Untitled
56 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

According to the 2021 National Survey on Drug Use and Health, which substance was most commonly misused?

  • Prescription pain medication
  • Alcohol
  • Cocaine
  • Marijuana (correct)

According to the CDC's 2022 Clinical Practice Guidelines for Prescribing Opioids, what is the preferred type of opioid for acute pain?

  • Combination opioids containing acetaminophen
  • Any opioid type, as long as the patient is closely monitored
  • Long-acting (XR) opioids at the highest effective dose
  • Short-acting (IR) opioids at the lowest effective dose (correct)

According to the CDC's 2022 Clinical Practice Guidelines for Prescribing Opioids, what is the recommended rate for tapering opioids when discontinuing them?

  • Taper by 50% per week
  • Taper by 10% per month, or as the patient tolerates (correct)
  • Taper by 25% per week
  • Abruptly stop the medication

Before prescribing opioids, what does the CDC recommend to check?

<p>Prescription Drug Monitoring Program (PDMP) (C)</p> Signup and view all the answers

Which of the following is NOT typically a responsibility of opioid prescribing?

<p>Mandatory home visits (D)</p> Signup and view all the answers

Why are Morphine Milligram Equivalents (MMEs) used in opioid prescribing?

<p>To standardize the dose of opioids prescribed in comparison to a dose of morphine (B)</p> Signup and view all the answers

According to the information provided, what is the primary goal when determining whether or not to initiate opioids for pain?

<p>Maximize non-opioid therapy over opioids first (C)</p> Signup and view all the answers

A patient is administered a medication that binds to opioid receptors, preventing the binding of other substances and reversing the effects of opioids. Which type of drug is this patient most likely given?

<p>Opioid antagonist (B)</p> Signup and view all the answers

A patient who is physiologically dependent on opioids abruptly stops using them. Which type of opioid withdrawal is this patient most likely experiencing?

<p>Spontaneous withdrawal (A)</p> Signup and view all the answers

A patient who is physiologically dependent on opioids and has opioids in their system is administered naloxone. Which type of opioid withdrawal is this patient most likely experiencing?

<p>Precipitated withdrawal (D)</p> Signup and view all the answers

Which set of symptoms is most indicative of opioid intoxication?

<p>Constricted pupils, respiratory distress, confusion, somnolence, and constipation (B)</p> Signup and view all the answers

A 21-year-old female presents with nausea, vomiting, body aches, sweating, fatigue, chills, constant yawning, and irritability. She initially denies drug use but later admits to daily use of pressed fentanyl pills. What is the most likely cause of her symptoms?

<p>Opioid withdrawal (C)</p> Signup and view all the answers

A patient with a known history of opioid dependence is prescribed buprenorphine. What is the primary mechanism by which buprenorphine can precipitate withdrawal symptoms?

<p>Buprenorphine's high affinity for opioid receptors displaces other opioids, while its partial agonist activity provides less overall receptor activation. (C)</p> Signup and view all the answers

A patient undergoing opioid withdrawal is experiencing severe gastrointestinal distress. Which of the following physiological mechanisms is least likely to contribute to this symptom?

<p>Up-regulation of gastrointestinal opioid receptors enhancing sensitivity to endogenous opioids. (D)</p> Signup and view all the answers

Which of the following statements most accurately describes the difference between opioid tolerance and opioid dependence?

<p>Tolerance involves needing a higher dose to achieve the same effect, while dependence involves experiencing withdrawal symptoms upon cessation. (D)</p> Signup and view all the answers

Considering the patient's escalating fentanyl use to maintain normalcy and prevent withdrawal, which neurobiological adaptation is most likely occurring in her brain?

<p>Downregulation of opioid receptors and decreased dopamine release in the reward pathway. (B)</p> Signup and view all the answers

The patient is concerned about failing a urine drug screen during her clinical rotations. Given her reported fentanyl use, what is the most appropriate and sensitive method to confirm fentanyl use?

