Podcast
Questions and Answers
According to the 2021 National Survey on Drug Use and Health, which substance was most commonly misused?
According to the 2021 National Survey on Drug Use and Health, which substance was most commonly misused?
- Prescription pain medication
- Alcohol
- Cocaine
- Marijuana (correct)
According to the CDC's 2022 Clinical Practice Guidelines for Prescribing Opioids, what is the preferred type of opioid for acute pain?
According to the CDC's 2022 Clinical Practice Guidelines for Prescribing Opioids, what is the preferred type of opioid for acute pain?
- Combination opioids containing acetaminophen
- Any opioid type, as long as the patient is closely monitored
- Long-acting (XR) opioids at the highest effective dose
- Short-acting (IR) opioids at the lowest effective dose (correct)
According to the CDC's 2022 Clinical Practice Guidelines for Prescribing Opioids, what is the recommended rate for tapering opioids when discontinuing them?
According to the CDC's 2022 Clinical Practice Guidelines for Prescribing Opioids, what is the recommended rate for tapering opioids when discontinuing them?
- Taper by 50% per week
- Taper by 10% per month, or as the patient tolerates (correct)
- Taper by 25% per week
- Abruptly stop the medication
Before prescribing opioids, what does the CDC recommend to check?
Before prescribing opioids, what does the CDC recommend to check?
Which of the following is NOT typically a responsibility of opioid prescribing?
Which of the following is NOT typically a responsibility of opioid prescribing?
Why are Morphine Milligram Equivalents (MMEs) used in opioid prescribing?
Why are Morphine Milligram Equivalents (MMEs) used in opioid prescribing?
According to the information provided, what is the primary goal when determining whether or not to initiate opioids for pain?
According to the information provided, what is the primary goal when determining whether or not to initiate opioids for pain?
A patient is administered a medication that binds to opioid receptors, preventing the binding of other substances and reversing the effects of opioids. Which type of drug is this patient most likely given?
A patient is administered a medication that binds to opioid receptors, preventing the binding of other substances and reversing the effects of opioids. Which type of drug is this patient most likely given?
A patient who is physiologically dependent on opioids abruptly stops using them. Which type of opioid withdrawal is this patient most likely experiencing?
A patient who is physiologically dependent on opioids abruptly stops using them. Which type of opioid withdrawal is this patient most likely experiencing?
A patient who is physiologically dependent on opioids and has opioids in their system is administered naloxone. Which type of opioid withdrawal is this patient most likely experiencing?
A patient who is physiologically dependent on opioids and has opioids in their system is administered naloxone. Which type of opioid withdrawal is this patient most likely experiencing?
Which set of symptoms is most indicative of opioid intoxication?
Which set of symptoms is most indicative of opioid intoxication?
A 21-year-old female presents with nausea, vomiting, body aches, sweating, fatigue, chills, constant yawning, and irritability. She initially denies drug use but later admits to daily use of pressed fentanyl pills. What is the most likely cause of her symptoms?
A 21-year-old female presents with nausea, vomiting, body aches, sweating, fatigue, chills, constant yawning, and irritability. She initially denies drug use but later admits to daily use of pressed fentanyl pills. What is the most likely cause of her symptoms?
A patient with a known history of opioid dependence is prescribed buprenorphine. What is the primary mechanism by which buprenorphine can precipitate withdrawal symptoms?
A patient with a known history of opioid dependence is prescribed buprenorphine. What is the primary mechanism by which buprenorphine can precipitate withdrawal symptoms?
A patient undergoing opioid withdrawal is experiencing severe gastrointestinal distress. Which of the following physiological mechanisms is least likely to contribute to this symptom?
A patient undergoing opioid withdrawal is experiencing severe gastrointestinal distress. Which of the following physiological mechanisms is least likely to contribute to this symptom?
Which of the following statements most accurately describes the difference between opioid tolerance and opioid dependence?
Which of the following statements most accurately describes the difference between opioid tolerance and opioid dependence?
