Fat-Soluble Vitamins: Vitamin A Properties
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Fat-Soluble Vitamins: Vitamin A Properties

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What are the four fat-soluble vitamins, and what are some good dietary sources for each?

The four fat-soluble vitamins are vitamins A, D, E, and K. Good dietary sources of vitamin A include sweet potatoes, carrots, and dark leafy greens. Vitamin D can be found in fatty fish, fortified dairy products, and sunlight exposure. Vitamin E is abundant in nuts and seeds, such as almonds and sunflower seeds. Vitamin K is found in leafy greens, such as spinach and kale.

What are the major functions of vitamin A in the body, and what health problems are associated with its deficiency?

Vitamin A is essential for vision, immune function, and gene transcription. A deficiency in vitamin A can lead to night blindness, impaired immune function, and skin problems.

What is the primary function of vitamin K in the body, and how does it interact with calcium?

Vitamin K is necessary for blood clotting and bone health. It helps to activate proteins that bind to calcium, which is essential for bone mineralization.

What are the consequences of excessive intake of fat-soluble vitamins, and how do they differ from water-soluble vitamins?

<p>Excessive intake of fat-soluble vitamins can lead to toxicity, as they are stored in the body and can accumulate over time. This is in contrast to water-soluble vitamins, which are readily excreted in the urine.</p> Signup and view all the answers

How do the recommended dietary allowances (RDAs) for fat-soluble vitamins vary across different age groups and populations?

<p>The RDAs for fat-soluble vitamins vary based on age, sex, and other factors such as pregnancy and breastfeeding. For example, the RDA for vitamin D is higher for older adults and pregnant women.</p> Signup and view all the answers

What is the function of vitamin A in the production, maturation, and maintenance of epithelial cells?

<p>Vitamin A is necessary for the production, maturation, and maintenance of epithelial cells, which form protective tissues that line the body, including skin and linings of the digestive, respiratory, and reproductive tracts.</p> Signup and view all the answers

What is the consequence of vitamin A deficiency on mucus-secreting epithelial cells?

<p>Vitamin A deficiency causes mucus-secreting epithelial cells to deteriorate and no longer produce mucus.</p> Signup and view all the answers

What is the adult RDA for vitamin A, and what is the unit of measurement?

<p><strong>700–900 mcg RAE</strong></p> Signup and view all the answers

What is the role of vitamin A in the immune system?

<p>Vitamin A plays a role in regulating the activity of the immune system.</p> Signup and view all the answers

What are the major dietary sources of vitamin D?

<p>Vitamin D–fortified milk, fortified cereals, fish liver oils, and fatty fish.</p> Signup and view all the answers

What is the adult Upper Level (UL) for vitamin E?

<p><strong>1000 mg/day</strong></p> Signup and view all the answers

What is the function of vitamin K in the body?

<p>Production of active blood-clotting factors.</p> Signup and view all the answers

What role does vitamin A play in bone growth and development?

<p>Vitamin A participates with other vitamins and minerals in the bone remodeling process.</p> Signup and view all the answers

What is the consequence of vitamin E deficiency on the immune system?

<p>Reduced immune system function.</p> Signup and view all the answers

What is the function of rods in the retina?

<p>Rods enable us to adapt to poorly lit environments and see objects as shades of black.</p> Signup and view all the answers

What are the major signs and symptoms of vitamin D deficiency in children and adults?

<p>Rickets in children and osteomalacia in adults, characterized by soft bones, depressed growth, and reduced immune system functioning.</p> Signup and view all the answers

What is the result of the visual process shown in Figure 8.8?

<p>Some retinal is destroyed, and rods remove some retinol from the bloodstream and convert it to retinal to replace it.</p> Signup and view all the answers

What is night blindness, and what causes it?

<p>Night blindness is the inability to see in dim light, and it occurs if retinol is unavailable.</p> Signup and view all the answers

What is the importance of vitamin A in reproductive health?