<p>Urine drug screen specifically for fentanyl and its metabolites, norfentanyl and despropionylfentanyl. (A)</p> Signup and view all the answers

Considering the patient's expressed desire to stop using fentanyl due to concerns about her medical school career, which of the following would be the MOST appropriate initial treatment strategy?

<p>Referral for medically-supervised detoxification utilizing a slow taper with buprenorphine. (A)</p> Signup and view all the answers

The patient admits to using fentanyl in class to prevent withdrawal symptoms. From an ethical perspective, which principle is MOST compromised by this behavior?

<p>Non-maleficence, as her actions could potentially impair her ability to provide safe patient care in the future. (A)</p> Signup and view all the answers

Which of the following best represents the DSM-5 criteria met by the patient that would determine a diagnosis of Opioid Use Disorder?

<p>All of the above. (D)</p> Signup and view all the answers

What is the MOST crucial next step in assessing this patient after establishing a diagnosis of Opioid Use Disorder?

<p>Exploring the patient's readiness for change and motivational interviewing to enhance her willingness to engage in treatment. (A)</p> Signup and view all the answers

The patient's mother expresses concerns about her daughter's increased withdrawal from the family. Which of the following strategies would be MOST effective in involving the family in the patient's treatment?

<p>Referring the patient and her family to a family therapy program specializing in substance use disorders, while respecting patient confidentiality. (D)</p> Signup and view all the answers

Given that the patient has experimented with IV fentanyl use, what harm reduction strategy is MOST critical to address immediately?

<p>Providing education on safe injection practices, including using sterile needles, avoiding sharing needles, and proper wound care. (C)</p> Signup and view all the answers

A patient is experiencing opioid withdrawal symptoms and is considering buprenorphine induction in an outpatient setting. What strategy minimizes the risk of precipitated withdrawal?

<p>Starting with a low dose of buprenorphine (e.g., 2-4mg) and gradually increasing it while monitoring the patient's response and withdrawal symptoms. (C)</p> Signup and view all the answers

Which of the following statements accurately compares methadone and buprenorphine regarding their accessibility and risk of overdose?

<p>Buprenorphine is generally more accessible in outpatient clinics, whereas methadone has a higher risk of overdose with concurrent opioid use. (B)</p> Signup and view all the answers

A patient with a history of opioid use disorder is interested in starting naltrexone. What is the most critical consideration before initiating naltrexone therapy?

<p>Ensuring the patient has been opioid-free for at least 10 days to avoid precipitated withdrawal. (D)</p> Signup and view all the answers

A patient reports experiencing significant anxiety and restlessness during opioid withdrawal. Which adjunctive medication would be the MOST effective first-line treatment for these specific symptoms?

<p>Clonidine (D)</p> Signup and view all the answers

When initiating medication-assisted treatment for opioid use disorder, which factor most significantly influences the choice between methadone, buprenorphine, and naltrexone?

<p>The stage of the patient's opioid use, risk of precipitated withdrawal, and access to treatment. (A)</p> Signup and view all the answers

A patient is undergoing buprenorphine induction and reports feeling worse despite dose adjustments. They exhibit increased withdrawal symptoms. What is the most likely explanation for this?

<p>The patient has recently used an opioid, leading to precipitated withdrawal. (A)</p> Signup and view all the answers

A patient with opioid use disorder is being discharged from inpatient treatment. What is the most significant advantage of prescribing IM naltrexone over oral naltrexone in this scenario?

<p>IM naltrexone ensures medication adherence, eliminating concerns about missed doses. (C)</p> Signup and view all the answers

What is the primary mechanism by which naltrexone prevents overdose?

<p>By blocking opioid receptors in the brain, preventing opioids from producing their euphoric and respiratory depressant effects. (D)</p> Signup and view all the answers

Which of the following factors contribute significantly to an individual's risk of developing a substance use disorder?

