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Questions and Answers
Which type of proteins have a long cylindrical shape and low solubility in water?
Which type of proteins have a long cylindrical shape and low solubility in water?
What is a common characteristic of fibrous proteins?
What is a common characteristic of fibrous proteins?
Which of the following is an example of a fibrous protein?
Which of the following is an example of a fibrous protein?
Which organ/tissue has collagen fibers that are arranged at an angle to each other to resist mechanical shear from any direction?
Which organ/tissue has collagen fibers that are arranged at an angle to each other to resist mechanical shear from any direction?
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How many distinct types of collagen are found in the human body?
How many distinct types of collagen are found in the human body?
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What is the main function of collagen in the human body?
What is the main function of collagen in the human body?
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Which type of collagen is a major component of the basal lamina?
Which type of collagen is a major component of the basal lamina?
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What is the repeating banding pattern observed in collagen fibrils?
What is the repeating banding pattern observed in collagen fibrils?
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Which type of collagen is involved in Classical Ehlers Danlos Syndrome?
Which type of collagen is involved in Classical Ehlers Danlos Syndrome?
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Which type of collagen is found in the dermis, bone, tendon, dentin, fascias, sclera, organ capsules, and fibrous cartilage?
Which type of collagen is found in the dermis, bone, tendon, dentin, fascias, sclera, organ capsules, and fibrous cartilage?
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Which type of collagen is involved in the structural maintenance of expansible organs such as smooth muscle, endoneurium, arteries, uterus, liver, spleen, kidney, and lung?
Which type of collagen is involved in the structural maintenance of expansible organs such as smooth muscle, endoneurium, arteries, uterus, liver, spleen, kidney, and lung?
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Which type of collagen is a major component of the basal lamina in epithelial and endothelial tissues?
Which type of collagen is a major component of the basal lamina in epithelial and endothelial tissues?
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Which amino acid is frequently found in the X position of the repeating triplets in collagen?
Which amino acid is frequently found in the X position of the repeating triplets in collagen?
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What is the primary role of glycine in the collagen helix?
What is the primary role of glycine in the collagen helix?
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How many residues are there per turn in the helices of collagen?
How many residues are there per turn in the helices of collagen?
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Which amino acid is responsible for conferring rigidity to the collagen triple helix?
Which amino acid is responsible for conferring rigidity to the collagen triple helix?
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Which amino acid is involved in H-bond formation that helps to stabilize the collagen triple helix?
Which amino acid is involved in H-bond formation that helps to stabilize the collagen triple helix?
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Which amino acid is the site of attachment of carbohydrate moieties in collagen?
Which amino acid is the site of attachment of carbohydrate moieties in collagen?
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Which modification is essential for enhancing the stability and function of collagen chains?
Which modification is essential for enhancing the stability and function of collagen chains?
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What facilitates the assembly of collagen chains into a triple helical structure?
What facilitates the assembly of collagen chains into a triple helical structure?
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Where are the mature collagen molecules secreted into?
Where are the mature collagen molecules secreted into?
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Which of the following is required for the post-translational hydroxylation of proline and lysine in collagen synthesis?
Which of the following is required for the post-translational hydroxylation of proline and lysine in collagen synthesis?
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Which process involves the glycosylation of hydroxylysine residues in collagen synthesis?
Which process involves the glycosylation of hydroxylysine residues in collagen synthesis?
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What is the role of Vitamin C (Ascorbate) in collagen synthesis?
What is the role of Vitamin C (Ascorbate) in collagen synthesis?
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Which direction does the winding of the triple helix occur in collagen formation?
Which direction does the winding of the triple helix occur in collagen formation?
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What initiates the winding of the triple helix in collagen formation?
What initiates the winding of the triple helix in collagen formation?
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What is the order of events in collagen formation?
What is the order of events in collagen formation?
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Which organelle is responsible for the release of completed procollagen from the cell?
Which organelle is responsible for the release of completed procollagen from the cell?
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What is the role of N- and C- procollagen peptidases in collagen formation?
What is the role of N- and C- procollagen peptidases in collagen formation?
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How is completed procollagen released from the cell?
How is completed procollagen released from the cell?
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Which enzyme catalyzes the conversion of lysine residues into its aldehyde derivative allysine in collagen fibrils?
Which enzyme catalyzes the conversion of lysine residues into its aldehyde derivative allysine in collagen fibrils?
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What is the primary role of cross-linking in the fibrillar array of collagen molecules?
What is the primary role of cross-linking in the fibrillar array of collagen molecules?
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What is the function of lysyl oxidase in collagen synthesis?
What is the function of lysyl oxidase in collagen synthesis?
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Which of the following is a consequence of the overlapping individual triple strands in collagen fibril formation?
Which of the following is a consequence of the overlapping individual triple strands in collagen fibril formation?
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What is the key characteristic of the mesoscopic structures formed during collagen fibril formation?
What is the key characteristic of the mesoscopic structures formed during collagen fibril formation?
