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Questions and Answers
What is the primary function of the plasma membrane?
What is the primary function of the plasma membrane?
- To facilitate chemical reactions
- To control traffic into and out of the cell (correct)
- To store genetic information
- To produce energy for the cell
Which statement best describes the Fluid Mosaic Model?
Which statement best describes the Fluid Mosaic Model?
- The membrane consists of a uniform layer of phospholipids only.
- The membrane is static and does not allow for movement.
- The membrane is a mosaic of proteins embedded in a fluid bilayer. (correct)
- The membrane is a rigid structure with fixed proteins.
What are phospholipids primarily known for in the plasma membrane?
What are phospholipids primarily known for in the plasma membrane?
- Serving as receptors for signaling molecules
- Being the most abundant lipid in the membrane (correct)
- Facilitating active transport across the membrane
- Providing structural stability
Which of the following mechanisms does NOT contribute to selective permeability of the plasma membrane?
Which of the following mechanisms does NOT contribute to selective permeability of the plasma membrane?
What is a characteristic feature of membrane proteins?
What is a characteristic feature of membrane proteins?
How do hydrophobic interactions contribute to plasma membrane structure?
How do hydrophobic interactions contribute to plasma membrane structure?
Which component of the plasma membrane is responsible for selective transport of molecules?
Which component of the plasma membrane is responsible for selective transport of molecules?
What effect do temperature changes have on membrane fluidity?
What effect do temperature changes have on membrane fluidity?
What role do membrane carbohydrates play in cell recognition?
What role do membrane carbohydrates play in cell recognition?
Which of the following best describes glycoproteins?
Which of the following best describes glycoproteins?
What mechanism is involved in the rejection of foreign cells by the immune system?
What mechanism is involved in the rejection of foreign cells by the immune system?
Which statement is true about gap junctions?
Which statement is true about gap junctions?
What property of the cell membrane primarily limits the passage of many molecules?
What property of the cell membrane primarily limits the passage of many molecules?
How do large uncharged polar molecules generally cross the cell membrane?
How do large uncharged polar molecules generally cross the cell membrane?
What is the function of microfilaments in relation to membrane proteins?
What is the function of microfilaments in relation to membrane proteins?
What happens to a cell placed in a hypotonic solution?
What happens to a cell placed in a hypotonic solution?
Which of these is NOT a characteristic of cell-cell recognition?
Which of these is NOT a characteristic of cell-cell recognition?
In which type of solution does a cell maintain its volume without net movement of water?
In which type of solution does a cell maintain its volume without net movement of water?
What is the primary effect of placing a plant cell in a hypertonic solution?
What is the primary effect of placing a plant cell in a hypertonic solution?
What is the definition of tonicity?
What is the definition of tonicity?
What occurs when an animal cell is placed in an isotonic environment?
What occurs when an animal cell is placed in an isotonic environment?
What primarily happens to an animal cell in a hypertonic solution?
What primarily happens to an animal cell in a hypertonic solution?
How does a plant cell respond to a hypotonic environment?
How does a plant cell respond to a hypotonic environment?
What is the result of increasing salinity in a lake for animal cells?
What is the result of increasing salinity in a lake for animal cells?
What is the main function of transport proteins in facilitated diffusion?
What is the main function of transport proteins in facilitated diffusion?
Which type of transport protein provides specific passageways for molecules and ions?
Which type of transport protein provides specific passageways for molecules and ions?
How do aquaporins function in plant and animal cells?
How do aquaporins function in plant and animal cells?
What distinguishes gated ion channels from non-gated ion channels?
What distinguishes gated ion channels from non-gated ion channels?
Which stimulus can cause a gated ion channel to open or close?
Which stimulus can cause a gated ion channel to open or close?
Which characteristic is true of non-gated or leak channels?
Which characteristic is true of non-gated or leak channels?
What process is plasmolysis associated with in plant cells?
What process is plasmolysis associated with in plant cells?
What is the primary role of carrier proteins in facilitated diffusion?
What is the primary role of carrier proteins in facilitated diffusion?
What triggers the opening of mechanically-gated ion channels?
What triggers the opening of mechanically-gated ion channels?
What is the primary defect in the chloride channels of individuals with cystic fibrosis?
What is the primary defect in the chloride channels of individuals with cystic fibrosis?