<p>Early initiation of substance use combined with a history of adverse childhood experiences. (D)</p> Signup and view all the answers

Why is the CAGE questionnaire not recommended as a sole screening tool for alcohol use disorder in primary care settings?

<p>It primarily identifies individuals already experiencing significant consequences of their drinking. (B)</p> Signup and view all the answers

In a busy primary care clinic, what is the primary advantage of using the NIAAA Single Alcohol Screening Question (SASQ) over other screening tools like AUDIT-C?

<p>It can be easily integrated into routine clinical conversations due to its brevity. (D)</p> Signup and view all the answers

According to the provided data, approximately what percentage of the United States population aged 12 and older experienced Alcohol Use Disorder (AUD) in the past year?

<p>10.5% (A)</p> Signup and view all the answers

A 30-year-old male patient reports consuming 6-8 alcoholic beverages every night to help him sleep. He denies any negative consequences but expresses concern about potential long-term health effects. Which screening tool is MOST appropriate?

<p>Employ the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) to quantify his alcohol consumption. (C)</p> Signup and view all the answers

A researcher is designing a study to identify risk factors for alcohol use disorder in adolescents. Which combination of factors would provide the strongest predictive value?

<p>Family history of addiction and history of adverse childhood experiences. (A)</p> Signup and view all the answers

A primary care physician is implementing routine alcohol screening in their practice. Which strategy would be MOST effective in ensuring the screening process is both efficient and comprehensive?

<p>Use the NIAAA Single Alcohol Screening Question (SASQ) as an initial screen, followed by the AUDIT-C for positive responses. (B)</p> Signup and view all the answers

During a clinical interview, a patient minimizes their alcohol consumption, stating they only drink 'socially' on weekends. However, their medical history reveals elevated liver enzymes and frequent emergency room visits for minor injuries. Which screening approach is MOST justified?

<p>Administer a comprehensive screening tool, such as the AUDIT, despite the patient's initial minimization. (B)</p> Signup and view all the answers

A patient presents with vital signs indicative of tachycardia, hypertension, and hyperthermia, alongside physical findings of mydriasis, diaphoresis, piloerection, and tremors. Considering these signs and symptoms in the context of substance use disorders, which of the following is the MOST likely underlying physiological process?

<p>Sympathetic nervous system hyperactivity secondary to opioid withdrawal. (D)</p> Signup and view all the answers

Methadone maintenance therapy (MMT) is subject to specific regulations due to its pharmacological profile and potential for misuse. Which of the following statements BEST describes a primary regulatory consideration that differentiates methadone dispensing from buprenorphine dispensing in the treatment of Opioid Use Disorder (OUD)?

<p>Federal regulations mandate that methadone for OUD treatment must primarily be dispensed through specialized Opioid Treatment Programs (OTPs), while buprenorphine has broader dispensing access due to its lower overdose risk profile. (A)</p> Signup and view all the answers

Considering the pharmacological differences between methadone and buprenorphine in the treatment of Opioid Use Disorder (OUD), which statement accurately contrasts their receptor binding profiles and resulting clinical implications?

<p>Buprenorphine's high affinity and partial agonism at the mu-opioid receptor contribute to its ceiling effect, limiting the maximal opioid effect and reducing overdose potential compared to methadone's full mu-opioid agonism. (B)</p> Signup and view all the answers

A patient with Opioid Use Disorder (OUD) is being considered for buprenorphine treatment. Given the available formulations of buprenorphine, which of the following is MOST appropriate for initiating outpatient treatment in a setting where diversion and misuse are significant concerns within the patient's community?

<p>Sublingual buprenorphine-naloxone combination (Suboxone) to deter intravenous misuse and diversion. (B)</p> Signup and view all the answers

In the context of Medication for Opioid Use Disorder (MOUD), the inclusion of naloxone in combination with buprenorphine (e.g., Suboxone) serves a specific purpose related to harm reduction. Which of the following BEST describes the primary rationale for incorporating naloxone in this formulation?