<p>Vitamin A is required for maintaining the epithelial cells that line the reproductive tracts of men and women, and a lack of vitamin A can reduce fertility.</p> Signup and view all the answers

What is the benefit of consuming dark green leaves of lettuce, cabbage, or broccoli?

<p>These darkly pigmented parts of the plants contribute more provitamin A carotenoids to our diet.</p> Signup and view all the answers

What are some animal foods that are good sources of preformed vitamin A?

<p>Liver, butter, fish liver oils, and eggs are good sources of preformed vitamin A.</p> Signup and view all the answers

How much retinol does the body obtain from beta-carotene in a food?

<p>The body obtains only 1 mcg of retinol from every 12 mcg of beta-carotene in a food.</p> Signup and view all the answers

What is the function of cones in the retina?

<p>Cones are responsible for color vision and function in well-lit environments.</p> Signup and view all the answers

What is the role of vitamin A in the immune system?

<p>Vitamin A helps to fight infections.</p> Signup and view all the answers

What are some plant-based foods that are rich sources of beta-carotene?

<p>Carrots, spinach, pumpkin, sweet potatoes, broccoli, mangoes, and cantaloupe are rich sources of beta-carotene.</p> Signup and view all the answers

What happens to plant cells when they are exposed to heat?

<p>Plant cells break down and release carotenoids.</p> Signup and view all the answers

What is the purpose of lutein and zeaxanthin in the human body?

<p>They function as beneficial antioxidants in the human body.</p> Signup and view all the answers

Why do darkly pigmented fruits and vegetables contain more beta-carotene and other provitamin A carotenoids?

<p>Because they contain more beta-carotene and other provitamin A carotenoids.</p> Signup and view all the answers

Who is at risk for vitamin A deficiency?

<p>Preschool children who do not eat enough vegetables, urban poor, older adults, and people with severe alcoholism, fat malabsorption, or liver diseases.</p> Signup and view all the answers

What happens to epithelial cells in a person suffering from chronic vitamin A deficiency?

<p>They accumulate keratin and eventually harden and stop producing mucus.</p> Signup and view all the answers

What is the consequence of untreated xerophthalmia?

<p>Blindness.</p> Signup and view all the answers

Why is vitamin A deficiency a significant public health concern in developing nations?

<p>It can cause blindness and reduces the effectiveness of the immune system, leading to death from infections such as measles.</p> Signup and view all the answers

What is the recommended dietary allowance (RDA) for vitamin A?

<p>700 mcg RAE (women) to 900 mcg RAE (men).</p> Signup and view all the answers

What is the source of data for Table 8.3?

<p>U.S. Department of Agriculture, Agricultural Research Service: FoodData Central, 2019.</p> Signup and view all the answers

What is the purpose of fortifying commonly eaten foods with vitamin A?

<p>To reduce the prevalence of vitamin A deficiency in countries where it is widespread.</p> Signup and view all the answers

What is the risk of taking vitamin A supplements during pregnancy without consulting a physician?

<p>Excess vitamin A can cause birth defects.</p> Signup and view all the answers

What is the recommended daily intake of vitamin A for adults to prevent toxicity?

<p>3000 mcg/day</p> Signup and view all the answers

What is the purpose of Golden Rice, and what nutrient does it contain?

<p>Golden Rice was developed to provide a rich source of beta-carotene for vitamin A-deficient populations.</p> Signup and view all the answers

What is carotenodermia, and what is its cause?

<p>Carotenodermia is a yellow-orange discoloration of the skin caused by consuming too much beta-carotene-rich produce or taking beta-carotene supplements.</p> Signup and view all the answers

Why should women of childbearing age avoid pregnancy while using medications derived from vitamin A?

<p>Vitamin A derivatives can cause miscarriage or severe birth defects in the offspring.</p> Signup and view all the answers

What is the historical significance of cod liver oil in relation to vitamin D?

<p>Cod liver oil contains a fat-soluble factor that prevents and treats rickets.</p> Signup and view all the answers

What is the primary symptom of rickets, and how does it affect the bones?

<p>Soft and misshapen bones, particularly in the legs, which can bow under the weight of carrying the upper part of the body.</p> Signup and view all the answers

What is the classification of vitamin D, and why is it considered a hormone?

