answers

What happens as a result of corticosteroid drugs?

<p>The airways are less inflamed and less likely to react to asthma triggers, allowing people with symptoms of asthma to have better control over their condition.</p> Signup and view all the answers

What are systemic corticosteroids, although not short acting, used for?

<p>Moderate and severe exacerbations and as an adjunct to SABAs to speed recovery and prevent recurrence of exacerbations.</p> Signup and view all the answers

What may be prescribed for all but the mildest acute exacerbation?

<p>Oral systemic corticosteroids, such as prednisone.</p> Signup and view all the answers

Who are systemic corticosteroids unnecessary for?

<p>Patients whose PEF normalizes after 1 or 2 bronchodilator doses.</p> Signup and view all the answers

What are higher doses of prednisone (50 to 60 mg once a day) prescribed for?

<p>For the management of more severe exacerbations requiring in-patient care.</p> Signup and view all the answers

What are lower doses (40 mg once a day) of prednisone reserved for?

<p>For outpatient treatment of milder exacerbations.</p> Signup and view all the answers

Although evidence about optimal dose and duration is weak, what systemic corticosteroid treatment duration is recommended?

<p>5 to 7 days, or as adequate by most guidelines and should be tailored to the severity and duration of an exacerbation (see the section Long-Term Strategies for Controlling Asthma).</p> Signup and view all the answers

4 long-term asthma control drugs that help prevent asthma attacks:

<ol> <li>Inhaled corticosteroids (ICS)</li> <li>Long-acting beta-agonists (LABAs)</li> <li>Inhaled mast cell stabilizers</li> <li>Leukotriene modifiers</li> </ol> Signup and view all the answers

What are the most potent and consistently effective anti-inflammatory medications currently available for long-term control of asthma?

<p>Inhaled corticosteroids (ICS).</p> Signup and view all the answers

What do inhaled corticosteroids block?

<p>Late-phase reaction to allergens, reduce airway hyperresponsiveness, and inhibit inflammatory cell migration and activation.</p> Signup and view all the answers

What may account for the efficacy of inhaled corticosteroids as preventive therapy?

<p>The broad action of ICS on the inflammatory process.</p> Signup and view all the answers

How often do inhaled corticosteroids need to be taken for best results?

<p>Daily.</p> Signup and view all the answers

When can some improvement in asthma symptoms be seen after regular inhaled corticosteroid use?

<p>After 3 months of daily use.</p> Signup and view all the answers

7 clinical effects of inhaled corticosteroids:

<ol> <li>Reduction in severity of symptoms</li> <li>Improvement in PEF, asthma control, and quality of life</li> <li>Diminished airway hyperresponsiveness</li> <li>Prevention of exacerbations</li> <li>Reduction in the need for systemic corticosteroid medications</li> <li>Reduced emergency department care, hospitalizations, and deaths due to asthma</li> <li>Possible attenuation of loss of lung function</li> </ol> Signup and view all the answers

What do inhaled corticosteroid anti-inflammatory medications cause?

<p>A reduction in inflammation in airway tissue or airway secretions and thus decrease the intensity of airway hyperresponsiveness.</p> Signup and view all the answers

Why can many drugs may be considered anti-inflammatory?

<p>Because many factors contribute to the inflammatory response</p> Signup and view all the answers

Which anti-inflammatory actions are responsible for corticosteroid drugs’ therapeutic effects in asthma?

<p>Unknown - it is not yet established.</p> Signup and view all the answers

What are inhaled corticosteroids commonly prescribed as?

<p>As a hydrofluoroalkane (HFA) inhaler, also known as an MDI.</p> Signup and view all the answers

What do inhaled corticosteroid dosing guidelines depend on?

<p>On the severity or duration of an asthma exacerbation.</p> Signup and view all the answers

2/4 examples of other common medications include a combination of corticosteroids and a long-acting bronchodilator drug (LABA):

<ol> <li>Fluticasone and salmeterol (Advair)</li> <li>Budesonide and formoterol (Symbicort)</li> </ol> Signup and view all the answers

What are bronchodilators that have a duration of bronchodilation of ≥12 hours after a single dose called?

