Find Out Your Longevity Potential

20-30%

They are looking for genes that allow for long life and collect blood samples and medical histories from centenarians around the world.

Apolipoprotein E, CDKN2B, ABO blood groups, and SH2B3.

<p>Mutations in mtDNA might result from free radical oxidation by the byproducts of metabolism, but this remains to be proved. Mistakes by the mitochondrial DNA polymerase might also be involved.</p> Signup and view all the answers

<p>Mitochondria have an intimate role in many key cell processes and their mitochondrial DNA (mtDNA) has more mutations in older individuals, potentially causing deficiencies in cell respiration that result in signs associated with aging in mice. Mutations in genes involved in energy reactions in mitochondria have been shown to greatly increase the lifespan of the worm C. elegans.</p> Signup and view all the answers

<p>Antioxidants actually reduced life span in mutant worms with beneficial mutations in two genes involved in energy reactions in mitochondria. One possibility is that the oxidizing compounds might signal other pathways to turn on, and those pathways might extend life span in the worms.</p> Signup and view all the answers