Considering the patient's escalating fentanyl use to maintain normalcy and prevent withdrawal, which neurobiological adaptation is most likely occurring in her brain?
Considering the patient's escalating fentanyl use to maintain normalcy and prevent withdrawal, which neurobiological adaptation is most likely occurring in her brain?
The patient is concerned about failing a urine drug screen during her clinical rotations. Given her reported fentanyl use, what is the most appropriate and sensitive method to confirm fentanyl use?
The patient is concerned about failing a urine drug screen during her clinical rotations. Given her reported fentanyl use, what is the most appropriate and sensitive method to confirm fentanyl use?
Considering the patient's expressed desire to stop using fentanyl due to concerns about her medical school career, which of the following would be the MOST appropriate initial treatment strategy?
Considering the patient's expressed desire to stop using fentanyl due to concerns about her medical school career, which of the following would be the MOST appropriate initial treatment strategy?
The patient admits to using fentanyl in class to prevent withdrawal symptoms. From an ethical perspective, which principle is MOST compromised by this behavior?
The patient admits to using fentanyl in class to prevent withdrawal symptoms. From an ethical perspective, which principle is MOST compromised by this behavior?
Which of the following best represents the DSM-5 criteria met by the patient that would determine a diagnosis of Opioid Use Disorder?
Which of the following best represents the DSM-5 criteria met by the patient that would determine a diagnosis of Opioid Use Disorder?
What is the MOST crucial next step in assessing this patient after establishing a diagnosis of Opioid Use Disorder?
What is the MOST crucial next step in assessing this patient after establishing a diagnosis of Opioid Use Disorder?
The patient's mother expresses concerns about her daughter's increased withdrawal from the family. Which of the following strategies would be MOST effective in involving the family in the patient's treatment?
The patient's mother expresses concerns about her daughter's increased withdrawal from the family. Which of the following strategies would be MOST effective in involving the family in the patient's treatment?
Given that the patient has experimented with IV fentanyl use, what harm reduction strategy is MOST critical to address immediately?
Given that the patient has experimented with IV fentanyl use, what harm reduction strategy is MOST critical to address immediately?
A patient is experiencing opioid withdrawal symptoms and is considering buprenorphine induction in an outpatient setting. What strategy minimizes the risk of precipitated withdrawal?
A patient is experiencing opioid withdrawal symptoms and is considering buprenorphine induction in an outpatient setting. What strategy minimizes the risk of precipitated withdrawal?
Which of the following statements accurately compares methadone and buprenorphine regarding their accessibility and risk of overdose?
Which of the following statements accurately compares methadone and buprenorphine regarding their accessibility and risk of overdose?
A patient with a history of opioid use disorder is interested in starting naltrexone. What is the most critical consideration before initiating naltrexone therapy?
A patient with a history of opioid use disorder is interested in starting naltrexone. What is the most critical consideration before initiating naltrexone therapy?
A patient reports experiencing significant anxiety and restlessness during opioid withdrawal. Which adjunctive medication would be the MOST effective first-line treatment for these specific symptoms?
A patient reports experiencing significant anxiety and restlessness during opioid withdrawal. Which adjunctive medication would be the MOST effective first-line treatment for these specific symptoms?
When initiating medication-assisted treatment for opioid use disorder, which factor most significantly influences the choice between methadone, buprenorphine, and naltrexone?
When initiating medication-assisted treatment for opioid use disorder, which factor most significantly influences the choice between methadone, buprenorphine, and naltrexone?
A patient is undergoing buprenorphine induction and reports feeling worse despite dose adjustments. They exhibit increased withdrawal symptoms. What is the most likely explanation for this?
A patient is undergoing buprenorphine induction and reports feeling worse despite dose adjustments. They exhibit increased withdrawal symptoms. What is the most likely explanation for this?
A patient with opioid use disorder is being discharged from inpatient treatment. What is the most significant advantage of prescribing IM naltrexone over oral naltrexone in this scenario?
A patient with opioid use disorder is being discharged from inpatient treatment. What is the most significant advantage of prescribing IM naltrexone over oral naltrexone in this scenario?
