FDA-Approved Treatments for Postpartum Depression and Bipolar Disorders Part 1

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What is the major difference between Major Depressive Disorder (MDD) and Bipolar 2?

MDD is unipolar, while Bipolar 2 involves hypomania

What is the potential risk of using antidepressants without mood stabilizers for patients with bipolar depression?

Risk of switching from depression to hypomania or mania

Which Over-The-Counter (OTC) product is known for having the most potential drug interactions with CYP3A4 drugs?

St John’s Wort

What is the therapeutic level range for lithium used in bipolar disorder treatment?

<p>0.6-1.2 mEq/L</p> Signup and view all the answers

In a patient with minimal adverse drug reactions (ADRs) at 600 mg/day of lithium and a steady-state level of 0.3 mEq/L, what would be the appropriate recommendation?

<p>Increase the patient’s lithium dose by 150-300 mg per day</p> Signup and view all the answers

Which Over-The-Counter (OTC) pain medications have the potential to increase lithium levels?

<p>NSAIDs like ibuprofen and naproxen</p> Signup and view all the answers

What baseline labs are essential before initiating lithium treatment?

<p><strong>BUN and SCr:</strong> to assess renal function</p> Signup and view all the answers

Which baseline lab test is NOT necessary before initiating lithium treatment?

<p><strong>Urine specific gravity</strong> to assess kidney function</p> Signup and view all the answers

What is the recommended timing for drawing lithium levels post-dose to assess therapeutic levels?

<p>@ 10-12 hours post-dose</p> Signup and view all the answers

If a patient has a steady-state lithium level of 1.5 mEq/L at a dose of 600 mg/day but experiences severe adverse effects, what would be the recommended approach?

<p>Decrease the dose by 150-300 mg/day and monitor levels closely</p> Signup and view all the answers

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