30 Questions
Why is D-Glucose sweet, but L-glucose has a slightly salty taste?
The stereochemistry of glucose affects its taste.
Which type of flavoring materials are considered effective in masking the taste of bitter drugs?
Cocoa-flavored vehicles
Why is the selection of flavoring agents important based on the age of the patient?
Different age groups prefer different flavors.
What type of flavors are frequently used to combat sour or acid-tasting drugs?
Raspberry and citrus flavors
How do structural changes impact the taste of compounds according to the text?
Even simple structural changes can alter taste.
Why are cocoa-flavored vehicles considered effective for bitter drugs?
Cocoa-flavored vehicles have pleasant masking properties.
Which statement about the oil-water partition coefficient is true?
It measures a molecule's preference for the lipophilic phase.
What is the primary factor that determines the extent of drug dissociation or ionization?
The pH of the medium containing the drug.
Which statement about hygroscopic powders is true?
They tend to absorb moisture from the air.
What is the primary reason for adjusting the pH of the vehicle in drug formulation?
To control the drug's solubility and stability.
Which statement about the dissociation constant (pKa) is true?
It is usually determined by potentiometric titration.
Which statement about deliquescent powders is true?
They tend to absorb moisture from the air and liquefy.
Why is it important to weigh hygroscopic or deliquescent powders quickly?
To avoid absorbing moisture from the air and giving inaccurate weights
In what type of containers should solvates and hydrates be packaged?
Tight containers
Why are many drugs used as their 'salts'?
To increase their aqueous solubility
What defines the portion of a drug in solution that will be absorbed for systemic effect?
Dissociation constant
Why is it recommended to store all chemicals in 'tight' containers?
To minimize exposure to high humidity
What happens when a hygroscopic powder absorbs moisture from the air during weighing?
It increases its weight inaccurately
How many pilot-scale batches of the drug substance should be manufactured for data collection?
At least three
What should the packaging for the drug substance stability studies simulate?
The packaging proposed for final product
How many batches of the manufactured dosage form should be included in the stability studies?
At least three
Which of the following attributes should NOT be tested during the stability studies?
Manufacturing process attributes
What type of products may require separate protocols for stability studies?
Biotechnological/biological products
What is an example of a functionality test mentioned in the text?
Metered-dose delivery system test
Which of the following sulfite agents is NOT covered by the FDA regulations?
Potassium sulfite
Why does the FDA permit the use of sulfites in prescription products?
There are no generally suitable substitutes for sulfites to maintain potency in certain medications.
What is the purpose of using an inert gas like nitrogen to replace the air in the packaging of oxygen-sensitive drugs?
To prevent the drug from reacting with the air.
What is the purpose of using antioxidants in certain pharmaceutical preparations?
To help stabilize the drug and maintain its potency.
What can happen if certain antioxidants are used in pharmaceutical preparations?
The antioxidants can inactivate the drug they were intended to stabilize.
Which of the following is NOT a reason why oxygen may be a concern in the storage and preparation of certain pharmaceutical products?
Oxygen can improve the taste and appearance of certain drugs.
Learn about the factors that influence taste perception, such as the structure of organic compounds, the presence of nitrogen-containing compounds, and the impact of structural changes on taste. Discover how different compounds affect sweetness, bitterness, and other taste sensations.
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