<p>Vitamin D is a hormone because it is a fat-soluble factor needed for proper bone health.</p> Signup and view all the answers

How does vitamin A toxicity affect the liver, and what are the resulting symptoms?

<p>Vitamin A toxicity damages the liver, causing symptoms such as headache, nausea, vomiting, visual disturbances, hair loss, bone pain, and bone fractures.</p> Signup and view all the answers

Why are women of childbearing age advised to limit their intake of vitamin A-rich foods, such as liver and fish liver oils?

<p>To prevent excessive intake of vitamin A, which can cause birth defects and toxicity symptoms.</p> Signup and view all the answers

What is the main drawback of using sunscreen to protect against skin cancer, in terms of vitamin D synthesis?

<p>It limits skin's ability to synthesize previtamin vitamin D3.</p> Signup and view all the answers

Why do breastfed infants with dark skin and minimal sunlight exposure need vitamin D supplements?

<p>Because breast milk contains insufficient amounts of vitamin D to prevent rickets.</p> Signup and view all the answers

What are the characteristic symptoms of osteomalacia, the adult form of rickets?

<p>Soft and weak bones that break easily, and muscle weakness.</p> Signup and view all the answers

How does aging affect the production of vitamin D3 in skin?

<p>Production of vitamin D3 in skin declines with age.</p> Signup and view all the answers

What type of skin cancer is often linked to UV radiation exposure?

<p>Melanoma, the most deadly form of skin cancer.</p> Signup and view all the answers

Why are adults who are confined indoors or almost fully covered during the day at risk of osteomalacia?

<p>Because they have limited skin exposure to sunlight, leading to vitamin D deficiency.</p> Signup and view all the answers

How much vitamin D do breastfed infants need to consume daily to prevent rickets?

<p>10 mcg (400 IU) of vitamin D per day.</p> Signup and view all the answers

Why is vitamin D a 'nutrient of public health concern' in the United States?

<p>Because many Americans do not consume enough vitamin D to meet the RDA.</p> Signup and view all the answers

What is the recommended daily intake of vitamin D for adults under 70 years of age?

<p>15 mcg/day.</p> Signup and view all the answers

What is the benefit of exposing skin to sunlight for about 15 minutes before applying sunscreen?

<p>It allows the body to make some active vitamin D.</p> Signup and view all the answers

Why did Amanda's doctor prescribe her a daily supplement of vitamin D?

<p>Because few foods are good sources of vitamin D, and she will need to maintain a healthy blood level of the fat-soluble vitamin for the rest of her life.</p> Signup and view all the answers

What is the primary source of vitamin D for people who live north of the 33rd parallel during the winter months?

<p>Supplements, as the sun's rays are blocked by the atmosphere during this time.</p> Signup and view all the answers

Why is it important to check the ingredient lists and Nutrition Facts panels of food products for vitamin D?

<p>Because only a few foods are naturally rich in vitamin D, and many products are fortified with it.</p> Signup and view all the answers

What is the potential consequence of not taking vitamin D supplements if you have a deficiency, like Amanda?

<p>Soft and weak bones, as vitamin D is essential for bone health.</p> Signup and view all the answers

Why is it not recommended to take vitamin D supplements unless you have a deficiency?

<p>Because vitamin D can be toxic in excess.</p> Signup and view all the answers

What is the reason Amanda 'crisps' when she gets exposed to the sun?

<p>Because she has red hair, which makes her more susceptible to sun damage.</p> Signup and view all the answers

What is the role of UV radiation in vitamin D synthesis?

<p>UV radiation triggers the production of previtamin D in the skin.</p> Signup and view all the answers

Why do people living north of the 33rd parallel need to take vitamin D supplements during the winter?

<p>Because the sun's rays are weaker and more oblique during the winter months, making it harder to synthesize vitamin D.</p> Signup and view all the answers

What is the effect of clouds, shade, window glass, and air pollution on vitamin D synthesis?