<p>To function as an abuse deterrent by precipitating withdrawal symptoms if the combination product is misused via injection by opioid-dependent individuals. (B)</p> Signup and view all the answers

A patient is initiated on methadone for Opioid Use Disorder (OUD) at an Opioid Treatment Program (OTP). When counseling this patient about methadone, which of the following statements is MOST critical to emphasize regarding the medication's risk profile?

<p>The long half-life of methadone, while beneficial for once-daily dosing, increases the risk of unintentional overdose, particularly during induction and dose titration. (B)</p> Signup and view all the answers

A clinician is initiating buprenorphine treatment for a patient with Opioid Use Disorder (OUD) in an outpatient setting. To determine the appropriate timing for buprenorphine induction, which of the following assessment tools is MOST crucial to employ and interpret?

<p>The Clinical Opiate Withdrawal Scale (COWS) to ensure the patient has achieved a sufficient level of opioid withdrawal prior to buprenorphine administration. (B)</p> Signup and view all the answers

For a patient with chronic pain and co-occurring Opioid Use Disorder (OUD) who requires long-term opioid agonist therapy, which buprenorphine formulation would be LEAST suitable due to its primary indication and route of administration?

<p>Transdermal buprenorphine patch (Butrans) primarily indicated for chronic pain management, not OUD. (C)</p> Signup and view all the answers

What is the primary difference between opioids and opiates?

<p>Opioids are synthetic, while opiates are natural. (A)</p> Signup and view all the answers

What is the primary function of mu receptors in the body?

<p>Mediate pain relief and euphoria (B)</p> Signup and view all the answers

Which of the following are signs of opioid intoxication? (Select all that apply)

<p>Decreased respiration (B), Euphoria (C)</p> Signup and view all the answers

Which of the following are key findings of opiate withdrawal? (Select all that apply)

<p>Goosebumps (A), Yawning (B)</p> Signup and view all the answers

What is the mechanism of action (MOA) of Methadone?

<p>Full Opioid Agonist (A)</p> Signup and view all the answers

What is one of the most effective adjunctive therapies for opioid withdrawal?

<p>Clonidine (A)</p> Signup and view all the answers

Alcohol works on what receptors? (Select all that apply)

<p>GABA (A), Glutamate (B)</p> Signup and view all the answers

Delirium Tremens is defined as:

<p>A severe form of alcohol withdrawal that includes confusion and tremors (A)</p> Signup and view all the answers

Which of the following are treatment options for alcohol withdrawal management? (Select all that apply)

<p>Benzodiazepines (A), Barbiturates (B)</p> Signup and view all the answers

Flashcards

Opiate Misuse Rate

Rate of opiate misuse among chronic pain patients in treatment.

Opioid Initiation: First Step

Maximize non-opioid therapy first, and discuss risk vs benefit.

Opioid Selection for Acute Pain

Prefer short-acting (IR) over long-acting (XR) for acute pain, using the lowest possible dose.

Opioid Tapering

Reduce dose by 10% per month or as patient tolerates; do not stop abruptly.

Signup and view all the flashcards

PDMP Checks

Check Prescription Drug Monitoring Program before every opioid prescription.

Signup and view all the flashcards

PDMP Meaning

A program to monitor prescription drug dispensing.

Signup and view all the flashcards

MME Meaning

Standardizes opioid doses relative to morphine.

Signup and view all the flashcards

Opioid Prescribing Responsibilities

Informed consent, treatment agreements, collaboration with specialists.

Signup and view all the flashcards

Agonist

A substance that binds to a receptor and activates it, producing a response.

Signup and view all the flashcards

Antagonist

A substance that blocks or reverses the effects of an agonist; it prevents receptor activation.

Signup and view all the flashcards

Opioid Intoxication Signs

Pinpoint pupils, respiratory depression, confusion, sleepiness, and constipation.