<p>Long-acting beta-agonists.</p> Signup and view all the answers

Why is frequent and chronic use of LABAs discouraged?

<p>Because this may disguise poorly controlled persistent asthma.</p> Signup and view all the answers

What can overuse of LABAs in treating acute asthma exacerbations result in?

<p>In patient deaths.</p> Signup and view all the answers

What is the name of an inhaled bronchodilator that has duration of bronchodilation of at least 12 hours after a single dose?

<p>Salmeterol (Serevent Diskus).</p> Signup and view all the answers

3 common examples of LABAs: (Acronym: FASt)

<ol> <li>Flovent</li> <li>Advair</li> <li>Serevent.</li> </ol> Signup and view all the answers

In what form are LABA medications available?

<p>As a dry powder that is taken using a small, handheld device called a dry powder inhaler.</p> Signup and view all the answers

How many doses does a DPI Diskus contain?

<p>Up to 60 doses of medication.</p> Signup and view all the answers

What does a DPI diskus contain to count down the number of doses remaining?

<p>A dose indicator.</p> Signup and view all the answers

What is an alternative, but not preferred, medication for the treatment of mild persistent asthma?

<p>Mast cell stabilizers.</p> Signup and view all the answers

What are inhaled mast cell stabilizers also used as other than treatment of mild persistent asthma?

<p>Preventive treatment prior to exercise or unavoidable exposure to known allergens.</p> Signup and view all the answers

What mast cell stabilizer may be used as a nebulized treatment prior to exercise or unavoidable exposure to known allergens?

<p>Cromolyn sodium.</p> Signup and view all the answers

Although experts do not currently recommend cromolyn for routine use for asthma due to its lower efficacy relative to other therapies, what may the drug be considered for?

<p>Exercise-induced bronchospasm.</p> Signup and view all the answers

Although cromolyn can be used for bronchospasm, use of what is needed is preferred instead?

<p>Regular controller therapy with ICS or a combination of SABAs and corticosteroids.</p> Signup and view all the answers

What may leukotriene modifiers be used for?

<p>For the treatment of certain conditions associated with allergic response or asthma.</p> Signup and view all the answers

What 3 substances are leukotrienes released from?

<p>From mast cells, basophils, and eosinophils.</p> Signup and view all the answers

What health condition is leukotriene receptor occupation the pathophysiology of?

<p>Asthma.</p> Signup and view all the answers

What do leukotriene-receptor antagonists, such as montelukast (Singulair), prevent leukotrienes from doing?

<p>From binding to their receptors.</p> Signup and view all the answers

What is the only way that leukotriene modifiers are administered?

<p>Orally as tablets.</p> Signup and view all the answers

What have leukotriene modifiers been shown to decrease and be effective in?

<p>In people with allergic rhinitis.</p> Signup and view all the answers

What makes the use of montelukast less desirable?

<p>Its increased risk of adverse consequences.</p> Signup and view all the answers

The FDA issued a black box warning for which medication in March 2020 to describe possible serious mental health side effects?

<p>Montekluast.</p> Signup and view all the answers

What is it recommended that montelukast be reserved only for?

<p>For treating allergic rhinitis in patients for whom other allergy medicines are ineffective or poorly tolerated.</p> Signup and view all the answers

What 3 elements does determining whether control of asthma is effective include?

Signup and view all the answers

3 steps of determining the effectiveness of asthma medication:

<ol> <li>Assessing the severity of the asthma with lung function measures (e.g., spirometer)</li> <li>Recording vital signs (including pulse oximetry and peak flow meter readings)</li> <li>Performing a physical examination to identify signs and symptoms</li> </ol> Signup and view all the answers

Ideally, what would the AT will that allows him/ her to provide SABA to patients with an asthma exacerbation, and what must it be consistent with?

<p>A standing order that is consistent with her legally authorized scope of practice and local medical directives.</p> Signup and view all the answers

When administering bronchodilator treatment, should the AT should delay patient transport to hospital?