What effect does the high concentration of intracellular Cl- have in cystic fibrosis?
What effect does the high concentration of intracellular Cl- have in cystic fibrosis?
Which of the following accurately describes the mechanism of carrier proteins?
Which of the following accurately describes the mechanism of carrier proteins?
What is the primary consequence of defective carrier proteins in cystinuria?
What is the primary consequence of defective carrier proteins in cystinuria?
What common complication arises from the accumulation of thick mucus in cystic fibrosis patients?
What common complication arises from the accumulation of thick mucus in cystic fibrosis patients?
How does extracellular Cl- contribute to mucus quality in cystic fibrosis?
How does extracellular Cl- contribute to mucus quality in cystic fibrosis?
What is a common symptom of cystinuria due to the accumulation of cystine?
What is a common symptom of cystinuria due to the accumulation of cystine?
What is the main purpose of active transport in cells?
What is the main purpose of active transport in cells?
Which of the following accurately describes the sodium-potassium pump?
Which of the following accurately describes the sodium-potassium pump?
What is generated across a membrane by an electrogenic pump?
What is generated across a membrane by an electrogenic pump?
Which component is crucial for the functioning of cotransport systems?
Which component is crucial for the functioning of cotransport systems?
What role does ATP play in active transport?
What role does ATP play in active transport?
What happens when the proton pump operates in plant cells?
What happens when the proton pump operates in plant cells?
What is a key benefit of having a high concentration of ions outside the cell in the context of cotransport?
What is a key benefit of having a high concentration of ions outside the cell in the context of cotransport?
Which of the following is an example of an electrogenic pump?
Which of the following is an example of an electrogenic pump?
Flashcards
Plasma membrane function
Plasma membrane function
Separates the cell from its surroundings, controlling traffic of substances in and out, and exhibiting selective permeability.
Phospholipids
Phospholipids
The most abundant lipid in the plasma membrane, an amphipathic molecule with both hydrophilic and hydrophobic regions.
Fluid Mosaic Model
Fluid Mosaic Model
A model describing the plasma membrane as a mosaic of proteins embedded in a fluid phospholipid bilayer.
Selective permeability
Selective permeability
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Membrane fluidity
Membrane fluidity
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Hydrophobic region
Hydrophobic region
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Hydrophilic region
Hydrophilic region
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Membrane proteins role
Membrane proteins role
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Cell-cell recognition
Cell-cell recognition
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Membrane carbohydrates
Membrane carbohydrates
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Cell recognition molecules
Cell recognition molecules
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Intercellular joining molecules
Intercellular joining molecules
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Gap junctions
Gap junctions
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Tight junctions
Tight junctions
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Cytoskeleton attachment
Cytoskeleton attachment
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Plasmolysis
Plasmolysis
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Passive Transport
Passive Transport
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Facilitated Diffusion
Facilitated Diffusion
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Transport Proteins
Transport Proteins
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Channel Protein
Channel Protein
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Aquaporins
Aquaporins
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Ion Channel
Ion Channel
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Gated Ion Channels
Gated Ion Channels
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Tonicity
Tonicity
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Isotonic solution
Isotonic solution
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Hypertonic solution
Hypertonic solution
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Hypotonic solution
Hypotonic solution
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What happens to an animal cell in a hypotonic solution?
What happens to an animal cell in a hypotonic solution?
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What happens to an animal cell in a hypertonic solution?
What happens to an animal cell in a hypertonic solution?
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What happens to a plant cell in a hypotonic solution?
What happens to a plant cell in a hypotonic solution?
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What happens to a plant cell in a hypertonic solution?
What happens to a plant cell in a hypertonic solution?
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Mechanically-gated channels
Mechanically-gated channels
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Cystic Fibrosis: Defective protein
Cystic Fibrosis: Defective protein
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Cystic Fibrosis: Mucus buildup
Cystic Fibrosis: Mucus buildup
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Cystinuria: Defective carrier protein
Cystinuria: Defective carrier protein
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Facilitated diffusion: Carrier proteins
Facilitated diffusion: Carrier proteins
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Carrier protein function
Carrier protein function
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Glucose transport: Carrier protein
Glucose transport: Carrier protein
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Cystinuria: Cystine buildup
Cystinuria: Cystine buildup
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Electrogenic Pump
Electrogenic Pump
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Sodium-Potassium Pump
Sodium-Potassium Pump
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Proton Pump
Proton Pump
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Cotransport
Cotransport
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H+ - sucrose cotransporter
H+ - sucrose cotransporter
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What does active transport require?