What is the primary mechanism by which naltrexone prevents overdose?
What is the primary mechanism by which naltrexone prevents overdose?
Which of the following factors contribute significantly to an individual's risk of developing a substance use disorder?
Which of the following factors contribute significantly to an individual's risk of developing a substance use disorder?
Why is the CAGE questionnaire not recommended as a sole screening tool for alcohol use disorder in primary care settings?
Why is the CAGE questionnaire not recommended as a sole screening tool for alcohol use disorder in primary care settings?
In a busy primary care clinic, what is the primary advantage of using the NIAAA Single Alcohol Screening Question (SASQ) over other screening tools like AUDIT-C?
In a busy primary care clinic, what is the primary advantage of using the NIAAA Single Alcohol Screening Question (SASQ) over other screening tools like AUDIT-C?
According to the provided data, approximately what percentage of the United States population aged 12 and older experienced Alcohol Use Disorder (AUD) in the past year?
According to the provided data, approximately what percentage of the United States population aged 12 and older experienced Alcohol Use Disorder (AUD) in the past year?
A 30-year-old male patient reports consuming 6-8 alcoholic beverages every night to help him sleep. He denies any negative consequences but expresses concern about potential long-term health effects. Which screening tool is MOST appropriate?
A 30-year-old male patient reports consuming 6-8 alcoholic beverages every night to help him sleep. He denies any negative consequences but expresses concern about potential long-term health effects. Which screening tool is MOST appropriate?
A researcher is designing a study to identify risk factors for alcohol use disorder in adolescents. Which combination of factors would provide the strongest predictive value?
A researcher is designing a study to identify risk factors for alcohol use disorder in adolescents. Which combination of factors would provide the strongest predictive value?
A primary care physician is implementing routine alcohol screening in their practice. Which strategy would be MOST effective in ensuring the screening process is both efficient and comprehensive?
A primary care physician is implementing routine alcohol screening in their practice. Which strategy would be MOST effective in ensuring the screening process is both efficient and comprehensive?
During a clinical interview, a patient minimizes their alcohol consumption, stating they only drink 'socially' on weekends. However, their medical history reveals elevated liver enzymes and frequent emergency room visits for minor injuries. Which screening approach is MOST justified?
During a clinical interview, a patient minimizes their alcohol consumption, stating they only drink 'socially' on weekends. However, their medical history reveals elevated liver enzymes and frequent emergency room visits for minor injuries. Which screening approach is MOST justified?
A patient presents with vital signs indicative of tachycardia, hypertension, and hyperthermia, alongside physical findings of mydriasis, diaphoresis, piloerection, and tremors. Considering these signs and symptoms in the context of substance use disorders, which of the following is the MOST likely underlying physiological process?
A patient presents with vital signs indicative of tachycardia, hypertension, and hyperthermia, alongside physical findings of mydriasis, diaphoresis, piloerection, and tremors. Considering these signs and symptoms in the context of substance use disorders, which of the following is the MOST likely underlying physiological process?
Methadone maintenance therapy (MMT) is subject to specific regulations due to its pharmacological profile and potential for misuse. Which of the following statements BEST describes a primary regulatory consideration that differentiates methadone dispensing from buprenorphine dispensing in the treatment of Opioid Use Disorder (OUD)?
Methadone maintenance therapy (MMT) is subject to specific regulations due to its pharmacological profile and potential for misuse. Which of the following statements BEST describes a primary regulatory consideration that differentiates methadone dispensing from buprenorphine dispensing in the treatment of Opioid Use Disorder (OUD)?
Considering the pharmacological differences between methadone and buprenorphine in the treatment of Opioid Use Disorder (OUD), which statement accurately contrasts their receptor binding profiles and resulting clinical implications?
Considering the pharmacological differences between methadone and buprenorphine in the treatment of Opioid Use Disorder (OUD), which statement accurately contrasts their receptor binding profiles and resulting clinical implications?