<p>They limit the amount of UV radiation that reaches the skin, making it harder to synthesize vitamin D.</p> Signup and view all the answers

Why was cod liver oil traditionally given to children to prevent rickets?

<p>Because it is a rich source of vitamin D, which is essential for bone health.</p> Signup and view all the answers

What is the effect of taking vitamin D supplements that provide more than 400 IU per day on the risk of hip fracture?

<p>Some studies found a lower risk of hip fracture, while others indicated that supplementation with higher amounts of vitamin D might increase risks of hip fracture and heart disease.</p> Signup and view all the answers

How does vitamin D deficiency contribute to osteoporosis?

<p>Vitamin D deficiency reduces calcium absorption, which contributes to osteoporosis.</p> Signup and view all the answers

What is the consequence of excess vitamin D consumption?

<p>Excess calcium is absorbed from foods, deposited in soft tissues, and can cause cellular death, along with other symptoms such as muscular weakness, loss of appetite, diarrhea, vomiting, and mental confusion.</p> Signup and view all the answers

What is the role of vitamin E in the body?

<p>Vitamin E is an antioxidant that protects polyunsaturated fatty acids in cell membranes from oxidative damage, which may be associated with atherosclerosis, cancer, and premature cellular aging and death, and also maintains immune system function.</p> Signup and view all the answers

What are some dietary sources of vitamin E?

<p>Rich sources include sunflower seeds, almonds, plant oils (sunflower, safflower, canola, and olive oils), products made from vitamin E-rich plant oils (margarines and salad dressings), fish, whole grains, nuts, seeds, and certain vegetables.</p> Signup and view all the answers

Why is it important to store vegetable oils properly?

<p>To prevent rancidity and oxidative damage of vitamin E, store unopened containers of oil in a cool, dark cabinet or pantry, and refrigerate opened containers.</p> Signup and view all the answers

What is the consequence of vitamin D toxicity on the body?

<p>Excess calcium is deposited in soft tissues, including kidneys, heart, and blood vessels, which can interfere with cell function and cause cellular death.</p> Signup and view all the answers

Why is it important to consume vitamin E-rich foods?

<p>To protect polyunsaturated fatty acids in cell membranes from oxidative damage, which may be associated with atherosclerosis, cancer, and premature cellular aging and death.</p> Signup and view all the answers

What is the effect of vitamin D deficiency on older adults?

<p>Older adults are more likely to develop vitamin D deficiency, which increases the risk of bone fractures and osteoporosis.</p> Signup and view all the answers

Why is vitamin E an important antioxidant?

<p>Vitamin E protects unsaturated fatty acids in cell membranes from oxidative damage, which can cause cellular death and contribute to atherosclerosis, cancer, and premature cellular aging.</p> Signup and view all the answers

What factors influence the amount of vitamin E retained in food?

<p>Harvesting, processing, storage, and cooking methods</p> Signup and view all the answers

Why may premature infants have low vitamin E stores?

<p>Because vitamin E is transferred from mother to fetus late in pregnancy</p> Signup and view all the answers

What is the primary function of vitamin K in the body?

<p>Blood clotting</p> Signup and view all the answers

What is the UL for vitamin E in healthy adults?

<p>1000 mg/day of alpha-tocopherol</p> Signup and view all the answers

Why may taking vitamin E supplements interfere with blood clotting?

<p>Because it may interact with vitamin K's role in blood clotting</p> Signup and view all the answers

What is the effect of vitamin E deficiency on the nervous and immune systems?

<p>Reduced functioning of the nervous and immune systems</p> Signup and view all the answers

Why is vitamin K necessary for blood clotting?

<p>Because it helps activate clotting factors in the liver</p> Signup and view all the answers

What is phylloquinone, and where is it found?

<p>A compound found in plants, particularly in fermented foods</p> Signup and view all the answers

What is the effect of vitamin E deficiency on premature infants?

<p>Development of signs of vitamin E deficiency</p> Signup and view all the answers

Why is fat necessary for the absorption of vitamin K?

