Questions and Answers
What is the drug class of Ethacrynic acid?
What action does Ethacrynic acid have?
Inhibits NaCl absorption in ascending limb of Henle
What are the uses of Ethacrynic acid?
Edema from HF, liver cirrhosis, renal disease, hypercalcemia; used when patient is allergic to sulfa.
Which assessments are important for Ethacrynic acid?
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How should Ethacrynic acid be administered?
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What is a common adverse drug reaction (ADR) of Ethacrynic acid?
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What are serious adverse drug reactions (ADRs) associated with Ethacrynic acid?
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Which drugs interact with Ethacrynic acid?
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Study Notes
Ethacrynic Acid Overview
- Ethacrynic acid is a non-sulfonamide loop diuretic, distinct from other diuretics that may contain sulfonamide components.
Mechanism of Action
- It inhibits sodium chloride (NaCl) absorption specifically in the ascending limb of the Loop of Henle, contributing to its diuretic effect.
Clinical Uses
- Prescribed for edema related to heart failure (HF), liver cirrhosis, renal disease, and hypercalcemia.
- Particularly beneficial for patients with a sulfa allergy unable to use other loop diuretics.
Patient Assessment
- Regular monitoring includes vital signs, lung sounds, weight, edema, electrolytes, liver function tests (LFTs), blood urea nitrogen (BUN), mental status, baseline glucose, and hearing ability.
Administration Guidelines
- Recommended to take ethacrynic acid with food to enhance absorption.
- Avoid dosing past mid-afternoon to prevent nocturia.
Common Adverse Drug Reactions (ADRs)
- Orthostatic hypotension is a frequent side effect, necessitating caution when changing positions.
Serious Adverse Drug Reactions (ADRs)
- Potential serious side effects include electrolyte imbalances, dehydration, hyperglycemia, dizziness, deafness, tinnitus, gastrointestinal bleeding, and diarrhea.
Drug Interactions
- Caution with concurrent use of non-steroidal anti-inflammatory drugs (NSAIDs), digoxin, and steroids due to potential interactions that may exacerbate side effects or reduce efficacy.
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Description
This quiz explores the essential aspects of ethacrynic acid, a unique loop diuretic. It covers its mechanism of action, clinical uses, patient assessment parameters, and administration guidelines, making it essential for healthcare professionals. Understand the critical elements surrounding this medication, especially for patients with sulfa allergies.
