Podcast
Questions and Answers
Which of the following events initiates the process of increased endothelial permeability in fatty streak formation?
Which of the following events initiates the process of increased endothelial permeability in fatty streak formation?
- Phagocytosis of LDLs
- Systemic inflammation
- Endothelial cell injury (correct)
- Elevated levels of LDLs
What is the role of monocytes in the development of atherosclerosis?
What is the role of monocytes in the development of atherosclerosis?
- They produce fibrous cap over the plaque
- They recruit additional inflammatory cells
- They invade the intima and proliferate
- They differentiate into macrophages and phagocytose LDLs (correct)
Which of the following components is recruited in response to inflammatory signals during plaque growth?
Which of the following components is recruited in response to inflammatory signals during plaque growth?
- all the above (correct)
- Platelets
- T lymphocytes
- Dendritic cells
What is the main function of vascular smooth muscle cells during plaque growth?
What is the main function of vascular smooth muscle cells during plaque growth?
What is the term used to describe the stage of atherosclerosis where the necrotic plaque core is initially covered by a fibrous cap and endothelial cells?
What is the term used to describe the stage of atherosclerosis where the necrotic plaque core is initially covered by a fibrous cap and endothelial cells?
What is the main cause of vascular lumen narrowing in atherosclerosis?
What is the main cause of vascular lumen narrowing in atherosclerosis?
What is the underlying cause of coronary, cerebral, and peripheral vascular disease?
What is the underlying cause of coronary, cerebral, and peripheral vascular disease?
What is the main component of plaques formed in atherosclerosis?
What is the main component of plaques formed in atherosclerosis?
What initiates the recruitment of monocytes to the intima in atherosclerosis?
What initiates the recruitment of monocytes to the intima in atherosclerosis?
What is the term used to describe the process of cholesterol accumulation in the evolving lesion during atherosclerosis?
What is the term used to describe the process of cholesterol accumulation in the evolving lesion during atherosclerosis?
Which of the following factors can contribute to the progression of vessel narrowing?
Which of the following factors can contribute to the progression of vessel narrowing?
What can cause the rapid formation of a large thrombus that completely occludes the artery?
What can cause the rapid formation of a large thrombus that completely occludes the artery?
Which cells favor fortification of the fibrous cap in plaques?
Which cells favor fortification of the fibrous cap in plaques?
What can weaken the fibrous cap of a plaque and predispose it to rupture?
What can weaken the fibrous cap of a plaque and predispose it to rupture?
What can lead to the formation of a vascular aneurysm downstream from a large atherosclerotic plaque?
What can lead to the formation of a vascular aneurysm downstream from a large atherosclerotic plaque?
What is the role of neovascularization in plaque development?
What is the role of neovascularization in plaque development?
What is the consequence of plaque rupture healing with fibrosis?
What is the consequence of plaque rupture healing with fibrosis?
Which cells secrete collagen- and elastin-degrading matrix metalloproteinases (MMP) in response to inflammatory cytokines?
Which cells secrete collagen- and elastin-degrading matrix metalloproteinases (MMP) in response to inflammatory cytokines?
What is the role of matrix metalloproteinases (MMP) in plaque development?
What is the role of matrix metalloproteinases (MMP) in plaque development?
What causes further changes in hemodynamic forces that increase wall tension in the presence of a large atherosclerotic plaque?
What causes further changes in hemodynamic forces that increase wall tension in the presence of a large atherosclerotic plaque?
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