<p>Because it helps solubilize vitamin K, facilitating absorption in the small intestine</p> Signup and view all the answers

What is the role of vitamin K in bone mineralization and which protein is involved in this process?

<p>Vitamin K helps bone-building cells produce osteocalcin, a protein needed for normal bone mineralization.</p> Signup and view all the answers

Why do people who take warfarin need to maintain consistent dietary intakes of vitamin K?

<p>Because vitamin K can interfere with warfarin’s ‘blood-thinning’ activity.</p> Signup and view all the answers

What is the consequence of vitamin K deficiency in infants, and how is it prevented?

<p>Vitamin K–deficient infants are at risk of serious bleeding because their bodies are unable to make certain blood-clotting factors. It is prevented by giving newborns a single injection of vitamin K.</p> Signup and view all the answers

What are some reliable food sources of vitamin K?

<p>Green leafy vegetables, such as kale, turnip greens, salad greens, cabbage, and spinach; broccoli; and green beans. Also, soybean and canola oils, and products made from these oils, such as salad dressing.</p> Signup and view all the answers

What is the Adequate Intake (AI) for vitamin K in adult men and women?

<p>120 mcg/day for men and 90 mcg/day for women.</p> Signup and view all the answers

What are some conditions that can contribute to a deficiency of vitamin K?

<p>Liver diseases, conditions that impair fat absorption, such as cystic fibrosis, and long-term antibiotic therapy.</p> Signup and view all the answers

What is the most reliable sign of vitamin K deficiency?

<p>An increase in the time it takes for blood to clot.</p> Signup and view all the answers

What is the importance of vitamin K in blood clotting?

<p>Vitamin K is necessary for the production of certain blood-clotting factors, including prothrombin.</p> Signup and view all the answers

What is the chemical structure of vitamin K like, and how does it respond to cooking?

<p>The chemical structure of vitamin K is very stable and resists being destroyed by usual cooking methods.</p> Signup and view all the answers

What is the consequence of excessive intake of vitamin K?

<p>There is no reported harm to humans from ingesting amounts of natural forms of vitamin K that exceed the AIs.</p> Signup and view all the answers

What was the mistake that Douglas Mawson and Xavier Mertz made during their expedition that led to severe illness and death?

<p>Eating their sled dogs' livers, which contained high amounts of vitamin A, toxic to humans.</p> Signup and view all the answers

What is the primary source of vitamin D for the body?

<p>Sunlight exposure, which converts a cholesterol derivative into previtamin D3 in the skin.</p> Signup and view all the answers

What is the role of the kidneys in the production of active vitamin D?

<p>The kidneys convert 25-OH vitamin D into the active hormone, vitamin D.</p> Signup and view all the answers

What is the percentage of calcium absorption in the small intestine when the body lacks vitamin D?

<p>10-15%</p> Signup and view all the answers

What is the effect of vitamin D deficiency on bone health?

<p>Bone cells cannot deposit enough calcium and phosphorus, leading to weak bones.</p> Signup and view all the answers

What is another role of vitamin D in the body besides bone health?

<p>Regulating neuromuscular and immune function, and reducing inflammation.</p> Signup and view all the answers

Why did Amanda Croker's family doctor prescribe her vitamin D supplements?

<p>Because her blood test showed that she didn't have enough vitamin D in her body.</p> Signup and view all the answers

What is the relationship between sunlight exposure and vitamin D production in the body?

<p>Sunlight exposure stimulates the production of vitamin D in the skin.</p> Signup and view all the answers

What is the consequence of severe vitamin D deficiency in the body?

<p>Weak bones, and increased risk of certain diseases such as osteoporosis and certain cancers.</p> Signup and view all the answers

Why is vitamin D often called the 'sunshine vitamin'?