A patient with Opioid Use Disorder (OUD) is being considered for buprenorphine treatment. Given the available formulations of buprenorphine, which of the following is MOST appropriate for initiating outpatient treatment in a setting where diversion and misuse are significant concerns within the patient's community?
A patient with Opioid Use Disorder (OUD) is being considered for buprenorphine treatment. Given the available formulations of buprenorphine, which of the following is MOST appropriate for initiating outpatient treatment in a setting where diversion and misuse are significant concerns within the patient's community?
In the context of Medication for Opioid Use Disorder (MOUD), the inclusion of naloxone in combination with buprenorphine (e.g., Suboxone) serves a specific purpose related to harm reduction. Which of the following BEST describes the primary rationale for incorporating naloxone in this formulation?
In the context of Medication for Opioid Use Disorder (MOUD), the inclusion of naloxone in combination with buprenorphine (e.g., Suboxone) serves a specific purpose related to harm reduction. Which of the following BEST describes the primary rationale for incorporating naloxone in this formulation?
A patient is initiated on methadone for Opioid Use Disorder (OUD) at an Opioid Treatment Program (OTP). When counseling this patient about methadone, which of the following statements is MOST critical to emphasize regarding the medication's risk profile?
A patient is initiated on methadone for Opioid Use Disorder (OUD) at an Opioid Treatment Program (OTP). When counseling this patient about methadone, which of the following statements is MOST critical to emphasize regarding the medication's risk profile?
A clinician is initiating buprenorphine treatment for a patient with Opioid Use Disorder (OUD) in an outpatient setting. To determine the appropriate timing for buprenorphine induction, which of the following assessment tools is MOST crucial to employ and interpret?
A clinician is initiating buprenorphine treatment for a patient with Opioid Use Disorder (OUD) in an outpatient setting. To determine the appropriate timing for buprenorphine induction, which of the following assessment tools is MOST crucial to employ and interpret?
For a patient with chronic pain and co-occurring Opioid Use Disorder (OUD) who requires long-term opioid agonist therapy, which buprenorphine formulation would be LEAST suitable due to its primary indication and route of administration?
For a patient with chronic pain and co-occurring Opioid Use Disorder (OUD) who requires long-term opioid agonist therapy, which buprenorphine formulation would be LEAST suitable due to its primary indication and route of administration?
What is the primary difference between opioids and opiates?
What is the primary difference between opioids and opiates?
What is the primary function of mu receptors in the body?
What is the primary function of mu receptors in the body?
Which of the following are signs of opioid intoxication? (Select all that apply)
Which of the following are signs of opioid intoxication? (Select all that apply)
Which of the following are key findings of opiate withdrawal? (Select all that apply)
Which of the following are key findings of opiate withdrawal? (Select all that apply)
What is the mechanism of action (MOA) of Methadone?
What is the mechanism of action (MOA) of Methadone?
What is one of the most effective adjunctive therapies for opioid withdrawal?
What is one of the most effective adjunctive therapies for opioid withdrawal?
Alcohol works on what receptors? (Select all that apply)
Alcohol works on what receptors? (Select all that apply)
Delirium Tremens is defined as:
Delirium Tremens is defined as:
Which of the following are treatment options for alcohol withdrawal management? (Select all that apply)
Which of the following are treatment options for alcohol withdrawal management? (Select all that apply)
Flashcards
Opiate Misuse Rate
Opiate Misuse Rate
Rate of opiate misuse among chronic pain patients in treatment.
Opioid Initiation: First Step
Opioid Initiation: First Step
Maximize non-opioid therapy first, and discuss risk vs benefit.
Opioid Selection for Acute Pain
Opioid Selection for Acute Pain
Prefer short-acting (IR) over long-acting (XR) for acute pain, using the lowest possible dose.