Signup and view all the flashcards

Spontaneous Opioid Withdrawal

Withdrawal caused by abrupt cessation or reduction of opioid use in a dependent individual.

Signup and view all the flashcards

Precipitated Opioid Withdrawal

Withdrawal triggered by administering an opioid antagonist (like naloxone) or partial agonist (like buprenorphine).

Signup and view all the flashcards

Opioid Withdrawal Symptoms

Nausea, vomiting, body aches, sweating, fatigue, chills, yawning, and irritability.

Signup and view all the flashcards

Opioid Tolerance

The diminishing effect of a drug with repeated use, requiring increased doses to achieve the same effect.

Signup and view all the flashcards

Opioid Dependence

Physical adaptation to a drug, where the body requires the drug to function normally, leading to withdrawal symptoms upon cessation.

Signup and view all the flashcards

Opioid Use Disorder (OUD)

A problematic pattern of opioid use leading to clinically significant impairment or distress.

Signup and view all the flashcards

OUD Severity

DSM-5 criteria for OUD. Mild (2-3 criteria met), Moderate (4-5), Severe(6+).

Signup and view all the flashcards

Opioid Withdrawal

Physical and psychological symptoms that occur when opioid use is reduced or stopped.

Signup and view all the flashcards

Common Opioid Withdrawal Symptoms

Nausea, vomiting, body aches, sweating, fatigue, chills, yawning, and irritability.

Signup and view all the flashcards

Using to Avoid Withdrawal

Using a substance to avoid withdrawal symptoms.

Signup and view all the flashcards

Increased Dosage

Needing more of a substance to achieve the same effect.

Signup and view all the flashcards

Initial Denial of Substance Use

The patient initially denied substance use due to fear of judgment or consequences.

Signup and view all the flashcards

Progression of OUD

Fentanyl's use to get "high" and help relax, but now using to feel normal and to avoid the negative effects of withdrawl.

Signup and view all the flashcards

Clonidine Use

Anxiety and restlessness relief during opioid withdrawal.

Signup and view all the flashcards

Naltrexone & Withdrawal

Medication that will cause withdrawal if given too soon.

Signup and view all the flashcards

Naltrexone Function

Blocks opioid effects, prevents overdose.

Signup and view all the flashcards

Methadone Initiation

No risk of precipitated withdrawal, immediately helps withdrawal symptoms.

Signup and view all the flashcards

Buprenorphine Initiation

Risk of precipitated withdrawal, needs some withdrawal to begin.

Signup and view all the flashcards

Naltrexone Initiation

No support for withdrawal, needs 10+ days of opioid abstinence.

Signup and view all the flashcards

Naltrexone

An opioid antagonist that can prevent overdose.

Signup and view all the flashcards

Infectious Disease Screening

HIV and Hep C.

Signup and view all the flashcards

MOUD Definition

Medications used to treat Opioid Use Disorder, including Methadone, Buprenorphine, and Naltrexone.

Signup and view all the flashcards

Methadone

A full opioid agonist with a long half-life, used in opioid use disorder treatment.

Signup and view all the flashcards

Methadone Formulations

Liquid for OUD and tablets for pain management

Signup and view all the flashcards

Buprenorphine

Partial opioid agonist with high affinity for the mu receptor used to treat opioid use disorder.

Signup and view all the flashcards

Buprenorphine Formulations

Sublingual, Injectable, Patches, Buccal

Signup and view all the flashcards

Buprenorphine vs Buprenorphine-Naloxone

Buprenorphine is the medication itself; buprenorphine-naloxone prevents misuse because naloxone is activated when tampered with or misused.

Signup and view all the flashcards

Buprenorphine Dosages

Typical dose is 8-2mg BID to TID, ceiling effect at 24mg

Signup and view all the flashcards

COWS Score

Clinical Opiate Withdrawal Scale: Used to find if Buprenorphine can be used to treat the patient.