<p>Because it is synthesized in the skin upon exposure to sunlight, specifically UVB radiation.</p> Signup and view all the answers

Study Notes

Fat-Soluble Vitamins

  • There are four fat-soluble vitamins: vitamins A, D, E, and K
  • These vitamins are essential for various bodily functions and can be obtained from dietary sources or supplements

Vitamin A

  • Vitamin A is a family of compounds that includes retinol, a key form of the vitamin in the body
  • Functions of vitamin A:
    • Involved in vision, particularly in dim light
    • Necessary for epithelial cell development, growth, and maintenance
    • Important for immune system function and fertility
    • Plays a role in bone growth and development
  • Food sources of vitamin A:
    • Preformed vitamin A: liver, milk, fortified cereals
    • Provitamin A (beta-carotene): yellow, orange, and dark green fruits and vegetables
  • Deficiency symptoms:
    • Night blindness
    • Dry skin
    • Poor growth
    • Reduced immune system function
    • Xerophthalmia (dry eye)
  • Toxicity symptoms:
    • Nausea and vomiting
    • Headaches
    • Bone pain and fractures
    • Hair loss
    • Liver damage

Vitamin D

  • Vitamin D is actually a hormone that can be synthesized in the skin upon exposure to sunlight
  • Functions of vitamin D:
    • Necessary for calcium and phosphorus metabolism
    • Essential for bone health and development
    • Involved in immune system function and regulation of cell growth
  • Food sources of vitamin D:
    • Fatty fish, fish liver oils, and fortified dairy products
  • Deficiency symptoms:
    • Rickets in children
    • Osteomalacia in adults
    • Soft bones
    • Depressed growth
    • Reduced immune system function
  • Toxicity symptoms:
    • Poor growth
    • Calcium deposits in soft tissues### Vitamin D
  • Vitamin D is also known as the "sunshine vitamin" because the body synthesizes it when skin is exposed to sunlight.
  • Limited sun exposure can lead to vitamin D deficiency, which can cause soft and weak bones (osteomalacia) and increase the risk of skin cancer.
  • Vitamin D is essential for bone health, as it helps the body absorb calcium.
  • Dark-skinned individuals, older adults, and people who live in areas with limited sunlight are at a higher risk of vitamin D deficiency.
  • The RDA for vitamin D is 15 mcg/day for adults under 70 years old, and 20 mcg/day for adults over 70 years old.
  • Food sources of vitamin D include fatty fish, fortified milk, and cereals.
  • Vitamin D supplements can be toxic in high doses, and can cause calcium deposits in soft tissues, leading to cellular death.

Sunlight Exposure and Vitamin D

  • Sunlight exposure is necessary for vitamin D synthesis, but excessive exposure increases the risk of skin cancer.
  • The amount of time needed to spend in the sun to form adequate amounts of vitamin D depends on location, time of day, and skin color.
  • People living north of the 33rd parallel may not get enough vitamin D from sunlight during the winter months.
  • Clouds, shade, window glass, and air pollution can reduce UV radiation and limit vitamin D production.

Vitamin D Deficiency and Osteomalacia

  • Vitamin D deficiency can cause osteomalacia, a condition characterized by soft and weak bones.
  • Breastfed infants, especially those with dark skin, are at a higher risk of vitamin D deficiency and osteomalacia.
  • Adults who are confined indoors, have kidney or liver disease, or have intestinal disorders are also at risk of osteomalacia.
  • Vitamin D supplements can help prevent osteomalacia in high-risk individuals.

Vitamin E

  • Vitamin E is an antioxidant that protects cell membranes from damage caused by free radicals.
  • Food sources of vitamin E include sunflower seeds, almonds, plant oils, fish, whole grains, and nuts.
  • Vitamin E deficiency is rare, but can occur in people with diseases that interfere with fat absorption.
  • Vitamin E deficiency can cause nerve damage, loss of neuromuscular control, and blindness.

Vitamin K

  • Vitamin K is necessary for blood clotting and bone health.
  • Food sources of vitamin K include green leafy vegetables, broccoli, and soybean oil.
  • Vitamin K deficiency is rare, but can occur in people with liver disease, conditions that impair fat absorption, and those taking long-term antibiotics.
  • Newborns are generally given a vitamin K injection to prevent deficiency.
  • Vitamin K deficiency can cause bleeding disorders and increased risk of osteoporosis.

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