Fibrous Dysplasia
10 Questions
2 Views
3.6 Stars

Fibrous Dysplasia

Test your knowledge on fibrous dysplasia, a benign medullary fibro-osseous process that affects bones. This quiz covers the different forms of the condition, its causes, diagnosis, and management. Learn about the typical clinical and radiographic features, as well as the potential complications associated with fibrous dysplasia. Test yourself on this topic and gain a better understanding of this condition.


Questions and Answers

What is fibrous dysplasia?

A benign medullary fibro-osseous process that affects any bone

Which form of fibrous dysplasia is more common?

Monostotic form

At what age is the monostotic form of fibrous dysplasia usually asymptomatic?

Early adulthood

What percentage of cases does the polyostotic form of fibrous dysplasia account for?

<p>20-30%</p> Signup and view all the answers

What is the genetic mutation linked to fibrous dysplasia?

<p>Postzygotic activating missense GNAS mutations</p> Signup and view all the answers

How is the diagnosis of fibrous dysplasia mainly based?

<p>Clinical and typical radiographic features</p> Signup and view all the answers

When is histological confirmation indicated in cases of fibrous dysplasia?

<p>In isolated monostotic lesions with clinical symptoms or other concerning features</p> Signup and view all the answers

What is the aim of management for fibrous dysplasia?

<p>To establish the extent of the disease and the maintenance of bone quality via dietary measures and exercise</p> Signup and view all the answers

Is treatment usually required for fibrous dysplasia?

<p>No</p> Signup and view all the answers

What are the complications of fibrous dysplasia?

<p>Pathological fractures and sarcomatous dedifferentiation</p> Signup and view all the answers

Study Notes

  • Fibrous dysplasia is a benign medullary fibro-osseous process that affects any bone.
  • It can occur in a monostotic form involving only one bone or a polyostotic form involving multiple bones.
  • The monostotic form is far more common accounting for 70-80% of cases and is usually asymptomatic until the 2nd to 3rd decade.
  • The polyostotic form accounts for 20-30% and presents earlier, typically in childhood.
  • Fibrous dysplasia is linked to postzygotic activating missense GNAS mutations that encode the alpha subunit of the stimulatory G-protein.
  • The diagnosis of fibrous dysplasia is mainly based on clinical and typical radiographic features.
  • Histological confirmation is indicated in cases with atypical imaging appearance or in isolated monostotic lesions with clinical symptoms or other concerning features.
  • Management aims to establish the extent of the disease and the maintenance of bone quality via dietary measures and exercise.
  • The prognosis is excellent and usually, no other treatment is required.
  • Complications include pathological fractures and sarcomatous dedifferentiation, which is more common in the polyostotic form.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

More Quizzes Like This

Fibrous Dysplasia
16 questions
Fibrous Dysplasia
16 questions
Fibrous Dysplasia
4 questions

Fibrous Dysplasia

LawAbidingNurture avatar
LawAbidingNurture
Use Quizgecko on...
Browser
Browser