Podcast
Questions and Answers
What is the central role of WDR5 in the MLL1 complex?
What is the central role of WDR5 in the MLL1 complex?
- Deacetylating histones in the complex
- Enhancing the methyltransferase activity of MLL1 (correct)
- Recognizing N-terminal polypeptide chains of H4 for methylation
- Inhibiting histone methylation in the complex
Which structural motif is found in many lysine methyltransferases responsible for adding methyl groups from SAM to histone proteins?
Which structural motif is found in many lysine methyltransferases responsible for adding methyl groups from SAM to histone proteins?
- Arginine domain
- AdoMet group
- CH3 group
- SET domain (correct)
Which protein in the MLL complex is essential for H3K4 trimethylation?
Which protein in the MLL complex is essential for H3K4 trimethylation?
- G9a
- RbBP5 (correct)
- SUV39H1
- Ash2L
Which HMT enzyme is known as a monomethyltransferase for lysine 4 of histone H3?
Which HMT enzyme is known as a monomethyltransferase for lysine 4 of histone H3?
What is the function of G9a in relation to gene repression and heterochromatin formation?
What is the function of G9a in relation to gene repression and heterochromatin formation?
Which lysine of histones H3 and H4 is monomethylated by SET 7/9?
Which lysine of histones H3 and H4 is monomethylated by SET 7/9?
Which mark is associated with dysregulation of G9a and implicated in various diseases including cancer?
Which mark is associated with dysregulation of G9a and implicated in various diseases including cancer?
Which of the following is NOT true about SET 7/9 enzyme?
Which of the following is NOT true about SET 7/9 enzyme?
Which enzyme is known as one of the chief effectors of H3K4 methylation?
Which enzyme is known as one of the chief effectors of H3K4 methylation?
Which protein is responsible for adding trimethyl groups to lysine 9 of histone H3?
Which protein is responsible for adding trimethyl groups to lysine 9 of histone H3?
What is the function of ANK repeats in G9a?
What is the function of ANK repeats in G9a?
What observable characteristics can result from mutations in Drosophila proteins related to the SET domain?
What observable characteristics can result from mutations in Drosophila proteins related to the SET domain?
What is the main function of SUV39H1?
What is the main function of SUV39H1?
Which domain is essential for SUV39H1 to bind trimethylated H3K9?
Which domain is essential for SUV39H1 to bind trimethylated H3K9?
What is the significance of H3K9me3 marks at centromeres?
What is the significance of H3K9me3 marks at centromeres?
Which enzyme is generally associated with facultative heterochromatin rather than constitutive heterochromatin?
Which enzyme is generally associated with facultative heterochromatin rather than constitutive heterochromatin?
What is the main difference between SUV39H1 and G9a regarding methylation activity?
What is the main difference between SUV39H1 and G9a regarding methylation activity?
Which protein is known for maintaining the structure and function of centromeres?
Which protein is known for maintaining the structure and function of centromeres?
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