<p>No.</p> Signup and view all the answers

Can bronchodilator treatment be repeated while transporting the patient?

<p>Yes.</p> Signup and view all the answers

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How many times is repeated bronchodilator treatment limited to?

<p>To a maximum of 3 bronchodilator treatments during the first hour and then 1 per hour thereafter.</p> Signup and view all the answers

When can the prescriber use the patient’s data to reassess her medication and carefully titrate it down in a stepwise protocol to the minimum dose necessary for maintaining control?

<p>Once asthma control is achieved and has been sustained ≥3 months.</p> Signup and view all the answers

3 elements of asthma control:

<ol> <li>Preventing exacerbation—In particular, prevention focuses on EIA.</li> <li>Reducing impairment—Includes preventing asthma symptoms, reducing rescue medication use, maintaining lung function, and maintaining normal physical activity levels and attendance at work or school.</li> <li>Reducing risk—Minimizing the need for emergency department visits and hospitalizations and preventing repeated asthma attacks.</li> </ol> Signup and view all the answers

To assess the patient’s need and response to asthma medication, what should be found?

<p>The patient’s personal best peak flow meter assessment.</p> Signup and view all the answers

When should the peak flow assessment device be used?

<p>When asthma is under good control (e.g., the patient feels good and has no symptoms).</p> Signup and view all the answers

To work with the patient in determining her individual personal best peak flow number, instruct her to take peak flow readings at the following four times:

<ol> <li>At least twice a day for 2 to 3 weeks</li> <li>On waking in the morning and in late afternoon or early evening</li> <li>15-20 minutes after taking her short-acting rescue inhaler</li> <li>Other times as directed by her prescriber</li> </ol> Signup and view all the answers

In general, patients with well-controlled asthma should fit the following profile with 7 parts to it:

<ol> <li>Few, if any, asthma symptoms</li> <li>Few, if any, awakenings during the night caused by asthma symptoms</li> <li>No need to take time off from school or work due to asthma</li> <li>Few or no limits on full participation in physical activities</li> <li>No emergency department visits</li> <li>No hospital stays</li> <li>Few or no side effects from asthma medicines</li> </ol> Signup and view all the answers

Recommendations for preventing exacerbation of exercise-induced asthma:

<ol> <li>Encourage physical activity - for most patients, EIA should not limit participation in any activity they choose.</li> <li>Encourage an extended warm-up period - in cold weather, athletes should wear a mask or scarf over the mouth.</li> <li>Teach patients to take treatment before exercise - SABAs will prevent symptoms in most patients.</li> <li>For prophylaxis, use a rapid-acting SABA, such as albuterol, inhaled 10 to 15 minutes before exercise. The AT should be aware that excessive overuse of a SABA can lead to an increased tolerance to the medication, resulting in decreased effectiveness.</li> <li>The frequent need (≥3 times per day) for SABA therapy during practice or an athletic event should cause concern, and a physician should evaluate the patient before return to participation.</li> <li>ATs should understand the use, misuse, and abuse of SABAs. A history of cough, shortness of breath, chest pain or tightness, wheezing, or endurance problems during exercise suggests exercise-induced bronchospasm (EIB).</li> <li>Consider long-term control medication. EIB is often a marker of inadequate asthma control and responds well to regular anti-inflammatory therapy.</li> <li>Long-acting beta-2 agonists should, in general, be used only for asthma prophylaxis and control. They are usually combined with an inhaled corticosteroid.</li> <li>Frequent or chronic use of long-acting beta-agonists to prevent symptoms is discouraged, since it may disguise poorly controlled persistent asthma.</li> </ol> Signup and view all the answers

What is a certified asthma educator?

<p>Typically a licensed HCP (e.g., nurse, respiratory therapist, pharmacist) with an additional certification in asthma education.</p> Signup and view all the answers

What must people who are not HCPs do to become a certified asthma educator?

<p>Having ≥1,000 hours of relevant experience and pass the National Asthma Educator Certification Board Exam.</p> Signup and view all the answers

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Paris

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