Opioid Tapering
Opioid Tapering
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PDMP Checks
PDMP Checks
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PDMP Meaning
PDMP Meaning
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MME Meaning
MME Meaning
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Opioid Prescribing Responsibilities
Opioid Prescribing Responsibilities
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Agonist
Agonist
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Antagonist
Antagonist
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Opioid Intoxication Signs
Opioid Intoxication Signs
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Spontaneous Opioid Withdrawal
Spontaneous Opioid Withdrawal
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Precipitated Opioid Withdrawal
Precipitated Opioid Withdrawal
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Opioid Withdrawal Symptoms
Opioid Withdrawal Symptoms
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Opioid Tolerance
Opioid Tolerance
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Opioid Dependence
Opioid Dependence
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Opioid Use Disorder (OUD)
Opioid Use Disorder (OUD)
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OUD Severity
OUD Severity
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Opioid Withdrawal
Opioid Withdrawal
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Common Opioid Withdrawal Symptoms
Common Opioid Withdrawal Symptoms
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Using to Avoid Withdrawal
Using to Avoid Withdrawal
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Increased Dosage
Increased Dosage
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Initial Denial of Substance Use
Initial Denial of Substance Use
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Progression of OUD
Progression of OUD
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Clonidine Use
Clonidine Use
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Naltrexone & Withdrawal
Naltrexone & Withdrawal
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Naltrexone Function
Naltrexone Function
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Methadone Initiation
Methadone Initiation
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Buprenorphine Initiation
Buprenorphine Initiation
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Naltrexone Initiation
Naltrexone Initiation
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Naltrexone
Naltrexone
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Infectious Disease Screening
Infectious Disease Screening
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MOUD Definition
MOUD Definition
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Methadone
Methadone
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Methadone Formulations
Methadone Formulations
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Buprenorphine
Buprenorphine
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Buprenorphine Formulations
Buprenorphine Formulations
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Buprenorphine vs Buprenorphine-Naloxone
Buprenorphine vs Buprenorphine-Naloxone
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Buprenorphine Dosages
Buprenorphine Dosages
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COWS Score
COWS Score
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Alcohol Use Disorder (AUD)
Alcohol Use Disorder (AUD)
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AUD Prevalence (2022)
AUD Prevalence (2022)
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Risk Factors for Use Disorder
Risk Factors for Use Disorder
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NIAAA Single Alcohol Screening Question (SASQ)
NIAAA Single Alcohol Screening Question (SASQ)
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AUDIT-C
AUDIT-C
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CAGE
CAGE
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Positive Screening Follow-up
Positive Screening Follow-up
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AUDIT
AUDIT
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Study Notes
- Substance Use Disorders covered in Clinical Medicine II, Spring 2025
Objectives for Studying Substance Use Disorders:
- Summarize primary care management concepts for chronic pain patients.
- Outline opioid prescribing risks and responsibilities.
- Calculate MME (morphine milligram equivalents) and discuss its role in pharmacologic management of acute and chronic pain.
- Explain how to evaluate risks for opiate-related harms and how to implement a risk reduction strategy.
- Understand why avoiding opiates with benzodiazepines is important.
- Learn how to diagnose and manage opioid use disorders and pharmacologic treatment options.
- Learn how to diagnose and manage alcohol use disorder, noting screening tools, acute intoxication, and withdrawal.
- Explain the general principles of psychosocial and pharmacological treatment of alcohol and other non-opiate substance use disorders.
- Summarize harm reduction strategies for people with substance use disorders.
Terminology:
- "People who use drugs" is preferred over "drug user/addict."
- "Return to use" is preferred over "relapse."
- "Urine drug screen, oral drug screen" is preferred over "drug test, UA."
- "Substance use disorder" is preferred over "chemical dependency."
- "Recovery" is preferred over "sobriety."
- "Misuse, inappropriate use" is preferred over "abuse."
- "Negative, positive, substance free, appropriate" are preferred over "urine clean/dirty."
- "Substance use disorder" is preferred over "habit."
- "Person with alcohol use disorder" is preferred over "alcoholic."
- "Substance use disorder" is preferred over "drug problem."
- "Actively not using, in recovery" is preferred over "clean/sober."
- "Actively using" is preferred over "dirty."
- "Person in recovery" is preferred over "former addict."
History of Opioid Use:
- In the 1990s, there was a big push by pharmaceutical companies to consider "pain as the fifth vital sign."
