EZH2 Binding and H3K27 Methylation Quiz
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Questions and Answers

What is the central role of WDR5 in the MLL1 complex?

  • Deacetylating histones in the complex
  • Enhancing the methyltransferase activity of MLL1 (correct)
  • Recognizing N-terminal polypeptide chains of H4 for methylation
  • Inhibiting histone methylation in the complex

    • Which structural motif is found in many lysine methyltransferases responsible for adding methyl groups from SAM to histone proteins?

  • Arginine domain
  • AdoMet group
  • CH3 group
  • SET domain (correct)

    • Which protein in the MLL complex is essential for H3K4 trimethylation?

  • G9a
  • RbBP5 (correct)
  • SUV39H1
  • Ash2L

    • Which HMT enzyme is known as a monomethyltransferase for lysine 4 of histone H3?

    <p>SET 7/9</p> Signup and view all the answers

    What is the function of G9a in relation to gene repression and heterochromatin formation?

    <p>Promoting gene silencing and heterochromatin formation</p> Signup and view all the answers

    Which lysine of histones H3 and H4 is monomethylated by SET 7/9?

    <p>H3K4</p> Signup and view all the answers

    Which mark is associated with dysregulation of G9a and implicated in various diseases including cancer?

    <p>H3K9me2/3</p> Signup and view all the answers

    Which of the following is NOT true about SET 7/9 enzyme?

    <p>It catalyzes di- or trimethylation of H3K4.</p> Signup and view all the answers

    Which enzyme is known as one of the chief effectors of H3K4 methylation?

    <p>MLL1</p> Signup and view all the answers

    Which protein is responsible for adding trimethyl groups to lysine 9 of histone H3?

    <p>G9a</p> Signup and view all the answers

    What is the function of ANK repeats in G9a?

    <p>Facilitating <strong>protein-protein interactions</strong> in diverse families</p> Signup and view all the answers

    What observable characteristics can result from mutations in Drosophila proteins related to the SET domain?

    <p>Delayed development</p> Signup and view all the answers

    What is the main function of SUV39H1?

    <p>Methylates Lys 9 of histone H3</p> Signup and view all the answers

    Which domain is essential for SUV39H1 to bind trimethylated H3K9?

    <p>Chromodomain</p> Signup and view all the answers

    What is the significance of H3K9me3 marks at centromeres?

    <p>They play a role in centromere stability</p> Signup and view all the answers

    Which enzyme is generally associated with facultative heterochromatin rather than constitutive heterochromatin?

    <p>G9a</p> Signup and view all the answers

    What is the main difference between SUV39H1 and G9a regarding methylation activity?

    <p>G9a can trimethylate H3K9 while SUV39H1 cannot</p> Signup and view all the answers

    Which protein is known for maintaining the structure and function of centromeres?

    <p>SUV39H1</p> Signup and view all the answers

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