Factors Affecting Tissue Repair

Infection = One of the most important causes of delayed healing Diabetes = Compromises tissue repair for many reasons Nutritional status = Profound effects on repair; inhibits collagen synthesis and retards healing Vitamin C deficiency = Inhibits collagen synthesis and retards healing

Infection = Clinically important cause of delayed healing Diabetes = Metabolic disease compromising tissue repair Nutritional status = Profound effects on repair; protein deficiency inhibits collagen synthesis Protein deficiency = Inhibits collagen synthesis and retards healing

Causes delayed healing = Infection Compromises tissue repair for many reasons = Diabetes Inhibits collagen synthesis and retards healing = Nutritional status Has profound effects on repair = Nutritional status

<p>Glucocorticoids (steroids) = Inhibition of TGF-β production resulting in weakness of the scar Mechanical factors such as increased local pressure or torsion = Impact on tissue repair due to increased pressure or torsion Poor perfusion due to peripheral vascular disease = Effect on tissue repair due to inadequate blood flow Foreign bodies such as fragments of steel, glass, or bone = Impediment to healing by perpetuating chronic inflammation</p> Signup and view all the answers

<p>Glucocorticoids (steroids) have well-documented antiinflammatory effects = Inhibition of TGF-β production resulting in weakness of the scar Mechanical factors such as increased local pressure or torsion = Impact on tissue repair due to increased pressure or torsion Poor perfusion, due to peripheral vascular disease = Effect on tissue repair due to inadequate blood flow Foreign bodies such as fragments of steel, glass, or even bone impede healing by perpetuating chronic inflammation = Impediment to healing by perpetuating chronic inflammation</p> Signup and view all the answers

<p>Glucocorticoids (steroids) = Have well-documented antiinflammatory effects Mechanical factors such as increased local pressure or torsion = Cause impact on tissue repair due to increased pressure or torsion Poor perfusion due to peripheral vascular disease = Results in inadequate blood flow affecting tissue repair Foreign bodies such as fragments of steel, glass, or bone = Impede healing by perpetuating chronic inflammation</p> Signup and view all the answers