- Drug companies marketed and promoted opioids while minimizing the risks.
- In July 2021, a $26 billion multistate settlement agreement was reached.
- Minnesota will receive $300 million over the next 18 years from this settlement.
Epidemiology of Opiate Misuse:
- The rate of opiate prescription misuse among patients receiving treatment for chronic pain is 21%-29%.
- In 2021, 40 million people reported using illicit drugs.
- Prescription pain medication misuse continued to be second only to marijuana for illicit drug use.
2022 CDC Guidelines for Prescribing Opioids:
- Address whether or not to initiate opioids for pain.
- Address which opioids and dosages should be selected.
- Address the duration of the initial prescription and follow-up care
- Address assessment of risk and potential harms of opioid use.
- For maximizing non-opioid therapy over opioids is recommended, discuss the risk vs benefit
- Short-acting drugs over long-acting for acute pain and using the lowest dose possible is recommended
- Tapering recommended at 10% a month or as tolerated, not doing so abrubtly
- PDMP check before every prescription, caution with opioids and discuss treatment options for withdrawls
Responsibilities of Opioid Prescribing:
- Prescription drug monitoring programs.
- Informed consent.
- Treatment agreements.
- Collaboration with teams of pain specialists, addiction specialists, mental health, and pharmacists.
- morphine milligram equivalents Efforts (MMEs) aid in standardizing opioid doses compared to morphine
Opioid Use Disorder:
- Opiates are derived from opium, including heroin, morphine, and codeine.
- Opioids include opiates and other synthetic opioids like fentanyl and oxycodone.
- Fentanyl is available by prescription and IV (surgery) but is also made synthetically.
- Common forms of fentanyl include Perc30s, The blues, Fetty and Tranq
- Fentanyl can be used by smoking (straw and foil), IN and injection
Opioid Pathophysiology:
- There are Mu, kappa, and delta opioid receptors.
- Mu receptors mediate analgesia, physical dependence, respiratory depression, gastrointestinal dysmotility, and euphoria
- Low response in hypercarbia, decrease in hypoxia, and decreased response to decreased stimulus to breath and development of apnea
- Kappa receptors mediate: analgesia, diuresis, miosis, and dysphoria
- Delta receptors mediate: cough suppression, analgesia and inhibition of Dopamine
Opioid Intoxication:
- Constricted pupils.
- Respiratory distress.
- Confusion/disorientation.
- Somnolence.
- Constipation.
Opioid Withdrawal:
- Spontaneous withdrawal occurs when a physiologically dependent patient reduces or stops opioid use abruptly.
- Precipitated withdrawal can occur when an opioid antagonist or partial agonist is administered to a physiologically dependent patient
Treating Opioid Use Disorders:
- Methadone:
- Full opioid agonist.
- Long half-life (8-59 hours, average 24 hours.)
- Dispensed in methadone clinics or hospitals.
- The patient does not need health insurance
- Formulations include liquid for OUD and tablets for pain.
- No maximum dose needs to be titrated
- The patient doesn't need to wait for withdrawal to start
- Need to go to OTP “Methadone Clinic", starts with daily dosing
- There is high risk for overdose as a full agonist
- Buprenorphine:
- Partial opioid agonist.
- High affinity at the Mu Receptor
- The patient can start treatment today in the clinic
- Formulations include sublingual tablets, films, injectable depot, and buccal films.
- It will be mixed with naloxone unless tampered or misused, otherwise it is just deterrent for diversion
- Doses are generally 2-0.5mg, 4-1mg, 8-2mg, 12-3mg, typical dose is 8-2mg BID to TID
- Can assess COWS Score. If >8, can start buprenorphine, if still experiencing withdrawals throughout day, could give additional 8-16mg later in day for 1-3 days
- May start full agonist opioid as well
- Check up on withdrawal.
- Full agonism leads to partical agonism causing withdrawal
- Naltrexone:
- Opioid antagonist.
- Oral and IM monthly formulations.