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What is the significance of the staggered arrangement of collagen triple strands in fibril formation?
What is the significance of the staggered arrangement of collagen triple strands in fibril formation?
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Which enzyme is responsible for the degradation of collagen during tissue remodeling or in response to growth/injury of tissue?
Which enzyme is responsible for the degradation of collagen during tissue remodeling or in response to growth/injury of tissue?
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What happens to collagen during degradation?
What happens to collagen during degradation?
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What is the effect of a mutation that interferes with the ability of collagen to form cross-linked fibrils?
What is the effect of a mutation that interferes with the ability of collagen to form cross-linked fibrils?
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Which of the following is NOT a function of collagen in maintaining homeostasis?
Which of the following is NOT a function of collagen in maintaining homeostasis?
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What is the role of collagen in wound healing?
What is the role of collagen in wound healing?
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How does collagen contribute to vascular health?
How does collagen contribute to vascular health?
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Which type of collagen is primarily affected in Classical Ehlers Danlos Syndrome?
Which type of collagen is primarily affected in Classical Ehlers Danlos Syndrome?
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Which type of collagen is primarily affected in the Vascular type of Ehlers Danlos Syndrome?
Which type of collagen is primarily affected in the Vascular type of Ehlers Danlos Syndrome?
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Which enzyme is responsible for the pathogenesis of the Kyphoscoliotic type of Ehlers Danlos Syndrome?
Which enzyme is responsible for the pathogenesis of the Kyphoscoliotic type of Ehlers Danlos Syndrome?
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Which type of Ehlers Danlos Syndrome is the most common?
Which type of Ehlers Danlos Syndrome is the most common?
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What is the genetic basis for Classical EDS (cEDS)?
What is the genetic basis for Classical EDS (cEDS)?
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Which type of collagen is primarily affected in Vascular EDS (vEDS)?
Which type of collagen is primarily affected in Vascular EDS (vEDS)?
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Which type of Osteogenesis Imperfecta is characterized by fractures secondary to minor trauma in infancy?
Which type of Osteogenesis Imperfecta is characterized by fractures secondary to minor trauma in infancy?
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Which type of Osteogenesis Imperfecta is more severe and results in death in utero or neonatally from pulmonary hypoplasia?
Which type of Osteogenesis Imperfecta is more severe and results in death in utero or neonatally from pulmonary hypoplasia?
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Which type of Osteogenesis Imperfecta is characterized by similar mutations at the Gly position, causing deformities but not lethality?
Which type of Osteogenesis Imperfecta is characterized by similar mutations at the Gly position, causing deformities but not lethality?
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Which of the following is a symptom of scurvy, a condition resulting from vitamin C deficiency?
Which of the following is a symptom of scurvy, a condition resulting from vitamin C deficiency?
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Which protein gives tissues and organs the capacity to stretch without tearing?
Which protein gives tissues and organs the capacity to stretch without tearing?
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Where is elastin found in the body?
Where is elastin found in the body?
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Which statement about collagen is correct?
Which statement about collagen is correct?
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What is the primary function of elastin in the human body?
What is the primary function of elastin in the human body?
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Where is tropoelastin synthesized in the cell?
Where is tropoelastin synthesized in the cell?
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Which protein is responsible for elastogenesis?
Which protein is responsible for elastogenesis?
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What is the molecular weight of elastin?
What is the molecular weight of elastin?
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Which cross-link is unique to elastin?
Which cross-link is unique to elastin?
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Which of the following characteristics is NOT exhibited by mature, extracellular elastin?
Which of the following characteristics is NOT exhibited by mature, extracellular elastin?
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What is the primary function of mature, extracellular elastin?
What is the primary function of mature, extracellular elastin?
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Which of the following is a key characteristic of the conformation of mature, extracellular elastin?
Which of the following is a key characteristic of the conformation of mature, extracellular elastin?
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Which enzyme is responsible for the degradation of elastin in the extracellular space?
Which enzyme is responsible for the degradation of elastin in the extracellular space?
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What is the clinical significance of emphysema in individuals with genetic absence of α1-antitrypsin?
What is the clinical significance of emphysema in individuals with genetic absence of α1-antitrypsin?
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What is the primary symptom of emphysema?
What is the primary symptom of emphysema?
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Which of the following is NOT a characteristic of α-keratins?
Which of the following is NOT a characteristic of α-keratins?
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What is the result of the tandem repetition of a 7-residue segment in α-keratins?
What is the result of the tandem repetition of a 7-residue segment in α-keratins?
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What is the role of the polar edge in α-keratins?
What is the role of the polar edge in α-keratins?
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Which structure is formed when two keratin α chains combine in a coiled coil formation?
Which structure is formed when two keratin α chains combine in a coiled coil formation?
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How many protofilaments combine to form a filament (protofibril)?
How many protofilaments combine to form a filament (protofibril)?
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What is the primary cause of changes in hair wave appearance during permanent waving?
What is the primary cause of changes in hair wave appearance during permanent waving?
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