Signup and view all the flashcards

Alcohol Use Disorder (AUD)

A problematic pattern of alcohol use leading to clinically significant impairment or distress.

Signup and view all the flashcards

AUD Prevalence (2022)

In 2022, 10.5% of the population aged 12 and older had AUD.

Signup and view all the flashcards

Risk Factors for Use Disorder

Age of first use, family history of addiction, and adverse childhood experiences.

Signup and view all the flashcards

NIAAA Single Alcohol Screening Question (SASQ)

Asks how many times in the past year the patient had 4+ (women) or 5+ (men) drinks in a day; one or more warrants follow-up.

Signup and view all the flashcards

AUDIT-C

Asks about frequency of drinking, typical quantity, and frequency of heavy drinking (6+ drinks).

Signup and view all the flashcards

CAGE

Cut down, Annoyed, Guilty, Eye-opener. Not recommended as a standalone screening tool.

Signup and view all the flashcards

Positive Screening Follow-up

Once a patient screens positive, further assessment and intervention are necessary.

Signup and view all the flashcards

AUDIT

Identifies the frequency, and quantity of alcohol consumption.

Signup and view all the flashcards

Study Notes

  • Substance Use Disorders covered in Clinical Medicine II, Spring 2025

Objectives for Studying Substance Use Disorders:

  • Summarize primary care management concepts for chronic pain patients.
  • Outline opioid prescribing risks and responsibilities.
  • Calculate MME (morphine milligram equivalents) and discuss its role in pharmacologic management of acute and chronic pain.
  • Explain how to evaluate risks for opiate-related harms and how to implement a risk reduction strategy.
  • Understand why avoiding opiates with benzodiazepines is important.
  • Learn how to diagnose and manage opioid use disorders and pharmacologic treatment options.
  • Learn how to diagnose and manage alcohol use disorder, noting screening tools, acute intoxication, and withdrawal.
  • Explain the general principles of psychosocial and pharmacological treatment of alcohol and other non-opiate substance use disorders.
  • Summarize harm reduction strategies for people with substance use disorders.

Terminology:

  • "People who use drugs" is preferred over "drug user/addict."
  • "Return to use" is preferred over "relapse."
  • "Urine drug screen, oral drug screen" is preferred over "drug test, UA."
  • "Substance use disorder" is preferred over "chemical dependency."
  • "Recovery" is preferred over "sobriety."
  • "Misuse, inappropriate use" is preferred over "abuse."
  • "Negative, positive, substance free, appropriate" are preferred over "urine clean/dirty."
  • "Substance use disorder" is preferred over "habit."
  • "Person with alcohol use disorder" is preferred over "alcoholic."
  • "Substance use disorder" is preferred over "drug problem."
  • "Actively not using, in recovery" is preferred over "clean/sober."
  • "Actively using" is preferred over "dirty."
  • "Person in recovery" is preferred over "former addict."

History of Opioid Use:

  • In the 1990s, there was a big push by pharmaceutical companies to consider "pain as the fifth vital sign."
  • Drug companies marketed and promoted opioids while minimizing the risks.
  • In July 2021, a $26 billion multistate settlement agreement was reached.
  • Minnesota will receive $300 million over the next 18 years from this settlement.

Epidemiology of Opiate Misuse:

  • The rate of opiate prescription misuse among patients receiving treatment for chronic pain is 21%-29%.
  • In 2021, 40 million people reported using illicit drugs.
  • Prescription pain medication misuse continued to be second only to marijuana for illicit drug use.

