10 Questions
What is the average life span of RBCs in the bloodstream?
90-120 days
Where does lysis of RBCs normally occur?
Liver, spleen, and bone marrow
How many RBCs are broken down in the human body approximately every hour?
100-200 million
What happens to Fe2+ after the breakdown of RBCs?
Transported with transferrin for next heme biosynthesis
Which process describes the breakdown of RBCs occurring outside of the bloodstream in the reticuloendothelial system?
Extravascular lysis in the ER
Which other hemoproteins contain heme groups that are degraded by the same pathway as Hb?
Cytochrome c
What is the fate of Fe2+ after being transported with transferrin post-breakdown of RBCs?
Utilized in the synthesis of heme
Where in the human body does the breakdown of RBCs lead to the production of new heme through a specific pathway?
Bone marrow
Apart from Hb, which other type of protein contains heme groups that follow a similar degradation pathway?
Myoglobin
In the human body, approximately how many RBCs are broken down every hour?
100-200 million
Learn about the life span of red blood cells in the blood stream, the process of phagocytosis and lysis, both extravascularly and intravascularly. Explore the breakdown of RBCs, transportation of Fe2+ with transferrin, and its utilization in heme biosynthesis.
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