lecture 19 quiz- immunology

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Questions and Answers

What is the primary function of antibodies in the clearance of pathogens?

  • Antibodies prevent viruses from infecting host cells.
  • Antibodies regulate the overall immune response to maintain balance.
  • Antibodies enhance the complement system and facilitate phagocytosis. (correct)
  • Antibodies directly kill extracellular bacteria and fungi.

Where are antibodies typically produced in relation to the site of infection?

  • Antibodies are produced at a distance from the site of infection and travel through the bloodstream. (correct)
  • Antibodies are produced in the bone marrow and travel to the site of infection.
  • Antibodies are produced at the site of infection.
  • Antibodies are produced in the lymph nodes closest to the site of infection.

Which of the following is the primary target of antibodies?

  • Viruses after they have been produced in infected cells
  • Viruses before they infect host cells
  • Intracellular bacteria
  • Extracellular bacteria and fungi (correct)

What is the role of antibodies in vaccine-induced immunity?

<p>Antibodies provide protection against subsequent infection by stimulating the production of antibodies specific to particular antigens. (D)</p> Signup and view all the answers

How can antibodies contribute to tissue damage?

<p>Antibodies can trigger immune responses that inadvertently damage normal tissues, leading to autoimmune diseases or contributing to transplant rejection. (D)</p> Signup and view all the answers

What is the importance of maintaining a balanced immune response involving antibodies?

<p>Excessive antibody production or activity can lead to immune-mediated tissue damage and contribute to the development of immune-related disorders. (C)</p> Signup and view all the answers

What is the role of FcγRs expressed by macrophages and neutrophils?

<p>Promoting opsonization of antibody-coated pathogens (D)</p> Signup and view all the answers

What is the function of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) found in some Fc receptors?

<p>Dampening immune responses by inhibiting cell activation (D)</p> Signup and view all the answers

How does phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in Fc receptors affect cellular responses?

<p>Leads to activation of downstream signaling cascades (A)</p> Signup and view all the answers

Which cellular responses are typically triggered by the activation of Fc receptors?

<p>Phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), or cytokine release (B)</p> Signup and view all the answers

What is the main role of Fc receptors in mediating immune responses?

<p>Balancing immune responses to prevent excessive inflammation or tissue damage (C)</p> Signup and view all the answers

How do Fc receptors contribute to antibody-coated pathogen clearance?

<p>By phagocytosing antibody-coated pathogens through opsonization (D)</p> Signup and view all the answers

What is the primary function of Fc receptors on immune cells?

<p>To bind to the Fc region of antibodies and facilitate immune responses (B)</p> Signup and view all the answers

Which of the following is NOT a characteristic of the diversity of Fc receptors?

<p>Fc receptors can directly induce phagocytosis of antibody-bound targets (A)</p> Signup and view all the answers

How do different antibody isotypes interact with Fc receptors?

<p>Fc gamma receptors primarily recognize IgG antibodies (D)</p> Signup and view all the answers

What is the relationship between leukocyte populations and Fc receptor expression?

<p>Leukocytes express specific Fc receptors that mediate cell type-specific responses (B)</p> Signup and view all the answers

Which of the following is a key consequence of the diversity of Fc receptors?

<p>It allows for nuanced and tailored immune responses to different antibody-antigen complexes (C)</p> Signup and view all the answers

How do Fc receptors contribute to the opsonization of pathogens?

<p>Fc receptors facilitate the recognition and binding of antibody-coated pathogens by phagocytes (B)</p> Signup and view all the answers

What is the primary function of the complement system in the immune response?

<p>To opsonize pathogens and facilitate their recognition and elimination by phagocytic cells (B)</p> Signup and view all the answers

Which complement protein is primarily responsible for the opsonization of pathogens?

<p>C3b (D)</p> Signup and view all the answers

What is the primary consequence of the formation of the membrane attack complex (MAC) during complement activation?

<p>Lysis of the target pathogen's cell membrane (C)</p> Signup and view all the answers

How does the complement system contribute to the amplification of the immune response against pathogens?

<p>By recruiting and activating additional immune cells, stimulating the release of inflammatory mediators, and increasing vascular permeability (C)</p> Signup and view all the answers

What is the primary role of the complement system in the elimination of pathogens?

<p>To facilitate the recognition and ingestion of pathogens by phagocytic cells (B)</p> Signup and view all the answers

How is the activation of the complement system regulated to prevent excessive tissue damage?

<p>By the presence of regulatory proteins that prevent excessive activation (C)</p> Signup and view all the answers

Which of the following statements about the alternative pathway of complement activation is correct?

<p>It can be spontaneously initiated by the hydrolysis of C3. (B)</p> Signup and view all the answers

Which of the following is a consequence of complement activation?

<p>All of the above. (D)</p> Signup and view all the answers

Which pathway of complement activation is initiated by the binding of mannose-binding lectin or ficolins to microbial carbohydrates?

<p>Lectin pathway (B)</p> Signup and view all the answers

What is the central component of the complement cascade that is cleaved and activated, regardless of the pathway?

<p>C3 (A)</p> Signup and view all the answers

Which of the following statements about the classical pathway of complement activation is correct?

<p>It is initiated by the binding of C1 complex to antigen-antibody complexes, primarily IgM or IgG antibodies. (C)</p> Signup and view all the answers

Which of the following statements about the regulation of complement activation is correct?

<p>Regulatory proteins ensure that complement is only activated under appropriate conditions and is properly controlled to maintain immune homeostasis. (D)</p> Signup and view all the answers

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