2022 CDC Guidelines for Prescribing Opioids:

  • Address whether or not to initiate opioids for pain.
  • Address which opioids and dosages should be selected.
  • Address the duration of the initial prescription and follow-up care
  • Address assessment of risk and potential harms of opioid use.
  • For maximizing non-opioid therapy over opioids is recommended, discuss the risk vs benefit
  • Short-acting drugs over long-acting for acute pain and using the lowest dose possible is recommended
  • Tapering recommended at 10% a month or as tolerated, not doing so abrubtly
  • PDMP check before every prescription, caution with opioids and discuss treatment options for withdrawls

Responsibilities of Opioid Prescribing:

  • Prescription drug monitoring programs.
  • Informed consent.
  • Treatment agreements.
  • Collaboration with teams of pain specialists, addiction specialists, mental health, and pharmacists.
  • morphine milligram equivalents Efforts (MMEs) aid in standardizing opioid doses compared to morphine

Opioid Use Disorder:

  • Opiates are derived from opium, including heroin, morphine, and codeine.
  • Opioids include opiates and other synthetic opioids like fentanyl and oxycodone.
  • Fentanyl is available by prescription and IV (surgery) but is also made synthetically.
  • Common forms of fentanyl include Perc30s, The blues, Fetty and Tranq
  • Fentanyl can be used by smoking (straw and foil), IN and injection

Opioid Pathophysiology:

  • There are Mu, kappa, and delta opioid receptors.
  • Mu receptors mediate analgesia, physical dependence, respiratory depression, gastrointestinal dysmotility, and euphoria
  • Low response in hypercarbia, decrease in hypoxia, and decreased response to decreased stimulus to breath and development of apnea
  • Kappa receptors mediate: analgesia, diuresis, miosis, and dysphoria
  • Delta receptors mediate: cough suppression, analgesia and inhibition of Dopamine

Opioid Intoxication:

  • Constricted pupils.
  • Respiratory distress.
  • Confusion/disorientation.
  • Somnolence.
  • Constipation.

Opioid Withdrawal:

  • Spontaneous withdrawal occurs when a physiologically dependent patient reduces or stops opioid use abruptly.
  • Precipitated withdrawal can occur when an opioid antagonist or partial agonist is administered to a physiologically dependent patient

Treating Opioid Use Disorders:

  • Methadone:
    • Full opioid agonist.
    • Long half-life (8-59 hours, average 24 hours.)
    • Dispensed in methadone clinics or hospitals.
    • The patient does not need health insurance
    • Formulations include liquid for OUD and tablets for pain.
    • No maximum dose needs to be titrated
    • The patient doesn't need to wait for withdrawal to start
    • Need to go to OTP “Methadone Clinic", starts with daily dosing
    • There is high risk for overdose as a full agonist
  • Buprenorphine:
    • Partial opioid agonist.
    • High affinity at the Mu Receptor
    • The patient can start treatment today in the clinic
    • Formulations include sublingual tablets, films, injectable depot, and buccal films.
    • It will be mixed with naloxone unless tampered or misused, otherwise it is just deterrent for diversion
    • Doses are generally 2-0.5mg, 4-1mg, 8-2mg, 12-3mg, typical dose is 8-2mg BID to TID
    • Can assess COWS Score. If >8, can start buprenorphine, if still experiencing withdrawals throughout day, could give additional 8-16mg later in day for 1-3 days
  • May start full agonist opioid as well
    • Check up on withdrawal.
    • Full agonism leads to partical agonism causing withdrawal
  • Naltrexone:
    • Opioid antagonist.
    • Oral and IM monthly formulations.

Adjunctive Therapies for Opioid Withdrawal:

  • Clonidine for anxiety and restlessness.
  • Hydroxyzine for anxiety.
  • Ondansetron for nausea.
  • Tylenol/ibuprofen for body aches.
  • Gabapentin for body aches and anxiety.
  • Olanzapine for agitation.
  • Lorazepam for severe anxiety/agitation.

Additional Workup Considerations:

  • Infectious disease screening for HIV and Hep C.
  • Consider STI screening.
  • Urine pregnancy test.

