Questions and Answers
What is the therapeutic class of ethosuximide?
What is the pharmacologic class of ethosuximide?
Succinimide
What is ethosuximide primarily used for?
To treat absence seizures
What precaution should be taken regarding the withdrawal of ethosuximide?
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How long does it take for ethosuximide to reach peak absorption?
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What are some adverse effects of ethosuximide?
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In which conditions should ethosuximide not be used?
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Ginkgo can reduce the therapeutic effectiveness of ethosuximide.
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What is the recommended treatment for an overdose of ethosuximide?
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Study Notes
Ethosuximide Overview
- Ethosuximide is classified as an anti-seizure drug and falls under the pharmacologic class of succinimides.
- Primarily used to treat absence seizures (petit mal seizures) in both adults and children, either alone or in conjunction with other medications.
Administration and Alerts
- Abrupt withdrawal can lead to the onset of tonic-clonic seizures; therefore, it is crucial to taper off the medication gradually.
- Categorized as pregnancy category C, indicating potential risks during pregnancy.
Pharmacokinetics
- Ethosuximide is absorbed via the gastrointestinal tract, with an onset time of approximately 4 hours; the peak and duration of action can vary.
Adverse Effects
- Patients should monitor and report any worsening symptoms such as mood changes, anxiety, depression, or thoughts of self-harm.
- Common adverse effects include stomach upset, mild nausea, diuresis, changes in weight, headache, dizziness, drowsiness, and issues with balance or coordination.
Contraindications
- Usage is not recommended for individuals with known hypersensitivity or severe liver and kidney disease.
Drug Interactions
- Ethosuximide may increase serum levels of phenytoin, which can lead to toxic effects.
- Co-administration with valproic acid may result in fluctuating serum levels, complicating therapeutic management.
Herbal and Food Interactions
- Ginkgo biloba may reduce the therapeutic effectiveness of ethosuximide, potentially compromising seizure control.
Overdose Treatment
- In the event of an overdose, induce emesis unless the patient is comatose.
- Other effective treatments include gastric lavage, activated charcoal, cathartics, or even hemodialysis to assist in eliminating ethosuximide from the system.
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Description
Test your knowledge about Ethosuximide, an important anti-seizure medication. These flashcards cover its therapeutic class, pharmacologic class, and actions in treating absence seizures. Perfect for students in pharmacology or medical studies.
