Fate of RBCs in the Blood Stream
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Questions and Answers

What is the average life span of RBCs in the bloodstream?

  • 120-150 days
  • 60-90 days
  • 90-120 days (correct)
  • 150-180 days

Where does lysis of RBCs normally occur?

  • Heart
  • Lungs
  • Liver, spleen, and bone marrow (correct)
  • Kidneys

How many RBCs are broken down in the human body approximately every hour?

  • 50-100 million
  • 20-50 million
  • 200-300 million
  • 100-200 million (correct)

What happens to Fe2+ after the breakdown of RBCs?

<p>Transported with transferrin for next heme biosynthesis (A)</p> Signup and view all the answers

Which process describes the breakdown of RBCs occurring outside of the bloodstream in the reticuloendothelial system?

<p>Extravascular lysis in the ER (A)</p> Signup and view all the answers

Which other hemoproteins contain heme groups that are degraded by the same pathway as Hb?

<p><em>Cytochrome c</em> (C)</p> Signup and view all the answers

What is the fate of Fe2+ after being transported with transferrin post-breakdown of RBCs?

<p>Utilized in the synthesis of heme (A)</p> Signup and view all the answers

Where in the human body does the breakdown of RBCs lead to the production of new heme through a specific pathway?

<p>Bone marrow (C)</p> Signup and view all the answers

Apart from Hb, which other type of protein contains heme groups that follow a similar degradation pathway?

<p>Myoglobin (D)</p> Signup and view all the answers

In the human body, approximately how many RBCs are broken down every hour?

<p>100-200 million (C)</p> Signup and view all the answers

Flashcards

RBC Lifespan

The average lifespan of red blood cells in the bloodstream is 90 to 120 days.

Where are RBCs broken down?

Red blood cells are primarily broken down in the liver, spleen, and bone marrow.

RBC Breakdown Rate

Approximately 100 to 200 million red blood cells are broken down in the human body every hour.

Iron's Fate After RBC Breakdown

Iron (Fe2+) from broken-down red blood cells is transported with transferrin to be used in the synthesis of new heme.

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Extravascular Lysis

Extravascular lysis refers to the process of red blood cell breakdown occurring outside the bloodstream within the reticuloendothelial system.

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Hemoproteins with Similar Degradation Pathways

Hemoglobin, myoglobin, and cytochrome c are hemoproteins that contain heme groups which are degraded via the same pathway.

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Iron's Role in Heme Synthesis

Following transportation with transferrin, iron (Fe2+) is utilized in the synthesis of heme.

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Heme Synthesis in Bone Marrow

The breakdown of red blood cells in the bone marrow leads to the production of new heme through a specific pathway.

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Myoglobin's Degradation Pathway

Myoglobin, a protein responsible for oxygen storage in muscles, also contains heme groups that follow a similar degradation pathway to hemoglobin.

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RBC Breakdown Rate

Approximately 100 to 200 million red blood cells are broken down in the human body every hour.

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