Fatty Acid Synthesis
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Questions and Answers

What is the role of 3-Ketoacyl-ACP synthase in fatty acid synthesis?

  • To reduce the keto group to an alcohol
  • To synthesize malonyl-CoA
  • To create a double bond between carbons 2 and 3
  • To elongate the fatty acid chain (correct)

Which enzyme is responsible for reducing the keto group to an alcohol in fatty acid synthesis?

  • 3-Ketoacyl-ACP reductase (correct)
  • 3-Hydroxyacyl-ACP dehydratase
  • Enoyl-ACP reductase
  • Acetyl-CoA carboxylase

What is the role of Acyl Carrier Protein (ACP) in fatty acid synthesis?

  • To carry the growing fatty acid chain (correct)
  • To synthesize malonyl-CoA
  • To release the completed fatty acid
  • To reduce NADP+ to NADPH

What is the byproduct of the reaction catalyzed by 3-Hydroxyacyl-ACP dehydratase?

<p>Water (A)</p> Signup and view all the answers

What is the reducing power for fatty acid synthesis?

<p>NADPH (B)</p> Signup and view all the answers

How many cycles of fatty acid synthesis are required to produce a 16-carbon saturated fatty acid?

<p>7 (A)</p> Signup and view all the answers

What is the function of acetyl-CoA carboxylase in the fatty acid synthesis pathway?

<p>To add CO2 to the acetyl group, producing malonyl-CoA (B)</p> Signup and view all the answers

What is the role of the acyl carrier protein (ACP) in fatty acid synthesis?

<p>To temporarily hold the growing fatty acid chain (D)</p> Signup and view all the answers

What is the source of energy for the condensation reaction between the acetyl group and the malonyl group?

<p>From the decarboxylation of malonyl-CoA (D)</p> Signup and view all the answers

What is the product of the condensation reaction between the acetyl group and the malonyl group?

<p>A 4-carbon fatty acid chain (D)</p> Signup and view all the answers

What is the primary function of acetyl-CoA carboxylase in fatty acid biosynthesis?

<p>To synthesize malonyl-CoA from acetyl-CoA (C)</p> Signup and view all the answers

What is the role of NADPH in the fatty acid synthesis pathway?

<p>None of the above (D)</p> Signup and view all the answers

What is the enzyme responsible for transferring the acetyl group from acetyl-CoA to the cysteine residue of ACP?

<p>Acetyl-CoA-ACP acetyltransacylase (D)</p> Signup and view all the answers

How is acetyl-CoA transported from the mitochondria to the cytosol?

<p>By being shuttled as citrate (A)</p> Signup and view all the answers

What is the role of citrate in regulating fatty acid synthesis?

<p>It serves as a high energy signal to enhance fatty acid synthesis (A)</p> Signup and view all the answers

What is the source of NADPH required for fatty acid synthesis?

<p>The conversion of malate to pyruvate (C)</p> Signup and view all the answers

How is acetyl-CoA carboxylase regulated in the short-term?

<p>Through allosteric activation by citrate and inhibition by long-chain fatty acyl-CoA (C)</p> Signup and view all the answers

What is the purpose of malonyl-CoA in fatty acid synthesis?

<p>To participate in the repetitive synthesis of fatty acids (A)</p> Signup and view all the answers

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