Fertilization and Early Embryo Development
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Questions and Answers

What is superfecundation?

  • Fertilization of a single ovum during different menstrual cycles
  • Fertilization of multiple ova by sperms from separate acts of coitus (correct)
  • Fertilization that occurs outside the uterine cavity
  • Fertilization of multiple ova by the same sperm during one act

What characterizes the morula stage?

  • Consists of 8 cells and enters the uterine cavity
  • Consists of 16 to 32 cells and is formed 3 days after fertilization (correct)
  • Is the last stage before implantation occurs
  • Contains a blastocoele filled with fluid

During which stage does the blastocyst begin to form?

  • 4 days after fertilization (correct)
  • At the morula stage
  • Immediately after fertilization
  • 2 days after fertilization

What is the function of the trophoblast in the blastocyst?

<p>To create the placenta that nurtures the embryo (C)</p> Signup and view all the answers

What occurs during the cleavage or segmentation process?

<p>The zygote experiences repeated mitosis, increasing the number of cells (B)</p> Signup and view all the answers

What is the site of fertilization in human reproduction?

<p>Ampulla of uterine tube (A)</p> Signup and view all the answers

What is the purpose of capacitation in sperm?

<p>To remove seminal plasma proteins from the sperm (C)</p> Signup and view all the answers

Which enzyme helps sperm penetrate the corona radiata during fertilization?

<p>Hyaluronidase (D)</p> Signup and view all the answers

What reaction occurs to prevent polyspermy after fertilization?

<p>Zona cortical reaction (C)</p> Signup and view all the answers

What event follows the fusion of oocyte and sperm plasma membranes?

<p>Second meiosis resumes in the oocyte (D)</p> Signup and view all the answers

What type of anomaly involves being pregnant without fertilization?

<p>Parthenogenesis (D)</p> Signup and view all the answers

What determines the sex of the embryo?

<p>The chromosome carried by the sperm (D)</p> Signup and view all the answers

What is the chromosomal configuration of a zygote?

<p>46S chromosomes (C)</p> Signup and view all the answers

Flashcards

Fertilization

The joining of male and female gametes (sperm and egg).

Site of Fertilization

The ampulla of the uterine tube.

Capacitation

The process of sperm activation in the female reproductive tract.

Acrosomal Reaction

Release of enzymes from the sperm's head to penetrate the egg's outer layers.

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Zona Pellucida

The protective layer around the egg.

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Embryo Sex Determination

The process where the presence of X or Y chromosome from the sperm determines the embryo's sex.

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Parthenogenesis

Development of an embryo without fertilization.

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Dispermy

Fertilization of an egg by two sperm.

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Superfecundation

Fertilization of two or more eggs in the same menstrual cycle by sperm from separate acts of intercourse.

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Cleavage (Segmentation)

Repeated cell division of the zygote that increases the number of cells rapidly in the uterine tube.

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Morula Stage

A 16 to 32 cell stage within the zona pellucida, which occurs after fertilization and enters the uterine cavity.

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Blastocyst Stage

A stage of development after the morula, characterized by a fluid-filled cavity (blastocele) and distinct outer cells (trophoblast) forming the fetal part of the placenta

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Inner Cell Mass (Embryoblast)

The cellular mass at one pole of the blastocyst, developing into the embryo.

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Study Notes

Fertilization

  • Definition: The union of male and female gametes
  • Location: Ampulla of the uterine tube
  • Steps:
    • Sperm deposited in the posterior fornix of the vagina (200-600 million)
    • Capacitation: Removal of proteins from sperm's head, making it more active. Happens in the female reproductive tract (5-7 hrs)
    • Acrosomal reaction: Enzymes released from the acrosome of the sperm to penetrate the corona radiata and zona pellucida.
    • Fusion of sperm and egg membranes
    • Zona cortical reaction: Prevents polyspermy (multiple sperm fertilizing an egg)
    • Second oocyte resumes meiosis, forming a female pronucleus
    • Male pronucleus formation (tail lost, nucleus enlarges)
    • Union of pronuclei: Formation of zygote (46 chromosomes)

First Week Results

  • Sex determination: Y chromosome → male; X chromosome → female
  • Health assessment of the embryo
  • Resumption of meiosis II
  • Restoration of normal diploid chromosomes (46)
  • Initiation of zygote cell division

Anomalies

  • Parthenogenesis: Embryo development without fertilization (all offspring female)
  • Dispermy (triploidy): Two sperm fertilize one ovum (zygote with 3 sets of chromosomes)
  • Superfecundation: Two ova are released and fertilized by sperm in the same menstrual cycle

Cleavage (Segmentation)

  • Definition: Repeated mitosis of blastomeres (cells) to increase cell number within the fallopian tube
  • Steps:
    • 2-cell stage, 4-cell stage, 8-cell stage...etc.
    • Morula stage: (16-32) cells; formed 3 days after fertilization; enters uterine cavity
    • Blastocyst/Blastula stage: (4th day)
      • Blastocele: Fluid-filled cavity
      • Trophoblast: Outer layer of cells, forms part of placenta
      • Inner cell mass (embryoblast): Mass of cells that form the embryo

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Description

This quiz covers the complex process of fertilization, including the steps from gamete union to the formation of a zygote. It also addresses key developments during the first week after fertilization, such as sex determination and chromosome restoration. Test your understanding of these fundamental concepts in human reproduction.

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