What does active transport require?
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Why do cells need active transport?
Why do cells need active transport?
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Study Notes
Plasma Membrane Transport
- Chapter 3 of BIO091, Semester 1, 2024/2025
- Learning outcomes:
- List components of plasma membrane and their function
- Describe plasma membrane structure and the functions of components
- Explain the role of membrane proteins
- Explain how membrane structure results in selective permeability
- Explain various transport mechanisms across the membrane
Membrane Components and Organization
- The plasma membrane separates the living cell from its surroundings.
- It controls traffic into and out of the cell
- It exhibits selective permeability.
- Phospholipids: The most abundant lipid in the plasma membrane, amphipathic (hydrophobic and hydrophilic regions).
Structure of Plasma Membrane - Fluid Mosaic Model
- Proposed by Singer and Nicolson in 1972.
- The membrane is a mosaic of proteins embedded in a fluid bilayer of phospholipids.
Membrane Proteins and Their Functions
- Peripheral proteins: Not embedded in the lipid bilayer, located on the inner or outer surface, usually bound to exposed regions of integral proteins through noncovalent interactions.
- Integral proteins: Penetrate the hydrophobic core; amphipathic proteins.
- Hydrophilic segments are non-helical in contact with intracellular and extracellular fluids.
- Hydrophobic segments are a-helical secondary structures or rolled-up B-pleated sheets).
- Six major functions of membrane proteins:
- Transport proteins
- Involved in enzymatic activity
- Involved in signal transduction processes
- Involved in cell-cell recognition
- As intercellular joining molecules
- Attach to the cytoskeleton and extracellular matrix (ECM)
Membrane Structure Results in Selective Permeability
- Small hydrophobic molecules: Can dissolve in the lipid bilayer and pass through it. (e.g., hydrocarbons, gases like CO2 and O2, and small polar but uncharged molecules like H2O and ethanol).
- Hydrophilic molecules: Cannot easily pass through the hydrophobic core of the membrane, and often require transport proteins. (e.g., large uncharged polar molecules like glucose, small ions such as H+, Na+ and K+).
- Transport Proteins: Allow movement of hydrophilic molecules or ions across the membrane.
- Channel proteins: Hydrophilic channels that specific molecules or ions use as tunnels.
- Aquaporins: Specific channel proteins that facilitate the passage of water.
- Ion channels: Non-gated (leak): Always open and responsible for permeability of specific types of ions.
- Gated: Open or close in response to stimulus (chemical, electrical or mechanical).
- Carrier proteins: Bind to molecules and change shape to pass them across the membrane, specific to the substance it moves.
- Channel proteins: Hydrophilic channels that specific molecules or ions use as tunnels.
Passive Transport
- Types of passive transports:
- Simple Diffusion
- Osmosis
- Facilitated Diffusion.
- Substances move down their concentration gradient without energy input.
Active Transport
- Movement of ions or molecules across the membrane against their concentration gradient (needs energy).
- Uses carrier proteins, requiring ATP.
- Types of active transport:
- Electrogenic pump: Transport protein that generates a voltage across a membrane (e.g sodium-potassium pump, proton pump).
- Cotransport: Two different solutes are transported simultaneously. One solute moves down its concentration gradient, providing the energy to move the other solute against its concentration gradient (e.g. H+-sucrose cotransporter, Na+-glucose cotransporter).
- Bulk transport:
- Endocytosis—movement of materials into the cell by forming vesicles. Examples include Phagocytosis, Pinocytosis, and receptor-mediated endocytosis.
- Exocytosis—movement of materials out of the cell by fusion of vesicles with the plasma membrane.
Diseases Related to Transport Proteins
- Cystic Fibrosis: Genetic disease causing defective or absent chloride channels, resulting in mucus buildup in various organs.
- Cystinuria: Inherited disease causing accumulation of cystine leading to crystals and stones blocking the kidneys, ureters, or bladder.
- Hypercholesterolemia: Disease related to defective or missing LDL receptor proteins causing cholesterol accumulation in the blood, contributing to early atherosclerosis.
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