Fatty Acid Synthesis: The Spiral of Fatty Acid Synthesis
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Questions and Answers

What is the primary site of fatty acid synthesis in most animal tissues?

  • Endoplasmic reticulum
  • Golgi apparatus
  • Cytosol (correct)
  • Mitochondrial matrix
  • Which of the following is NOT a cofactor required for acetyl-CoA carboxylation?

  • Mn2+
  • ATP
  • Bioreactor (correct)
  • NADPH
  • What is the product of the committed step in fatty acid synthesis?

  • Malonyl-CoA (correct)
  • Citrate
  • Palmitic acid
  • Acetyl-CoA
  • In which of the following tissues is fatty acid synthesis less prominent?

    <p>Skeletal muscle</p> Signup and view all the answers

    What is the mechanism by which acetyl-CoA units are transported out of the mitochondrial matrix?

    <p>Citrate shuttle</p> Signup and view all the answers

    What is the maximum length of fatty acid chains synthesized through the fatty acid synthesis pathway?

    <p>C16</p> Signup and view all the answers

    What is the role of ATP in the first step of lipogenesis?

    <p>To carboxylate biotin</p> Signup and view all the answers

    What is the effect of high fat diets on the regulation of acetyl-CoA carboxylase?

    <p>Decreased activity</p> Signup and view all the answers

    Which of the following domains of the fatty acid synthase complex is involved in the release of palmitate?

    <p>Domain 3</p> Signup and view all the answers

    What is the role of malonyl-CoA in the regulation of lipogenesis?

    <p>Activator of fatty acid synthase</p> Signup and view all the answers

    What is the effect of insulin on the regulation of lipogenesis?

    <p>Activates lipogenesis</p> Signup and view all the answers

    What is the role of the –SH group of the ACP in the condensation reaction of lipogenesis?

    <p>Accepts the acetyl group from acetyl-CoA</p> Signup and view all the answers

    What is the role of enoyl reductase enzyme in the spiral of fatty acid synthesis?

    <p>To reduce the crotonyl-enzyme to butyryl-enzyme</p> Signup and view all the answers

    What is the outcome of the first turn in the spiral of fatty acid synthesis?

    <p>Formation of a C4-acyl enzyme</p> Signup and view all the answers

    What is the function of the SH group of ACP in the fatty acid synthesis pathway?

    <p>To bind to and displace the saturated acyl residue</p> Signup and view all the answers

    What is the fate of the C16-acyl enzyme formed in the fatty acid synthesis pathway?

    <p>It is not a substrate for the condensing enzyme and is released as free palmitate</p> Signup and view all the answers

    What is the role of the thiol groups of cysteine residues in the fatty acid synthesis pathway?

    <p>To bind to the acetyl-CoA and malonyl-CoA molecules</p> Signup and view all the answers

    How many times is the elongation step repeated in the fatty acid synthesis pathway?

    <p>6 times</p> Signup and view all the answers

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