Adjunctive Therapies for Opioid Withdrawal:
- Clonidine for anxiety and restlessness.
- Hydroxyzine for anxiety.
- Ondansetron for nausea.
- Tylenol/ibuprofen for body aches.
- Gabapentin for body aches and anxiety.
- Olanzapine for agitation.
- Lorazepam for severe anxiety/agitation.
Additional Workup Considerations:
- Infectious disease screening for HIV and Hep C.
- Consider STI screening.
- Urine pregnancy test.
Diagnosing Opioid Use Disorder (DSM-V Criteria):
- The DSM-V criteria for opioid use disorder includes impaired control, social impairment, risky use, and pharmacological criteria for alcohol/substance use.
- Impaired Control: Substance taken in larger amounts or for longer than intended, persistent desire or unsuccessful efforts to cut down, time spent obtaining/using/recovering from substance, craving
- Social Impairment: Failure to fulfill major obligations, use despite social/interpersonal problems, giving up important activities
- Risky Use: Recurrent use in hazardous situations & despite knowledge of physical/psychological problems
- Pharmacological Criteria: Tolerance or withdrawal
- These two criteria alone don't equal OUD
- Severity is determined by the number of criteria met: 2-3 (mild), 4-5 (moderate), 6+ (severe).
Alcohol Use - Epidemiology:
- In 2022, 29.5 million people ages 12 and older had AUD in the past year (10.5% of the population).
- Age of first use
- First use history
- Adulthood adverse events
Screening Recomendations by USPSTF:
- NIAAA Single Alcohol Screening Question (SASQ): How many times in the past year have you had (4 for women, 5 for men) or more drinks in a day?
- Response of one or more warrants follow-up with easier integration into clinical conversations.
- Avoid CAGE since It only captures patients already experiencing adverse consequences
- Alcohol Use Disorders Identification Test-Consumption (AUDIT-C)
- How often you drink containing alcohol this year?
- How many drinks are you typically having on a typical day when you drink?
- How often did you have six or more drinks this year?
Additional Recommendations
- If they have AUD (alcohol use disorder), assess for withdrawl
- Assess history of seizures and complicated withdrawl
- Assess daily alcohol use 2-3 weeks beforehand
Alcohol Withdrawl Pathophysiology:
- GABA is an inhibitory neurotransmitter that stop when enhanced, and Glutamate is an excitatory amino acid when inhibited absorption
- Constant presence of ethanol preserves homeostasis between the two and the abrupt cessation unmasks adaptive to resulting overactivity of CNS
Alchohol Withdrawl Manifestations:
- Insomnia, tremors, anxiety, nausea/vomiting, anorexia, headache, diaphoresis, palpitations
- Manifest soon 6 hours after cessation, Usually peaks 12-48 hours and resolves within 48-72 hours
Severe Manifestations
- Seizures for 12-48 hours after last drink for folks with chronic seizures
- Hallucinations 12-24 hours after last drink mostly visual
Alcohol Use Disorder - Treatment:
- Benzodiazepines (IV)
- Phenobarbitals
- Disulfiram and naltrexone (PO)
- Give dose treatment based on CIWA Scale
- Give naltrexone 50mgs for first line treatment that work downstream on dopaming to “Blunts “reward” after drinking
- Give Acamprosate TID, 666mgs Work at glutamate/NMDA receptors and CCBs but is beneficial if already abstinent
- Give Gabapentin, inhibits alpha-2 unit of CCBs, decreasing abnormal excitement of brain
Other Substances and Treatment:
- Cocaine
- Meth
- Adderall
Symptoms of Stimulants
- Hyperfocus
- Cardiac arrest and arrest
- Meth eyes
Treatment Options:
- CBT (cognitive behavioral therapy)
- Contingency Management
- Access to food and shelter
- Naltrexone
Other Substances that need a Harm Reduction Approach
- Psychedelics-Shrooms
- Kratom-stimulant
- GHB- chems drug
- LSD and PCP
Harm Reduction
- Fentanyl strips
- Clear needles
- Narcan and Naloxone will save lives.
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