Podcast
Questions and Answers
Which tissue type lines the inner surface of the eyelid, facing the eye?
Which tissue type lines the inner surface of the eyelid, facing the eye?
- Conjunctiva (correct)
- Subcutaneous fat
- Dermis
- Epidermis
What is the primary function of the eyelids, as described?
What is the primary function of the eyelids, as described?
- To focus light onto the retina
- To regulate intraocular pressure
- To cover, protect the eye, and contribute to the tear film (correct)
- To produce melanin for UV protection
Obstruction of the sebaceous glands of the eyelid can lead to which condition?
Obstruction of the sebaceous glands of the eyelid can lead to which condition?
- Chalazion (correct)
- Arcus senilis
- Pterygium
- Pinguecula
What is the most common type of malignancy found on the eyelid?
What is the most common type of malignancy found on the eyelid?
Why is prompt treatment of invasive basal cell carcinoma of the eyelid necessary?
Why is prompt treatment of invasive basal cell carcinoma of the eyelid necessary?
Which area of the eyelid is most prone to basal cell carcinoma?
Which area of the eyelid is most prone to basal cell carcinoma?
Sebaceous carcinoma of the eyelid can mimic which other conditions?
Sebaceous carcinoma of the eyelid can mimic which other conditions?
What is a significant risk associated with sebaceous carcinoma of the eyelid?
What is a significant risk associated with sebaceous carcinoma of the eyelid?
To which regional lymph nodes does sebaceous carcinoma of the eyelid typically spread first?
To which regional lymph nodes does sebaceous carcinoma of the eyelid typically spread first?
In the context of sebaceous carcinoma, what is 'Pagetoid spread'?
In the context of sebaceous carcinoma, what is 'Pagetoid spread'?
Which syndrome is less likely to be associated with sebaceous neoplasms of the eyelid compared to sebaceous neoplasms elsewhere on the body?
Which syndrome is less likely to be associated with sebaceous neoplasms of the eyelid compared to sebaceous neoplasms elsewhere on the body?
In individuals with AIDS, Kaposi sarcoma of the conjunctiva may be mistaken for which condition?
In individuals with AIDS, Kaposi sarcoma of the conjunctiva may be mistaken for which condition?
Besides the lacrimal gland ductules, through which system could sebaceous carcinoma spread?
Besides the lacrimal gland ductules, through which system could sebaceous carcinoma spread?
What cytological feature is particularly helpful in the diagnosis of moderately or well-differentiated sebaceous carcinoma?
What cytological feature is particularly helpful in the diagnosis of moderately or well-differentiated sebaceous carcinoma?
Which of the following factors would LEAST assist in differentiating sebaceous carcinoma from Bowenoid actinic keratosis during microscopic examination of the eyelid?
Which of the following factors would LEAST assist in differentiating sebaceous carcinoma from Bowenoid actinic keratosis during microscopic examination of the eyelid?
Flashcards
Eyelid Function
Eyelid Function
Covers and protects the eye and generates components of the tear film.
Chalazion (Lipogranuloma)
Chalazion (Lipogranuloma)
Granulomatous response due to blocked sebaceous glands, commonly from blepharitis.
Basal Cell Carcinoma of Eyelid
Basal Cell Carcinoma of Eyelid
Most common malignancy of the eyelid, often on the lower lid or medial canthus.
Sebaceous Carcinoma of Eyelid
Sebaceous Carcinoma of Eyelid
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Sebaceous Carcinoma Morphology
Sebaceous Carcinoma Morphology
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Pagetoid Spread
Pagetoid Spread
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Kaposi Sarcoma in AIDS
Kaposi Sarcoma in AIDS
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Basal Cell Carcinoma - Key point
Basal Cell Carcinoma - Key point
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Sebaceous Carcinoma - Key point
Sebaceous Carcinoma - Key point
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Study Notes
- The eyelid consists of skin externally and conjunctiva (mucosa) on the surface facing the eye
- Eyelids protect the eye and produce components of the tear film
- Blockage of sebaceous glands due to blepharitis or neoplasm can cause lipid extravasation, leading to granulomatous response, forming lipogranuloma or chalazion
Neoplasms
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Basal cell carcinoma is the most frequent malignancy of the eyelid
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Melanomas of the eyelid skin are rare
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Eyelid neoplasms can cause tissue distortion and prevent complete eyelid closure, and prompt treatment is needed to prevent corneal damage from air exposure
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Basal cell carcinoma often occurs on the lower eyelid and medial canthus
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Sebaceous carcinoma can appear as a local mass like chalazion or diffusely thicken the eyelid
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It can resemble blepharitis or ocular cicatricial pemphigoid due to intraepithelial spread, similar to Paget disease
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Sebaceous carcinoma tends to spread to the parotid and submandibular nodes first and has a mortality rate of up to 22%
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Eyelid sebaceous carcinoma is less associated with Muir-Torre syndrome than sebaceous neoplasms elsewhere
Morphology
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Moderately or well-differentiated sebaceous carcinoma shows cytoplasmic vacuolization, which aids in diagnosis
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This cancer can resemble other malignancies, including basal cell carcinoma, making correct diagnosis challenging
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Pagetoid spread can mimic Bowenoid actinic keratosis in the eyelid and carcinoma in situ in the conjunctiva
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Sebaceous carcinoma can spread through the conjunctival epithelium and epidermis to the lacrimal drainage system and nasopharynx and may also extend into the lacrimal gland
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In AIDS patients, Kaposi sarcoma can occur in the eyelid or conjunctiva
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Kaposi sarcoma appears purple in the eyelid due to its location in the dermis
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It appears bright red in the conjunctiva and can be mistaken for a subconjunctival hemorrhage
Key Concepts
- Basal cell carcinoma is the most common and locally invasive primary malignancy of the eyelid
- Sebaceous carcinoma of the eyelid can metastasize, making it a serious, potentially life-threatening condition
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