Diagnosing Opioid Use Disorder (DSM-V Criteria):

  • The DSM-V criteria for opioid use disorder includes impaired control, social impairment, risky use, and pharmacological criteria for alcohol/substance use.
    • Impaired Control: Substance taken in larger amounts or for longer than intended, persistent desire or unsuccessful efforts to cut down, time spent obtaining/using/recovering from substance, craving
    • Social Impairment: Failure to fulfill major obligations, use despite social/interpersonal problems, giving up important activities
    • Risky Use: Recurrent use in hazardous situations & despite knowledge of physical/psychological problems
    • Pharmacological Criteria: Tolerance or withdrawal
  • These two criteria alone don't equal OUD
  • Severity is determined by the number of criteria met: 2-3 (mild), 4-5 (moderate), 6+ (severe).

Alcohol Use - Epidemiology:

  • In 2022, 29.5 million people ages 12 and older had AUD in the past year (10.5% of the population).
  • Age of first use
  • First use history
  • Adulthood adverse events

Screening Recomendations by USPSTF:

  • NIAAA Single Alcohol Screening Question (SASQ): How many times in the past year have you had (4 for women, 5 for men) or more drinks in a day?
  • Response of one or more warrants follow-up with easier integration into clinical conversations.
  • Avoid CAGE since It only captures patients already experiencing adverse consequences
  • Alcohol Use Disorders Identification Test-Consumption (AUDIT-C)
    • How often you drink containing alcohol this year?
    • How many drinks are you typically having on a typical day when you drink?
    • How often did you have six or more drinks this year?

Additional Recommendations

  • If they have AUD (alcohol use disorder), assess for withdrawl
  • Assess history of seizures and complicated withdrawl
  • Assess daily alcohol use 2-3 weeks beforehand

Alcohol Withdrawl Pathophysiology:

  • GABA is an inhibitory neurotransmitter that stop when enhanced, and Glutamate is an excitatory amino acid when inhibited absorption
  • Constant presence of ethanol preserves homeostasis between the two and the abrupt cessation unmasks adaptive to resulting overactivity of CNS

Alchohol Withdrawl Manifestations:

  • Insomnia, tremors, anxiety, nausea/vomiting, anorexia, headache, diaphoresis, palpitations
  • Manifest soon 6 hours after cessation, Usually peaks 12-48 hours and resolves within 48-72 hours

Severe Manifestations

  • Seizures for 12-48 hours after last drink for folks with chronic seizures
  • Hallucinations 12-24 hours after last drink mostly visual

Alcohol Use Disorder - Treatment:

  • Benzodiazepines (IV)
  • Phenobarbitals
  • Disulfiram and naltrexone (PO)
  • Give dose treatment based on CIWA Scale
  • Give naltrexone 50mgs for first line treatment that work downstream on dopaming to “Blunts “reward” after drinking
  • Give Acamprosate TID, 666mgs Work at glutamate/NMDA receptors and CCBs but is beneficial if already abstinent
  • Give Gabapentin, inhibits alpha-2 unit of CCBs, decreasing abnormal excitement of brain

Other Substances and Treatment:

  • Cocaine
  • Meth
  • Adderall

Symptoms of Stimulants

  • Hyperfocus
  • Cardiac arrest and arrest
  • Meth eyes

Treatment Options:

  • CBT (cognitive behavioral therapy)
  • Contingency Management
  • Access to food and shelter
  • Naltrexone

Other Substances that need a Harm Reduction Approach

  • Psychedelics-Shrooms
  • Kratom-stimulant
  • GHB- chems drug
  • LSD and PCP

Harm Reduction

  • Fentanyl strips
  • Clear needles
  • Narcan and Naloxone will save lives.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

More Like This

Untitled
110 questions

Untitled

ComfortingAquamarine avatar
ComfortingAquamarine
Untitled Quiz
6 questions

Untitled Quiz

AdoredHealing avatar
AdoredHealing
Untitled
6 questions

Untitled

StrikingParadise avatar
StrikingParadise
Untitled Quiz
18 questions

Untitled Quiz

RighteousIguana avatar
RighteousIguana
Use Quizgecko on...
Browser
Browser